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1. 发明申请

US20140336743A1 DEVICE FOR PERFORMING DIAGNOSTICS AND/OR THERAPY 审中-公开
标题翻译：用于执行诊断和/或治疗的设备
公开(公告)号：US20140336743A1
公开(公告)日：2014-11-13
申请号：US14361658
申请日：2012-11-30
申请人： Rainer ZOTZ
发明人： Rainer Zotz
IPC分类号： A61B5/00 , A61B5/145 , A61B5/055 , A61F2/04 , A61N7/00 , A61F2/82 , A61F2/95 , A61B5/0205 , A61B8/12
CPC分类号： A61B5/6869 , A61B5/02055 , A61B5/024 , A61B5/0402 , A61B5/0422 , A61B5/055 , A61B5/08 , A61B5/0816 , A61B5/1451 , A61B5/686 , A61B8/12 , A61B8/13 , A61B8/445 , A61B8/483 , A61B2017/00243 , A61B2017/2215 , A61B2090/374 , A61B2560/066 , A61F2/04 , A61F2/2481 , A61F2/82 , A61F2/95 , A61M1/106 , A61M1/1068 , A61M1/12 , A61M1/127 , A61M2205/058 , A61M2205/8243 , A61M2210/1014 , A61M2230/04 , A61M2230/50 , A61N7/00 , A61N2007/0043 , A61N2007/0078
摘要： The disclosure relates to a device for performing diagnostics and/or therapy and related kit, system, computer program, methods and computer readable mediums. The device of this disclosure has the advantages that the device does not need access to the pericardium and that the whole system including kit and device can be removed after diagnostics/therapy. A device for performing diagnostics and/or therapy of an organ in the thoracic cavity, comprising an organ support (10), which organ support (10) is devised to be arranged exterior to an organ, and comprises: a flexible structure (14), such as a fabric, net, coil, bag or mesh, which is configured to cover a region of the organ, the region comprising at least the surface at an apex of the organ; at least one actuator (16), such as a motor, for actuating a movement of the flexible structure (14) for the therapy, and optionally at least one transducer (18), is provided.
摘要翻译：本公开涉及用于执行诊断和/或治疗的装置和相关工具包，系统，计算机程序，方法和计算机可读介质。本公开的装置具有以下优点：该装置不需要进入心包，并且在诊断/治疗之后可以去除包括套件和装置的整个系统。一种用于执行胸腔器官的诊断和/或治疗的装置，包括器官支撑件（10），所述器官支撑件（10）被设计为布置在器官外部，并且包括：柔性结构（14），例如织物，网，线圈，袋或网，其被构造成覆盖器官的区域，所述区域至少包括器官顶端的表面; 提供了用于致动用于治疗的柔性结构（14）的运动的至少一个致动器（16），例如马达，以及可选地至少一个换能器（18）。

2. 发明申请

US20140296728A1 Method And System For Quantifying Timing Discrepancies Between Inspiratory Effort And Ventilatory Assist 审中-公开
标题翻译：用于量化呼吸作用与通气辅助之间时间差异的方法和系统
公开(公告)号：US20140296728A1
公开(公告)日：2014-10-02
申请号：US14355777
申请日：2012-11-16
申请人： St. Michael's Hosptial
发明人： Christer Sinderby , Norman Comtois , Jennifer Beck , Pär Emtell , Michael Kock
IPC分类号： A61M16/00 , A61B5/04 , A61B5/00 , A61B5/08
CPC分类号： A61M16/0051 , A61B5/04001 , A61B5/04884 , A61B5/08 , A61B5/0809 , A61B5/742 , A61M16/0069 , A61M16/021 , A61M2016/0021 , A61M2205/502 , A61M2210/1014 , A61M2230/40 , A61M2230/60
摘要： The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.
摘要翻译：本公开涉及一种用于量化吸气作用和通气辅助之间的时间差异的方法和系统。通过将神经吸引的开始时间与通气辅助的开始时间进行比较来确定触发误差。通过将神经吸引的结束时间与通气辅助的结束时间进行比较来确定循环关闭错误。当触发错误低于第一阈值并且循环关闭错误低于第二阈值时，通气辅助被同步。呼吸辅助的特征还可以是早期或晚期触发以及早期或晚期循环。呼吸机的触发器可以根据触发误差进行调整，并且可以根据循环关闭错误来调整呼吸机的循环。

3. 发明授权

US08551009B2 Method and system for determining dynamically respiratory features in spontaneously breathing patients receiving mechanical ventilatory assist 有权
标题翻译：用于确定自发呼吸患者接受机械通气辅助的动态呼吸特征的方法和系统
公开(公告)号：US08551009B2
公开(公告)日：2013-10-08
申请号：US12161373
申请日：2007-01-19
申请人： Christer Sinderby
发明人： Christer Sinderby
IPC分类号： A61B5/085
CPC分类号： A61B5/08 , A61M16/026 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2210/1014 , A61M2230/08 , A61M2230/42
摘要： A method for determining dynamically a respiratory feature in a spontaneously breathing patient receiving mechanical ventilatory assist comprises: modifying a level of mechanical ventilatory assist to the patient, measuring an airway pressure, detecting a change of gradient of the measured airway pressure and determining the respiratory feature based on the measured airway pressure upon detecting the change of gradient of the airway pressure. Furthermore, the method also comprises: measuring a respiratory neural drive of the patient and detecting a lowest level of the measured respiratory neural drive for determining the respiratory feature based on the detected lowest level of respiratory neural drive.
摘要翻译：用于动态地确定接受机械通气辅助的自发呼吸患者中的呼吸特征的方法包括：修改对患者的机械通气辅助水平，测量气道压力，检测所测量的气道压力的梯度变化并确定呼吸特征基于在检测到气道压力的梯度变化时测量的气道压力。此外，该方法还包括：测量患者的呼吸神经驱动，并且基于检测到的最低水平的呼吸神经驱动来检测测量的呼吸神经驱动器的最低水平以确定呼吸特征。

4. 发明授权

US08485980B2 Electrode positioning 有权
标题翻译：电极定位
公开(公告)号：US08485980B2
公开(公告)日：2013-07-16
申请号：US12239134
申请日：2008-09-26
申请人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
发明人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
IPC分类号： A61B5/08 , A61B5/042
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： In a method and device for positioning a linear array of electrodes mounted on a distal end section of an elongated flexible member in a patient's respiratory airways at the level of the patient's diaphragm, a length of the elongated flexible member pre-determined to position the linear array of electrodes at the level of the patient's diaphragm is inserted through the patient's respiratory airways. Signals representative of an electrical activity of the patient's diaphragm (EAdi) are detected through the electrodes of the linear array, a presence or absence of ECG signal components is detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways is detected in response to the presence or absence of the ECG signal components in the EAdi signals. Also, lower esophageal sphincter activity may be detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways determined in response to the detected lower esophageal sphincter. Finally, an end-expiratory occlusion of the patient's respiratory airways may be performed to verify that the electrical activity of the diaphragm coincides with a negative deflection of the patient's respiratory airways pressure again in view of determining adequate positioning of the linear array of electrodes.
摘要翻译：在用于定位安装在患者呼吸气道中的细长柔性构件的远端部分上的电极的线性阵列的方法和装置中，该患者的呼吸气道位于患者隔膜的水平面处，预定的细长柔性构件的长度定位成线性患者隔膜水平面上的电极阵列插入病人的呼吸道。通过线性阵列的电极检测代表患者隔膜（EADi）的电活动的信号，在EAdi信号中检测到ECG信号分量的存在或不存在，以及患者的电极线性阵列的位置响应EADi信号中ECG信号分量的存在或不存在来检测呼吸气道。此外，可以在EAdi信号中检测到较低的食管括约肌活动，并且响应于检测到的食管下括约肌确定患者呼吸气道中的电极线性阵列的位置。最后，考虑到确定电极的线性阵列的适当定位，可以执行患者呼吸气道的呼气末阻塞以验证隔膜的电活动与患者的呼吸气道压力的负偏转重合。

5. 发明申请

US20120000467A1 Ventilator-Initiated Prompt Regarding Auto-PEEP Detection During Volume Ventilation Of Triggering Patient Exhibiting Obstructive Component 失效
标题翻译：通气机启动关于自动PEEP检测的快速检测在触发患者体积通气期间阻塞性成分
公开(公告)号：US20120000467A1
公开(公告)日：2012-01-05
申请号：US12826828
申请日：2010-06-30
申请人： Gary Milne , Kirk Hensley , Peter R. Doyle , Gardner Kimm
发明人： Gary Milne , Kirk Hensley , Peter R. Doyle , Gardner Kimm
IPC分类号： A61M16/00 , G06F3/048
CPC分类号： A61M16/0063 , A61M16/0051 , A61M16/026 , A61M16/0833 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2205/502 , A61M2205/584 , A61M2210/1014 , A61M2230/20 , A61M2230/43
摘要： This disclosure describes systems and methods for monitoring and evaluating ventilatory parameters, analyzing those parameters and providing useful notifications and recommendations to clinicians. That is, modern ventilators monitor, evaluate, and graphically represent multiple ventilatory parameters. However, many clinicians may not easily recognize data patterns and correlations indicative of certain patient conditions, changes in patient condition, and/or effectiveness of ventilatory treatment. Further, clinicians may not readily determine appropriate ventilatory adjustments that may address certain patient conditions and/or the effectiveness of ventilatory treatment. Specifically, clinicians may not readily detect or recognize the presence of Auto-PEEP during volume ventilation of a triggering patient exhibiting an obstructive component. According to embodiments, a ventilator may be configured to monitor and evaluate diverse ventilatory parameters to detect Auto-PEEP and may issue notifications and recommendations suitable for a triggering patient to the clinician when Auto-PEEP is implicated. The suitable notifications and recommendations may further be provided in a hierarchical format.
摘要翻译：本公开描述了监测和评估通气参数的系统和方法，分析这些参数并向临床医生提供有用的通知和建议。也就是说，现代呼吸机监测，评估和图形化地表示多种通气参数。然而，许多临床医生可能不容易识别指示某些患者状况，患者状况变化和/或通气治疗有效性的数据模式和相关性。此外，临床医生可能不能容易地确定可以解决某些患者状况和/或通气治疗的有效性的适当的通气调节。具体来说，临床医生在展示阻塞性成分的触发患者的体积通气期间可能不容易地检测或识别Auto-PEEP的存在。根据实施例，呼吸机可以被配置为监测和评估各种通气参数以检测自动PEEP，并且当涉及自动PEEP时，可以发出适合于触发患者的通知和建议给临床医生。可以以分层格式进一步提供合适的通知和建议。

6. 发明申请

US20100228142A1 Method and System for Determining Dynamically Respiratory Features in Spontaneoulsy Breathing Patients Receiving Mechanical Ventilatory Assist 有权
标题翻译：用于确定接受机械通气辅助的呼吸呼吸器官动态呼吸特征的方法和系统
公开(公告)号：US20100228142A1
公开(公告)日：2010-09-09
申请号：US12161373
申请日：2007-01-19
申请人： Christer Sinderby
发明人： Christer Sinderby
IPC分类号： A61B5/085 , A61B5/08 , A61B5/11 , A61M16/00
CPC分类号： A61B5/08 , A61M16/026 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2210/1014 , A61M2230/08 , A61M2230/42
摘要： A method for determining dynamically a respiratory feature in a spontaneously breathing patient receiving mechanical ventilatory assist comprises: modifying a level of mechanical ventilatory assist to the patient, measuring an airway pressure, detecting a change of gradient of the measured airway pressure and determining the respiratory feature based on the measured airway pressure upon detecting the change of gradient of the airway pressure. Furthermore, the method also comprises: measuring a respiratory neural drive of the patient and detecting a lowest level of the measured respiratory neural drive for determining the respiratory feature based on the detected lowest level of respiratory neural drive.
摘要翻译：用于动态地确定接受机械通气辅助的自发呼吸患者中的呼吸特征的方法包括：修改对患者的机械通气辅助水平，测量气道压力，检测所测量的气道压力的梯度变化并确定呼吸特征基于在检测到气道压力的梯度变化时测量的气道压力。此外，该方法还包括：测量患者的呼吸神经驱动，并且基于检测到的最低水平的呼吸神经驱动来检测测量的呼吸神经驱动器的最低水平以确定呼吸特征。

7. 发明申请

US20100180896A1 CONTROL UNIT AND DISPLAY UNIT FOR AN EMG CONTROLLED VENTILATOR 有权
标题翻译：控制单元和EMG控制通风器的显示单元
公开(公告)号：US20100180896A1
公开(公告)日：2010-07-22
申请号：US12597642
申请日：2007-04-27
申请人： Karin Blomquist , Fredrik Jalde
发明人： Karin Blomquist , Fredrik Jalde
IPC分类号： A61M16/00
CPC分类号： A61B5/04884 , A61B5/06 , A61B5/065 , A61M16/0051 , A61M16/024 , A61M16/12 , A61M2205/3331 , A61M2205/502 , A61M2205/584 , A61M2210/1014 , A61M2210/105 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： A control unit for controlling a ventilator that provides EMG controlled ventilation to a patient receives EMG signals from an esophageal catheter inserted into the patient and selects, dependent on the EMG signal, at least one signal for controlling the ventilator. A user interface unit operates by the control unit indicates the position of the catheter relative to the patient's diaphragm based on the selected signal. The position information may be presented in relation to signal curves representing the catheter signal or as an elongate vertical shape representing the catheter, the display unit being operated to indicate on the elongate vertical shape the position of the diaphragm.
摘要翻译：用于控制向患者提供EMG控制的通气的呼吸机的控制单元从插入患者的食管导管接收EMG信号，并根据EMG信号选择用于控制呼吸机的至少一个信号。控制单元操作的用户接口单元基于所选择的信号指示导管相对于患者隔膜的位置。位置信息可以关于代表导管信号的信号曲线或作为表示导管的细长垂直形状来呈现，显示单元被操作以在细长的垂直形状上指示隔膜的位置。

8. 发明申请

US20090137911A1 Electrode Positioning 有权
标题翻译：电极定位
公开(公告)号：US20090137911A1
公开(公告)日：2009-05-28
申请号：US12239134
申请日：2008-09-26
申请人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
发明人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
IPC分类号： A61B18/00 , A61B5/02
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： In a method and device for positioning a linear array of electrodes mounted on a distal end section of an elongated flexible member in a patient's respiratory airways at the level of the patient's diaphragm, a length of the elongated flexible member pre-determined to position the linear array of electrodes at the level of the patient's diaphragm is inserted through the patient's respiratory airways. Signals representative of an electrical activity of the patient's diaphragm (EAdi) are detected through the electrodes of the linear array, a presence or absence of ECG signal components is detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways is detected in response to the presence or absence of the ECG signal components in the EAdi signals. Also, lower esophageal sphincter activity may be detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways determined in response to the detected lower esophageal sphincter. Finally, an end-expiratory occlusion of the patient's respiratory airways may be performed to verify that the electrical activity of the diaphragm coincides with a negative deflection of the patient's respiratory airways pressure again in view of determining adequate positioning of the linear array of electrodes.
摘要翻译：在用于定位安装在患者呼吸气道中的细长柔性构件的远端部分上的电极的线性阵列的方法和装置中，该患者的呼吸气道位于患者隔膜的水平面处，预定的细长柔性构件的长度定位成线性患者隔膜水平面上的电极阵列插入病人的呼吸道。通过线性阵列的电极检测代表患者隔膜（EADi）的电活动的信号，在EAdi信号中检测到ECG信号分量的存在或不存在，以及患者的电极线性阵列的位置响应EADi信号中ECG信号分量的存在或不存在来检测呼吸气道。此外，可以在EAdi信号中检测到较低的食管括约肌活动，并且响应于检测到的食管下括约肌确定患者呼吸气道中的电极线性阵列的位置。最后，考虑到确定电极的线性阵列的适当定位，可以执行患者呼吸气道的呼气末阻塞以验证隔膜的电活动与患者的呼吸气道压力的负偏转重合。

9. 发明授权

US06411843B1 Method and apparatus for producing a model EMG signal from a measured EMG signal 有权
标题翻译：用于从测量的EMG信号产生模型EMG信号的方法和装置
公开(公告)号：US06411843B1
公开(公告)日：2002-06-25
申请号：US09567795
申请日：2000-05-09
申请人： Jaroslaw Zarychta
发明人： Jaroslaw Zarychta
IPC分类号： A61B504
CPC分类号： A61B5/0488 , A61M16/024 , A61M2210/1014 , A61M2230/04 , A61M2230/08 , A61M2230/60
摘要： A model EMG signal is produced from a measured EMG signal that includes a patient's EMG signal and ECG signal by processing the measured EMG signal to produce a logic signal that is in a first binary state in the absence of a P wave, a QRS complex and a T wave of an ECG cycle of the measured EMG signal and that is in a second binary state during at least one of the P wave, the QRS complex and the T wave of the ECG cycle. The measured EMG signal is processed to produce a first envelope signal. The model EMG signal is produced as a function of the first envelope signal when the logic signal is in the first binary state and the absence of the first envelope signal when the logic signal is in the second binary state.
摘要翻译：通过处理所测量的EMG信号，产生一个逻辑信号，该测量的EMG信号包括患者的EMG信号和ECG信号，以产生在不存在P波，QRS波段的情况下处于第一二进制状态的逻辑信号，测量的EMG信号的ECG周期的T波，并且在ECG周期的P波，QRS波形和T波中的至少一个期间处于第二二进制状态。所测量的EMG信号被处理以产生第一包络信号。当逻辑信号处于第一二进制状态并且当逻辑信号处于第二二进制状态时，不存在第一包络信号，产生作为第一包络信号的函数的模型EMG信号。

10. 发明授权

US5820560A Inspiratory proportional pressure assist ventilation controlled by a diaphragm electromyographic signal 失效
标题翻译：吸气比例压力辅助通气由隔膜肌电信号控制
公开(公告)号：US5820560A
公开(公告)日：1998-10-13
申请号：US848295
申请日：1997-04-29
申请人： Christer Sinderby , Alejandro Grassino , Sven Friberg , Lars Lindstrom
发明人： Christer Sinderby , Alejandro Grassino , Sven Friberg , Lars Lindstrom
IPC分类号： A61B5/0488 , A61M16/00 , A61M16/20 , A61B5/04
CPC分类号： A61B5/04884 , A61M16/00 , A61M16/202 , A61M2016/0021 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： To control a lung ventilator comprising an inspiratory implement to be worn by the patient, an air supply system for supplying air to the inspiratory implement, and a control unit for controlling the air supply system, electromyographic signals produced by the patient's diaphragm are detected by an array of electrodes passing through the center of the patient's diaphragm depolarizing region. The position of the center of the patient's diaphragm depolarizing region is determined through detection of a reversal of polarity of the electromyographic component of the electrode-detected electromyographic signals. First and second electromyographic signals detected by the electrodes of the array on opposite sides of the patient's diaphragm depolarizing region are subtracted from each other, this subtraction cancelling the noise components of the first and second electromyographic signals but adding the respective electromyographic components of these first and second signals together to produce an electromyographic signal having an improved signal-to-noise ratio, having a reduced electrode-position-induced filter effect, and being representative of a demand to inspire from the patient's brain. The electromyographic signal of improved signal-to-noise ratio is finally supplied as input signal to the control unit of the lung ventilator for controlling the air supply system and therefore the inspiration assist in relation to the electromyographic signal of improved signal-to-noise ratio and of reduced electrode-position-induced filter effect, and therefore in relation to the demand to inspire from the patient's brain.
摘要翻译：为了控制包括由患者佩戴的吸气器具的肺呼吸机，用于向吸气器具供应空气的空气供应系统和用于控制空气供应系统的控制单元，由患者隔膜产生的肌电信号由穿过患者隔膜去极化区域的中心的电极阵列。通过检测电极检测肌电信号的肌电分量的极性的反转来确定患者隔膜去极化区域的中心位置。在患者的隔膜去极化区域的相对侧上由阵列的电极检测到的第一和第二肌电信号相减，该减法消除第一和第二肌电信号的噪声分量，但是将这些第一和第二肌电信号的各个肌电分量加到第二信号在一起以产生具有改善的信噪比的肌电信号，具有降低的电极位置诱导的滤波效应，并且代表从患者的大脑启发的需求。改进的信噪比的肌电信号最终作为输入信号提供给肺呼吸机的控制单元，用于控制供气系统，因此与提高信噪比的肌电信号相关的吸气辅助并且减少电极位置诱导的过滤效应，因此与从患者脑部激发的需求相关。

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