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1. 发明授权

US08527036B2 Catheter positioning method and computerized control unit for implementing the method 有权
标题翻译：导管定位方法和计算机控制单元实现该方法
公开(公告)号：US08527036B2
公开(公告)日：2013-09-03
申请号：US12238938
申请日：2008-09-26
申请人： Fredrik Jalde , Joachim Saellvin , Christer Sinderby
发明人： Fredrik Jalde , Joachim Saellvin , Christer Sinderby
IPC分类号： A61B5/04 , A61M16/00
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： A control unit for a ventilator is arranged to receive, from each of a number of electrode pairs on an esophageal catheter a bioelectric signal having an ECG component. The control unit has a calculating unit that determines the ECG component of each of the bioelectric signals and a position unit that determines the position of the catheter in relation to the patient's diaphragm based on a comparison the amplitudes of ECG components of the bioelectric signals.
摘要翻译：用于呼吸机的控制单元布置成从食管导管上的多个电极对中的每一个接收具有ECG分量的生物电信号。控制单元具有计算单元，其基于比较生物电信号的ECG分量的幅度，确定每个生物电信号的ECG分量和确定导管相对于患者隔膜的位置的位置单元。

2. 发明申请

US20090084382A1 CATHETER POSITIONING METHOD AND COMPUTERIZED CONTROL UNIT FOR IMPLEMENTING THE METHOD 有权
标题翻译：导线定位方法和实现方法的计算机控制单元
公开(公告)号：US20090084382A1
公开(公告)日：2009-04-02
申请号：US12238938
申请日：2008-09-26
申请人： Fredrik Jalde , Joachim Saellvin , Christer Sinderby
发明人： Fredrik Jalde , Joachim Saellvin , Christer Sinderby
IPC分类号： A61M16/00
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： A control unit for a ventilator is arranged to receive, from each of a number of electrode pairs on an esophageal catheter a bioelectric signal having an ECG component. The control unit has a calculating unit that determines the ECG component of each of the bioelectric signals and a position unit that determines the position of the catheter in relation to the patient's diaphragm based on a comparison the amplitudes of ECG components of the bioelectric signals.
摘要翻译：用于呼吸机的控制单元布置成从食管导管上的多个电极对中的每一个接收具有ECG分量的生物电信号。控制单元具有计算单元，其基于比较生物电信号的ECG分量的幅度，确定每个生物电信号的ECG分量和确定导管相对于患者隔膜的位置的位置单元。

3. 发明授权

US08485980B2 Electrode positioning 有权
标题翻译：电极定位
公开(公告)号：US08485980B2
公开(公告)日：2013-07-16
申请号：US12239134
申请日：2008-09-26
申请人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
发明人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
IPC分类号： A61B5/08 , A61B5/042
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： In a method and device for positioning a linear array of electrodes mounted on a distal end section of an elongated flexible member in a patient's respiratory airways at the level of the patient's diaphragm, a length of the elongated flexible member pre-determined to position the linear array of electrodes at the level of the patient's diaphragm is inserted through the patient's respiratory airways. Signals representative of an electrical activity of the patient's diaphragm (EAdi) are detected through the electrodes of the linear array, a presence or absence of ECG signal components is detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways is detected in response to the presence or absence of the ECG signal components in the EAdi signals. Also, lower esophageal sphincter activity may be detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways determined in response to the detected lower esophageal sphincter. Finally, an end-expiratory occlusion of the patient's respiratory airways may be performed to verify that the electrical activity of the diaphragm coincides with a negative deflection of the patient's respiratory airways pressure again in view of determining adequate positioning of the linear array of electrodes.
摘要翻译：在用于定位安装在患者呼吸气道中的细长柔性构件的远端部分上的电极的线性阵列的方法和装置中，该患者的呼吸气道位于患者隔膜的水平面处，预定的细长柔性构件的长度定位成线性患者隔膜水平面上的电极阵列插入病人的呼吸道。通过线性阵列的电极检测代表患者隔膜（EADi）的电活动的信号，在EAdi信号中检测到ECG信号分量的存在或不存在，以及患者的电极线性阵列的位置响应EADi信号中ECG信号分量的存在或不存在来检测呼吸气道。此外，可以在EAdi信号中检测到较低的食管括约肌活动，并且响应于检测到的食管下括约肌确定患者呼吸气道中的电极线性阵列的位置。最后，考虑到确定电极的线性阵列的适当定位，可以执行患者呼吸气道的呼气末阻塞以验证隔膜的电活动与患者的呼吸气道压力的负偏转重合。

4. 发明申请

US20090137911A1 Electrode Positioning 有权
标题翻译：电极定位
公开(公告)号：US20090137911A1
公开(公告)日：2009-05-28
申请号：US12239134
申请日：2008-09-26
申请人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
发明人： Christer Sinderby , Jennifer Beck , Fredrik Jalde , Joachim Sallvin
IPC分类号： A61B18/00 , A61B5/02
CPC分类号： A61B5/08 , A61B5/0421 , A61B5/0488 , A61M16/00 , A61M16/024 , A61M2016/0021 , A61M2202/0208 , A61M2210/1014 , A61M2210/105 , A61M2230/04 , A61M2230/08 , A61M2230/60 , A61M2230/005
摘要： In a method and device for positioning a linear array of electrodes mounted on a distal end section of an elongated flexible member in a patient's respiratory airways at the level of the patient's diaphragm, a length of the elongated flexible member pre-determined to position the linear array of electrodes at the level of the patient's diaphragm is inserted through the patient's respiratory airways. Signals representative of an electrical activity of the patient's diaphragm (EAdi) are detected through the electrodes of the linear array, a presence or absence of ECG signal components is detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways is detected in response to the presence or absence of the ECG signal components in the EAdi signals. Also, lower esophageal sphincter activity may be detected in the EAdi signals, and the position of the linear array of electrodes in the patient's respiratory airways determined in response to the detected lower esophageal sphincter. Finally, an end-expiratory occlusion of the patient's respiratory airways may be performed to verify that the electrical activity of the diaphragm coincides with a negative deflection of the patient's respiratory airways pressure again in view of determining adequate positioning of the linear array of electrodes.
摘要翻译：在用于定位安装在患者呼吸气道中的细长柔性构件的远端部分上的电极的线性阵列的方法和装置中，该患者的呼吸气道位于患者隔膜的水平面处，预定的细长柔性构件的长度定位成线性患者隔膜水平面上的电极阵列插入病人的呼吸道。通过线性阵列的电极检测代表患者隔膜（EADi）的电活动的信号，在EAdi信号中检测到ECG信号分量的存在或不存在，以及患者的电极线性阵列的位置响应EADi信号中ECG信号分量的存在或不存在来检测呼吸气道。此外，可以在EAdi信号中检测到较低的食管括约肌活动，并且响应于检测到的食管下括约肌确定患者呼吸气道中的电极线性阵列的位置。最后，考虑到确定电极的线性阵列的适当定位，可以执行患者呼吸气道的呼气末阻塞以验证隔膜的电活动与患者的呼吸气道压力的负偏转重合。

5. 发明授权

US08256419B2 Method and device using myoelectrical activity for optimizing a patient's ventilatory assist 有权
标题翻译：使用肌电活动来优化患者通气辅助的方法和装置
公开(公告)号：US08256419B2
公开(公告)日：2012-09-04
申请号：US10589385
申请日：2005-02-18
申请人： Christer Sinderby , Jennifer Beck , Jadranka Spahija , Lars Lindstrom
发明人： Christer Sinderby , Jennifer Beck , Jadranka Spahija , Lars Lindstrom
IPC分类号： A61M11/00
CPC分类号： A61B5/6853 , A61B5/037 , A61B5/0488 , A61B5/0492 , A61M16/026 , A61M2016/0036 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： The present invention relates to a method and device for determining a level of ventilatory assist to a ventilator-dependent patient, in which a critical threshold of a respiration-related feature is calculated. Fatigue of a respiratory muscle of the ventilator-dependent patient develops when the critical threshold is reached by the respiration-related feature. The level of ventilatory assist to the ventilator-dependent patient is controlled in relation to the critical threshold of the respiration-related feature so as to prevent fatigue of the patient's respiratory muscle.
摘要翻译：本发明涉及一种用于确定通气机构依赖患者的通气辅助水平的方法和装置，其中计算呼吸相关特征的临界阈值。当与呼吸机相关的特征达到临界阈值时，依赖呼吸机的患者的呼吸肌肉的疲劳发展。相对于呼吸相关特征的临界阈值控制对通气机相关患者的通气辅助水平，以防止患者呼吸肌的疲劳。

6. 发明申请

US20120006327A1 Method and Device for Determining a Level of Ventilatory Assist to a Patient 有权
标题翻译：用于确定患者通气辅助水平的方法和装置
公开(公告)号：US20120006327A1
公开(公告)日：2012-01-12
申请号：US13144129
申请日：2010-01-14
申请人： Christer Sinderby , Jennifer Beck
发明人： Christer Sinderby , Jennifer Beck
IPC分类号： A61M16/00
CPC分类号： A61M16/0051 , A61B5/0488 , A61B5/08 , A61M16/026 , A61M2016/0027
摘要： A method and device for determining a level of ventilatory assist to be delivered to a patient by a mechanical ventilator in response to a measure of a patient's neural respiratory drive multiplied by an amplification factor, wherein an existing predicted ventilatory assist pressure is calculated and an existing resulting pressure delivered to the patient by the mechanical ventilator is measured. The amplification factor is changed from an existing amplification factor to a new amplification factor, a new predicted ventilatory assist pressure is calculated using the new amplification factor, and a new resulting pressure delivered to the patient by the mechanical ventilator after the amplification factor has been changed is measured. The new and existing predicted ventilatory assist pressures are compared to determine an anticipated change in pressure that will be delivered to the patient, and the new and existing resulting pressures are compared to determine an actual change in pressure delivered to the patient by the mechanical ventilator. The anticipated and actual changes in pressure are compared and a decision to increase, maintain or decrease the amplification factor is delivered in response to the comparison between the anticipated change and the actual change in pressure.
摘要翻译：一种方法和装置，用于响应于患者的神经呼吸驱动器的乘积乘以放大系数来确定由机械呼吸机传送给患者的通气辅助水平，其中计算现有预测的通气辅助压力并存在现有的测量由机械呼吸机输送给病人的压力。放大因子从现有的放大因子改变为新的放大因子，使用新的放大因子计算新的预测的通气辅助压力，并且在放大因子被改变之后由机械呼吸机传递给患者的新的所得压力被测量。比较新的和现有的预测的通气辅助压力以确定将被递送给患者的预期压力变化，并且比较新的和现有的所得压力，以确定由机械呼吸机传递给患者的压力的实际变化。比较压力的预期和实际变化，并响应于预期变化与实际压力变化之间的比较来提供增加，维持或降低放大系数的决定。

7. 发明授权

US07661427B2 Proportional pressure assist ventilation controlled by a diaphragm electromyographic signal 有权
标题翻译：比例压力辅助通气由隔膜肌电信号控制
公开(公告)号：US07661427B2
公开(公告)日：2010-02-16
申请号：US10405291
申请日：2003-04-02
申请人： Christer Sinderby , Jennifer Beck
发明人： Christer Sinderby , Jennifer Beck
IPC分类号： A61B5/04 , F16K31/02
CPC分类号： A61B5/0492 , A61M16/0051 , A61M16/026 , A61M2210/1014 , A61M2230/08 , A61M2230/60 , Y10S128/925
摘要： A closed loop system uses (a) the intensity of the diaphragm electromyogram (EMG) for a given inspiratory volume; (b) the inspiratory volume for a given EMG intensity; or (c) a combination of (a) and (b); in view of controlling the level of gas flow, gas volume or gas pressure delivered by a mechanical (lung) ventilator. The closed loop ventilator system enables for automatic or manual adjustment of the level of inspiratory support in proportion to changes in the neuro-ventilatory efficiency such that the neural drive remains stable at a desired target level. An alarm can also be used to detect changes in neuroventilatory efficiency in view of performing manual adjustments.
摘要翻译：闭环系统使用（a）给定吸气体积的隔膜肌电图（EMG）的强度; （b）给定EMG强度的吸气量; 或（c）（a）和（b）的组合; 考虑到控制由机械（肺）通气机输送的气体流量，气体体积或气体压力的水平。闭环呼吸机系统能够与神经通气效率的变化成比例地自动或手动地调整吸气支持水平，使得神经驱动器保持稳定在期望的目标水平。鉴于执行手动调整，报警器也可用于检测神经病效率的变化。

8. 发明授权

US07021310B1 Proportional pressure assist ventilation controlled by a diaphragm electromyographic signal 有权
公开(公告)号：US07021310B1
公开(公告)日：2006-04-04
申请号：US09701824
申请日：1999-06-04
申请人： Christer Sinderby , Jennifer Beck
发明人： Christer Sinderby , Jennifer Beck
IPC分类号： A61M16/00 , A62B7/00 , F16K31/02
CPC分类号： A61B5/0492 , A61M16/0051 , A61M16/026 , A61M2210/1014 , A61M2230/08 , A61M2230/60 , Y10S128/925
摘要： A closed loop system uses (a) the intensity of the diaphragm electromyogram (EMG) for a given inspiratory volume; (b) the inspiratory volume for a given EMG intensity; or (c) a combination of (a) and (b); in view of controlling the level of gas flow, gas volume or gas pressure delivered by a mechanical (lung) ventilator. The closed loop ventilator system enables for automatic or manual adjustment of the level of inspiratory support in proportion to changes in the neuro-ventilatory efficiency such that the neural drive remains stable at a desired target level. An alarm can also be used to detect changes in neuroventilatory efficiency in view of performing manual adjustments.

9. 发明申请

US20060060190A1 Target drive ventilation gain controller and method 审中-公开
标题翻译：目标驱动通风增益控制器和方法
公开(公告)号：US20060060190A1
公开(公告)日：2006-03-23
申请号：US11268117
申请日：2005-11-07
申请人： Christer Sinderby
发明人： Christer Sinderby
IPC分类号： A61M11/00 , A61M16/00
CPC分类号： A61N1/05 , A61M16/026 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： A gain controller and method for controlling the value of a gain is used in conjunction with an electrode array for detecting a signal representative of respiratory drive output of a patient during inspiration, and a lung ventilator for assisting inspiration of the patient. The gain controller comprises an input for receiving the signal representative of respiratory drive output; a comparator for determining whether the signal representative of respiratory drive output is higher or lower than a target drive signal; and a gain adjustment unit for increasing the value of a gain when the amplitude of the signal representative of respiratory drive output is higher than the amplitude of the target drive signal and for decreasing the value of this gain when the amplitude of the signal representative of respiratory drive output is lower than the amplitude of the target drive signal. The gain is applied to the signal representative of respiratory drive output to produce an amplified respiratory drive output representative signal used for controlling the lung ventilator. The advantage of target drive ventilation is that this mode of ventilation does not depend on pressure, flow or volume measurements. A leaky ventilatory line will introduce a change in respiratory drive which will change the ventilatory assist in order to return the respiratory drive to its target level. Also, changes in the patient's metabolic or patho-physiological status which result in altered respiratory drive will be compensated.
摘要翻译：用于控制增益值的增益控制器和方法与用于在吸气期间检测代表患者的呼吸驱动输出的信号的电极阵列结合使用，以及用于辅助患者的吸气的肺呼吸机。增益控制器包括用于接收代表呼吸驱动输出的信号的输入端; 用于确定代表呼吸驱动输出的信号是否高于或低于目标驱动信号的比较器; 以及增益调整单元，用于当表示呼吸驱动输出的信号的幅度高于目标驱动信号的幅度时增加增益的值，并且当表示呼吸的信号的幅度时减小该增益的值驱动输出低于目标驱动信号的幅度。增益被应用于代表呼吸驱动输出的信号，以产生用于控制肺呼吸机的放大的呼吸驱动输出代表信号。目标驱动器通风的优点在于这种通风方式不依赖于压力，流量或体积测量。泄漏的通气线将引入呼吸驱动器的变化，这将改变通气辅助以使呼吸驱动器返回到其目标水平。此外，患者代谢或病理生理状态的变化导致呼吸道传播改变将得到补偿。

10. 发明授权

US09968750B2 Method and system for patient-synchronized ventilatory assist with endotracheal through-flow 有权
公开(公告)号：US09968750B2
公开(公告)日：2018-05-15
申请号：US13806816
申请日：2011-06-29
申请人： Christer Sinderby , Jennifer Beck
发明人： Christer Sinderby , Jennifer Beck
IPC分类号： A61M16/00 , A61M16/04 , A61M16/10 , A61M16/12 , A61M16/16 , A61M16/20 , A61B5/0488 , A61B5/087 , A61B5/00
CPC分类号： A61M16/0003 , A61B5/0488 , A61B5/087 , A61B5/4836 , A61M16/00 , A61M16/0012 , A61M16/0051 , A61M16/0069 , A61M16/024 , A61M16/04 , A61M16/042 , A61M16/0486 , A61M16/1005 , A61M16/12 , A61M16/125 , A61M16/16 , A61M16/161 , A61M16/202 , A61M16/205 , A61M2016/0018 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2202/0208 , A61M2210/1014 , A61M2230/08 , A61M2230/60
摘要： A ventilatory assist system and method are disclosed. The system comprises a tube for connection to a patient's airway, inspiratory and expiratory tube lumens connected to the tube, an inspiratory air source connected to the inspiration tube lumen, and a controller of air pressure in the expiratory tube lumen. The pressure controller is responsive to a physiological breathing signal representative of patient's inspiratory effort to allow air flow through the expiratory tube lumen during a patient's expiration phase, partially restricting the air flow through the expiratory tube lumen to a so minimum air flow during a patient's inspiration phase. During both respiratory phases, a unidirectional air flow is produced through the inspiratory and expiratory tube lumens to prevent air expired by the patient from being breathed again. The physiological breathing signal allows synchronization of the ventilatory assist with breathing efforts of the patient.

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