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31. 发明授权

US5615673A Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes 失效
标题翻译：用于分析血气和分析物的拉曼光谱仪的装置和方法
公开(公告)号：US5615673A
公开(公告)日：1997-04-01
申请号：US410927
申请日：1995-03-27
申请人： Andrew J. Berger , James F. Brennan, III , Ramanchandra R. Dasari , Michael S. Feld , Irving Itzkan , Kaz Tanaka , Yang Wang
发明人： Andrew J. Berger , James F. Brennan, III , Ramanchandra R. Dasari , Michael S. Feld , Irving Itzkan , Kaz Tanaka , Yang Wang
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1459 , G01N21/65
CPC分类号： G01J3/02 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , G01J3/021 , G01J3/0221 , G01N21/65 , A61B2562/12 , G01N2021/656
摘要： The present invention relates to systems of methods of measuring selected analytes in blood and tissue using Raman spectroscopy to aid in diagnosis. More particularly, Raman spectra are collected and analyzed to measure the concentration of dissolved gases and other analytes of interest in blood. Methods include in vivo transdermal and continuous monitoring as well as in vitro blood analysis.
摘要翻译：本发明涉及使用拉曼光谱法测量血液和组织中选定分析物以辅助诊断的方法的系统。更具体地，收集和分析拉曼光谱，以测量溶解气体和其他有关血液中分析物的浓度。方法包括体内透皮和连续监测以及体外血液分析。

32. 发明授权

US5452723A Calibrated spectrographic imaging 失效
标题翻译：校准的光谱成像
公开(公告)号：US5452723A
公开(公告)日：1995-09-26
申请号：US920135
申请日：1992-07-24
申请人： Jun Wu , Michael S. Feld , Richard P. Rava , Firooz Partovi
发明人： Jun Wu , Michael S. Feld , Richard P. Rava , Firooz Partovi
IPC分类号： A61B5/00 , G01N21/49 , G01N21/64 , A61B6/00
CPC分类号： G01N21/6486 , A61B5/0059 , G01N21/49 , G01N21/65 , A61B2562/146
摘要： The present application is directed to the use of photon migration analysis to provide a method of analyzing the diffuse reflectance, fluorescence, Raman or other types of spectra obtained from tissue. This procedure provides a means for processing spectral data such that the distortion in fluorescence spectra, for example, caused by the interplay of a variety of factors such as scattering, absorption, geometry and boundary conditions, can be precisely removed simply by measuring the diffuse reflectance spectrum as well as a second selected spectrum, such as fluorescence, and adjust the spectrum with the reflectance spectrum as described herein. By this procedure, the sample-to-sample variability is minimized. The intrinsic spectrum extracted by this procedure can be easily deconvoluted and provide quantitative information about the physicochemical composition of tissue. Analytical procedures for clinical diagnosis have been developed based on this method.
摘要翻译：本申请涉及使用光子迁移分析来提供从组织获得的漫反射，荧光，拉曼或其它类型的光谱的分析方法。该过程提供了处理光谱数据的手段，使得例如由诸如散射，吸收，几何和边界条件等各种因素的相互作用引起的荧光光谱的失真可以通过简单地通过测量漫反射光谱以及第二选定的光谱，例如荧光，并且如本文所述用反射光谱调节光谱。通过这个过程，样品到样品的变异性最小化。通过该方法提取的固有光谱可以容易地去卷积，并提供关于组织的物理化学组成的定量信息。基于此方法开发了临床诊断分析手段。

33. 发明申请

US20100094135A1 SYSTEMS AND METHODS FOR PHASE MEASUREMENTS 有权
标题翻译：用于相位测量的系统和方法
公开(公告)号：US20100094135A1
公开(公告)日：2010-04-15
申请号：US12494605
申请日：2009-06-30
申请人： Christopher M. Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra R. Dasari , Michael S. Feld
发明人： Christopher M. Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra R. Dasari , Michael S. Feld
IPC分类号： A61B6/00 , G01B9/02 , A61B3/10
CPC分类号： G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
摘要翻译：本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。实施例涉及用于用光成像小生物物体的光学装置。这些实施方案可以应用于例如细胞生理学和神经科学领域。这些优选实施例基于相位测量和成像技术的原理。使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生在本发明的系统中。

34. 发明申请

US20090125242A1 Tomographic phase microscopy 有权
标题翻译：断层相显微镜
公开(公告)号：US20090125242A1
公开(公告)日：2009-05-14
申请号：US12218029
申请日：2008-07-10
申请人： Wonshik Choi , Ramachandra Rao Dasari , Christopher M. Fang-Yen , Michael S. Feld
发明人： Wonshik Choi , Ramachandra Rao Dasari , Christopher M. Fang-Yen , Michael S. Feld
IPC分类号： G01N33/48 , G01N21/41
CPC分类号： G01N21/45 , G01N21/51 , G01N21/6458 , G01N21/6486 , G01N2021/458 , G01N2201/061 , G01N2201/105 , G01N2201/12
摘要： The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.
摘要翻译：本发明涉及使用具有可变照明角度的移相激光干涉显微镜在生活或非活细胞，组织或生物体中定量三维映射折射率的系统和方法。优选的实施方案提供细胞和多细胞生物的层析成像，以及在组织光散射中具有多种应用的高分辨率显微镜中细胞结构的时间依赖性变化和样品诱导的像差的定量表征。

35. 发明授权

US07235045B2 Fluorescence imaging endoscope 失效
标题翻译：荧光成像内窥镜
公开(公告)号：US07235045B2
公开(公告)日：2007-06-26
申请号：US10393028
申请日：2003-03-20
申请人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
发明人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
IPC分类号： A61B1/04 , A61B1/06
CPC分类号： G01J3/4406 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0232 , G01J3/10 , G01N21/6456 , G01N2021/6417 , G01N2021/6421 , G01N2021/6484
摘要： An endoscope having an optical guide that is optically coupled to a first broadband light source and a second laser light source that emits light at a wavelength in a range of 350 nm to 420 nm. The endoscope has an image sensor at a distal end and collects a reflectance image including red, green and blue components with the image sensor in response to illumination by said broadband light source. The image sensor also collects an autofluorescence image having a blue component, a green component and a red component. A processor processes the fluorescence image by determining a ratio of the fluorescence image and the reflectance image to provide a processed fluorescence image.
摘要翻译：一种具有与第一宽带光源光学耦合的光导的内窥镜和发射在350nm至420nm范围内的波长的光的第二激光光源。内窥镜在远端具有图像传感器，并响应于所述宽带光源的照明，利用图像传感器收集包括红色，绿色和蓝色分量的反射图像。图像传感器还收集具有蓝色分量，绿色分量和红色分量的自发荧光图像。处理器通过确定荧光图像和反射率图像的比例来处理荧光图像以提供经处理的荧光图像。

36. 发明授权

US06847456B2 Methods and systems using field-based light scattering spectroscopy 有权
标题翻译：使用基于场的光散射光谱的方法和系统
公开(公告)号：US06847456B2
公开(公告)日：2005-01-25
申请号：US09844286
申请日：2001-04-27
申请人： Changhuei Yang , Adam P. Wax , Lev T. Perelman , Ramachandra R. Dasari , Michael S. Feld
发明人： Changhuei Yang , Adam P. Wax , Lev T. Perelman , Ramachandra R. Dasari , Michael S. Feld
IPC分类号： G01B9/02 , A61B5/00 , G01N21/17 , G01N21/27 , G01N21/45 , G01N21/47
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , G01N21/45
摘要： The present invention relates to systems and methods of field-based light scattering spectroscopy. These systems and methods provide for the diagnosis of tissue by measuring the size and distribution of cellular characteristics. Field based measurements provide phase information resulting from the interaction of scatterers within the material and the incident wavefront. These measurements can be used to provide three dimensional images of tissue.
摘要翻译：本发明涉及基于场的光散射光谱的系统和方法。这些系统和方法通过测量细胞特征的大小和分布来提供对组织的诊断。基于场的测量提供由材料内的散射体与入射波前的相互作用产生的相位信息。这些测量可用于提供组织的三维图像。

37. 发明授权

US06537211B1 Flourescence imaging endoscope 失效
标题翻译：荧光成像内窥镜
公开(公告)号：US06537211B1
公开(公告)日：2003-03-25
申请号：US09238664
申请日：1999-01-26
申请人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
发明人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
IPC分类号： A61B106
CPC分类号： G01J3/4406 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0232 , G01J3/10 , G01N21/6456 , G01N2021/6417 , G01N2021/6421 , G01N2021/6484
摘要： The present invention relates to a fluorescence endoscope imaging system. The system uses first and second light sources to provide fluorescence and reflectance images of tissue being examined. The imaging system also includes an electronic controller that actuates the illumination of the system by switching current through the first light source between a first illumination level and a second illumination level such that the tissue is illuminated at the first or second illumination level. An imaging device mounted at the distal end of the device is used to collect both images.
摘要翻译：本发明涉及一种荧光内窥镜成像系统。该系统使用第一和第二光源来提供正在检查的组织的荧光和反射图像。成像系统还包括电子控制器，其通过在第一照明水平和第二照明水平之间切换通过第一光源的电流来致动系统的照明，使得组织以第一或第二照明水平照亮。安装在设备远端的成像装置用于收集两个图像。

38. 发明授权

US6091984A Measuring tissue morphology 失效
标题翻译：测量组织形态
公开(公告)号：US6091984A
公开(公告)日：2000-07-18
申请号：US948734
申请日：1997-10-10
申请人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
发明人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
IPC分类号： G01N21/17 , A61B5/00 , A61B10/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/0086
摘要： The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.
摘要翻译：本发明涉及用于使用光学辐射测量诸如组织的材料的一种或多种物理特性的系统和方法。该系统可以使用由组织层散射的光来确定例如组织层中的核的大小以帮助表征组织。这些方法可以包括使用光纤装置来递送和收集来自感兴趣的组织区域的光，以诊断例如组织是正常还是癌前。

39. 发明授权

US5919140A Optical imaging using time gated scattered light 失效
标题翻译：光学成像使用时间门控散射光
公开(公告)号：US5919140A
公开(公告)日：1999-07-06
申请号：US549623
申请日：1995-10-27
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rao Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rao Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B5/00 , G01N21/47 , A61B6/00
CPC分类号： G01N21/4795 , A61B5/0073
摘要： The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.
摘要翻译：本发明涉及时间门控散射光的使用，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供用于诊断目的的内部身体结构的三维的医学成像。

40. 发明授权

US5345941A Contour mapping of spectral diagnostics 失效
标题翻译：光谱诊断的轮廓映射
公开(公告)号：US5345941A
公开(公告)日：1994-09-13
申请号：US24674
申请日：1993-03-01
申请人： Richard P. Rava , Rebecca Richards-Kortum , Michael S. Feld , Joseph J. Baraga
发明人： Richard P. Rava , Rebecca Richards-Kortum , Michael S. Feld , Joseph J. Baraga
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： G01J3/4406 , A61B5/0059 , G01N21/6456 , G01N2021/6417 , G01N2021/6419 , G01N2021/6484
摘要： The present invention relates to a method of generating and processing spectral information arising from the laser induced fluorescence of tissue. The intensity of fluorescence is recorded as a function of both excitation and emission wavelengths and contour maps of tissue fluorescence are generated which are useful in the diagnosis of condition of the tissue under examination.
摘要翻译：本发明涉及一种生成和处理由激光诱导的组织荧光产生的光谱信息的方法。记录荧光的强度作为激发和发射波长的函数，并且产生组织荧光的轮廓图，其可用于诊断被检组织的状况。

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