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1. 发明授权

US06922583B1 Method for measuring tissue morphology 有权
标题翻译：测量组织形态的方法
公开(公告)号：US06922583B1
公开(公告)日：2005-07-26
申请号：US09545992
申请日：2000-04-10
申请人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
发明人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
IPC分类号： G01N21/17 , A61B5/00 , A61B10/00 , A61B6/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/0086
摘要： The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.
摘要翻译：本发明涉及用于使用光学辐射测量诸如组织的材料的一种或多种物理特性的系统和方法。该系统可以使用由组织层散射的光来确定例如组织层中的核的大小以帮助表征组织。这些方法可以包括使用光纤装置来递送和收集来自感兴趣的组织区域的光，以诊断例如组织是正常还是癌前。

2. 发明授权

US6091984A Measuring tissue morphology 失效
标题翻译：测量组织形态
公开(公告)号：US6091984A
公开(公告)日：2000-07-18
申请号：US948734
申请日：1997-10-10
申请人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
发明人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
IPC分类号： G01N21/17 , A61B5/00 , A61B10/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/0086
摘要： The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.
摘要翻译：本发明涉及用于使用光学辐射测量诸如组织的材料的一种或多种物理特性的系统和方法。该系统可以使用由组织层散射的光来确定例如组织层中的核的大小以帮助表征组织。这些方法可以包括使用光纤装置来递送和收集来自感兴趣的组织区域的光，以诊断例如组织是正常还是癌前。

3. 发明授权

US6070583A Optical imaging of tissue using inelastically scattered light 失效
标题翻译：使用非弹性散射光进行组织的光学成像
公开(公告)号：US6070583A
公开(公告)日：2000-06-06
申请号：US391209
申请日：1995-02-21
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Roa Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Roa Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B5/00 , G01N21/47 , A61B6/00
CPC分类号： A61B5/0073 , G01N21/4795
摘要： The present invention relates to the use of inelastically scattered light, particularly fluorescent and Raman scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions as well as histological information that can be used for diagnosing disease and various medical conditions.
摘要翻译：本发明涉及非弹性散射光，特别是荧光和拉曼散射光的用途，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供三维医学成像以及可用于诊断疾病和各种医疗状况的组织学信息。

4. 发明授权

US06321111B1 Optical imaging using time gated scattered light 失效
标题翻译：光学成像使用时间门控散射光
公开(公告)号：US06321111B1
公开(公告)日：2001-11-20
申请号：US09347050
申请日：1999-07-02
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rac Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rac Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B600
CPC分类号： G01N21/4795 , A61B5/0073
摘要： The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.
摘要翻译：本发明涉及时间门控散射光的使用，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供用于诊断目的的内部身体结构的三维的医学成像。

5. 发明授权

US5919140A Optical imaging using time gated scattered light 失效
标题翻译：光学成像使用时间门控散射光
公开(公告)号：US5919140A
公开(公告)日：1999-07-06
申请号：US549623
申请日：1995-10-27
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rao Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rao Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B5/00 , G01N21/47 , A61B6/00
CPC分类号： G01N21/4795 , A61B5/0073
摘要： The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.
摘要翻译：本发明涉及时间门控散射光的使用，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供用于诊断目的的内部身体结构的三维的医学成像。

6. 发明授权

US06847456B2 Methods and systems using field-based light scattering spectroscopy 有权
标题翻译：使用基于场的光散射光谱的方法和系统
公开(公告)号：US06847456B2
公开(公告)日：2005-01-25
申请号：US09844286
申请日：2001-04-27
申请人： Changhuei Yang , Adam P. Wax , Lev T. Perelman , Ramachandra R. Dasari , Michael S. Feld
发明人： Changhuei Yang , Adam P. Wax , Lev T. Perelman , Ramachandra R. Dasari , Michael S. Feld
IPC分类号： G01B9/02 , A61B5/00 , G01N21/17 , G01N21/27 , G01N21/45 , G01N21/47
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , G01N21/45
摘要： The present invention relates to systems and methods of field-based light scattering spectroscopy. These systems and methods provide for the diagnosis of tissue by measuring the size and distribution of cellular characteristics. Field based measurements provide phase information resulting from the interaction of scatterers within the material and the incident wavefront. These measurements can be used to provide three dimensional images of tissue.
摘要翻译：本发明涉及基于场的光散射光谱的系统和方法。这些系统和方法通过测量细胞特征的大小和分布来提供对组织的诊断。基于场的测量提供由材料内的散射体与入射波前的相互作用产生的相位信息。这些测量可用于提供组织的三维图像。

7. 发明授权

US08634067B2 Method and apparatus for detecting microscopic objects 有权
标题翻译：用于检测微观物体的方法和装置
公开(公告)号：US08634067B2
公开(公告)日：2014-01-21
申请号：US11596096
申请日：2005-05-11
申请人： Lev T. Perelman , Juan G. Alvarez , Mark D. Modell
发明人： Lev T. Perelman , Juan G. Alvarez , Mark D. Modell
IPC分类号： G01N21/00
CPC分类号： G02B21/0052
摘要： Apparatus including a broadband illumination source and a confocal optical system. The confocal optical system is configured and arranged to receive a portion of light projected onto an object by the broadband illumination source. The apparatus can include an illumination source, a confocal optical system, and at least one detector configured and arranged to receive angularly separated light corresponding to a confocal volume. There is also provided a light scattering spectroscopic device including a broadband illumination source, a two-dimensional detector, and a spectral separation device configured and arranged to receive scattered light from an object and to direct at least a portion of the scattered light onto the two-dimensional detector. The method and apparatus can combine confocal microscopy techniques with light scattering spectroscopy techniques to create a confocal light scattering spectroscopy (CLSS) system.
摘要翻译：装置包括宽带照明源和共焦光学系统。共焦光学系统被配置和布置成通过宽带照明源接收投射到物体上的一部分光。该装置可以包括照明源，共焦光学系统和至少一个被配置和布置为接收对应于共焦体积的角度分离的光的检测器。还提供了一种包括宽带照明源，二维检测器和光谱分离装置的光散射光谱装置，其被配置和布置成接收来自物体的散射光并将至少一部分散射光引导到二维维度检测器。该方法和装置可以将共焦显微技术与光散射光谱学技术结合起来，以产生共焦光散射光谱（CLSS）系统。

8. 发明授权

US09788728B2 Endoscopic polarized multispectral light scattering scanning method 有权
公开(公告)号：US09788728B2
公开(公告)日：2017-10-17
申请号：US13145851
申请日：2010-01-22
申请人： Lev T. Perelman
发明人： Lev T. Perelman
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0062 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： Method and system for early detection of precancerous and other abnormal changes in tissue of various organs. The system comprises a combination of endoscopic scanning with light scattering spectroscopy and improves detection of abnormalities that may otherwise remain undetected. The system may include a probe that collects data of quality that is independent of a distance of the probe from the scanned tissue. During endoscopy, tissue of an organ is imaged using polarized multispectral light scattering scanning and results are presented to a user in a manner that allows detecting abnormal morphological and biochemical changes in the tissue. A determination of whether to perform biopsy may be performed while the endoscopy is being performed, which thus provides guided biopsy. An entire surface of the organ may be rapidly scanned and results of the scanning are analyzed with a reduced time delay.

9. 发明申请

US20120041290A1 ENDOSCOPIC POLARIZED MULTISPECTRAL LIGHT SCATTERING SCANNING METHOD 有权
标题翻译：内窥镜极化多光谱散射扫描方法
公开(公告)号：US20120041290A1
公开(公告)日：2012-02-16
申请号：US13145851
申请日：2010-01-22
申请人： Lev T. Perelman
发明人： Lev T. Perelman
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： A61B5/0062 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： Method and system for early detection of precancerous and other abnormal changes in tissue of various organs. The system comprises a combination of endoscopic scanning with light scattering spectroscopy and improves detection of abnormalities that may otherwise remain undetected. The system may include a probe that collects data of quality that is independent of a distance of the probe from the scanned tissue. During endoscopy, tissue of an organ is imaged using polarized multispectral light scattering scanning and results are presented to a user in a manner that allows detecting abnormal morphological and biochemical changes in the tissue. A determination of whether to perform biopsy may be performed while the endoscopy is being performed, which thus provides guided biopsy. An entire surface of the organ may be rapidly scanned and results of the scanning are analyzed with a reduced time delay.
摘要翻译：早期检测各种器官组织中癌前期和其他异常变化的方法和系统。该系统包括内窥镜扫描与光散射光谱的组合，并且改善了否则将被检测不到的异常的检测。该系统可以包括探针，该探针收集独立于探测器与扫描组织的距离的质量数据。在内窥镜检查期间，使用偏振多光谱光散射扫描对器官的组织进行成像，并且以允许检测组织中异常形态和生物化学变化的方式将结果呈现给使用者。可以在执行内窥镜检查时进行是否进行活组织检查的确定，由此提供引导活检。可以快速扫描器官的整个表面，并以缩短的时间延迟来分析扫描结果。

10. 发明申请

US20110122487A1 Method and Apparatus For Detecting Microscopic Objects 有权
标题翻译：用于检测微观物体的方法和装置
公开(公告)号：US20110122487A1
公开(公告)日：2011-05-26
申请号：US11596096
申请日：2005-05-11
申请人： Lev T. Perelman , Juan G. Alvarez , Mark Modell
发明人： Lev T. Perelman , Juan G. Alvarez , Mark Modell
IPC分类号： G02B21/00
CPC分类号： G02B21/0052
摘要： Apparatus including a broadband illumination source and a confocal optical system. The confocal optical system is configured and arranged to receive a portion of light projected onto an object by the broadband illumination source. The apparatus can include an illumination source, a confocal optical system, and at least one detector configured and arranged to receive angularly separated light corresponding to a confocal volume. There is also provided a light scattering spectroscopic device including a broadband illumination source, a two-dimensional detector, and a spectral separation device configured and arranged to receive scattered light from an object and to direct at least a portion of the scattered light onto the two-dimensional detector. The method and apparatus can combine confocal microscopy techniques with light scattering spectroscopy techniques to create a confocal light scattering spectroscopy (CLSS) system.
摘要翻译：装置包括宽带照明源和共焦光学系统。共焦光学系统被配置和布置成通过宽带照明源接收投射到物体上的一部分光。该装置可以包括照明源，共焦光学系统和至少一个被配置和布置为接收对应于共焦体积的角度分离的光的检测器。还提供了一种包括宽带照明源，二维检测器和光谱分离装置的光散射光谱装置，其被配置和布置成接收来自物体的散射光并将至少一部分散射光引导到二维维度检测器。该方法和装置可以将共焦显微技术与光散射光谱学技术结合起来，以产生共焦光散射光谱（CLSS）系统。

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