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1. 发明授权

US06321111B1 Optical imaging using time gated scattered light 失效
标题翻译：光学成像使用时间门控散射光
公开(公告)号：US06321111B1
公开(公告)日：2001-11-20
申请号：US09347050
申请日：1999-07-02
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rac Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rac Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B600
CPC分类号： G01N21/4795 , A61B5/0073
摘要： The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.
摘要翻译：本发明涉及时间门控散射光的使用，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供用于诊断目的的内部身体结构的三维的医学成像。

2. 发明授权

US5312396A Pulsed laser system for the surgical removal of tissue 失效
标题翻译：脉冲激光系统用于手术切除组织
公开(公告)号：US5312396A
公开(公告)日：1994-05-17
申请号：US644202
申请日：1991-01-22
申请人： Michael S. Feld , Irving Itzkan , Douglas Albagli , Joseph A. Izatt , Gary B. Hayes , Richard Rava
发明人： Michael S. Feld , Irving Itzkan , Douglas Albagli , Joseph A. Izatt , Gary B. Hayes , Richard Rava
IPC分类号： A61B17/00 , A61B18/20 , A61B18/24 , A61B18/26 , B23K26/06 , A61B17/36 , A61N3/00
CPC分类号： B23K26/0665 , A61B18/245 , B23K26/06 , B23K26/064 , A61B2017/00154 , A61B2018/207
摘要： Removal of body tissue with a long pulsed lasers is achieved such that sufficient energy to remove tissue is transmitted to the desired body without damaging an optical fiber transmitting the laser radiation. Pairs of pulses having the same or different wavelengths are coupled to more effectively remove tissue from the surgical site.
摘要翻译：实现用长脉冲激光去除身体组织，使得足够的能量去除组织被传递到所需的身体，而不损害透射激光辐射的光纤。具有相同或不同波长的脉冲对被耦合以更有效地从手术部位去除组织。

3. 发明申请

US20050003376A1 Single molecule detection with surface-enhanced raman scattering and applications in DNA or RNA sequencing 审中-公开
标题翻译：单分子检测，具有表面增强的拉曼散射和在DNA或RNA测序中的应用
公开(公告)号：US20050003376A1
公开(公告)日：2005-01-06
申请号：US10723174
申请日：2003-11-26
申请人： Katrin Kneipp , Harald Kneipp , Irving Itzkan , Ramachandra Dasari , Michael Feld
发明人： Katrin Kneipp , Harald Kneipp , Irving Itzkan , Ramachandra Dasari , Michael Feld
IPC分类号： C12Q1/68 , G01N21/64 , G01N21/65 , G01N33/53 , G01N33/543
CPC分类号： G01N21/658 , C12Q1/6816 , G01N33/5308 , C12Q2565/632
摘要： Surface-enhanced spectroscopy, such as surface-enhanced Raman spectroscopy employs aggregates that are of a size that allows easy handling. The aggregates are generally at least about 500 nm in dimension. The aggregates can be made of metal particles of size less than 100 nm, allowing enhanced spectroscopic techniques that operate at high sensitivity. This allows the use of larger, easily-handleable aggregates. Signals are determined that are caused by single analytes adsorbed to single aggregates, or single analytes adsorbed on a surface. The single analytes can be DNA or RNA fragments comprising at least one base.
摘要翻译：表面增强光谱，如表面增强拉曼光谱法使用尺寸允许容易处理的聚集体。聚集体的尺寸通常为至少约500nm。聚集体可以由尺寸小于100nm的金属颗粒制成，允许以高灵敏度操作的增强的光谱技术。这允许使用更大，易于处理的聚集体。确定由单一分析物吸附到单个聚集体或吸附在表面上的单一分析物引起的信号。单一分析物可以是包含至少一个碱基的DNA或RNA片段。

4. 发明授权

US4733660A Laser system for providing target specific energy deposition and damage 失效
标题翻译：激光系统提供目标比能量沉积和损伤
公开(公告)号：US4733660A
公开(公告)日：1988-03-29
申请号：US940195
申请日：1986-12-10
申请人： Irving Itzkan
发明人： Irving Itzkan
IPC分类号： B23K26/10 , A61B20060101 , A61B17/00 , A61B18/00 , A61B18/20 , A61B18/22 , A61N5/06 , A61B17/36
CPC分类号： A61B18/203 , A61B18/22 , A61B2017/00756 , A61B2018/00029 , A61B2018/00452 , A61B2018/2085
摘要： A hand piece for use with a laser includes a scanning mechanism which controls dosimetry of radiation applied to a target area which is adjustable to limit thermal diffusion from the light absorbing portion of the irradiated target site for selective target specific energy deposition. When used for dermatologic purposes, the adjustable scanning mechanism permits radiation to impinge on tissue for a predetermined period of time for the selective necrosis of highly-filled blood vessels, while leaving adjacent tissue and empty blood vessels undamaged. The dwell time of the laser beam is designed to match the diffusion time for thermal destruction of the wall of the abnormal vessel, with the dwell time adjusted by the scanning rate.
摘要翻译：与激光一起使用的手持件包括扫描机构，其控制施加到目标区域的辐射的剂量测定，该目标区域是可调节的，以限制从被照射的靶位点的光吸收部分的热扩散用于选择性目标比能量沉积。当用于皮肤病学目的时，可调节的扫描机制允许辐射在组织上冲击预定的时间段，用于选择性高度填充的血管的坏死，同时使相邻的组织和空的血管没有损伤。激光束的停留时间被设计成匹配异常容器的壁的热破坏的扩散时间，停留时间由扫描速率调整。

5. 发明授权

US4468279A Method for laser melting of silicon 失效
标题翻译：激光熔化硅的方法
公开(公告)号：US4468279A
公开(公告)日：1984-08-28
申请号：US408393
申请日：1982-08-16
申请人： Irving Itzkan
发明人： Irving Itzkan
IPC分类号： C30B15/02 , C30B15/16
CPC分类号： C30B15/16 , C30B15/02 , Y10S117/904
摘要： A method for laser melting of silicon for the production of boules pulled from a pool of liquid ultraclean or ultrapure silicon wherein the boules are used for producing silicon wafers suitable for use in the electronics field. A laser beam, preferably P polarized, is directed at an angle of about 88 degrees to the normal to the surface of silicon disposed in conventional melting apparatus. A suitable mirror is preferably provided to capture and reflect that portion of the laser beam reflected from the surface of the pool. Use of the present invention permits continuous operation by adding solid silicon and melting it at the point of impingement of the laser beam with up to about 96% absorption of laser energy at this point, thereby permitting the provision of heat in a very controlled manner in a continuous ultraclean silicon crystal growth process.
摘要翻译：一种用于激光熔化硅的方法，用于生产从液体超纯或超纯硅液池中抽出的毛坯，其中所述毛坯用于生产适用于电子领域的硅片。优选P极化的激光束以与常规熔化装置中设置的硅表面法线约88度的角度相对。优选地提供合适的反射镜以捕获并反射从池的表面反射的那部分激光束。本发明的使用允许通过添加固体硅并在激光束的冲击点使其熔化，从而在该点处高达约96％的激光能量吸收，从而允许以非常受控的方式提供热量连续超纯硅晶体生长工艺。

6. 发明授权

US06922583B1 Method for measuring tissue morphology 有权
标题翻译：测量组织形态的方法
公开(公告)号：US06922583B1
公开(公告)日：2005-07-26
申请号：US09545992
申请日：2000-04-10
申请人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
发明人： Lev T. Perelman , Vadim Backman , Michael S. Feld , George Zonios , Irving Itzkan , Ramasamy Manoharan
IPC分类号： G01N21/17 , A61B5/00 , A61B10/00 , A61B6/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/0086
摘要： The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.
摘要翻译：本发明涉及用于使用光学辐射测量诸如组织的材料的一种或多种物理特性的系统和方法。该系统可以使用由组织层散射的光来确定例如组织层中的核的大小以帮助表征组织。这些方法可以包括使用光纤装置来递送和收集来自感兴趣的组织区域的光，以诊断例如组织是正常还是癌前。

7. 发明授权

US06624890B2 Polarized light scattering spectroscopy of tissue 失效
公开(公告)号：US06624890B2
公开(公告)日：2003-09-23
申请号：US10155194
申请日：2002-05-24
申请人： Vadim Backman , Ramachandra R. Dasari , Rajan Gurjar , Irving Itzkan , Lev Perelman , Michael S. Feld
发明人： Vadim Backman , Ramachandra R. Dasari , Rajan Gurjar , Irving Itzkan , Lev Perelman , Michael S. Feld
IPC分类号： G01J400
CPC分类号： A61B5/0084 , A61B5/0075
摘要： The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of back-scattered light from such tissues is preserved while the contribution of diffusely scattered light from underlying tissues can be removed. A fiber optic system for delivery and collection of light can be used to measure tissues within the human body.

8. 发明授权

US06404497B1 Polarized light scattering spectroscopy of tissue 有权
标题翻译：组织的偏振光散射光谱
公开(公告)号：US06404497B1
公开(公告)日：2002-06-11
申请号：US09237153
申请日：1999-01-25
申请人： Vadim Backman , Ramanchandra R. Dasari , Rajan Gurjar , Irving Itzkan , Lev Perelman , Michael S. Feld
发明人： Vadim Backman , Ramanchandra R. Dasari , Rajan Gurjar , Irving Itzkan , Lev Perelman , Michael S. Feld
IPC分类号： G01J400
CPC分类号： A61B5/0084 , A61B5/0075
摘要： The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of backscattered light from such tissues is preserved while the contribution of diffusely scattered light from underlying tissues can be removed. A fiber optic system for delivery and collection of light can be used to measure tissues within the human body.
摘要翻译：本发明涉及使用偏振光来测量组织的性质。更具体地，偏振光可用于检测组织中的发育不良，因为来自这些组织的反向散射光的偏振被保留，同时可以去除来自下层组织的漫散射光的贡献。用于光的传送和收集的光纤系统可用于测量人体内的组织。

9. 发明授权

US6070583A Optical imaging of tissue using inelastically scattered light 失效
标题翻译：使用非弹性散射光进行组织的光学成像
公开(公告)号：US6070583A
公开(公告)日：2000-06-06
申请号：US391209
申请日：1995-02-21
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Roa Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Roa Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B5/00 , G01N21/47 , A61B6/00
CPC分类号： A61B5/0073 , G01N21/4795
摘要： The present invention relates to the use of inelastically scattered light, particularly fluorescent and Raman scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions as well as histological information that can be used for diagnosing disease and various medical conditions.
摘要翻译：本发明涉及非弹性散射光，特别是荧光和拉曼散射光的用途，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供三维医学成像以及可用于诊断疾病和各种医疗状况的组织学信息。

10. 发明授权

US5615673A Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes 失效
标题翻译：用于分析血气和分析物的拉曼光谱仪的装置和方法
公开(公告)号：US5615673A
公开(公告)日：1997-04-01
申请号：US410927
申请日：1995-03-27
申请人： Andrew J. Berger , James F. Brennan, III , Ramanchandra R. Dasari , Michael S. Feld , Irving Itzkan , Kaz Tanaka , Yang Wang
发明人： Andrew J. Berger , James F. Brennan, III , Ramanchandra R. Dasari , Michael S. Feld , Irving Itzkan , Kaz Tanaka , Yang Wang
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1459 , G01N21/65
CPC分类号： G01J3/02 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , G01J3/021 , G01J3/0221 , G01N21/65 , A61B2562/12 , G01N2021/656
摘要： The present invention relates to systems of methods of measuring selected analytes in blood and tissue using Raman spectroscopy to aid in diagnosis. More particularly, Raman spectra are collected and analyzed to measure the concentration of dissolved gases and other analytes of interest in blood. Methods include in vivo transdermal and continuous monitoring as well as in vitro blood analysis.
摘要翻译：本发明涉及使用拉曼光谱法测量血液和组织中选定分析物以辅助诊断的方法的系统。更具体地，收集和分析拉曼光谱，以测量溶解气体和其他有关血液中分析物的浓度。方法包括体内透皮和连续监测以及体外血液分析。

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