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21. 发明申请

US20140315282A1 MICROINJECTOR MOUNTING MODULE AND NEEDLE-HOLDER COMPONENT 审中-公开
标题翻译：微型安装模块和针座组件
公开(公告)号：US20140315282A1
公开(公告)日：2014-10-23
申请号：US14358036
申请日：2013-01-10
申请人： HUNAN CHANGSHA AO FIGURE BIOLOGICAL TECHNOLOGY CO., LTD.
发明人： Jianjun Peng
IPC分类号： C12N15/89
CPC分类号： C12N15/89 , C12M33/04 , C12M35/00
摘要： A microinjector needle mounting module and a needle holder assembly, comprising a micro-injection needle (1), a needle seat (2) and a needle holder (3); the microinjector mounting module is formed by means of inserting the rear end of the microinjector (1) into a hole in the base (21) of the needle seat; the needle holder (3) is provided with an inner hole (32) passing through the barrel body; a conical socket (24) is provided inside the needle seat (2) and one end of the needle-holder (3) is provided with a conical connector (31), said conical connector (31) and conical socket (24) thus constituting a mutually-complementary insertion connection. In addition to a micro-injection needle being assembled with the needle seat to form a mounting module, other micro-operation needles such as holding pipettes or biopsy needles can also be assembled into a mounting module with said needle seat.
摘要翻译：一种微型注射针安装模块和针保持器组件，包括微注射针（1），针座（2）和针保持器（3）; 微型注射器安装模块通过将微型注射器（1）的后端插入针座的基座（21）中的孔中而形成; 针保持器（3）设置有穿过筒体的内孔（32）; 在针座（2）的内部设有锥形插座（24），针架（3）的一端设置有圆锥形连接器（31），所述锥形连接器（31）和锥形插座（24）构成互补的插入连接。除了与针座组装以形成安装模块的微型注射针之外，还可以将其它微操作针（例如保持移液管或活检针）组装到具有所述针座的安装模块中。

22. 发明申请

US20140227785A1 METHODS AND DEVICES FOR CHARGED MOLECULE MANIPULATION 审中-公开
标题翻译：用于充电分子操作的方法和装置
公开(公告)号：US20140227785A1
公开(公告)日：2014-08-14
申请号：US14103618
申请日：2013-12-11
申请人： Brigham Young University
发明人： Quentin T. Aten , Larry L. Howell , Brian D. Jensen , Sandra Burnett
IPC分类号： C12N15/89
CPC分类号： C12N15/89 , C12M35/02
摘要： Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at least a portion of the charged molecular material becomes associated with the needle structure, moving the needle structure and the first locus relative to one another, and discharging the needle structure to disassociate the charged molecular material at a second locus.
摘要翻译：提供了操作分子材料的系统和方法。在一个方面，例如，用于操纵分子材料的方法可以包括在液体环境中的第一位置处将不带电的针结构定位成与电荷分子材料电接近，对针结构进行充电，使得至少一部分带电分子材料与针结构相关联，使针结构和第一轨迹相对移动，并且排出针结构以在第二位置分离带电分子材料。

23. 发明授权

US08519101B2 Nucleic acid encoding a silk protein and a method of producing a silk thread using same 失效
标题翻译：编码丝蛋白的核酸和使用其制造丝线的方法
公开(公告)号：US08519101B2
公开(公告)日：2013-08-27
申请号：US13764124
申请日：2013-02-11
申请人： Okamoto Corporation
发明人： Tianfu Zhao , Masao Nakagaki
IPC分类号： A61K38/39 , C12P21/02 , C12N15/12 , C12N15/85 , C12N15/89
CPC分类号： C07K14/43518 , A01K67/0333 , A01K67/0339 , A01K2217/052 , A01K2227/706 , A01K2267/01 , A01K2267/02 , C12N15/8509
摘要： Disclosed are a protein encoded by any one of nucleic acids (i) to (iv): (i) a nucleic acid having a base sequence of SEQ ID NO: 1; (ii) a nucleic acid encoding a protein having an amino acid sequence of SEQ ID NO: 2; (iii) a nucleic acid encoding a dragline protein and having a sequence identity of 90% or more with the nucleic acid (i); (iv) a nucleic acid which encodes a dragline protein and hybridizes with a complementary chain of the nucleic acid (i) under stringent conditions, and a silk thread containing the protein.
摘要翻译：公开了由核酸（i）至（iv）中的任一种编码的蛋白质：（i）具有SEQ ID NO：1的碱基序列的核酸; （ii）编码具有SEQ ID NO：2的氨基酸序列的蛋白质的核酸; （iii）编码牵引蛋白并与核酸（i）具有90％或更高的序列同一性的核酸; （iv）编码牵引蛋白并在严格条件下与核酸（i）的互补链杂交的核酸和含有蛋白质的丝线。

24. 发明申请

US20130145488A1 MESOPOROUS SILICA NANOPARTICLES SUITABLE FOR CO-DELIVERY 审中-公开
标题翻译：适合交付的多孔二氧化硅纳米颗粒
公开(公告)号：US20130145488A1
公开(公告)日：2013-06-06
申请号：US13707233
申请日：2012-12-06
申请人： Kan Wang , Brian G. Trewyn , Susana Martin-Ortigosa , Justin Valenstein
发明人： Kan Wang , Brian G. Trewyn , Susana Martin-Ortigosa , Justin Valenstein , Victor Shang-Yi Lin
IPC分类号： C12N15/89
CPC分类号： C12N15/895
摘要： The invention provides gold-plated mesoporous silicate bodies comprising pores and at least one agent and methods of using those bodies.
摘要翻译：本发明提供了包含孔和至少一种试剂的镀金介孔硅酸盐物质和使用这些物质的方法。

25. 发明申请

US20130023052A1 MANIPULATOR SYSTEM AND MANIPULATION METHOD OF MICROMANIPULATION TARGET OBJECT 审中-公开
标题翻译：微型目标对象的操纵系统和操纵方法
公开(公告)号：US20130023052A1
公开(公告)日：2013-01-24
申请号：US13637364
申请日：2011-08-08
申请人： Nobuaki Tanaka
发明人： Nobuaki Tanaka
IPC分类号： C12M1/42 , C12N15/89 , C12M1/34
CPC分类号： G02B21/32
摘要： A manipulator system and a manipulation method of a micromanipulation target object, which are capable of automatically executing a variety of operations about a micromanipulation target object such as an ovum that have hitherto required a skilled technique, are disclosed. A manipulator system includes: a microscope unit observing a micromanipulation target object; a pair of manipulators being electrically drivable in X-, Y- and Z-axis three directions for manipulating the micromanipulation target object; a sample stage receiving a placement of the micromanipulation target object and being electrically drivable in X-Y axis plane directions; a control unit controlling the drive of the manipulators and the drive of the sample stage; and a manipulation unit driving the manipulators and the sample stage via the control unit, wherein a manipulation tool is fitted to the manipulator, the control unit gets stored with positional information of the manipulation tool with respect to a plurality of regions set for the micromanipulation target object, and at least one of relative movements between the regions of the manipulation tool by the sample stage and/or the manipulator is automatically conducted based on the stored positional information.
摘要翻译：公开了一种能够自动执行关于诸如迄今需要熟练技术的卵子的微操作目标对象的各种操作的微操作目标对象的操纵器系统和操纵方法。操纵器系统包括：观察显微操作目标物体的显微镜单元; 一对操纵器可在X，Y轴和Z轴三个方向上电驱动，用于操纵显微操作目标物体; 样本台，其接收微操作目标物体的放置并在X-Y轴平面方向上电驱动; 控制单元，其控制所述操纵器的驱动和所述样品台的驱动; 以及操作单元，其经由所述控制单元驱动所述操纵器和所述样品台，其中，操作工具装配到所述操纵器，所述控制单元相对于为所述显微操纵目标设定的多个区域而存储有所述操作工具的位置信息并且基于所存储的位置信息自动地进行由样本台和/或操纵器在操作工具的区域之间的相对运动中的至少一个。

26. 发明申请

US20120276573A1 NANOTUBE STRUCTURES, METHODS OF MAKING NANOTUBE STRUCTURES, AND METHODS OF ACCESSING INTRACELLULAR SPACE 有权
标题翻译：纳米管结构，制备纳米管结构的方法和获取细胞内空间的方法
公开(公告)号：US20120276573A1
公开(公告)日：2012-11-01
申请号：US13455245
申请日：2012-04-25
申请人： Jules J. VanDersarl , Alexander M. Xu , Nicholas A. Melosh
发明人： Jules J. VanDersarl , Alexander M. Xu , Nicholas A. Melosh
IPC分类号： C12N5/071 , C12Q1/02 , C12N15/89 , B05D5/00 , B82Y5/00 , B82Y40/00 , B82B1/00
CPC分类号： C12N5/0075 , B82Y5/00 , B82Y40/00 , C12N5/0068 , C12N2521/00 , C12N2533/10 , C12N2533/30 , C12N2535/00
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making a structure including nanotubes, a structure including nanotubes, methods of delivering a fluid to a cell, methods of removing a fluid to a cell, methods of accessing intracellular space, and the like.
摘要翻译：根据本公开的目的，如本文所体现和广泛描述的，本公开的实施例在一个方面涉及制造包括纳米管的结构的方法，包括纳米管的结构，输送流体的方法将细胞除去流体的方法，细胞内空间的存取方法等。

27. 发明申请

US20120276537A1 HOMOLOGOUS RECOMBINATION IN THE OOCYTE 审中-公开
标题翻译：同卵生物的重组
公开(公告)号：US20120276537A1
公开(公告)日：2012-11-01
申请号：US13504587
申请日：2010-10-28
申请人： Ralf Kühn , Wolfgang Wurst , Melanie Meyer
发明人： Ralf Kühn , Wolfgang Wurst , Melanie Meyer
IPC分类号： C12N15/90 , C12Q1/68 , C12N15/89
CPC分类号： A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C12N9/22 , C12N15/8509 , C12N15/907
摘要： The present invention relates to a method of modifying a target sequence in the genome of a mammalian or avian oocyte by homologous recombination with a donor nucleic acid sequence, the method comprising the steps (a) introducing into the oocyte a zinc finger nuclease or a nucleic acid molecule encoding the zinc finger nuclease in expressible form, wherein the zinc finger nuclease specifically binds within the target sequence and introduces a double strand break within the target sequence; and (b) introducing a nucleic acid molecule into the oocyte, wherein the nucleic acid molecule comprises the donor nucleic acid sequence and regions homologous to the target sequence. The present invention further relates to a method of producing a non-human mammal or an avian carrying a modified target sequence in its genome.
摘要翻译：本发明涉及通过与供体核酸序列同源重组来修饰哺乳动物或禽类卵母细胞基因组中的靶序列的方法，所述方法包括以下步骤：（a）向卵母细胞中引入锌指核酸酶或核酸编码锌指核酸酶的可分解形式的酸分子，其中所述锌指核酸酶在靶序列内特异性结合并在靶序列内引入双链断裂; 和（b）将核酸分子引入所述卵母细胞中，其中所述核酸分子包含供体核酸序列和与靶序列同源的区域。本发明还涉及在其基因组中产生携带修饰的靶序列的非人哺乳动物或禽类的方法。

28. 发明申请

US20100281549A1 Transgenic Production In Saliva 有权
标题翻译：唾液转基因生产
公开(公告)号：US20100281549A1
公开(公告)日：2010-11-04
申请号：US12834534
申请日：2010-07-12
申请人： Jeffrey P. Erickson
发明人： Jeffrey P. Erickson
IPC分类号： A01K67/027 , C12P21/00 , C12N15/89
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/101 , A01K2227/105 , A01K2227/108 , A01K2267/01 , C07K14/75 , C12N2830/008
摘要： The invention relates to the production of proteins and other substances of interest in saliva of transgenic animals, particularly in mammals that produce large quantities of saliva, particularly monogastric ruminants, and ovine, caprine and bovine mammals. Preferred embodiments of the invention relate in particular to the production of foreign and modified proteins in the transgenic saliva of these animals, including particularly human fibrinogen, human prothrombin and human thrombin, among others. The invention relates as well to methods, devices, genetic constructs and to transgenic constructs for making the proteins and other substances of interest, to novel saliva and saliva-derived compositions, novel products produced from the saliva, and to uses of the saliva, saliva-derived compositions and novel products.
摘要翻译：本发明涉及转基因动物唾液中蛋白质和其他物质的生产，特别是在产生大量唾液，特别是单胃反刍动物的哺乳动物以及羊，羊和牛哺乳动物中。本发明的优选实施方案特别涉及这些动物的转基因唾液中的外源和修饰的蛋白质的生产，包括特别是人纤维蛋白原，人凝血酶原和人类凝血酶等。本发明还涉及方法，装置，遗传构建体和用于制备蛋白质和其它所关注物质的转基因构建体，新颖的唾液和唾液来源的组合物，从唾液产生的新产品以及唾液，唾液的使用衍生的组合物和新产品。

29. 发明申请

US20100077495A1 COMPOSITIONS AND METHODS FOR THE EXPRESSION OF NUCLEIC ACIDS 审中-公开
标题翻译：用于表达核酸的组合物和方法
公开(公告)号：US20100077495A1
公开(公告)日：2010-03-25
申请号：US12519349
申请日：2007-12-04
申请人： David P. Davis , Daniel C. Gray , Zhenyu Gu
发明人： David P. Davis , Daniel C. Gray , Zhenyu Gu
IPC分类号： C12N15/89 , C12N15/63 , A01K67/027 , C12N5/10
CPC分类号： C12N15/635 , C12N15/111 , C12N15/1135 , C12N15/1136 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/50 , C12N2330/30
摘要： Compositions and methods are provided herein for the expression of nucleic acids. Compositions and methods are also provided herein for inducible expression of nucleic acids in transgenic cells and animals using transposon-based nucleic acid constructs. Compositions and methods are also provided herein for modulation of endogenous gene expression.
摘要翻译：本文提供了用于表达核酸的组合物和方法。本文还提供了组合物和方法，用于使用基于转座子的核酸构建体在转基因细胞和动物中诱导性表达核酸。本文还提供了调节内源基因表达的组合物和方法。

30. 发明授权

US07534598B2 Apparatus and method for injecting substance into cell 失效
标题翻译：将物质注入细胞的装置和方法
公开(公告)号：US07534598B2
公开(公告)日：2009-05-19
申请号：US11067351
申请日：2005-02-28
申请人： Moritoshi Ando , Satoru Sakai
发明人： Moritoshi Ando , Satoru Sakai
IPC分类号： C12M1/42 , C12N15/89
CPC分类号： C12M35/02
摘要： A surface of a cell is irradiated with laser beam to make an opening in the cell membrane, and a drug fluid is inserted in the cell through the opening.
摘要翻译：用激光束照射细胞的表面以在细胞膜中形成开口，并且药物流体通过开口插入细胞中。

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