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    • 3. 发明授权
    • Low environmental impact pesticide made from “gras” ingredients for use against coqui frogs and other species
    • 用于克草蛙和其他物种的鹅肝成分制成的低环境影响农药
    • US08287919B2
    • 2012-10-16
    • US12763392
    • 2010-04-20
    • David P. Davis
    • David P. Davis
    • A01N59/06A61K33/06
    • A01N37/02A01N37/36A01N59/06A01N2300/00
    • The current invention involves compositions and methods for killing various soft-bodied animals of interest (more specifically, Coqui frogs and Coqui frog eggs are targeted) with a low pH adjusted pesticide. The method involves contacting the soft-bodied animal of interest with the low pH adjusted pesticide, wherein the pesticide is a propionic acid composition, a citric acid composition, an Acidic Calcium Sulfate (ACS) composition, or combination thereof. The preferred pesticide composition has a working concentration that is less than about 15% (w/v), and a pH less than about pH 2.5, which has a lethal effect on Coqui frogs, but is less phytotoxic than higher concentration pesticides. The method includes spraying any of the pH adjusted pesticides thoroughly an area inhabited by the soft-bodied animals of interest, which includes the under brush, under bushes, and typically any hiding places. On a large scale, the method contemplates filling various types of industrial spraying equipment with the pesticide and saturating entire pest inhabited areas.
    • 本发明涉及用低pH调节农药杀死感兴趣的各种软体动物的组合物和方法(更具体地说是Coqui青蛙和Coqui蛙卵)。 该方法包括将感兴趣的软体与低pH调节的农药接触,其中农药是丙酸组合物,柠檬酸组合物,酸式硫酸钙(ACS)组合物或其组合。 优选的农药组合物的工作浓度小于约15%(w / v),pH小于约pH 2.5,对柯奎青蛙具有致死作用,但比高浓度农药具有较少的植物毒性。 该方法包括将任何pH调节的农药彻底喷洒在感兴趣的软体动物区域内,该区域包括下刷,灌木丛下,通常是任何隐藏处。 在大规模的情况下,该方法考虑到使用农药填充各种工业喷涂设备,使整个有害生物区域饱和。
    • 5. 发明授权
    • Fibril-blocking peptide, a method for preventing fibril formation
    • 纤维蛋白阻断肽,一种预防原纤维形成的方法
    • US06878521B1
    • 2005-04-12
    • US09712819
    • 2000-11-13
    • Fred J. StevensYair ArgonDavid P. DavisRosemarie Raffen
    • Fred J. StevensYair ArgonDavid P. DavisRosemarie Raffen
    • A61K38/08G01N33/53G01N33/576
    • A61K38/08
    • A method of minimizing the aggregation tendencies of an amyloid forming protein is provided comprising identifying a portion of the protein that is critical to amyloid formation; and inserting a peptide at the portion. The invention also provides a peptide for insertion in an intact human kappa-IV light chain variable domain, the peptide comprising the following amino acid sequence Phe71-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77 (SEQ ID NO. 1) wherein the subscript numbers are the residue location points in the domain. A method for preventing amyloid formation in human kappa-IV light chain variable domain is also provided, the method comprising inserting the peptide Phe1-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77 (SEQ ID NO. 1) into the domain, wherein the subscript numbers indicate the residue location on the domain.
    • 提供了使淀粉样蛋白形成蛋白的聚集倾向最小化的方法,包括鉴定蛋白质对淀粉样蛋白形成至关重要的部分; 并在该部分插入肽。 本发明还提供了用于插入完整的人κ-轻链可变结构域的肽,所述肽包含以下氨基酸序列Phe71-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77(SEQ ID NO.1),其中 下标数字是域中的残留位置点。 还提供了用于预防人κ-IV轻链可变结构域中的淀粉样蛋白形成的方法,所述方法包括将肽Phe1-Thr72-Leu73-Thr74-Ile75-Ser76-Ser77(SEQ ID NO.1)插入结构域,其中 下标号表示域上的残留位置。