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21. 发明申请

US20160370369A1 ULTRAPURIFIED DsbA AND DsbC AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：超声DsbA和DsbC及其制备和使用方法
公开(公告)号：US20160370369A1
公开(公告)日：2016-12-22
申请号：US15061943
申请日：2016-03-04
申请人： Genentech, Inc.
发明人： Marc WONG , Liliana T. YEE , Amy LIM , Chris B. FONG
IPC分类号： G01N33/573 , C12N9/90 , C07K1/22 , C12N9/02 , C07K16/40
CPC分类号： G01N33/573 , A61K38/00 , C07K1/22 , C07K16/40 , C12N9/0051 , C12N9/90 , C12Y108/04002 , C12Y503/04001 , G01N2333/90212 , G01N2333/99 , Y02A50/473
摘要： The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.
摘要翻译：本发明提供以非常高的纯度生产二硫化物氧化还原酶A（DsbA）和二硫化物氧化还原酶C（DsbC）多肽的方法。还提供了超纯DsbA和DsbC及其使用方法，例如用于免疫测定以显示从细菌中产生的生物制剂中除去DsbA和DsbC。

22. 发明授权

US09260680B2 Prolamin-reduced beverages and methods for the preparation thereof 有权
标题翻译：减少精氨酸饮料及其制备方法
公开(公告)号：US09260680B2
公开(公告)日：2016-02-16
申请号：US11666718
申请日：2005-11-10
申请人： Ralf Pasternack , Stefan Marx , Dominik Jordan
发明人： Ralf Pasternack , Stefan Marx , Dominik Jordan
IPC分类号： A23L2/84 , C12C5/00 , A23L1/015 , A23L1/30 , C12C12/00
CPC分类号： C12C5/004 , A23L2/84 , A23L5/25 , A23L33/135 , C12C12/00 , C12Y101/03005 , C12Y110/03002 , C12Y111/01007 , C12Y114/18001 , C12Y203/02013 , C12Y503/04001
摘要： A process for the preparation of a beverage, a beverage base, a beverage concentrate or a beverage additive having a reduced prolamin content from prolamin-containing raw materials, comprising the following steps: a) contacting the beverage or a precursor of the beverage with cross-linking enzymes to obtain modified prolamin; b) removing the modified prolamin at least partially.
摘要翻译：一种用于制备饮酒，饮料基料，饮料浓缩物或具有从含醇溶蛋白原料中降低的醇溶蛋白含量的饮料添加剂的方法，包括以下步骤：a）使饮料或饮料的前体与十字连接酶获得改性醇溶蛋白; b）至少部分地去除改性的醇溶醇。

23. 发明授权

US09238817B2 Method for producing natively folded proteins in a prokaryotic host 有权
公开(公告)号：US09238817B2
公开(公告)日：2016-01-19
申请号：US13309722
申请日：2011-12-02
申请人： Lloyd Ruddock
发明人： Lloyd Ruddock
IPC分类号： C12P21/06 , C12N15/70 , C12N9/02 , C12N9/90 , C12P21/02
CPC分类号： C12P21/00 , C07K14/4703 , C07K14/51 , C07K14/53 , C07K14/54 , C07K14/5412 , C07K14/555 , C07K14/575 , C07K14/61 , C07K14/70596 , C12N9/0051 , C12N9/90 , C12N15/70 , C12P21/02 , C12Y108/03002 , C12Y503/04001
摘要： The present invention relates to a method for producing a protein of interest containing one or more disulfide bonds in its native state. The method comprises that a prokaryotic host cell is genetically engineered to express the protein of interest and a sulfhydryl oxidase in the cytoplasm of the host cell. The protein of interest is formed in a soluble form and contains disulfide bonds due to the presence of the sulfhydryl oxidase in the cytoplasm of said host cell. The present invention relates also to a prokaryotic host cell and a vector system for producing a protein of interest containing natively folded disulfide bonds.

24. 发明申请

US20140212923A1 Protein Expression 有权
标题翻译：蛋白质表达
公开(公告)号：US20140212923A1
公开(公告)日：2014-07-31
申请号：US14241505
申请日：2012-08-31
申请人： Roland Weis , Thomas Purkarthofer
发明人： Roland Weis , Thomas Purkarthofer
IPC分类号： C12P21/00
CPC分类号： C12P21/00 , C07K14/55 , C07K14/765 , C07K14/79 , C12N9/0006 , C12N9/90 , C12N15/815 , C12P21/02 , C12Y101/03013 , C12Y503/04001
摘要： The present invention relates to a genetically modified yeast cell comprising: —at least one recombinant promoter operably linked to at least one gene encoding a polypeptide or protein supporting the biosynthesis of polypeptides or proteins within said cell, said at least one gene being located at the native genomic locus of the genetically unmodified wild-type yeast cell, wherein the naturally occurring promoter of the at least one gene encoding the biosynthesis supporting polypeptide or protein is inactivated by at least one mutation within said naturally occurring promoter and, —a secretion cassette comprising a recombinant nucleic acid molecule encoding a protein or polypeptide of interest and a method for producing a recombinant protein or polypeptide of interest using such a cell.
摘要翻译：本发明涉及遗传修饰的酵母细胞，其包含：至少一个重组启动子，其可操作地连接至编码支持所述细胞内的多肽或蛋白质的生物合成的多肽或蛋白质的至少一个基因，所述至少一个基因位于遗传性未修饰的野生型酵母细胞的天然基因组座位，其中编码所述生物合成支持多肽或蛋白质的所述至少一个基因的天然存在的启动子通过所述天然存在的启动子内的至少一个突变而失活，以及包含编码感兴趣的蛋白质或多肽的重组核酸分子和使用这种细胞产生感兴趣的重组蛋白质或多肽的方法。

25. 发明授权

US07959916B2 Negative immunomodulation of immune responses by ERp5 有权
标题翻译： ERp5免疫反应的负免疫调节
公开(公告)号：US07959916B2
公开(公告)日：2011-06-14
申请号：US12108069
申请日：2008-04-23
申请人： Thomas Spies , Veronika Groh-Spies
发明人： Thomas Spies , Veronika Groh-Spies
IPC分类号： A61K39/395
CPC分类号： C12N15/1137 , C07K16/2833 , C07K16/40 , C12N2310/111 , C12N2310/14 , C12Y503/04001
摘要： The present invention relates to methods of treating immune disorders and cancers. In particular the invention provides methods of inhibiting the negative immunomodulatory effects of ERp-5 on T cells and dendritic cells, in conjunction with other surface receptors.
摘要翻译：本发明涉及治疗免疫疾病和癌症的方法。特别地，本发明提供了与其它表面受体结合来抑制ERp-5对T细胞和树突状细胞的负免疫调节作用的方法。

26. 发明申请

US20100310604A1 RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ 审中-公开
标题翻译：转基因植物中生产的重组流感病毒样芽孢杆菌（VLPS）表达HEMAGGLUTININ
公开(公告)号：US20100310604A1
公开(公告)日：2010-12-09
申请号：US12863772
申请日：2009-01-12
申请人： Marc-André D'Aoust , Manon Couture , Frédéric Ors , Sonia Trépanier , Pierre-Olivier Lavoie , Michéle Dargis , Louis-Philippe Vézina , Nathalie Landry
发明人： Marc-André D'Aoust , Manon Couture , Frédéric Ors , Sonia Trépanier , Pierre-Olivier Lavoie , Michéle Dargis , Louis-Philippe Vézina , Nathalie Landry
IPC分类号： A61K39/145 , C07H21/04 , C07K14/11 , A01H5/00 , A61P31/16 , A01H1/00
CPC分类号： C12N15/8258 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55583 , A61K2039/55588 , A61K2039/58 , C07K14/005 , C07K2319/02 , C07K2319/03 , C12N7/00 , C12N9/90 , C12N15/8257 , C12N2760/16022 , C12N2760/16122 , C12N2760/16123 , C12N2760/16133 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16234 , C12Y503/04001 , G06F9/505 , G06F2209/508
摘要： A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
摘要翻译：提供了在植物或植物的一部分内合成流感病毒样颗粒（VLP）的方法。该方法包括在植物中表达流感HA并通过尺寸排阻色谱法进行纯化。本发明还涉及包含流感HA蛋白和植物脂质的VLP。本发明还涉及编码流感HA以及载体的核酸。 VLP可用于制定流感疫苗，或可用于丰富现有疫苗。

27. 发明申请

US20090169552A1 NEGATIVE IMMUNOMODULATION OF IMMUNE RESPONSES BY ERp5 有权
标题翻译： ERP5对免疫应答的负面免疫调节作用
公开(公告)号：US20090169552A1
公开(公告)日：2009-07-02
申请号：US12108069
申请日：2008-04-23
申请人： Thomas Spies , Veronika Groh-Spies
发明人： Thomas Spies , Veronika Groh-Spies
IPC分类号： A61K39/395 , C12N5/06 , A61K38/16
CPC分类号： C12N15/1137 , C07K16/2833 , C07K16/40 , C12N2310/111 , C12N2310/14 , C12Y503/04001
摘要： The present invention relates to methods of treating immune disorders and cancers. In particular the invention provides methods of inhibiting the negative immunomodulatory effects of ERp-5 on T cells and dendritic cells, in conjunction with other surface receptors.
摘要翻译：本发明涉及治疗免疫疾病和癌症的方法。特别地，本发明提供了与其它表面受体结合来抑制ERp-5对T细胞和树突状细胞的负免疫调节作用的方法。

28. 发明授权

US07404952B2 Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis 失效
标题翻译：蛋白二硫键异构酶和ABC转运蛋白同源蛋白参与能量稳态调节
公开(公告)号：US07404952B2
公开(公告)日：2008-07-29
申请号：US11567079
申请日：2006-12-05
申请人： Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Thomas Hader , Arnd Steuernagel
发明人： Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Thomas Hader , Arnd Steuernagel
IPC分类号： A61K38/71 , C12N9/10 , C07K1/00
CPC分类号： A61K31/70 , A61K38/52 , C07K14/705 , C07K2319/00 , C12N9/90 , C12Y503/04001
摘要： The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.
摘要翻译：本发明公开了三种调节甘油三酯的能量稳态和代谢的新型蛋白质，以及鉴定和编码本发明公开的蛋白质的多核苷酸。本发明还涉及用于产生本发明的多肽和多核苷酸的载体，宿主细胞，抗体和重组方法。本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节相关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症以及相关疾病胰腺功能障碍（例如糖尿病），高血压，胰腺功能障碍，动脉硬化，冠状动脉疾病（CAD），冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石，癌症，糖尿病，例如生殖器官的癌症，睡眠呼吸暂停等。

29. 发明申请

US20070185048A1 Protein Disulfide Isomerase and ABC Transporter Homologous Proteins Involved in the Regulation of Energy Homeostasis 失效
标题翻译：蛋白二硫化物异构酶和ABC转运蛋白同源蛋白参与能量稳态调节
公开(公告)号：US20070185048A1
公开(公告)日：2007-08-09
申请号：US11567079
申请日：2006-12-05
申请人： Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Thomas Hader , Arnd Steuernagel
发明人： Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Thomas Hader , Arnd Steuernagel
IPC分类号： A61K48/00 , A01K67/027 , C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/90
CPC分类号： A61K31/70 , A61K38/52 , C07K14/705 , C07K2319/00 , C12N9/90 , C12Y503/04001
摘要： The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.
摘要翻译：本发明公开了三种调节甘油三酯的能量稳态和代谢的新型蛋白质，以及鉴定和编码本发明公开的蛋白质的多核苷酸。本发明还涉及用于产生本发明的多肽和多核苷酸的载体，宿主细胞，抗体和重组方法。本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节相关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症以及相关疾病胰腺功能障碍（例如糖尿病），高血压，胰腺功能障碍，动脉硬化，冠状动脉疾病（CAD），冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石，癌症，糖尿病，例如生殖器官的癌症，睡眠呼吸暂停等。

30. 发明申请

US20060199245A1 Conus protein disulfide isomerase 有权
标题翻译：圆锥蛋白二硫键异构酶
公开(公告)号：US20060199245A1
公开(公告)日：2006-09-07
申请号：US11216937
申请日：2005-08-31
申请人： Grzegorz Bulaj , Baldomero Olivera , Olga Buczek , James Garrett , Ian Goodsell
发明人： Grzegorz Bulaj , Baldomero Olivera , Olga Buczek , James Garrett , Ian Goodsell
IPC分类号： C12P21/06 , C07H21/04 , C12N9/90 , C12N5/06 , C12N5/08 , C12N1/16 , C12N1/18 , C12N1/21
CPC分类号： C07H21/04 , C12N9/90 , C12Y503/04001
摘要： Protein disulfide isomerase is a major component of Conus venom ducts. The invention relates to a protein disulfide isomerase (PDI) from Conus snails, a nucleic acid sequence encoding the Conus protein disulfide isomerase, and to methods for folding disulfide-rich peptides using a protein disulfide isomerase. Oxidative folding of conotoxin precursors, catalyzed by a PDI, was more efficient and decreased the number and concentration of transiently accumulated folding species. The PDI-assisted oxidative folding of conotoxins was also influenced by the propeptide relative to the mature peptide.
摘要翻译：蛋白二硫键异构酶是Conus毒液管的主要成分。本发明涉及来自Conus蜗牛的蛋白质二硫键异构酶（PDI），编码康科斯蛋白二硫键异构酶的核酸序列，以及使用蛋白质二硫键异构酶折叠富含二硫键的肽的方法。通过PDI催化的芋螺毒素前体的氧化折叠更有效，并且减少了瞬时积累的折叠物质的数量和浓度。脯氨酸的PDI辅助氧化折叠也受到前肽相对于成熟肽的影响。

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