专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20040203132A1 Conus protein disulfide isomerase 审中-公开
标题翻译：圆锥蛋白二硫键异构酶
公开(公告)号：US20040203132A1
公开(公告)日：2004-10-14
申请号：US10789450
申请日：2004-02-27
申请人： Cognetix, Inc.
发明人： Grzegorz Bulaj , Baldomero M. Olivera , Olga Buczek , James E. Garrett , Ian Goodsell
IPC分类号： C12N009/90 , C07H021/04
CPC分类号： C07H21/04 , C12N9/90 , C12Y503/04001
摘要： Protein disulfide isomerase is a major component of Conus venom ducts. The invention relates to a protein disulfide isomerase (PDI) from Conus snails, a nucleic acid sequence encoding the Conus protein disulfide isomerase, and to methods for folding disulfide-rich peptides using a protein disulfide isomerase. Oxidative folding of conotoxin precursors, catalyzed by a PDI, was more efficient and decreased the number and concentration of transiently accumulated folding species. The PDI-assisted oxidative folding of conotoxins was also influenced by the propeptide relative to the mature peptide.
摘要翻译：蛋白二硫键异构酶是Conus毒液管的主要成分。本发明涉及来自Conus蜗牛的蛋白质二硫键异构酶（PDI），编码康科斯蛋白二硫键异构酶的核酸序列，以及使用蛋白质二硫键异构酶折叠富含二硫键的肽的方法。通过PDI催化的芋螺毒素前体的氧化折叠更有效，并且减少了瞬时积累的折叠物质的数量和浓度。脯氨酸的PDI辅助氧化折叠也受到前肽相对于成熟肽的影响。

22. 发明申请

US20040097457A1 Protein disulfide isomerase and abc transporter homologous proteins involved in the regulation of energy homeostasis 失效
标题翻译：蛋白二硫键异构酶和abc转运蛋白同源蛋白参与能量稳态调节
公开(公告)号：US20040097457A1
公开(公告)日：2004-05-20
申请号：US10473696
申请日：2003-09-29
发明人： Karsten Eulenberg , Gunter Bronner , Thomas Ciossek , Thomas Hader , Arnd Steuernagel
IPC分类号： A61K048/00
CPC分类号： A61K31/70 , A61K38/52 , C07K14/705 , C07K2319/00 , C12N9/90 , C12Y503/04001
摘要： The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.
摘要翻译：本发明公开了三种调节甘油三酯的能量稳态和代谢的新型蛋白质，以及鉴定和编码本发明公开的蛋白质的多核苷酸。本发明还涉及用于产生本发明的多肽和多核苷酸的载体，宿主细胞，抗体和重组方法。本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节相关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症以及相关疾病胰腺功能障碍（例如糖尿病），高血压，胰腺功能障碍，动脉硬化，冠状动脉疾病（CAD），冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石，癌症，糖尿病，例如生殖器官的癌症，睡眠呼吸暂停等。

23. 发明申请

US20030124676A1 Increasing production of proteins in gram-positive microorganisms 失效
标题翻译：增加革兰氏阳性微生物中蛋白质的产量
公开(公告)号：US20030124676A1
公开(公告)日：2003-07-03
申请号：US10339278
申请日：2003-01-09
发明人： Wilhelmus J. Quax , Robert M. Caldwell
IPC分类号： C07H021/04 , C12N009/90 , C12P021/02 , C12N001/21 , C12N015/74
CPC分类号： C12N9/90 , C12Y503/04001
摘要： The present invention relates to secretion in Gram-positive microorganisms. The present invention provides the nuclei acid and amino acid sequences for the Bacillus subtilis disulfide bond isomerases, Dsb1 and Dsb2. The present invention also provides means for increasing the secretion of heterologous or homologous proteins in gram-positive microorganisms.
摘要翻译：本发明涉及革兰氏阳性微生物中的分泌。本发明提供枯草芽孢杆菌二硫键异构酶Dsb1和Dsb2的核酸和氨基酸序列。本发明还提供增加革兰氏阳性微生物中异源或同源蛋白质分泌的方法。

24. 发明授权

US06346244B1 Fungal protein disulfide isomerase 失效
标题翻译：真菌蛋白二硫键异构酶
公开(公告)号：US06346244B1
公开(公告)日：2002-02-12
申请号：US09262666
申请日：1999-03-04
申请人： Carsten Mailand Hjort
发明人： Carsten Mailand Hjort
IPC分类号： A61K3843
CPC分类号： D06M16/003 , A21D8/042 , A23K10/14 , A23L29/06 , A61K8/66 , A61K38/00 , A61Q5/00 , C12N9/90 , C12Y503/04001
摘要： The present invention relates to protein disulfide isomerases which are encoded by a nucleic acid sequence which hybridizes with (i) the DNA sequence of SEQ ID NO:1 or (ii) the DNA sequence of SEQ ID NO:2, under the following conditions: presoaking in 5×SSC and prehybridizing for 1 h at ˜40° C. in a solution of 5×SSC, 5×Denhardt's solution, 50 mM sodium phosphate, pH 6.8, and 50 &mgr;g of denatured sonicated calf thymus DNA, followed by hybridization in the same solution supplemented with 50 &mgr;Ci 32-P-dCTP labelled probe for 18 h at ˜40° C. followed by washing three times in 2×SSC, 0.2% SDS at 40° C. for 30 minutes; and fragments thereof. The present invention also relates to DNA sequences encoding the protein disulfide isomerases, compositions comprising said protein disulfide isomerases and methods of use thereof.
摘要翻译：本发明涉及由以下条件与（i）SEQ ID NO：1的DNA序列或（ii）SEQ ID NO：2的DNA序列杂交的核酸序列编码的蛋白质二硫键异构酶：在5xSSC中预浸泡，并在约40℃下在5xSSC，5xDenhardt溶液，50mM磷酸钠，pH6.8和50ml变性超声小牛胸腺DNA的溶液中预杂交1小时，然后在补充有 50μC32-P-dCTP标记的探针在〜40℃下培养18小时，然后在2xSSC，0.2％SDS中在40℃下洗涤3次30分钟; 及其片段。本发明还涉及编码蛋白质二硫键异构酶的DNA序列，包含所述蛋白质二硫键异构酶的组合物及其使用方法。

25. 发明授权

US06337193B1 Expression of manose-binding protein in methylotrophic yeast 失效
标题翻译：芒果结合蛋白在甲基营养酵母中的表达
公开(公告)号：US06337193B1
公开(公告)日：2002-01-08
申请号：US09198603
申请日：1998-11-24
申请人： Raymond E. Tully , G. Thomas Caltagirone , Shawn S. Moyer , Michael T. Ronning
发明人： Raymond E. Tully , G. Thomas Caltagirone , Shawn S. Moyer , Michael T. Ronning
IPC分类号： C12P2102
CPC分类号： C12N9/0071 , C07K14/47 , C07K2319/02 , C12N9/90 , C12Y114/11002 , C12Y503/04001
摘要： Expression of Mannose-Binding Protein in methylotrophic yeast strains is disclosed.
摘要翻译：甘露糖结合蛋白在甲基营养酵母菌株中的表达

26. 发明授权

US5676946A Phospholipase C homolog 失效
标题翻译：磷脂酶C同系物
公开(公告)号：US5676946A
公开(公告)日：1997-10-14
申请号：US726883
申请日：1996-10-04
申请人： Phillip R. Hawkins , Jeffrey J. Seilhamer
发明人： Phillip R. Hawkins , Jeffrey J. Seilhamer
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K38/46 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12P21/08 , C12N9/20 , C12N15/70
CPC分类号： C12N9/16 , A61K38/52 , C12Y503/04001
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel phospholipase C homolog (plch and PLCH). The present invention also provides for antisense molecules to the plch nucleotide sequences, expression vectors for the production of purified PLCH, antibodies capable of binding specifically to PLCH, hybridization probes or oligonucleotides for detecting excess PLCH-encoding nucleotide sequences, genetically engineered host cells for the expression of PLCH, diagnostic tests for activated, inflamed, diseased, and hydroxyurea-resistant cells and/or tissues based on PLCH-encoding nucleic acid molecules and antibodies capable of binding specifically to PLCH.
摘要翻译：本发明提供鉴定和编码新型磷脂酶C同源物（plch和PLCH）的核苷酸和氨基酸序列。本发明还提供了针对ch核苷酸序列的反义分子，用于产生纯化的PLCH的表达载体，能够特异性结合PLCH的抗体，用于检测过量PLCH编码核苷酸序列的杂交探针或寡核苷酸，用于 PLCH的表达，基于编码PLCH的核酸分子和能够特异性结合PLCH的抗体的活化，发炎，患病和羟基脲抗性细胞和/或组织的诊断试验。

27. 发明授权

US11919283B2 Method of providing insulation to a structure 有权
公开(公告)号：US11919283B2
公开(公告)日：2024-03-05
申请号：US16300608
申请日：2017-05-11
申请人： ROCKWOOL INTERNATIONAL A/S
发明人： Thomas Hjelmgaard , Lars Hald , Thomas Tielemann
IPC分类号： B32B37/12 , B32B5/12 , B32B5/26 , B32B7/12 , B32B15/14 , B32B19/04 , B32B37/14 , B32B37/18 , B32B38/00 , C03C13/06 , C03C25/26 , C03C25/32 , C03C25/321 , C03C25/328 , C08J5/04 , C08L1/28 , C08L3/02 , C08L5/12 , C08L89/06 , C09J5/00 , C09J11/06 , C09J101/28 , C09J103/02 , C09J105/00 , C09J105/04 , C09J105/06 , C09J105/12 , C09J189/00 , C09J189/06 , D04H1/413 , D04H1/4209 , D04H1/4218 , D04H1/4266 , D04H1/587 , D04H1/593 , D04H1/64 , D04H1/724 , D04H1/74 , D04H3/002 , D04H3/004 , E04B1/74 , E04B1/80 , E04B1/88 , E04B1/94 , E04C2/284 , E04D3/35 , E04F13/08 , C12N9/02 , C12N9/06 , C12N9/08 , C12N9/10 , C12N9/90 , E04B1/76
CPC分类号： B32B37/12 , B32B5/12 , B32B5/26 , B32B7/12 , B32B15/14 , B32B19/04 , B32B19/041 , B32B37/1207 , B32B37/146 , B32B37/18 , B32B38/0004 , C03C13/06 , C03C25/26 , C03C25/32 , C03C25/321 , C03C25/328 , C08J5/043 , C08L1/286 , C08L3/02 , C08L5/12 , C08L89/06 , C09H11/00 , C09J5/00 , C09J11/06 , C09J101/28 , C09J101/286 , C09J103/02 , C09J105/00 , C09J105/04 , C09J105/06 , C09J105/12 , C09J189/005 , C09J189/06 , D04H1/413 , D04H1/4209 , D04H1/4218 , D04H1/4266 , D04H1/587 , D04H1/593 , D04H1/64 , D04H1/724 , D04H1/74 , D04H3/002 , D04H3/004 , E04B1/74 , E04B1/80 , E04B1/88 , E04B1/94 , E04C2/284 , E04D3/352 , E04F13/0866 , B32B2037/1215 , B32B2037/1253 , B32B2037/1269 , B32B38/164 , B32B2250/20 , B32B2250/40 , B32B2255/02 , B32B2255/26 , B32B2262/108 , B32B2305/20 , B32B2305/72 , B32B2307/304 , B32B2307/732 , B32B2309/02 , B32B2315/14 , B32B2317/00 , B32B2419/06 , B32B2607/00 , C03C2213/00 , C03C2218/11 , C08J2301/28 , C08J2303/02 , C08J2389/06 , C08J2405/00 , C08J2405/04 , C08J2405/06 , C08J2405/12 , C08J2491/00 , C08J2493/00 , C08L2201/52 , C08L2205/03 , C09J2400/146 , C09J2401/00 , C09J2403/00 , C09J2405/00 , C09J2489/00 , C12N9/0022 , C12N9/0051 , C12N9/0059 , C12N9/0065 , C12N9/0071 , C12N9/1044 , C12N9/90 , C12Y104/03013 , C12Y108/03002 , C12Y110/03001 , C12Y111/01007 , C12Y114/18001 , C12Y203/01013 , C12Y203/02013 , C12Y503/04001 , D10B2505/20 , E04B2001/742 , E04B2001/743 , E04B2001/745 , E04B2001/7683 , C09J189/06 , C08L5/12
摘要： The present invention relates to a method of providing thermal and/or acoustic insulation to a structure, comprising the steps of: providing a substrate which comprises fibres; applying the substrate to the structure; blending the substrate with a binder composition before, during or after application of the substrate to the structure; allowing curing of the binder composition after the substrate and the binder composition have been applied to the structure; wherein the binder composition comprises at least one hydrocolloid. The present invention also relates to an insulated structure obtainable by said method.

28. 发明公开

US20230183671A1 DROPLETS AND METHOD FOR PRODUCING SAME 审中-公开
公开(公告)号：US20230183671A1
公开(公告)日：2023-06-15
申请号：US17926032
申请日：2021-06-04
申请人： TOHOKU UNIVERSITY , Tokushima University
发明人： Masaki OKUMURA , Motonori MATSUSAKI , Kenji INABA , Tomohide SAIO , Shingo KANEMURA
IPC分类号： C12N9/90 , C07K1/10
CPC分类号： C12N9/90 , C07K1/10 , C12Y503/04001
摘要： An object to be achieved by the present in is to prepare a droplet using a protein that has not been known heretofore to form a droplet. The present invention provides a droplet including an assembly of a protein, wherein the protein is a PDI family protein and/or an artificial protein, and contains a thioredoxin-like domain.

29. 发明申请

US20170088848A1 Recombinant Influenza Virus-Like Particles (VLPs) Produced in Transgenic Plants Expressing Hemagglutinin 审中-公开
公开(公告)号：US20170088848A1
公开(公告)日：2017-03-30
申请号：US15256119
申请日：2016-09-02
申请人： Medicago Inc.
发明人： Marc-Andre D'AOUST , Manon COUTURE , Frederic ORS , Sonia TREPANIER , Pierre-Olivier LAVOIE , Michele DARGIS , Louis-Philippe VEZINA , Nathalie LANDRY
IPC分类号： C12N15/82 , A61K39/145 , C12N7/00
CPC分类号： C12N15/8258 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55583 , A61K2039/55588 , A61K2039/58 , C07K14/005 , C07K2319/02 , C07K2319/03 , C12N7/00 , C12N9/90 , C12N15/8257 , C12N2760/16022 , C12N2760/16122 , C12N2760/16123 , C12N2760/16133 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16234 , C12Y503/04001 , G06F9/505 , G06F2209/508
摘要： A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plant lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

30. 发明申请

US20160370369A1 ULTRAPURIFIED DsbA AND DsbC AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：超声DsbA和DsbC及其制备和使用方法
公开(公告)号：US20160370369A1
公开(公告)日：2016-12-22
申请号：US15061943
申请日：2016-03-04
申请人： Genentech, Inc.
发明人： Marc WONG , Liliana T. YEE , Amy LIM , Chris B. FONG
IPC分类号： G01N33/573 , C12N9/90 , C07K1/22 , C12N9/02 , C07K16/40
CPC分类号： G01N33/573 , A61K38/00 , C07K1/22 , C07K16/40 , C12N9/0051 , C12N9/90 , C12Y108/04002 , C12Y503/04001 , G01N2333/90212 , G01N2333/99 , Y02A50/473
摘要： The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.
摘要翻译：本发明提供以非常高的纯度生产二硫化物氧化还原酶A（DsbA）和二硫化物氧化还原酶C（DsbC）多肽的方法。还提供了超纯DsbA和DsbC及其使用方法，例如用于免疫测定以显示从细菌中产生的生物制剂中除去DsbA和DsbC。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式