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1. 发明授权

US09506076B2 Methods and compositions for extending shelf life of plant products 有权
标题翻译：延长植物产品保存期限的方法和组成
公开(公告)号：US09506076B2
公开(公告)日：2016-11-29
申请号：US14035756
申请日：2013-09-24
申请人： SEMINIS VEGETABLE SEEDS, INC.
发明人： Michele Feikert , Byron Froman , Graeme S. Garvey , Leo Kelly , William Waycott
IPC分类号： C12N15/82 , C12N15/00 , A01H5/10 , C12N15/113 , A01H5/12 , C12Q1/68 , C12N9/02 , A01N57/16 , A01N65/12 , A23B7/155 , A01N25/00
CPC分类号： C12Q1/6895 , A01H5/12 , A01N25/00 , A01N57/16 , A01N65/12 , A23B7/155 , C12N9/0059 , C12N15/1137 , C12N15/8218 , C12N15/825 , C12N15/8261 , C12N15/8266 , C12Q1/686 , C12Y110/03001
摘要： The invention provides compositions and methods related to selective inhibition of PPO11 and use for improving shelf life of a plant or parts thereof. In accordance with the invention, for example, compositions for topical application to a plant or part thereof, are provided that can reduce browning of the plant or part thereof to extend shelf life.
摘要翻译：本发明提供了与选择性抑制PPO11有关的组合物和方法，并且用于改善植物或其部分的保质期。根据本发明，例如，提供用于局部施用于植物或其部分的组合物，其可以减少植物或其部分的褐变以延长保质期。

2. 发明申请

US20150140028A1 Recombinant Bacterium and Uses Thereof 有权
标题翻译：重组细菌及其用途
公开(公告)号：US20150140028A1
公开(公告)日：2015-05-21
申请号：US14516090
申请日：2014-10-16
申请人： National Research Council of Canada
发明人： Subash SAD , Lakshmi KRISHNAN , Fanny TZELEPIS , Valeria ALCON , Kevin G. YOUNG
IPC分类号： A61K39/00
CPC分类号： C07K14/77 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K2039/522 , A61K2039/523 , C07K14/195 , C07K14/4713 , C07K14/4748 , C07K14/70596 , C07K14/71 , C07K2319/036 , C07K2319/35 , C12N1/20 , C12N9/0059 , C12N9/2462 , C12N9/6494 , C12N2760/10034 , C12Y110/03001 , C12Y304/24011 , Y02A50/41
摘要： The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type III secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumour antigen. Methods of imparting immunity using the recombinant bacterium are also provided.
摘要翻译：本发明涉及表达被转移到宿主生物的胞质溶胶中的抗原的重组细菌及其应用。为此，本发明提供了一种重组细菌，其包含编码利用III型分泌系统转运至宿主细胞的胞质溶胶的抗原的核酸。重组细菌通常选自存在于吞噬细胞中的细胞内病原体，并且不能诱导快速的T细胞活化。易位抗原可以是病毒抗原，细菌抗原或肿瘤抗原。还提供了使用重组细菌赋予免疫力的方法。

3. 发明申请

US20140090098A1 METHODS AND COMPOSITIONS FOR EXTENDING SHELF LIFE OF PLANT PRODUCTS 有权
标题翻译：用于延长植物产品的寿命的方法和组合物
公开(公告)号：US20140090098A1
公开(公告)日：2014-03-27
申请号：US14035756
申请日：2013-09-24
申请人： Seminis Vegetable Seeds, Inc.
发明人： Michele Feikert , Byron Froman , Graeme S. Garvey , Leo Kelly , William Waycott
IPC分类号： C12N15/113 , C12Q1/68 , A01H5/12
CPC分类号： C12Q1/6895 , A01H5/12 , A01N25/00 , A01N57/16 , A01N65/12 , A23B7/155 , C12N9/0059 , C12N15/1137 , C12N15/8218 , C12N15/825 , C12N15/8261 , C12N15/8266 , C12Q1/686 , C12Y110/03001
摘要： The invention provides compositions and methods related to selective inhibition of PPO11 and use for improving shelf life of a plant or parts thereof. In accordance with the invention, for example, compositions for topical application to a plant or part thereof, are provided that can reduce browning of the plant or part thereof to extend shelf life.
摘要翻译：本发明提供了与选择性抑制PPO11有关的组合物和方法，并且用于改善植物或其部分的保质期。根据本发明，例如，提供用于局部施用于植物或其部分的组合物，其可以减少植物或其部分的褐变以延长保质期。

4. 发明申请

US20130156809A1 Recombinant Bacterium and Uses Thereof 审中-公开
公开(公告)号：US20130156809A1
公开(公告)日：2013-06-20
申请号：US13811690
申请日：2011-07-28
申请人： Subash Sad , Lakshmi Krishnan , Valeria Alcon , Kevin G. Young , Fanny Tzelepis
发明人： Subash Sad , Lakshmi Krishnan , Valeria Alcon , Kevin G. Young , Fanny Tzelepis
IPC分类号： A61K39/12 , A61K39/00
CPC分类号： C07K14/77 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K2039/522 , A61K2039/523 , C07K14/195 , C07K14/4713 , C07K14/4748 , C07K14/70596 , C07K14/71 , C07K2319/036 , C07K2319/35 , C12N1/20 , C12N9/0059 , C12N9/2462 , C12N9/6494 , C12N2760/10034 , C12Y110/03001 , C12Y304/24011 , Y02A50/41
摘要： The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type III secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumour antigen. Methods of imparting immunity using the recombinant bacterium are also provided.

5. 发明申请

US20130133107A1 GENES ENCODING NEMATODE TOXINS 有权
标题翻译：基因编码NEMATODE毒素
公开(公告)号：US20130133107A1
公开(公告)日：2013-05-23
申请号：US13747740
申请日：2013-01-23
申请人： Athenix Corporation
发明人： Cheryl L. Peters , Brian Vande Berg , Brian Carr , Julia T. Daum , Vadim Beilinson , Sandra Volrath , Candace Poutre , Kimberly Sampson
IPC分类号： C12N15/82
CPC分类号： C12N15/8241 , C12N9/0059 , C12N9/0071 , C12N15/8285 , C12Y110/03001 , C12Y114/18001 , Y02A40/164
摘要： Compositions and methods for conferring nematicidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions including a coding sequence for nematicidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated nematicidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules including nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4, 5, 8, 9, 13, 14, 47, 48, or 49, the nucleotide sequence set forth in SEQ ID NO:1, 2, 3, 6, 7, 10, 11, 12, 15, 45, or 46, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子的杀线虫活性的组合物和方法。提供了包含杀线虫多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中，用于在植物和细菌中转化和表达。组合物还包括转化的细菌，植物，植物细胞，组织和种子。特别地，提供了分离的杀线虫剂核酸分子。另外，包括对应于多核苷酸的氨基酸序列。特别地，本发明提供了分离的核酸分子，其包括编码SEQ ID NO：4,5,8,9,13,14,77,48或49所示氨基酸序列的核苷酸序列，所列出的核苷酸序列在SEQ ID NO：1,2,3,6,7,10,11，12，15，45或46中，以及其变体和片段。

6. 发明申请

US20080206399A1 Method and Use of a Laccase Enzyme in a Baked Product 审中-公开
标题翻译：烘焙产品中漆酶的方法和用途
公开(公告)号：US20080206399A1
公开(公告)日：2008-08-28
申请号：US11916763
申请日：2006-06-13
申请人： Hans Peter Heldt-Hansen , Todd Forman , Frank T. Rittig
发明人： Hans Peter Heldt-Hansen , Todd Forman , Frank T. Rittig
IPC分类号： A21D8/04
CPC分类号： C12Y110/03001 , A21D8/042 , A21D13/42 , C12Y110/03002 , C12Y110/03006 , C12Y111/01007
摘要： The present invention relates to a method of preparing a baked product from dried masa flour, wherein an enzyme capable of polymerizing polyphenolics is added to the dough, as well as to a use of such an enzyme in a baked product made from non-leavened dough comprising dried masa flour.
摘要翻译：本发明涉及一种从干燥的马莎粉中制备烘焙产品的方法，其中将能够聚合多酚的酶加入到面团中，以及在由未发酵的面团制成的焙烤产品中使用这种酶包括干燥的马莎粉。

7. 发明授权

US07125557B1 Nucleic acid molecule comprising a nucleic acid sequence which codes for a haemocyanin, and comprising at least one intron sequence 有权
标题翻译：核酸分子，其包含编码血蓝蛋白的核酸序列，并且包含至少一个内含子序列
公开(公告)号：US07125557B1
公开(公告)日：2006-10-24
申请号：US10049988
申请日：2000-08-21
申请人： Jürgen Markl , Benjamin Altenhein , Bernhard Lieb , Thomas Stiefel
发明人： Jürgen Markl , Benjamin Altenhein , Bernhard Lieb , Thomas Stiefel
IPC分类号： A61K47/00 , C07K14/00
CPC分类号： C12Y110/03001 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/43504 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12N9/0059 , G01N33/57496 , Y02A50/423 , Y10S530/855
摘要： A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and comprises at least one intron sequence, as well as haemocyanin fusion proteins. The construct furthermore can comprise a nucleic acid sequence that codes for an antigen. Host cells are also contemplated that contain the nucleic acid molecule or construct and a recombinant expression product thereof. The invention furthermore relates to a pharmaceutical composition that comprises the expression product and antibodies obtainable by immunization of an animal therewith, as well as the use the antibodies in screening methods for the identification of tumors.
摘要翻译：预期单独或具有适用于表达控制的启动子的核酸分子或构建体编码具有至少一个血蓝蛋白结构域的免疫学特性的血蓝蛋白，血蓝蛋白结构域或其片段，并且包含至少一个内含子序列，以及血蓝蛋白融合蛋白。该构建体还可以包含编码抗原的核酸序列。还考虑了含有核酸分子或构建体及其重组表达产物的宿主细胞。本发明还涉及一种药物组合物，其包含表达产物和通过用其免疫动物可获得的抗体，以及在用于鉴定肿瘤的筛选方法中使用该抗体。

8. 发明授权

US06821514B2 Compositions and methods relating to reduction of symptoms of autism 失效
标题翻译：与减少自闭症症状有关的组成和方法
公开(公告)号：US06821514B2
公开(公告)日：2004-11-23
申请号：US10313790
申请日：2002-12-06
申请人： Devin B. Houston
发明人： Devin B. Houston
IPC分类号： A61K3848
CPC分类号： C12N9/48 , A61K38/4813 , C12N9/0059 , C12Y110/03001 , C12Y304/14005 , A61K2300/00
摘要： Methods and compositions that can reduce the symptoms of autism in a human patient comprising administering a physiologically effective amount of one or both of a purified casomorphin inhibitor selected from the group consisting of a casomorphinase and a casomorphin ligand, and a physiologically effective amount of a purified gluteomorphin inhibitor selected from the group consisting of a gluteomorphinase and a gluteomorphin ligand, to a human patient in sufficient quantities to reduce the effects of the autism. In some embodiments, the compositions and methods further comprise a physiologically effective amount of an enkephalin inhibitor, preferably an enkephalinase, and a physiologically effective amount of an endorphin inhibitor, preferably an endorphinase.
摘要翻译：可以减轻人类患者自闭症症状的方法和组合物，其包括给予生理学有效量的选自下列药物的一种或两种纯化的casomorphin抑制剂：胱天肽酶和casomorphin配体，以及生理有效量的纯化麝香草素抑制剂，选自糠醛吗啡酶和钆蓝霉素配体，以足够的量向人类患者减轻自闭症的作用。在一些实施方案中，组合物和方法还包含生理有效量的脑啡肽抑制剂，优选脑啡肽酶和生理有效量的内啡肽抑制剂，优选内啡肽。

9. 发明申请

US20030170227A1 Compositions and methods relating to reduction of symptoms of autism 失效
公开(公告)号：US20030170227A1
公开(公告)日：2003-09-11
申请号：US10313790
申请日：2002-12-06
发明人： Devin B. Houston
IPC分类号： A61K038/48
CPC分类号： C12N9/48 , A61K38/4813 , C12N9/0059 , C12Y110/03001 , C12Y304/14005 , A61K2300/00
摘要： Methods and compositions that can reduce the symptoms of autism in a human patient comprising administering a physiologically effective amount of one or both of a purified casomorphin inhibitor selected from the group consisting of a casomorphinase and a casomorphin ligand, and a physiologically effective amount of a purified gluteomorphin inhibitor selected from the group consisting of a gluteomorphinase and a gluteomorphin ligand, to a human patient in sufficient quantities to reduce the effects of the autism. In some embodiments, the compositions and methods further comprise a physiologically effective amount of an enkephalin inhibitor, preferably an enkephalinase, and a physiologically effective amount of an endorphin inhibitor, preferably an endorphinase.

10. 发明申请

US20030131373A1 Materials and methods for the modification of plant lignin content 失效
标题翻译：修饰植物木质素含量的材料和方法
公开(公告)号：US20030131373A1
公开(公告)日：2003-07-10
申请号：US10174693
申请日：2002-06-18
发明人： Leonard N. Bloksberg , Ilkka Havukkala
IPC分类号： A01H005/00 , C12Q001/68 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/04
CPC分类号： C12Y110/03001 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0059 , C12N9/0061 , C12N9/0065 , C12N9/0071 , C12N9/0083 , C12N9/1007 , C12N9/1011 , C12N9/1051 , C12N9/2422 , C12N9/2445 , C12N9/86 , C12N9/88 , C12N9/93 , C12N15/8255 , C12Y110/03002 , C12Y114/13011 , C12Y201/01006 , C12Y302/01001 , C12Y302/01021
摘要： Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with genetic constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
摘要翻译：提供了与木质素生物合成途径相关的新型分离的多核苷酸和多肽，以及包括这些序列的遗传构建体。还公开了调节靶生物体中木质素含量，木质素结构和木质素组成的方法，所述方法包括将一种或多种本发明的多核苷酸掺入目标生物体的基因组中。

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