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21. 发明申请

US20130100439A1 SMART FIBER OPTIC SENSORS SYSTEMS AND METHODS FOR QUANTITATIVE OPTICAL SPECTROSCOPY 有权
标题翻译：智能光纤传感器系统和定量光学光谱的方法
公开(公告)号：US20130100439A1
公开(公告)日：2013-04-25
申请号：US13513458
申请日：2010-12-06
申请人： Bing Yu , Nirmala Ramanujam
发明人： Bing Yu , Nirmala Ramanujam
IPC分类号： G01N21/25
CPC分类号： G01N21/255 , A61B5/0075 , A61B5/0084 , A61B5/4331 , A61B5/4552 , A61B5/6885 , A61B2560/0228 , G01J3/0218 , G01J3/28 , G01J3/42 , G01L9/0079 , G01N21/274 , G01N21/645 , G01N2201/0627 , G01N2201/08
摘要： Smart fiber optic sensors, systems, and methods for performing quantitative optical spectroscopy are disclosed. In one embodiment, smart fiber optic sensor can include a sensing channel, a calibration channel, and a pressure sensing channel. External force or pressure can be calculated at pressure sensing channel for monitoring and controlling pressure at a sensor-specimen interface thereby ensuring more accurate specimen spectral data is collected. Contact pressure can be adjusted to remain within a specified range. A calibration light of the calibration channel and an illumination light of the sensing channel can be generated simultaneously from a shared light source. Pressure sensing channel can transmit light from a second light source and collect pressure spectral data.
摘要翻译：公开了用于执行定量光谱的智能光纤传感器，系统和方法。在一个实施例中，智能光纤传感器可以包括感测通道，校准通道和压力感测通道。可以在压力感测通道处计算外部力或压力，用于监测和控制传感器 - 样本接口处的压力，从而确保收集更准确的样本光谱数据。接触压力可以调整到一定范围内。可以从共享光源同时生成校准通道的校准光和感测通道的照明光。压力感测通道可以传输来自第二光源的光并收集压力光谱数据。

22. 发明申请

US20110059016A1 OPTICAL ASSAY SYSTEM WITH A MULTI-PROBE IMAGING ARRAY 审中-公开
标题翻译：具有多探针成像阵列的光学测量系统
公开(公告)号：US20110059016A1
公开(公告)日：2011-03-10
申请号：US12680302
申请日：2008-09-29
申请人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
发明人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
IPC分类号： A61K49/00 , C40B40/06 , C40B30/04 , C40B60/12 , A61P35/00
CPC分类号： G01N21/4795 , A61B5/0059 , G01N21/6456 , G01N21/6486 , G01N2021/4747 , G01N2021/6484
摘要： The subject matter described herein relates to an optical assay system having a multi-probe imaging array that orients a plurality of probes with respect to one another and to a sample. According to one aspect, the subject matter described herein includes a multi-probe imaging array for contacting biological samples and simultaneously illuminating a plurality of locations on the biological sample and collecting the reflected radiation from the locations. The multi-probe imaging array can be used for the rapid imaging of biological samples, for example, during surgery.
摘要翻译：本文所述的主题涉及具有多探针成像阵列的光学测定系统，所述多探针成像阵列使多个探针相对于彼此和样品定向。根据一个方面，本文所述的主题包括用于接触生物样品并同时照射生物样品上的多个位置并从该位置收集反射的辐射的多探针成像阵列。多探针成像阵列可用于生物样品的快速成像，例如在手术过程中。

23. 发明申请

US20050231728A1 Q-point stabilization for linear interferometric sensors using tunable diffraction grating 审中-公开
$Q-point stabilization for linear interferometric sensors using tunable diffraction grating$
标题翻译：使用可调谐衍射光栅的线性干涉测量传感器的Q点稳定
公开(公告)号：US20050231728A1
公开(公告)日：2005-10-20
申请号：US10824600
申请日：2004-04-15
申请人： Anbo Wang , Bing Yu
发明人： Anbo Wang , Bing Yu
IPC分类号： G01B9/02
CPC分类号： G01B9/02067 , G01B9/02007 , G01B9/02023 , G01B9/02041 , G01B2290/25
摘要： A linear interferometric sensor system in which the light output from the interferometric sensor is optically bandpass filtered before conversion to an electrical signal by an adjustable diffraction grating and the center wavelength of the adjustable diffraction grating is controlled by a feedback circuit responsive to the steady state component of the electrical signal corresponding to the filtered sensor return. The adjustable may comprise a diffraction grating a diffraction grating mounted on a motor driven rotary stage. The invention is particularly useful in self calibrating interferometric/intensity-based sensor configuration, but is also applicable in a wide variety of linear interferometric sensor configurations.
摘要翻译：线性干涉测量传感器系统，其中来自干涉测量传感器的光输出在通过可调节衍射光栅转换成电信号之前被光学带通滤波，并且可调节衍射光栅的中心波长由响应于稳态分量的反馈电路控制的电信号对应于滤波的传感器返回。可调节的可以包括衍射光栅，其安装在电机驱动的旋转台上的衍射光栅。本发明在自校准基于干涉/强度的传感器配置中特别有用，但也适用于各种各样的线性干涉测量传感器配置。

24. 发明授权

US5536305A Low leaching compositions for wood 失效
标题翻译：木材低浸出组合物
公开(公告)号：US5536305A
公开(公告)日：1996-07-16
申请号：US255503
申请日：1994-06-08
申请人： Bing Yu
发明人： Bing Yu
IPC分类号： B27K3/02 , A01N43/80 , B27K3/34 , B27K3/50 , A01N43/74
CPC分类号： A01N43/80 , Y10T428/31989
摘要： The invention concerns a wood preservative composition consisting essentially of (a) 4,5-dichloro-2-n-3-isothiazolone and optionally one or more other preservative compounds; (b) a surfactant system consisting of at least one surfactant selected from the group consisting of sulfates anionics, sulfonated anionics, sulfosuccinated anionics, quaternary ammonium cationics, and amphoterics; and (c) at least one non-polar organic solvent.
摘要翻译：本发明涉及基本上由（a）4,5-二氯-2-正-3-异噻唑酮和任选的一种或多种其它防腐剂组合物组成的木材防腐剂组合物; （b）表面活性剂体系，其由选自硫酸盐阴离子，磺化阴离子，磺基琥珀酸化阴离子，季铵阳离子和两性离子的至少一种表面活性剂体系组成; 和（c）至少一种非极性有机溶剂。

25. 发明授权

US5444078A Fully water-dilutable microemulsions 失效
标题翻译：全水可稀释的微乳液
公开(公告)号：US5444078A
公开(公告)日：1995-08-22
申请号：US130614
申请日：1993-10-01
申请人： Bing Yu , John R. Mattox
发明人： Bing Yu , John R. Mattox
IPC分类号： A01N25/02 , A01N25/04 , A01N25/14 , A01N25/30 , A01N33/22 , A01N37/06 , A01N43/653 , A01N43/80 , A61K9/107 , C02F1/50
CPC分类号： A01N25/02 , A01N25/04 , A61K9/1075 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/942 , Y10S514/943
摘要： Microemulsions of water-insoluble active ingredients, employing a special surfactant system and solvent system. These microemulsions remain thermodynamically stable over a wide range of water dilutions.
摘要翻译：微乳状水不溶性活性成分，采用特殊的表面活性剂体系和溶剂体系。这些微乳液在宽范围的水稀释下保持热力学稳定。

26. 发明授权

US10524647B2 Smartphone endoscope system 有权
公开(公告)号：US10524647B2
公开(公告)日：2020-01-07
申请号：US15500626
申请日：2015-07-31
申请人： Bing Yu , Vivek Krishna Nagarajan
发明人： Bing Yu , Vivek Krishna Nagarajan
IPC分类号： A61B1/07 , A61B1/04 , G01J3/36 , G01J3/44 , A61B5/00 , A61B1/00 , A61B1/06 , G01J3/02
摘要： A smartphone endoscope system includes a smartphone with first and second imaging sensors, and an imaging optics attachment. The imaging optics attachment includes a first and second imaging apparatus, the first imaging apparatus including a first light source, a beam splitter, an objective lens, and a fiber optic imaging bundle, wherein the fiber optic imaging bundle delivers excitation light to a target which emits a fluorescence emission and a reflectance emission both collected by the fiber optic imaging bundle and transmitted to the first imaging sensor. The second imaging apparatus includes a second light source, a DRS source fiber delivering broadband light to the target which produces a diffuse reflectance emission, a DRS detection fiber, a collimator, a slit, and a transmission grating wherein the transmission grating diffracts diffuse reflectance emission and creates diffracted light which is transmitted to a second imaging sensor.

27. 发明申请

US20170209033A1 A SMARTPHONE ENDOSCOPE SYSTEM 审中-公开
公开(公告)号：US20170209033A1
公开(公告)日：2017-07-27
申请号：US15500626
申请日：2015-07-31
申请人： Bing Yu , Vivek Krishna Nagarajan
发明人： Bing Yu , Vivek Krishna Nagarajan
IPC分类号： A61B1/07 , A61B1/04 , A61B1/06 , A61B1/00
摘要： A smartphone endoscope system includes a smartphone with first and second imaging sensors, and an imaging optics attachment. The imaging optics attachment includes a first and second imaging apparatus, the first imaging apparatus including a first light source, a beam splitter, an objective lens, and a fiber optic imaging bundle, wherein the fiber optic imaging bundle delivers excitation light to a target which emits a fluorescence emission and a reflectance emission both collected by the fiber optic imaging bundle and transmitted to the first imaging sensor. The second imaging apparatus includes a second light source, a DRS source fiber delivering broadband light to the target which produces a diffuse reflectance emission, a DRS detection fiber, a collimator, a slit, and a transmission grating wherein the transmission grating diffracts diffuse reflectance emission and creates diffracted light which is transmitted to a second imaging sensor.

28. 发明申请

US20160045102A1 MULTIMODAL ENDOSCOPE APPARATUS 审中-公开
标题翻译：多功能内窥镜装置
公开(公告)号：US20160045102A1
公开(公告)日：2016-02-18
申请号：US14824535
申请日：2015-08-12
申请人： Bing Yu
发明人： Bing Yu
IPC分类号： A61B1/07 , A61B1/00 , A61B5/00 , A61B1/04
CPC分类号： A61B1/07 , A61B1/00126 , A61B1/00167 , A61B1/00172 , A61B1/043 , A61B5/0035 , A61B5/0062 , A61B5/0066 , A61B5/0071 , A61B5/0086 , A61B5/0095
摘要： A multimodal endoscope apparatus includes optical components (couplers, collimators, mirrors, beam splitters, filters and the like) structured to work together to interact with a multimodal endoscope probe to provide at least two imaging modalities selected from fluorescence imaging, optical coherence tomography, and photoacoustic imaging. The multimodal endoscope probe includes a fiber optic imaging bundle including a multitude of optical fibers. In embodiments employing photoacoustic imaging, the multimodal endoscope probe further includes a polymer-Fabry-Perot interferometer. In some embodiments, a galvo scanner and fiber collimator are included and are together capable of directing light to a single optical fiber of the multitude optical fibers. The system is modular in some embodiments, allowing for switching of some components.
摘要翻译：多模式内窥镜装置包括被构造成一起工作以与多模式内窥镜探针相互作用的光学部件（耦合器，准直器，反射镜，分束器，滤波器等），以提供从荧光成像，光学相干断层摄影和光声成像。多模式内窥镜探针包括包括多根光纤的光纤成像束。在使用光声成像的实施例中，多模式内窥镜探针还包括聚合物法布里 - 珀罗干涉仪。在一些实施例中，包括电流计扫描器和光纤准直器，并且能够将光引导到多根光纤的单个光纤。在一些实施例中，系统是模块化的，允许切换一些组件。

29. 发明授权

US08804115B2 Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe 有权
标题翻译：使用自校准光纤探针执行光谱的系统和方法
公开(公告)号：US08804115B2
公开(公告)日：2014-08-12
申请号：US12989591
申请日：2009-04-27
申请人： Bing Yu , Nirmala Ramanujam
发明人： Bing Yu , Nirmala Ramanujam
IPC分类号： G01J3/00 , G01J3/40 , G01J3/42 , G01J3/28 , G01N21/47 , G01J3/02 , G01N21/27 , G01N21/49
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/28 , G01J2003/2866 , G01N21/274 , G01N21/474 , G01N21/49 , G01N2201/082
摘要： Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe are disclosed. One self-calibrating fiber optic probe includes a sensing channel for transmitting illumination light to a specimen and for collecting spectral data of the specimen. The spectral data includes the illumination light diffusely reflected from the specimen at one or more wavelengths. The self-calibrating fiber optic probe may also include a calibration channel for transmitting calibration light. The calibration light and the illumination light are generated simultaneously from a common light source. The calibration channel collects calibration spectral data associated with the calibration light contemporaneously with the collection of the spectral data of the specimen.
摘要翻译：公开了使用自校准光纤探针执行光谱的系统和方法。一个自校准光纤探针包括用于将照明光传输到样本并用于收集样本的光谱数据的感测通道。光谱数据包括在一个或多个波长处从样本漫反射的照明光。自校准光纤探针还可以包括用于传送校准光的校准通道。校准光和照明光从公共光源同时产生。校准通道与样品的光谱数据的收集同时收集与校准光相关联的校准光谱数据。

30. 发明申请

US20110105865A1 DIFFUSE REFLECTANCE SPECTROSCOPY DEVICE FOR QUANTIFYING TISSUE ABSORPTION AND SCATTERING 审中-公开
标题翻译：用于定量组织吸收和散射的折射率反射光谱装置
公开(公告)号：US20110105865A1
公开(公告)日：2011-05-05
申请号：US12989595
申请日：2009-04-24
申请人： Bing Yu , Nimala Ramanujan , Justin Y. Lo
发明人： Bing Yu , Nimala Ramanujan , Justin Y. Lo
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059
摘要： A diffuse reflectance spectroscopy system for quantifying electromagnetic absorption and scattering in a tissue is provided. Also provided are optical probes and methods for imaging a tissue mass. In some embodiments, the methods include the steps of contacting a tissue mass with an optical probe, wherein the optical probe includes at least one entity for emitting light that interacts with a tissue mass and then is remitted to a collecting entity, for collecting the light that has interacted with the tissue mass, wherein the collecting entity comprises a detector comprising one or more photodiodes; measuring turbid spectral data of the tissue mass using the optical probe; converting the turbid spectral data to at least one of absorption and scattering spectral data via a Monte Carlo algorithm or a diffusion algorithm; and quantifying tissue compositions and scatterer size in a tissue mass using the at least one of absorption and scattering spectral data.
摘要翻译：提供了用于量化组织中的电磁吸收和散射的漫反射光谱系统。还提供了用于成像组织块的光学探针和方法。在一些实施例中，所述方法包括使组织块与光学探针接触的步骤，其中所述光学探针包括用于发射与组织块相互作用的光的至少一个实体，然后被传送到收集实体，用于收集光其与所述组织块相互作用，其中所述收集实体包括检测器，所述检测器包括一个或多个光电二极管; 使用光学探针测量组织块的混浊光谱数据; 通过蒙特卡罗算法或扩散算法将混浊光谱数据转换成吸收和散射光谱数据中的至少一个; 以及使用吸收和散射光谱数据中的至少一个来定量组织块中的组织组成和散射体大小。

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