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1. 发明申请

US20110112435A1 SYSTEMS AND METHODS FOR SPECTRAL ANALYSIS OF A TISSUE MASS USING AN INSTRUMENT, AN OPTICAL PROBE, AND A MONTE CARLO OR A DIFFUSION ALGORITHM 有权
标题翻译：使用仪器，光学探头和蒙特卡罗或扩散算法对组织质量进行光谱分析的系统和方法
公开(公告)号：US20110112435A1
公开(公告)日：2011-05-12
申请号：US12680305
申请日：2008-09-29
申请人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
发明人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
IPC分类号： A61B10/02
CPC分类号： A61B5/0091 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/413 , A61B5/4312
摘要： Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an instrument is inserted into a tissue mass. A fiber optic probe is applied via the instrument into the tissue mass. Turbid spectral data of the tissue mass is measured using the fiber probe. The turbid spectral data is converted to absorption, scattering, and/or intrinsic fluorescence spectral data via a Monte Carlo algorithm or diffusion algorithm. Biomarker concentrations in the tissue mass are quantified using the absorption, scattering, and/or intrinsic fluorescence spectral data.
摘要翻译：提供了使用仪器，光学探针和蒙特卡洛算法或扩散算法对组织块进行光谱分析的系统和方法。根据一种方法，将器械插入组织块中。通过仪器将光纤探头施加到组织块中。使用光纤探针测量组织块的浊度光谱数据。通过蒙特卡罗算法或扩散算法将浊度光谱数据转换为吸收，散射和/或固有荧光光谱数据。使用吸收，散射和/或固有的荧光光谱数据来量化组织块中的生物标志物浓度。

2. 发明授权

US09820655B2 Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo or a diffusion algorithm 有权
公开(公告)号：US09820655B2
公开(公告)日：2017-11-21
申请号：US12680305
申请日：2008-09-29
申请人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
发明人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
IPC分类号： A61B5/00
CPC分类号： A61B5/0091 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/413 , A61B5/4312
摘要： Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an instrument is inserted into a tissue mass. A fiber optic probe is applied via the instrument into the tissue mass. Turbid spectral data of the tissue mass is measured using the fiber probe. The turbid spectral data is converted to absorption, scattering, and/or intrinsic fluorescence spectral data via a Monte Carlo algorithm or diffusion algorithm. Biomarker concentrations in the tissue mass are quantified using the absorption, scattering, and/or intrinsic fluorescence spectral data.

3. 发明申请

US20110059016A1 OPTICAL ASSAY SYSTEM WITH A MULTI-PROBE IMAGING ARRAY 审中-公开
标题翻译：具有多探针成像阵列的光学测量系统
公开(公告)号：US20110059016A1
公开(公告)日：2011-03-10
申请号：US12680302
申请日：2008-09-29
申请人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
发明人： Nirmala Ramanujam , Bing Yu , Jonathon Quincy Brown
IPC分类号： A61K49/00 , C40B40/06 , C40B30/04 , C40B60/12 , A61P35/00
CPC分类号： G01N21/4795 , A61B5/0059 , G01N21/6456 , G01N21/6486 , G01N2021/4747 , G01N2021/6484
摘要： The subject matter described herein relates to an optical assay system having a multi-probe imaging array that orients a plurality of probes with respect to one another and to a sample. According to one aspect, the subject matter described herein includes a multi-probe imaging array for contacting biological samples and simultaneously illuminating a plurality of locations on the biological sample and collecting the reflected radiation from the locations. The multi-probe imaging array can be used for the rapid imaging of biological samples, for example, during surgery.
摘要翻译：本文所述的主题涉及具有多探针成像阵列的光学测定系统，所述多探针成像阵列使多个探针相对于彼此和样品定向。根据一个方面，本文所述的主题包括用于接触生物样品并同时照射生物样品上的多个位置并从该位置收集反射的辐射的多探针成像阵列。多探针成像阵列可用于生物样品的快速成像，例如在手术过程中。

4. 发明申请

US20110295541A1 Systems and Methods for Performing Optical Spectroscopy Using a Self-Calibrating Fiber Optic Probe 有权
标题翻译：使用自校准光纤探头进行光谱分析的系统和方法
公开(公告)号：US20110295541A1
公开(公告)日：2011-12-01
申请号：US12989591
申请日：2009-04-27
申请人： Bing Yu , Nirmala Ramanujam
发明人： Bing Yu , Nirmala Ramanujam
IPC分类号： G01J3/40 , G06F19/00 , G01J3/28
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/28 , G01J2003/2866 , G01N21/274 , G01N21/474 , G01N21/49 , G01N2201/082
摘要： Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe are disclosed. One self-calibrating fiber optic probe includes a sensing channel for transmitting illumination light to a specimen and for collecting spectral data of the specimen. The spectral data includes the illumination light diffusely reflected from the specimen at one or more wavelengths. The self-calibrating fiber optic probe may also include a calibration channel for transmitting calibration light. The calibration light and the illumination light are generated simultaneously from a common light source. The calibration channel collects calibration spectral data associated with the calibration light contemporaneously with the collection of the spectral data of the specimen.
摘要翻译：公开了使用自校准光纤探针执行光谱的系统和方法。一个自校准光纤探针包括用于将照明光传输到样本并用于收集样本的光谱数据的感测通道。光谱数据包括在一个或多个波长处从样本漫反射的照明光。自校准光纤探针还可以包括用于传送校准光的校准通道。校准光和照明光从公共光源同时产生。校准通道与样品的光谱数据的收集同时收集与校准光相关联的校准光谱数据。

5. 发明授权

US09091637B2 Smart fiber optic sensors systems and methods for quantitative optical spectroscopy 有权
标题翻译：智能光纤传感器系统和定量光谱法的方法
公开(公告)号：US09091637B2
公开(公告)日：2015-07-28
申请号：US13513458
申请日：2010-12-06
申请人： Bing Yu , Nirmala Ramanujam
发明人： Bing Yu , Nirmala Ramanujam
IPC分类号： G01N21/00 , G01N21/25 , G01N21/27 , G01J3/28 , G01J3/42 , G01J3/02 , A61B5/00 , G01L9/00 , G01N21/64
CPC分类号： G01N21/255 , A61B5/0075 , A61B5/0084 , A61B5/4331 , A61B5/4552 , A61B5/6885 , A61B2560/0228 , G01J3/0218 , G01J3/28 , G01J3/42 , G01L9/0079 , G01N21/274 , G01N21/645 , G01N2201/0627 , G01N2201/08
摘要： Smart fiber optic sensors, systems, and methods for performing quantitative optical spectroscopy are disclosed. In one embodiment, smart fiber optic sensor can include a sensing channel, a calibration channel, and a pressure sensing channel. External force or pressure can be calculated at pressure sensing channel for monitoring and controlling pressure at a sensor-specimen interface thereby ensuring more accurate specimen spectral data is collected. Contact pressure can be adjusted to remain within a specified range. A calibration light of the calibration channel and an illumination light of the sensing channel can be generated simultaneously from a shared light source. Pressure sensing channel can transmit light from a second light source and collect pressure spectral data.
摘要翻译：公开了用于执行定量光谱的智能光纤传感器，系统和方法。在一个实施例中，智能光纤传感器可以包括感测通道，校准通道和压力感测通道。可以在压力感测通道处计算外部力或压力，用于监测和控制传感器 - 样本接口处的压力，从而确保收集更准确的样本光谱数据。接触压力可以调整到一定范围内。可以从共享光源同时生成校准通道的校准光和感测通道的照明光。压力感测通道可以传输来自第二光源的光并收集压力光谱数据。

6. 发明申请

US20130100439A1 SMART FIBER OPTIC SENSORS SYSTEMS AND METHODS FOR QUANTITATIVE OPTICAL SPECTROSCOPY 有权
标题翻译：智能光纤传感器系统和定量光学光谱的方法
公开(公告)号：US20130100439A1
公开(公告)日：2013-04-25
申请号：US13513458
申请日：2010-12-06
申请人： Bing Yu , Nirmala Ramanujam
发明人： Bing Yu , Nirmala Ramanujam
IPC分类号： G01N21/25
CPC分类号： G01N21/255 , A61B5/0075 , A61B5/0084 , A61B5/4331 , A61B5/4552 , A61B5/6885 , A61B2560/0228 , G01J3/0218 , G01J3/28 , G01J3/42 , G01L9/0079 , G01N21/274 , G01N21/645 , G01N2201/0627 , G01N2201/08
摘要： Smart fiber optic sensors, systems, and methods for performing quantitative optical spectroscopy are disclosed. In one embodiment, smart fiber optic sensor can include a sensing channel, a calibration channel, and a pressure sensing channel. External force or pressure can be calculated at pressure sensing channel for monitoring and controlling pressure at a sensor-specimen interface thereby ensuring more accurate specimen spectral data is collected. Contact pressure can be adjusted to remain within a specified range. A calibration light of the calibration channel and an illumination light of the sensing channel can be generated simultaneously from a shared light source. Pressure sensing channel can transmit light from a second light source and collect pressure spectral data.
摘要翻译：公开了用于执行定量光谱的智能光纤传感器，系统和方法。在一个实施例中，智能光纤传感器可以包括感测通道，校准通道和压力感测通道。可以在压力感测通道处计算外部力或压力，用于监测和控制传感器 - 样本接口处的压力，从而确保收集更准确的样本光谱数据。接触压力可以调整到一定范围内。可以从共享光源同时生成校准通道的校准光和感测通道的照明光。压力感测通道可以传输来自第二光源的光并收集压力光谱数据。

7. 发明授权

US08804115B2 Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe 有权
标题翻译：使用自校准光纤探针执行光谱的系统和方法
公开(公告)号：US08804115B2
公开(公告)日：2014-08-12
申请号：US12989591
申请日：2009-04-27
申请人： Bing Yu , Nirmala Ramanujam
发明人： Bing Yu , Nirmala Ramanujam
IPC分类号： G01J3/00 , G01J3/40 , G01J3/42 , G01J3/28 , G01N21/47 , G01J3/02 , G01N21/27 , G01N21/49
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/28 , G01J2003/2866 , G01N21/274 , G01N21/474 , G01N21/49 , G01N2201/082
摘要： Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe are disclosed. One self-calibrating fiber optic probe includes a sensing channel for transmitting illumination light to a specimen and for collecting spectral data of the specimen. The spectral data includes the illumination light diffusely reflected from the specimen at one or more wavelengths. The self-calibrating fiber optic probe may also include a calibration channel for transmitting calibration light. The calibration light and the illumination light are generated simultaneously from a common light source. The calibration channel collects calibration spectral data associated with the calibration light contemporaneously with the collection of the spectral data of the specimen.
摘要翻译：公开了使用自校准光纤探针执行光谱的系统和方法。一个自校准光纤探针包括用于将照明光传输到样本并用于收集样本的光谱数据的感测通道。光谱数据包括在一个或多个波长处从样本漫反射的照明光。自校准光纤探针还可以包括用于传送校准光的校准通道。校准光和照明光从公共光源同时产生。校准通道与样品的光谱数据的收集同时收集与校准光相关联的校准光谱数据。

8. 发明申请

US20100301229A1 OPTICAL ASSAY SYSTEM FOR INTRAOPERATIVE ASSESSMENT OF TUMOR MARGINS 有权
标题翻译：用于肿瘤标志物进行评估的光学测定系统
公开(公告)号：US20100301229A1
公开(公告)日：2010-12-02
申请号：US12830078
申请日：2010-07-02
申请人： Nirmala Ramanujam , Lee G. Wilke
发明人： Nirmala Ramanujam , Lee G. Wilke
IPC分类号： G01J1/58 , G01N21/01
CPC分类号： G01N21/4738
摘要： The subject matter described herein includes an optical assay system for intraoperative assessment of tumor margins. According to one aspect, the subject matter described herein includes a biological sample containment and illumination apparatus for holding a biological sample for illumination by a plurality of electromagnetic radiation probes. The biological sample containment and illumination apparatus includes a plurality of frame members positioned with respect to each other to form an interior space for receiving a biological sample. At least one of the plurality of frame members includes a plurality of probe receiving locations for receiving a plurality of electromagnetic radiation probes. The probe receiving locations position the probes with respect to the biological sample to allow illumination of plural locations of the biological sample by the probes.
摘要翻译：本文所述的主题包括用于术中评估肿瘤边缘的光学测定系统。根据一个方面，本文所述的主题包括用于通过多个电磁辐射探针保持用于照明的生物样品的生物样品容纳物和照明装置。生物样品容纳和照明装置包括相对于彼此定位的多个框架构件，以形成用于接收生物样品的内部空间。多个框架构件中的至少一个包括用于接收多个电磁辐射探针的多个探针接收位置。探针接收位置使探针相对于生物样品定位，以允许通过探针照射生物样品的多个位置。

9. 发明授权

US07751039B2 Optical assay system for intraoperative assessment of tumor margins 失效
标题翻译：用于术中评估肿瘤边缘的光学测定系统
公开(公告)号：US07751039B2
公开(公告)日：2010-07-06
申请号：US11729967
申请日：2007-03-29
申请人： Nirmala Ramanujam , Lee G. Wilke
发明人： Nirmala Ramanujam , Lee G. Wilke
IPC分类号： G01N21/01
CPC分类号： G01N21/4738
摘要： The subject matter described herein includes an optical assay system for intraoperative assessment of tumor margins. According to one aspect, the subject matter described herein includes a biological sample containment and illumination apparatus for holding a biological sample for illumination by a plurality of electromagnetic radiation probes. The biological sample containment and illumination apparatus includes a plurality of frame members positioned with respect to each other to form an interior space for receiving a biological sample. At least one of the plurality of frame members includes a plurality of probe receiving locations for receiving a plurality of electromagnetic radiation probes. The probe receiving locations position the probes with respect to the biological sample to allow illumination of plural locations of the biological sample by the probes.
摘要翻译：本文所述的主题包括用于术中评估肿瘤边缘的光学测定系统。根据一个方面，本文所述的主题包括用于通过多个电磁辐射探针保持用于照明的生物样品的生物样品容纳物和照明装置。生物样品容纳和照明装置包括相对于彼此定位的多个框架构件，以形成用于接收生物样品的内部空间。多个框架构件中的至少一个包括用于接收多个电磁辐射探针的多个探针接收位置。探针接收位置使探针相对于生物样品定位，以允许通过探针照射生物样品的多个位置。

10. 发明授权

US07236815B2 Method for probabilistically classifying tissue in vitro and in vivo using fluorescence spectroscopy 有权
标题翻译：使用荧光光谱法在体外和体内概率分类组织的方法
公开(公告)号：US07236815B2
公开(公告)日：2007-06-26
申请号：US10688152
申请日：2003-10-17
申请人： Rebecca Richards-Kortum , Nirmala Ramanujam , Anita Mahadevan-Jansen , Michele Follen , Urs Utzinger
发明人： Rebecca Richards-Kortum , Nirmala Ramanujam , Anita Mahadevan-Jansen , Michele Follen , Urs Utzinger
IPC分类号： A61B6/00
CPC分类号： G01N21/274 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/4331 , A61B5/7264 , G01N21/6486 , G01N2021/6417 , G01N2021/6419 , G01N2021/6484 , G06F19/00 , Y10S436/813
摘要： Fluorescence spectral data acquired from tissues in vivo or in vitro is processed in accordance with a multivariate statistical method to achieve the ability to probabilistically classify tissue in a diagnostically useful manner, such as by histopathological classification. The apparatus includes a controllable illumination device for emitting electromagnetic radiation selected to cause tissue to produce a fluorescence intensity spectrum. Also included are an optical system for applying the plurality of radiation wavelengths to a tissue sample, and a fluorescence intensity spectrum detecting device for detecting an intensity of fluorescence spectra emitted by the sample as a result of illumination by the controllable illumination device. The system also include a data processor, connected to the detecting device, for analyzing detected fluorescence spectra to calculate a probability that the sample belongs in a particular classification. The data processor analyzes the detected fluorescence spectra using a multivariate statistical method. The five primary steps involved in the multivariate statistical method are (i) preprocessing of spectral data from each patient to account for inter-patient variation, (ii) partitioning of the preprocessed spectral data from all patients into calibration and prediction sets, (iii) dimension reduction of the preprocessed spectra in the calibration set using principal component analysis, (iv) selection of the diagnostically most useful principal components using a two-sided unpaired student's t-test and (v) development of an optimal classification scheme based on logistic discrimination using the diagnostically useful principal component scores of the calibration set as inputs.
摘要翻译：根据多变量统计学方法处理从体内或体外组织获得的荧光光谱数据，以实现以诊断有用的方式（例如通过组织病理学分类）对组织进行概率分类的能力。该装置包括用于发射被选择使得组织产生荧光强度光谱的电磁辐射的可控照明装置。还包括用于将多个辐射波长施加到组织样本的光学系统和用于通过可控照明装置的照明来检测由样品发射的荧光光谱的强度的荧光强度光谱检测装置。该系统还包括连接到检测装置的数据处理器，用于分析检测到的荧光光谱以计算样品属于特定分类的概率。数据处理器使用多变量统计方法分析检测到的荧光光谱。多变量统计方法涉及的五个主要步骤是（i）从每个患者预处理光谱数据以考虑患者间变异，（ii）将预处理的光谱数据从所有患者划分为校准和预测组，（iii）使用主成分分析对校准集中的预处理光谱进行维数减少，（iv）使用双侧不配对的学生的t检验来选择诊断上最有用的主成分，以及（v）基于物流歧视开发最优分类方案使用校准集的诊断上有用的主成分分数作为输入。

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