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    • 23. 发明授权
    • Treatment of biological samples using dielectrophoresis
    • 使用介电电泳处理生物样品
    • US07988841B2
    • 2011-08-02
    • US11531679
    • 2006-09-13
    • Mario ScuratiTorsten MuellerThomas Schnelle
    • Mario ScuratiTorsten MuellerThomas Schnelle
    • B03C5/02
    • B03C5/026
    • A plurality of planar electrodes (5) in a microchannel (4) is used for separation, lysis and PCR in a chip (10). Cells from a sample are brought to the electrodes (5). Depending on sample properties, phase pattern, frequency and voltage of the electrodes and flow velocity are chosen to trap target cells (16) using DEP, whereas the majority of unwanted cells (17) flushes through. After separation the target cell (16) are lysed while still trapped. Lysis is carried out by applying RF pulses and/or thermally so as to change the dielectric properties of the trapped cells. After lysis, the target cells (16) are amplified within the microchannel (4), so as to obtain separation, lysis and PCR on same chip (1).
    • 微通道(4)中的多个平面电极(5)用于芯片(10)中的分离,裂解和PCR。 来自样品的细胞被带到电极(5)。 根据样品性质,选择电极的相图,频率和电压以及流速,以使用DEP捕获靶细胞(16),而大多数不需要的细胞(17)冲洗通过。 分离后,靶细胞(16)裂解,同时仍被捕获。 通过施加RF脉冲和/或热来进行裂解以改变被捕获的细胞的介电性质。 裂解后,在微通道(4)内扩增靶细胞(16),以在同一芯片(1)上获得分离,裂解和PCR。
    • 29. 发明申请
    • Method for forming a semiconductor product and semiconductor product
    • 用于形成半导体产品和半导体产品的方法
    • US20070077748A1
    • 2007-04-05
    • US11241877
    • 2005-09-30
    • Dominik OlligsHocine BoubekeurVeronika PoleiNicolas NagelTorsten MuellerLars BachThomas MikolajickJoachim Deppe
    • Dominik OlligsHocine BoubekeurVeronika PoleiNicolas NagelTorsten MuellerLars BachThomas MikolajickJoachim Deppe
    • H01L21/4763H01L21/3205H01L21/44
    • H01L27/115H01L21/76838H01L27/11521H01L27/11568
    • A semiconductor product (1) includes a plurality of wordlines extending along a first lateral direction (x) along a substrate surface (22) and also includes contact structures (3) as well as filling structures (4) therebetween. Along the first direction (x) the contact structures (3) and the filling structures (4) are arranged in alternating order between two respective wordlines. Each contact structure (3) serves to connect two active areas (23) separated by one respective trench isolation filling (24) to a respective bitline (14). Accordingly, the width of the first contact structures (3) is much larger than the width of the bitlines (14) along the first direction (x). According to embodiments of the invention, tapered upper portions (9) of the contact structures (3) are shaped, the upper portions (9) having a width being significantly smaller than the width of the contact structures (3) along the first direction (x). Thereby, forming the bitlines (14) in direct contact to top surfaces (7) of contact structures (3) is possible without the risk of short circuits between adjacent bitlines (14).
    • 半导体产品(1)包括沿衬底表面(22)沿着第一横向(x)延伸的多个字线,并且还包括接触结构(3)以及它们之间的填充结构(4)。 沿着第一方向(x),接触结构(3)和填充结构(4)以两个相应字线之间的交替顺序排列。 每个接触结构(3)用于将由一个相应的沟槽隔离填充物(24)分开的两个有效区域(23)连接到相应的位线(14)。 因此,第一接触结构(3)的宽度比沿着第一方向(x)的位线(14)的宽度大得多。 根据本发明的实施例,接触结构(3)的锥形上部(9)成形,上部(9)的宽度明显小于接触结构(3)沿着第一方向(3)的宽度 X)。 因此,形成与接触结构(3)的顶表面(7)直接接触的位线(14)是可能的,而不会在相邻位线(14)之间发生短路。
    • 30. 发明申请
    • Impedance measurement in a fluidic microsystem
    • 流体微系统中的阻抗测量
    • US20060243594A1
    • 2006-11-02
    • US10523175
    • 2003-07-28
    • Thomas SchnelleTorsten MuellerStephen Shirley
    • Thomas SchnelleTorsten MuellerStephen Shirley
    • B03C5/02
    • G01N15/1209G01N2015/1236G01N2015/1254
    • Described are a method and a measuring device for measuring the impedance in a fluidic microsystem comprising a compartment (10) through which a liquid comprising at least one suspended particle (16) flows, and in which at least one impedance detector (40) is arranged, by means of which for detection of the at least one particle at least one impedance value is acquired which is characteristic for the impedance of the compartment, and which in the presence of the at least one particle changes in a predetermined way, wherein focusing of the at least one particle takes place in a predetermined space relative to the impedance detector, wherein focusing involves a movement of the at least one particle relative to the fluid flowing in the compartment as a result of dielectrophoretic forces, which forces are exerted by means of at least two focusing electrodes (30).
    • 描述了一种用于测量流体微系统中的阻抗的方法和测量装置,其包括隔室(10),包括至少一个悬浮颗粒(16)的液体通过该隔室(10)流过,并且其中布置有至少一个阻抗检测器(40) 用于检测至少一个颗粒,获得至少一个阻抗值,该阻抗值是隔室的阻抗的特征,并且在至少一个颗粒的存在下以预定的方式改变,其中聚焦 所述至少一个颗粒相对于所述阻抗检测器发生在预定空间中,其中聚焦涉及所述至少一个颗粒相对于由于介电电泳力而在所述隔室中流动的流体的运动,所述力通过 至少两个聚焦电极(30)。