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    • 24. 发明申请
    • PROCESS AND APPARATUS FOR PREPARING A DIAGNOSTIC OR THERAPEUTIC AGENT
    • 用于制备诊断或治疗药物的方法和装置
    • US20090010852A1
    • 2009-01-08
    • US12163244
    • 2008-06-27
    • Rei ASAMIKenichi Kawabata
    • Rei ASAMIKenichi Kawabata
    • A61B8/00
    • A61K47/488A61K47/6907A61K49/223
    • Provided are a preparation process of a diagnostic or therapeutic agent having a step of adding, to a first fine emulsion having a particle size of 0.5 μm or less prepared by applying a predetermined pressure to a first mixture containing a first hydrophobic compound, an emulsifying agent, and an aqueous phase, a second hydrophobic compound compatible with the first hydrophobic compound, thereby preparing a second mixture; and a step of stirring and shaking the second mixture in a hermetically sealed state, thereby embedding the second hydrophobic compound in the first fine emulsion to prepare a second fine emulsion having a particle size of 0.5 μm or less; a diagnostic or therapeutic agent prepared by the process; and an apparatus for carrying out the process.
    • 提供了一种诊断或治疗剂的制备方法,其具有以下步骤:向通过对包含第一疏水性化合物的第一混合物施加预定压力制备的粒径为0.5μm或更小的第一微乳液,乳化剂 和水相,与第一疏水性化合物相容的第二疏水性化合物,从而制备第二混合物; 以及密闭状态下搅拌和摇动第二混合物的步骤,从而将第二疏水性化合物包埋在第一微细乳液中以制备粒径为0.5μm以下的第二细乳液; 通过该方法制备的诊断或治疗剂; 以及用于执行该过程的装置。