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1. 发明授权

US09078594B2 Ultrasound diagnostic and treatment device 有权
标题翻译：超声诊断和治疗装置
公开(公告)号：US09078594B2
公开(公告)日：2015-07-14
申请号：US13639109
申请日：2011-04-05
申请人： Kenichi Kawabata , Rei Asami
发明人： Kenichi Kawabata , Rei Asami
IPC分类号： A61B8/00 , A61B8/08 , A61N7/02 , A61B8/13 , A61B17/00 , A61B19/00 , A61N7/00
CPC分类号： A61B8/08 , A61B8/13 , A61B8/481 , A61B2017/00106 , A61B2090/378 , A61B2503/40 , A61N7/02 , A61N2007/0039 , A61N2007/0052 , A61N2007/0065 , A61N2007/027
摘要： Provided is an ultrasound diagnostic and treatment device for tumors which is used in combination with a phase-shift ultrasound contrast agent. By using a phase-shift ultrasound contrast agent, irradiating phase-shift ultrasonic waves from a phase-shift ultrasonic wave transmitter (18), irradiating ultrasonic waves for holding microbubbles from an ultrasonic wave transmitter (29) for holding microbubbles, and using a phase-shift detecting ultrasonic wave transceiver (19) to observe the phase shift, the ultrasound diagnostic and treatment device generates and holds the microbubbles in advance on the entire site (16) requiring treatment, and irradiates ultrasonic waves for treatment having a moderate intensity of 1 kW/cm2 or lower on the entire site (16) requiring treatment with the microbubbles as the target from a ultrasonic wave transmitter (20) for treatment.
摘要翻译：提供了一种与移相超声对比剂组合使用的用于肿瘤的超声诊断和治疗装置。通过使用移相超声造影剂，从相移超声波发射器（18）照射相移超声波，从用于保持微泡的超声波发射器（29）照射用于保持微泡的超声波，并使用相位检测超声波收发器（19）观察相位偏移，超声诊断和治疗装置预先在需要治疗的整个部位（16）上产生并保持微泡，并照射超声波治疗中等强度1 需要以微泡作为靶的处理的整个部位（16）的超声波发射器（20）进行处理。

2. 发明授权

US09067053B2 Ultrasonic treatment device 有权
标题翻译：超声波治疗仪
公开(公告)号：US09067053B2
公开(公告)日：2015-06-30
申请号：US13395198
申请日：2010-12-01
申请人： Rei Asami , Kenichi Kawabata
发明人： Rei Asami , Kenichi Kawabata
IPC分类号： A61B6/00 , A61N7/02 , A61B17/00 , A61B17/22 , A61N7/00
CPC分类号： A61N7/02 , A61B8/481 , A61B2017/00176 , A61B2017/22089 , A61N2007/0039
摘要： There is provided an ultrasonic treatment device that is minimally-invasive and that achieves embolization treatment having a high blood flow blocking effect. To this end, the ultrasonic treatment device is provided with a function to transmit to a target area of a subject both a bubble generation pulse that vaporizes a contrast agent, and a bubble generation pulse that causes the diameter of the formed bubble to increase.
摘要翻译：提供了一种微创的超声波处理装置，其具有高血流阻断作用的栓塞治疗。为此，超声处理装置具有向对象的目标区域发送气化造影剂的气泡生成脉冲和使形成的气泡的直径增大的气泡产生脉冲的功能。

3. 发明申请

US20140005537A1 Photoacoustic Measurement Device 审中-公开
标题翻译：光声测量装置
公开(公告)号：US20140005537A1
公开(公告)日：2014-01-02
申请号：US13984460
申请日：2012-02-06
申请人： Rei Asami , Kennichi Kawabata , Shinta Takano , Takashi Azuma
发明人： Rei Asami , Kennichi Kawabata , Shinta Takano , Takashi Azuma
IPC分类号： A61B5/00 , A61B8/14
CPC分类号： A61B5/0095 , A61B8/14 , A61K49/225 , A61K49/226 , G01N21/1702
摘要： A device and an agent for performing imaging in a deep part with high sensitivity and high resolution are to be provided. A photoacoustic measurement device (photoacoustic imaging device) performs light irradiation on an inspection area of a subject to which a photoacoustic agent generating an acoustic signal by causing phase change from a solid phase or a liquid phase to a gas phase by the light irradiation is administered, while the irradiated energy amount is increased, and detects the acoustic signal generated in the inspection area due to the light irradiation to form an imaged image of the inspection area based on the detected acoustic signal.
摘要翻译：提供用于以高灵敏度和高分辨率在深部进行成像的装置和代理。光声测量装置（光声成像装置）对被摄体的检查区域进行光照射，通过照射通过由光照射引起从固相或液相到气相的相变而产生声信号的光声剂，同时照射的能量增加，并且检测由于光照射而在检查区域中产生的声信号，以基于检测到的声信号形成检查区域的成像图像。

4. 发明申请

US20120172720A1 ULTRASONIC TREATMENT DEVICE 有权
标题翻译：超声处理装置
公开(公告)号：US20120172720A1
公开(公告)日：2012-07-05
申请号：US13395198
申请日：2010-12-01
申请人： Rei Asami , Kenichi Kawabata
发明人： Rei Asami , Kenichi Kawabata
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/02 , A61B8/481 , A61B2017/00176 , A61B2017/22089 , A61N2007/0039
摘要： There is provided an ultrasonic treatment device that is minimally-invasive and that achieves embolization treatment having a high blood flow blocking effect. To this end, the ultrasonic treatment device is provided with a function to transmit to a target area of a subject both a bubble generation pulse that vaporizes a contrast agent, and a bubble generation pulse that causes the diameter of the formed bubble to increase.
摘要翻译：提供了一种微创的超声波处理装置，其具有高血流阻断作用的栓塞治疗。为此，超声处理装置具有向对象的目标区域发送气化造影剂的气泡生成脉冲和使形成的气泡的直径增大的气泡产生脉冲的功能。

5. 发明授权

US08926948B2 Process and apparatus for preparing a diagnostic or therapeutic agent 有权
标题翻译：用于制备诊断或治疗剂的方法和装置
公开(公告)号：US08926948B2
公开(公告)日：2015-01-06
申请号：US12163244
申请日：2008-06-27
申请人： Rei Asami , Kenichi Kawabata
发明人： Rei Asami , Kenichi Kawabata
IPC分类号： A61B8/00 , A61K47/48 , A61K49/22
CPC分类号： A61K47/488 , A61K47/6907 , A61K49/223
摘要： Provided are a preparation process of a diagnostic or therapeutic agent having a step of adding, to a first fine emulsion having a particle size of 0.5 μm or less prepared by applying a predetermined pressure to a first mixture containing a first hydrophobic compound, an emulsifying agent, and an aqueous phase, a second hydrophobic compound compatible with the first hydrophobic compound, thereby preparing a second mixture; and a step of stirring and shaking the second mixture in a hermetically sealed state, thereby embedding the second hydrophobic compound in the first fine emulsion to prepare a second fine emulsion having a particle size of 0.5 μm or less; a diagnostic or therapeutic agent prepared by the process; and an apparatus for carrying out the process.
摘要翻译：提供了一种诊断或治疗剂的制备方法，其具有以下步骤：向通过对包含第一疏水性化合物的第一混合物施加预定压力制备的粒径为0.5μm以下的第一微乳液，乳化剂和水相，与第一疏水性化合物相容的第二疏水性化合物，从而制备第二混合物; 以及在气密密封状态下搅拌和摇动第二混合物的步骤，从而将第二疏水性化合物包埋在第一微细乳液中以制备粒径为0.5μm以下的第二细乳液; 通过该方法制备的诊断或治疗剂; 以及用于执行该过程的装置。

6. 发明申请

US20130053691A1 ULTRASOUND DIAGNOSTIC AND TREATMENT DEVICE 有权
标题翻译：超声波诊断和治疗装置
公开(公告)号：US20130053691A1
公开(公告)日：2013-02-28
申请号：US13639109
申请日：2011-04-05
申请人： Kenichi Kawabata , Rei Asami
发明人： Kenichi Kawabata , Rei Asami
IPC分类号： A61B8/14 , A61N7/02
CPC分类号： A61B8/08 , A61B8/13 , A61B8/481 , A61B2017/00106 , A61B2090/378 , A61B2503/40 , A61N7/02 , A61N2007/0039 , A61N2007/0052 , A61N2007/0065 , A61N2007/027
摘要： Provided is an ultrasound diagnostic and treatment device for tumors which is used in combination with a phase-shift ultrasound contrast agent. By using a phase-shift ultrasound contrast agent, irradiating phase-shift ultrasonic waves from a phase-shift ultrasonic wave transmitter (18), irradiating ultrasonic waves for holding microbubbles from an ultrasonic wave transmitter (29) for holding microbubbles, and using a phase-shift detecting ultrasonic wave transceiver (19) to observe the phase shift, the ultrasound diagnostic and treatment device generates and holds the microbubbles in advance on the entire site (16) requiring treatment, and irradiates ultrasonic waves for treatment having a moderate intensity of 1 kW/cm2 or lower on the entire site (16) requiring treatment with the microbubbles as the target from a ultrasonic wave transmitter (20) for treatment.
摘要翻译：提供了一种与移相超声对比剂组合使用的用于肿瘤的超声诊断和治疗装置。通过使用移相超声造影剂，从相移超声波发射器（18）照射相移超声波，从用于保持微泡的超声波发射器（29）照射用于保持微泡的超声波，并使用相位检测超声波收发器（19）观察相位偏移，超声诊断和治疗装置预先在需要治疗的整个部位（16）上产生并保持微泡，并照射超声波治疗中等强度1 需要以微泡作为靶的处理的整个部位（16）的超声波发射器（20）进行处理。

7. 发明申请

US20090010852A1 PROCESS AND APPARATUS FOR PREPARING A DIAGNOSTIC OR THERAPEUTIC AGENT 有权
标题翻译：用于制备诊断或治疗药物的方法和装置
公开(公告)号：US20090010852A1
公开(公告)日：2009-01-08
申请号：US12163244
申请日：2008-06-27
申请人： Rei ASAMI , Kenichi Kawabata
发明人： Rei ASAMI , Kenichi Kawabata
IPC分类号： A61B8/00
CPC分类号： A61K47/488 , A61K47/6907 , A61K49/223
摘要： Provided are a preparation process of a diagnostic or therapeutic agent having a step of adding, to a first fine emulsion having a particle size of 0.5 μm or less prepared by applying a predetermined pressure to a first mixture containing a first hydrophobic compound, an emulsifying agent, and an aqueous phase, a second hydrophobic compound compatible with the first hydrophobic compound, thereby preparing a second mixture; and a step of stirring and shaking the second mixture in a hermetically sealed state, thereby embedding the second hydrophobic compound in the first fine emulsion to prepare a second fine emulsion having a particle size of 0.5 μm or less; a diagnostic or therapeutic agent prepared by the process; and an apparatus for carrying out the process.
摘要翻译：提供了一种诊断或治疗剂的制备方法，其具有以下步骤：向通过对包含第一疏水性化合物的第一混合物施加预定压力制备的粒径为0.5μm或更小的第一微乳液，乳化剂和水相，与第一疏水性化合物相容的第二疏水性化合物，从而制备第二混合物; 以及密闭状态下搅拌和摇动第二混合物的步骤，从而将第二疏水性化合物包埋在第一微细乳液中以制备粒径为0.5μm以下的第二细乳液; 通过该方法制备的诊断或治疗剂; 以及用于执行该过程的装置。

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