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    • 1. 发明申请
    • PROCESS AND APPARATUS FOR PREPARING A DIAGNOSTIC OR THERAPEUTIC AGENT
    • 用于制备诊断或治疗药物的方法和装置
    • US20090010852A1
    • 2009-01-08
    • US12163244
    • 2008-06-27
    • Rei ASAMIKenichi Kawabata
    • Rei ASAMIKenichi Kawabata
    • A61B8/00
    • A61K47/488A61K47/6907A61K49/223
    • Provided are a preparation process of a diagnostic or therapeutic agent having a step of adding, to a first fine emulsion having a particle size of 0.5 μm or less prepared by applying a predetermined pressure to a first mixture containing a first hydrophobic compound, an emulsifying agent, and an aqueous phase, a second hydrophobic compound compatible with the first hydrophobic compound, thereby preparing a second mixture; and a step of stirring and shaking the second mixture in a hermetically sealed state, thereby embedding the second hydrophobic compound in the first fine emulsion to prepare a second fine emulsion having a particle size of 0.5 μm or less; a diagnostic or therapeutic agent prepared by the process; and an apparatus for carrying out the process.
    • 提供了一种诊断或治疗剂的制备方法,其具有以下步骤:向通过对包含第一疏水性化合物的第一混合物施加预定压力制备的粒径为0.5μm或更小的第一微乳液,乳化剂 和水相,与第一疏水性化合物相容的第二疏水性化合物,从而制备第二混合物; 以及密闭状态下搅拌和摇动第二混合物的步骤,从而将第二疏水性化合物包埋在第一微细乳液中以制备粒径为0.5μm以下的第二细乳液; 通过该方法制备的诊断或治疗剂; 以及用于执行该过程的装置。
    • 2. 发明授权
    • Process and apparatus for preparing a diagnostic or therapeutic agent
    • 用于制备诊断或治疗剂的方法和装置
    • US08926948B2
    • 2015-01-06
    • US12163244
    • 2008-06-27
    • Rei AsamiKenichi Kawabata
    • Rei AsamiKenichi Kawabata
    • A61B8/00A61K47/48A61K49/22
    • A61K47/488A61K47/6907A61K49/223
    • Provided are a preparation process of a diagnostic or therapeutic agent having a step of adding, to a first fine emulsion having a particle size of 0.5 μm or less prepared by applying a predetermined pressure to a first mixture containing a first hydrophobic compound, an emulsifying agent, and an aqueous phase, a second hydrophobic compound compatible with the first hydrophobic compound, thereby preparing a second mixture; and a step of stirring and shaking the second mixture in a hermetically sealed state, thereby embedding the second hydrophobic compound in the first fine emulsion to prepare a second fine emulsion having a particle size of 0.5 μm or less; a diagnostic or therapeutic agent prepared by the process; and an apparatus for carrying out the process.
    • 提供了一种诊断或治疗剂的制备方法,其具有以下步骤:向通过对包含第一疏水性化合物的第一混合物施加预定压力制备的粒径为0.5μm以下的第一微乳液,乳化剂 和水相,与第一疏水性化合物相容的第二疏水性化合物,从而制备第二混合物; 以及在气密密封状态下搅拌和摇动第二混合物的步骤,从而将第二疏水性化合物包埋在第一微细乳液中以制备粒径为0.5μm以下的第二细乳液; 通过该方法制备的诊断或治疗剂; 以及用于执行该过程的装置。
    • 3. 发明申请
    • ULTRASOUND DIAGNOSTIC AND TREATMENT DEVICE
    • 超声波诊断和治疗装置
    • US20130053691A1
    • 2013-02-28
    • US13639109
    • 2011-04-05
    • Kenichi KawabataRei Asami
    • Kenichi KawabataRei Asami
    • A61B8/14A61N7/02
    • A61B8/08A61B8/13A61B8/481A61B2017/00106A61B2090/378A61B2503/40A61N7/02A61N2007/0039A61N2007/0052A61N2007/0065A61N2007/027
    • Provided is an ultrasound diagnostic and treatment device for tumors which is used in combination with a phase-shift ultrasound contrast agent. By using a phase-shift ultrasound contrast agent, irradiating phase-shift ultrasonic waves from a phase-shift ultrasonic wave transmitter (18), irradiating ultrasonic waves for holding microbubbles from an ultrasonic wave transmitter (29) for holding microbubbles, and using a phase-shift detecting ultrasonic wave transceiver (19) to observe the phase shift, the ultrasound diagnostic and treatment device generates and holds the microbubbles in advance on the entire site (16) requiring treatment, and irradiates ultrasonic waves for treatment having a moderate intensity of 1 kW/cm2 or lower on the entire site (16) requiring treatment with the microbubbles as the target from a ultrasonic wave transmitter (20) for treatment.
    • 提供了一种与移相超声对比剂组合使用的用于肿瘤的超声诊断和治疗装置。 通过使用移相超声造影剂,从相移超声波发射器(18)照射相移超声波,从用于保持微泡的超声波发射器(29)照射用于保持微泡的超声波,并使用相位 检测超声波收发器(19)观察相位偏移,超声诊断和治疗装置预先在需要治疗的整个部位(16)上产生并保持微泡,并照射超声波治疗中等强度1 需要以微泡作为靶的处理的整个部位(16)的超声波发射器(20)进行处理。
    • 9. 发明授权
    • Image forming apparatus capable of electrostatically attracting sheet effectively
    • 能够有效地静电吸引片材的图像形成装置
    • US08204429B2
    • 2012-06-19
    • US12324542
    • 2008-11-26
    • Kenichi Kawabata
    • Kenichi Kawabata
    • G03G15/00B65H29/30
    • G03G15/234G03G2215/00654
    • In an image forming apparatus, a recording head discharges liquid droplets onto a sheet conveyed on a conveying belt to form an image on the sheet. A sheet discharge device is provided downstream from the conveying belt in a sheet conveyance direction and is intermittently driven independently of and in synchronization with the conveying belt to convey the sheet in a sheet discharging direction. A voltage application device applies a voltage to a charger. A distance between the charger and a nip portion formed between a pressing member and the conveying belt for duplex printing is set so that a voltage applied by the voltage application device increases a charged potential of the conveying belt in an area electrostatically attracting a trailing end of a predetermined sheet and a leading end of a subsequent sheet.
    • 在图像形成装置中,记录头将液滴排放到在传送带上传送的片材上,以在片材上形成图像。 片材排出装置在片材输送方向上设置在输送带的下游,并且与输送带独立地且与其同步地间歇地驱动,以将片材沿片材排出方向输送。 电压施加装置向充电器施加电压。 设置充电器和形成在按压构件和用于双面打印的输送带之间的夹持部之间的距离,使得由施加电压装置施加的电压在静电吸引尾部的区域中增加输送带的带电电位 预定片材和后续片材的前端。