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21. 发明申请

US20050032820A1 Novel spiro compounds 失效
公开(公告)号：US20050032820A1
公开(公告)日：2005-02-10
申请号：US10922869
申请日：2004-08-23
申请人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh , Masato Chiba
发明人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh , Masato Chiba
IPC分类号： C07D491/107 , A61K31/438 , A61P1/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P27/06 , A61P29/00 , A61P43/00 , C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10 , C07D519/00 , C07D487/14 , A61K31/4747 , A61K31/519
CPC分类号： C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10
摘要： A Compound represented by the general formula (I): wherein AR1 represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of hydroxy, halogen, nitro, lower alkyl, halo(lower)alkyl, hydroxy(lower)alkyl, cyclo(lower)alkyl, lower alkenyl, lower alkoxy, halo(lower)alkoxy, lower alkylthio, carboxyl, lower alkanoyl, lower alkoxycarbonyl, lower alkylene optionally substituted with oxo, and a group represented by the formula —Q—Ar2; Ar2represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of halogen, cyano, lower alkyl, halo(lower)alkyl, hydroxy(lower)alkyl, hydroxy, lower alkoxy, halo(lower)alkoxy, lower alkylamino, di-lower alkylamino, lower alkanoyl and aryl; n represents 0 or 1; Q represents a single bond or carbonyl; T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine, hydroxy substituted methine or nitrogen atom; Y represents an imino which may be substituted with lower alkyl, or oxygen; and a salt, ester or N-oxide derivative thereof exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis and the like, central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal and the like, metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia and the like, sexual and reproductive dysfunction, gastro-intestinal disorder, respiratory disorder, inflammation or glaucoma, and the like.

22. 发明授权

US06462053B1 Spiro compounds 失效
标题翻译：螺环化合物
公开(公告)号：US06462053B1
公开(公告)日：2002-10-08
申请号：US10101221
申请日：2002-03-20
申请人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh
发明人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh
IPC分类号： A61K34355
CPC分类号： C07D405/12 , C07D213/61 , C07D307/94 , C07D471/10 , C07D491/10
摘要： A method for treating a cardiovascular disorder, which involves administering to a patient in need a therapeutically effective amount of a compound of formula (I): wherein Ar1 represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of halogen, nitro, lower alkyl, halo(lower) alkyl, hydroxy(lower) alkyl, cyclo(lower) alkyl, lower alkenyl, lower alkoxy, halo(lower) alkoxy, lower alkylthio, carboxyl, lower alkanoyl, lower alkoxycarbonyl, lower alkylene optionally substituted with oxo, and a group represented by the formula —Q—Ar2; Ar2 represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of halogen, cyano, lower alkyl, halo(lower) alkyl, hydroxy(lower) alkyl, hydroxy, lower alkoxy, halo(lower) alkoxy, lower alkylamino, di-lower alkylamino, lower alkanoyl and aryl: n represents 0 or 1; Q represents a single bond or carbonyl; T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine; Y represents an imino which may be substituted with lower alkyl, or oxygen; or a salt or ester thereof.
摘要翻译：一种治疗心血管疾病的方法，其涉及向需要的患者施用治疗有效量的式（I）化合物：其中Ar1表示可被取代的芳基或杂芳基，所述取代基选自卤素，硝基，低级烷基，卤代（低级）烷基，羟基（低级）烷基，环（低级）烷基，低级烯基，低级烷氧基，卤代（低级）烷氧基，低级烷硫基，羧基，低级烷酰基，低级烷氧基羰基，任选被氧代取代的基团和由式-Q-Ar 2表示的基团; Ar 2表示可被取代的芳基或杂芳基，所述取代基选自卤素，氰基，低级烷基，卤代（低级）烷基，羟基（低级）烷基，羟基，低级烷氧基，卤代（低级）烷氧基，低级烷基氨基，二低级烷基氨基，低级烷酰基和芳基：n表示0或1; Q表示单键或羰基; T，U， W各自独立地表示硝基可以具有选自卤素，低级烷基，羟基和低级烷氧基的取代基的次甲基，其中至少两个表示所述次甲基; X表示次甲基; Y表示可以被取代的亚氨基与低级烷基或氧; 或其盐或酯。

23. 发明授权

US08123874B2 Soft magnetic material, dust core, method for manufacturing soft magnetic material, and method for manufacturing dust core 有权
标题翻译：软磁性材料，防尘芯，软磁材料的制造方法以及制造防尘芯的方法
公开(公告)号：US08123874B2
公开(公告)日：2012-02-28
申请号：US12518498
申请日：2008-09-03
申请人： Tomoyuki Ishimine , Toshihiro Sakamoto , Toru Maeda , Naoto Igarashi
发明人： Tomoyuki Ishimine , Toshihiro Sakamoto , Toru Maeda , Naoto Igarashi
IPC分类号： H01F1/20
CPC分类号： H01F3/02 , B22F1/0014 , B22F1/0062 , B22F1/007 , B22F2999/00 , C22C38/00 , C22C2202/02 , H01F1/24 , H01F1/26 , H01F1/33 , H01F41/0246 , Y10T428/2982 , B22F3/10 , B22F2201/02
摘要： A soft magnetic material, a dust core, a method for manufacturing the soft magnetic material, and a method for manufacturing the dust core that can improve DC bias characteristics are provided.A soft magnetic material includes a plurality of metal magnetic particles 10 whose coefficient of variation Cv (σ/μ), which is a ratio of a standard deviation (σ) of a particle size of the metal magnetic particles 10 to an average particle size (μ) thereof, is 0.40 or less and whose circularity Sf is 0.80 or more and 1 or less. The metal magnetic particles 10 preferably have an average particle size of 1 μm or more and 70 μm or less. The soft magnetic material preferably further includes an insulating coated film that surrounds a surface of each of the metal magnetic particles 10.
摘要翻译：提供软磁性材料，压粉芯，软磁性材料的制造方法以及可提高直流偏压特性的集尘芯的制造方法。软磁性材料包括多个金属磁性颗粒10，其金属磁性颗粒10的粒径与平均颗粒的标准偏差（＆sgr）的比值变化系数Cv（＆Sgr /μ）尺寸（μ）为0.40以下，圆形度Sf为0.80以上1以下。金属磁性粒子10的平均粒径优选为1μm以上且70μm以下。软磁性材料优选还包括围绕每个金属磁性颗粒10的表面的绝缘涂膜。

24. 发明授权

US07504412B2 Imidazopyridine derivatives 失效
标题翻译：咪唑并吡啶衍生物
公开(公告)号：US07504412B2
公开(公告)日：2009-03-17
申请号：US10567269
申请日：2004-08-13
申请人： Hiroyuki Kishino , Minoru Moriya , Toshihiro Sakamoto , Hidekazu Takahashi , Shunji Sakuraba , Takao Suzuki , Akio Kanatani
发明人： Hiroyuki Kishino , Minoru Moriya , Toshihiro Sakamoto , Hidekazu Takahashi , Shunji Sakuraba , Takao Suzuki , Akio Kanatani
IPC分类号： A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R1 and R2 may be the same or different and stand for C1-6 alkyl or the like, R3 and R4 stand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.
摘要翻译：本发明提供由通式[I]表示的咪唑并吡啶衍生物[其中R 1和R 2可以相同或不同，代表C 1-6烷基等，R 3和R 4代表氢原子，甲基等， W代表单环或双环3-至8-元芳族或脂族杂环等，Ar代表任选取代的芳族杂环等〕。这些化合物作为黑色素浓缩激素受体拮抗剂，可用作中枢神经系统疾病，心血管系统疾病和代谢紊乱的药物。

25. 发明申请

US20060106046A1 Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient 失效
标题翻译：黑色素浓缩激素受体拮抗剂含有哌啶衍生物作为活性成分
公开(公告)号：US20060106046A1
公开(公告)日：2006-05-18
申请号：US10544261
申请日：2004-02-09
申请人： Minoru Moriya , Toshihiro Sakamoto , Makoto Ishikawa , Akio Kanatani , Takehiro Fukami
发明人： Minoru Moriya , Toshihiro Sakamoto , Makoto Ishikawa , Akio Kanatani , Takehiro Fukami
IPC分类号： A61K31/4747 , A61K31/4545 , C07D471/10 , C07D401/02
CPC分类号： C07D401/04 , A61K31/438 , A61K31/4439 , A61K31/445 , C07D211/26 , C07D491/10
摘要： The invention provides melanin-concentrating hormone receptor antagonists containing as the active ingredient piperidine derivatives represented by the general formula [I]: [wherein R1 is hydrogen, hydroxyl, lower alkyl, or the like; R2, R3a, R3b, R4a, R4b, R5a, R5b and R6 each stands for hydrogen, halogen, or the like; W1 and W2 each independently stands for —O—, —CH2—, or the like; Y1, Y2, Y3 and Y4 stand for —CH—, —CF—, —N—, or the like; Z stands for lower alkyl, an aliphatic heterocyclic group, or the like; Ar is a mono- or bi-cyclic aliphatic heterocycle or an aromatic heterocycle; and n is an integer of 1 to 8]. The compounds act as antagonist against melanin-concentrating hormone receptor and are useful as drugs for central diseases, circulatory diseases, or metabolic diseases.
摘要翻译：本发明提供了含有作为活性成分的通式[I]表示的哌啶衍生物的黑色素浓缩激素受体拮抗剂：其中R 1是氢，羟基，低级烷基等; R 2，R 3，R 3b，R 4a，R 4b，R 4b， R 5a，R 5b和R 6各自代表氢，卤素等; W 1和W 2各自独立地代表-O-，-CH 2 - 等; Y 1，Y 2，Y 3和Y 4代表-CH - ， - CF - ， - N-等; Z代表低级烷基，脂族杂环基等; Ar是单环或双环脂族杂环或芳族杂环; n为1〜8的整数]。该化合物作为拮抗黑素浓缩激素受体的拮抗剂，可用作中枢疾病，循环系统疾病或代谢疾病的药物。

26. 发明授权

US6090054A Ultrasonic wave cosmetic device 失效
标题翻译：超声波化妆品装置
公开(公告)号：US6090054A
公开(公告)日：2000-07-18
申请号：US97113
申请日：1998-06-12
申请人： Hiroyuki Tagishi , Toshihiro Sakamoto , Kazuyasu Ikadai
发明人： Hiroyuki Tagishi , Toshihiro Sakamoto , Kazuyasu Ikadai
IPC分类号： A61H23/02 , A61H1/00
CPC分类号： A61H23/0245 , A61H2201/0176
摘要： An improved ultrasonic wave cosmetic device which is able to protect skin against burns. The ultrasonic wave cosmetic device for treating skin includes a probe head having a skin contact metal surface for contacting the skin to transmit an ultrasonic wave thereto, an ultrasonic wave vibration element for vibrating at an ultrasonic wave frequency in response to an output signal from an ultrasonic wave oscillation circuit, and a temperature sensor mounted in a manner directly contacting a side surface of the ultrasonic wave vibration element and a surface opposite the skin contact metal surface for detecting the temperature of the probe head. The temperature sensor feeds back signals to the oscillation circuit which terminates the oscillation output signal when the probe head gets too hot.
摘要翻译：一种改进的超声波化妆品，能够保护皮肤免受灼伤。用于治疗皮肤的超声波化妆品装置包括具有皮肤接触金属表面的探针头，用于接触皮肤以传送超声波，超声波振动元件，响应于来自超声波的输出信号以超声波频率振动波振荡电路和以与超声波振动元件的侧面直接接触的方式安装的温度传感器和与皮肤接触金属表面相对的表面，用于检测探头的温度。温度传感器将信号反馈到振荡电路，当探针头太热时终止振荡输出信号。

27. 发明授权

US5502015A Infrared transmitting barium fluoride sintered body 失效
标题翻译：红外透射钡氟化物烧结体
公开(公告)号：US5502015A
公开(公告)日：1996-03-26
申请号：US389420
申请日：1995-02-16
申请人： Kenichiro Shibata , Akihito Fujii , Toshihiro Sakamoto
发明人： Kenichiro Shibata , Akihito Fujii , Toshihiro Sakamoto
IPC分类号： C04B35/553
CPC分类号： C04B35/553
摘要： The present invention provides an infrared ray transmitting material, even large-sized one being manufacturable at a low price, consisting of a polycrystal not liable to cleavage, which makes only a slight absorption of infrared rays all over the region of 8-11 .mu.m wave lengths, thus being highly transmissive. The material is a polycrystalline barium fluoride sintered body excellent in transmission to infrared region of 8-11 .mu.m wave lengths, one that is most excellent in the infrared transmission being produced by a method comprising the hot press sintering and the HIP treatment in combination, one that gives somewhat inferior transmission but which is low-priced by a method comprising the CIP molding and the normal pressure sintering in combination, and one that regarded as intermediate between the aforementioned two by a method comprising the CIP molding, normal-pressure sintering and the HIP treatment in combination, in all cases entirely without addition of any binder or sintering aid.
摘要翻译：本发明提供一种红外线透射材料，即使是大尺寸的也可以以低价格制造，由不易裂开的多晶体组成，仅在8-11μm的区域内仅有轻微的红外线吸收波长，因此是高度透射的。该材料是通过包含热压烧结和HIP处理的方法制造的红外线透过率最高的8-11μm波长的透射率优异的多晶氟化钡烧结体，通过包括CIP成型和常压烧结的方法组合的方法，通过包括CIP成型，常压烧结和在所有情况下，组合的HIP处理完全不添加任何粘合剂或烧结助剂。

28. 发明申请

US20100044618A1 SOFT MAGNETIC MATERIAL, DUST CORE, METHOD FOR MANUFACTURING SOFT MAGNETIC MATERIAL, AND METHOD FOR MANUFACTURING DUST CORE 有权
标题翻译：软磁材料，软磁芯，制造软磁材料的方法和制造粉芯的方法
公开(公告)号：US20100044618A1
公开(公告)日：2010-02-25
申请号：US12518498
申请日：2008-09-03
申请人： Tomoyuki Ishimine , Toshihiro Sakamoto , Toru Maeda , Naoto Igarashi
发明人： Tomoyuki Ishimine , Toshihiro Sakamoto , Toru Maeda , Naoto Igarashi
IPC分类号： H01F1/04 , B32B5/16 , B05D7/00 , B22F1/00 , B22F1/02 , B05D5/00
CPC分类号： H01F3/02 , B22F1/0014 , B22F1/0062 , B22F1/007 , B22F2999/00 , C22C38/00 , C22C2202/02 , H01F1/24 , H01F1/26 , H01F1/33 , H01F41/0246 , Y10T428/2982 , B22F3/10 , B22F2201/02
摘要： A soft magnetic material, a dust core, a method for manufacturing the soft magnetic material, and a method for manufacturing the dust core that can improve DC bias characteristics are provided.A soft magnetic material includes a plurality of metal magnetic particles 10 whose coefficient of variation Cv (σ/μ), which is a ratio of a standard deviation (σ) of a particle size of the metal magnetic particles 10 to an average particle size (μ) thereof, is 0.40 or less and whose circularity Sf is 0.80 or more and 1 or less. The metal magnetic particles 10 preferably have an average particle size of 1 μm or more and 70 μm or less. The soft magnetic material preferably further includes an insulating coated film that surrounds a surface of each of the metal magnetic particles 10.
摘要翻译：提供软磁性材料，压粉芯，软磁性材料的制造方法以及可提高直流偏压特性的集尘芯的制造方法。软磁性材料包括多个金属磁性颗粒10，其金属磁性颗粒10的粒径与平均颗粒的标准偏差（＆sgr）的比值变化系数Cv（＆Sgr /μ）尺寸（μ）为0.40以下，圆形度Sf为0.80以上1以下。金属磁性粒子10的平均粒径优选为1μm以上且70μm以下。软磁性材料优选还包括围绕每个金属磁性颗粒10的表面的绝缘涂膜。

29. 发明申请

US20060147145A1 Optical modulator 有权
标题翻译：光调制器
公开(公告)号：US20060147145A1
公开(公告)日：2006-07-06
申请号：US10527214
申请日：2003-09-10
申请人： Takashi Shinriki , Toshihiro Sakamoto , Masanao Kurihara , Toru Sugamata , Norikazu Miyazaki
发明人： Takashi Shinriki , Toshihiro Sakamoto , Masanao Kurihara , Toru Sugamata , Norikazu Miyazaki
IPC分类号： G02F1/035
CPC分类号： G02F1/0305 , G02F1/0316 , G02F1/225
摘要： An optical modulator in which stabilized driving is realized over a long time by relaxing stress generated in a recess formed in the surface of a substrate in the optical modulator and controlling deterioration of optical modulation control caused by stress-strain in the substrate including an optical waveguide. The optical modulator comprises a substrate of a material exhibiting electrooptic effect, an optical waveguide (4) provided on the substrate, and control electrodes (20-25) for controlling the phase of light being guided through the optical waveguide characterized in that a recess (12) is provided in the surface of the substrate for forming the control electrodes, and the control electrode (24) being formed on the recess is provided with a stress relaxing means.
摘要翻译：一种光调制器，其特征在于，通过在形成于所述光调制器的基板的表面上形成的凹部中产生的应力，在长时间内实现稳定的驱动，并控制由包括光波导的基板中的应力应变引起的光调制控制的劣化。光学调制器包括具有电光效应的材料的衬底，设置在衬底上的光波导（4）和用于控制通过光波导引导的光的相位的控制电极（20-25），其特征在于，凹部 12）设置在用于形成控制电极的基板的表面中，并且形成在凹部上的控制电极（24）设置有应力缓和装置。

30. 发明授权

US06980705B2 Optical waveguide device 失效
标题翻译：光波导器件
公开(公告)号：US06980705B2
公开(公告)日：2005-12-27
申请号：US10451435
申请日：2001-11-28
申请人： Yasuyuki Miyama , Hirotoshi Nagata , Toshihiro Sakamoto
发明人： Yasuyuki Miyama , Hirotoshi Nagata , Toshihiro Sakamoto
IPC分类号： G02B6/12 , G02F1/03 , G02F1/035
CPC分类号： G02F1/0322 , G02F1/035 , G02F1/0356 , G02F2201/07 , G02F2201/16 , G02F2203/21 , G02F2203/50
摘要： A first film (8) is formed between a substrate (1) and a signal electrode (3); ground electrodes (5) and (6) which constitute an optical waveguide device (10), and a second film (9) is formed between the substrate (1) and a signal electrode (4); ground electrodes (6) and (7). An optical phase modulator (10A) is composed of the substrate (1), an optical waveguide (2), the signal electrode (3), the ground electrodes (5) and (6), and the first film (8). An optical intensity modulator (10B) is composed of the substrate (1), the optical waveguide (2), the signal electrode (4), the ground electrodes (6) and (7), and the second film (9). The optical waveguide device (10) is composed of the optical phase modulator (10A) and the optical intensity modulator (10B), which are integrated monolithically.
摘要翻译：第一膜（8）形成在基板（1）和信号电极（3）之间; 构成光波导装置（10）的接地电极（5）和（6），在基板（1）和信号电极（4）之间形成第二膜（9）。接地电极（6）和（7）。光学相位调制器（10A）由基片（1），光波导（2），信号电极（3），接地电极（5）和（6）和第一薄膜（8）构成。光强度调制器（10 B）由基板（1），光波导（2），信号电极（4），接地电极（6）和（7）和第二膜（9）构成。光波导装置（10）由光学相位调制器（10A）和光强度调制器（10B）组成，其被整体地集成。

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