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21. 发明申请

US20060219559A1 Capillary array and capillary electrophoresis apparatus 有权
公开(公告)号：US20060219559A1
公开(公告)日：2006-10-05
申请号：US11395158
申请日：2006-04-03
申请人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
发明人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
IPC分类号： G01N27/00
CPC分类号： G01N27/44708
摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.

22. 发明授权

US07883613B2 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US07883613B2
公开(公告)日：2011-02-08
申请号：US11806889
申请日：2007-06-05
申请人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
发明人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
IPC分类号： G01N27/453
CPC分类号： G01N27/44721
摘要： The present invention provides a capillary electrophoresis apparatus in which a capillary is easily attached to and detached from a migration medium filling unit without mixing impurities into the capillary. Mixture of impurities such as dust is also prevented when a capillary negative-electrode end is brought into contact with a sample stored in a vessel. Furthermore, temperature control is efficiently performed in the capillary. In the capillary electrophoresis apparatus, the whole of capillary array can be supported by grasping a grip portion by hand. A migration medium filling mechanism includes a slide mechanism which moves a polymer block with respect to a capillary head. The capillary electrophoresis apparatus includes a vessel in which a sample and a buffer can simultaneously be stored. Temperatures of the capillary and an irradiation and detection unit are controlled by a temperature control function provided in a thermostatic device.
摘要翻译：本发明提供了一种毛细管电泳装置，其中毛细管容易地连接到迁移介质填充单元并从迁移介质填充单元中分离而不将杂质混入毛细管中。当毛细管负极端与存储在容器中的样品接触时，也可以防止诸如灰尘等杂质的混合物。此外，在毛细管中有效地进行温度控制。在毛细管电泳装置中，通过用手抓握把手部分可以支撑整个毛细管阵列。迁移介质填充机构包括相对于毛细管头移动聚合物嵌段的滑动机构。毛细管电泳装置包括可以同时存储样品和缓冲液的容器。毛细管和照射和检测单元的温度由恒温装置中提供的温度控制功能控制。

23. 发明申请

US20060231400A1 Electrophoretic apparatus and electrophoretic method 有权
公开(公告)号：US20060231400A1
公开(公告)日：2006-10-19
申请号：US11397890
申请日：2006-04-05
申请人： Ryoji Inaba , Tomoyuki Sakai , Motohiro Yamazaki , Takashi Gomi , Kazumichi Imai
发明人： Ryoji Inaba , Tomoyuki Sakai , Motohiro Yamazaki , Takashi Gomi , Kazumichi Imai
IPC分类号： B01D57/02 , G01N27/00
CPC分类号： G01N27/44721 , G01N27/44782
摘要： The present invention relates to detection of an emission spectrum by irradiating excitation light onto a plurality of electrophoretic paths and dispersing fluorescent light output from the electrophoretic paths in a direction approximately vertical to an electrophoretic direction. According to the invention, since an emission spectrum to be detected does not substantially change over time, it becomes possible to make observed emission spectrums completely correspond to various fluorescent dyes or various bases.

24. 发明授权

US08545686B2 Electrophoretic apparatus and electrophoretic method 有权
标题翻译：电泳仪和电泳法
公开(公告)号：US08545686B2
公开(公告)日：2013-10-01
申请号：US11397890
申请日：2006-04-05
申请人： Ryoji Inaba , Tomoyuki Sakai , Motohiro Yamazaki , Takashi Gomi , Kazumichi Imai
发明人： Ryoji Inaba , Tomoyuki Sakai , Motohiro Yamazaki , Takashi Gomi , Kazumichi Imai
IPC分类号： G01N27/453 , G01N27/447
CPC分类号： G01N27/44721 , G01N27/44782
摘要： The present invention relates to detection of an emission spectrum by irradiating excitation light onto a plurality of electrophoretic paths and dispersing fluorescent light output from the electrophoretic paths in a direction approximately vertical to an electrophoretic direction. According to the invention, since an emission spectrum to be detected does not substantially change over time, it becomes possible to make observed emission spectrums completely correspond to various fluorescent dyes or various bases.
摘要翻译：本发明涉及通过将激发光照射到多个电泳路径上并且将电泳路径输出的荧光以大致垂直于电泳方向的方向分散的方式来检测发射光谱。根据本发明，由于要检测的发射光谱随时间基本上不变化，因此可以使观察到的发射光谱完全对应于各种荧光染料或各种基底。

25. 发明申请

US20090183990A1 CAPILLARY ARRAY UNIT AND CAPILLARY ELECTROPHORESIS APPARATUS 有权
标题翻译：毛细管阵列和毛细管电泳装置
公开(公告)号：US20090183990A1
公开(公告)日：2009-07-23
申请号：US12352238
申请日：2009-01-12
申请人： Tomohiro SHOJI , Toshiyuki Sakurai , Takashi Gomi , Ryoji Inaba
发明人： Tomohiro SHOJI , Toshiyuki Sakurai , Takashi Gomi , Ryoji Inaba
IPC分类号： G01N27/453
CPC分类号： G01N27/44782
摘要： In a capillary electrophoresis apparatus, a capillary array unit has a capillary array including capillaries having a capillary head and a detection unit, a frame for supporting the capillary array, and a load header for holding cathode ends of the capillaries. The frame has separators for separating and holding the capillaries. The capillary head, the detection unit, and the separators are disposed along one linear line. With this arrangement, there is provided the capillary array unit and the capillary electrophoresis apparatus which are arranged such that a job for mounting the capillary array can be executed easily.
摘要翻译：在毛细管电泳装置中，毛细管阵列单元具有毛细管阵列，其包括具有毛细管头和检测单元的毛细管，用于支撑毛细管阵列的框架和用于保持毛细血管的阴极端的负载头。框架具有用于分离和保持毛细管的分离器。毛细管头，检测单元和分离器沿着一条线性线设置。通过这种布置，提供了毛细管阵列单元和毛细管电泳装置，其布置成使得可以容易地执行用于安装毛细管阵列的作业。

26. 发明授权

US07473342B2 Capillary array and capillary electrophoresis apparatus 有权
标题翻译：毛细管阵列和毛细管电泳仪
公开(公告)号：US07473342B2
公开(公告)日：2009-01-06
申请号：US11395158
申请日：2006-04-03
申请人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
发明人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
IPC分类号： G01N27/00
CPC分类号： G01N27/44708
摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.
摘要翻译：在毛细管的温度不能根据毛细管产生的热量的变化而不能快速控制的情况下，不将样品的凝胶速度控制在一定程度以降低样品的分析性能。本发明旨在稳定电泳速度。其上布置有多个毛细管的基板的表面与能够进行温度控制的构件接触，从而控制毛细管的温度。由于根据本发明能够控制温度和毛细管的构件彼此直接接触，所以可以高精度地快速地控制毛细管的温度，使得电泳速度稳定。

27. 发明授权

US09393562B2 Analyzer 有权
标题翻译：分析仪
公开(公告)号：US09393562B2
公开(公告)日：2016-07-19
申请号：US13983340
申请日：2012-01-13
申请人： Takuya Matsui , Ryoji Inaba , Kazumichi Imai , Ryusuke Kimura
发明人： Takuya Matsui , Ryoji Inaba , Kazumichi Imai , Ryusuke Kimura
IPC分类号： C12Q1/68 , B01L3/00 , B01L3/02 , G01N35/10 , G01N35/00
CPC分类号： B01L3/502 , B01L3/0224 , B01L2300/026 , B01L2400/0406 , C12Q1/6869 , G01N35/0098 , G01N35/1002 , G01N35/1004 , G01N35/1095 , G01N2035/1039
摘要： Provided is an analyzer capable of reducing the amount of wasted reagents and shortening time required for solution sending, thus increasing throughput for analysis. A microsyringe sucks a minimum required amount of reagent that is substantially the same amount of capacity of a flow cell to a sampling nozzle. Then, the sampling nozzle is inserted into an injection port of the flow cell, and the reagent is injected into the flow cell by driving the microsyringe. The inside of the sampling nozzle is cleaned by moving the sampling nozzle to the cleaning tank and ejecting cleaning water from the sampling nozzle, and the outside of the sampling nozzle is cleaned by spraying cleaning water from an inner wall of the cleaning tank.
摘要翻译：提供了能够减少试剂浪费量和溶液发送所需时间缩短的分析装置，从而提高分析用量。微量注射器将最小所需量的试剂吸收到与采样喷嘴相当的流动池的容量基本上相同的量。然后，将取样喷嘴插入流通池的注入口，通过驱动微量注射器将试剂注入到流通池中。通过将采样喷嘴移动到清洗槽并从采样喷嘴喷射清洗水来清洁采样喷嘴的内部，并且通过从清洗槽的内壁喷射清洁水来清洁采样喷嘴的外部。

28. 发明授权

US08246806B2 Multi-capillary array electrophoresis device 有权
标题翻译：多毛细管阵列电泳装置
公开(公告)号：US08246806B2
公开(公告)日：2012-08-21
申请号：US11714222
申请日：2007-03-06
申请人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai , Eric S. Nordman
发明人： Ryoji Inaba , Tomohiro Shoji , Shozo Kasai , Masaya Kojima , Yasushi Shimizu , Seiichi Ugai , Eric S. Nordman
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44721
摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.
摘要翻译：电泳装置包括具有设置在阵列的毛细管之间的液体或固体的多毛细管阵列。液体或固体的折射率高于空气的折射率，小于水的折射率，并减少了由毛细管散射的激光束的数量。还提供了调节通过多毛细管阵列的毛细管的折射和反射的激发光束的方法，以减少激光束的强度损失并增加设置在毛细管中的各个样品的照射。

29. 发明申请

US20080296160A1 CAPILLARY ELECTROPHORESIS DEVICE 有权
标题翻译：毛细管电泳装置
公开(公告)号：US20080296160A1
公开(公告)日：2008-12-04
申请号：US12130330
申请日：2008-05-30
申请人： Takeshi OOURA , Ryoji Inaba
发明人： Takeshi OOURA , Ryoji Inaba
IPC分类号： C07K1/26
CPC分类号： G01N27/44704
摘要： Provided is a capillary electrophoresis device including a holder preventing a septum from coming off when a capillary is pulled out, and also allowing containers to be taken out in any order. In the capillary electrophoresis device for separating and analyzing a sample such as a DNA and a protein by electrophoresis, the holder includes: a septum having a capillary hole through which a capillary penetrates; a container for storing a solution; and a container-accommodation unit for accommodating the container. A hole formed in the septum engages with an engagement portion formed on the container, and thereby the septum is held to cover the container.
摘要翻译：本发明提供一种毛细管电泳装置，其包括：当毛细管被拉出时防止隔膜脱落的保持器，并且还允许以任何顺序取出容器。在用于通过电泳分离和分析诸如DNA和蛋白质的样品的毛细管电泳装置中，保持器包括：具有毛细管穿过的毛细孔的隔膜; 用于存储解决方案的容器; 以及用于容纳容器的容器收纳单元。形成在隔膜上的孔与形成在容器上的接合部接合，从而保持隔膜以覆盖容器。

30. 发明授权

US07459068B2 Multi-capillary electrophoresis apparatus 有权
标题翻译：多毛细管电泳仪
公开(公告)号：US07459068B2
公开(公告)日：2008-12-02
申请号：US10309729
申请日：2002-12-04
申请人： Eric S. Nordman , Miho Ozawa , Masaya Kojima , Ryoji Inaba , Yoshitaka Kodama , Motohiro Yamazaki
发明人： Eric S. Nordman , Miho Ozawa , Masaya Kojima , Ryoji Inaba , Yoshitaka Kodama , Motohiro Yamazaki
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44704 , G01N27/44708 , G01N27/44782
摘要： A multi-capillary electrophoresis apparatus is provided for reducing errors during analysis caused by fluctuations in electrophoresis time among plural capillaries of the apparatus. The multi-capillary electrophoresis apparatus can contain a multi-capillary array that has a separation medium filled therein for isolating a sample. A detector component can be provided at a position remote from a sample injecting end of the array for acquiring information from the sample. A buffer container can be provided for holding a buffer solution into which the sample injecting end can be immersed. One or more temperature controlling component devices can be arranged for controlling a temperature of the buffer solution, of the detector component, or of both the buffer solution and the detector component.
摘要翻译：提供了一种多毛细管电泳装置，用于减少由于装置的多个毛细管之间的电泳时间波动引起的分析过程中的误差。多毛细管电泳装置可以包含多个毛细管阵列，其具有填充在其中的分离介质，用于分离样品。可以在远离阵列的样品注入端的位置处提供检测器部件，以从样品获取信息。可以提供缓冲容器用于保持可以浸入样品注入端的缓冲溶液。可以布置一个或多个温度控制部件装置，用于控制缓冲溶液，检测器部件或缓冲溶液和检测器部件两者的温度。

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