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1. 发明授权

US08257569B2 Capillary array unit and capillary electrophoresis apparatus 有权
标题翻译：毛细管阵列单元和毛细管电泳仪
公开(公告)号：US08257569B2
公开(公告)日：2012-09-04
申请号：US12352238
申请日：2009-01-12
申请人： Tomohiro Shoji , Toshiyuki Sakurai , Takashi Gomi , Ryoji Inaba
发明人： Tomohiro Shoji , Toshiyuki Sakurai , Takashi Gomi , Ryoji Inaba
IPC分类号： G01N27/453
CPC分类号： G01N27/44782
摘要： In a capillary electrophoresis apparatus, a capillary array unit has a capillary array including capillaries having a capillary head and a detection unit, a frame for supporting the capillary array, and a load header for holding cathode ends of the capillaries. The frame has separators for separating and holding the capillaries. The capillary head, the detection unit, and the separators are disposed along one linear line. With this arrangement, there is provided the capillary array unit and the capillary electrophoresis apparatus which are arranged such that a job for mounting the capillary array can be executed easily.
摘要翻译：在毛细管电泳装置中，毛细管阵列单元具有毛细管阵列，其包括具有毛细管头和检测单元的毛细管，用于支撑毛细管阵列的框架和用于保持毛细血管的阴极端的负载头。框架具有用于分离和保持毛细管的分离器。毛细管头，检测单元和分离器沿着一条线性线设置。通过这种布置，提供了毛细管阵列单元和毛细管电泳装置，其布置成使得可以容易地执行用于安装毛细管阵列的作业。

2. 发明申请

US20090183990A1 CAPILLARY ARRAY UNIT AND CAPILLARY ELECTROPHORESIS APPARATUS 有权
标题翻译：毛细管阵列和毛细管电泳装置
公开(公告)号：US20090183990A1
公开(公告)日：2009-07-23
申请号：US12352238
申请日：2009-01-12
申请人： Tomohiro SHOJI , Toshiyuki Sakurai , Takashi Gomi , Ryoji Inaba
发明人： Tomohiro SHOJI , Toshiyuki Sakurai , Takashi Gomi , Ryoji Inaba
IPC分类号： G01N27/453
CPC分类号： G01N27/44782
摘要： In a capillary electrophoresis apparatus, a capillary array unit has a capillary array including capillaries having a capillary head and a detection unit, a frame for supporting the capillary array, and a load header for holding cathode ends of the capillaries. The frame has separators for separating and holding the capillaries. The capillary head, the detection unit, and the separators are disposed along one linear line. With this arrangement, there is provided the capillary array unit and the capillary electrophoresis apparatus which are arranged such that a job for mounting the capillary array can be executed easily.
摘要翻译：在毛细管电泳装置中，毛细管阵列单元具有毛细管阵列，其包括具有毛细管头和检测单元的毛细管，用于支撑毛细管阵列的框架和用于保持毛细血管的阴极端的负载头。框架具有用于分离和保持毛细管的分离器。毛细管头，检测单元和分离器沿着一条线性线设置。通过这种布置，提供了毛细管阵列单元和毛细管电泳装置，其布置成使得可以容易地执行用于安装毛细管阵列的作业。

3. 发明授权

US07943027B2 Electrophoresis unit and electrophoretic analysis method 有权
标题翻译：电泳单元和电泳分析方法
公开(公告)号：US07943027B2
公开(公告)日：2011-05-17
申请号：US11979570
申请日：2007-11-06
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D57/02 , C07K1/26 , G01N27/44721 , G01N27/44782
摘要： The object of the present invention is that a dynamic range is extended in an electrophoresis unit and concentration differences among a plurality of samples measured simultaneously are increased.An irradiation time to the samples is adjusted during analysis without changing a sampling time. By shortening the irradiation time, a fluorescence amount of the samples is reduced to cause signal intensity detected by a detector to physically decrease. If the irradiation time is very short (several 100 msec), the irradiation time and fluorescence intensity are in a direct proportional relationship. It is known that, if the irradiation time is reduced to 1/n, the fluorescence intensity, that is, signal intensity to be detected will be 1/n. Thus, for data whose irradiation time is reduced to 1/n during analysis, data obtained by multiplying a substantially measured value by n is used for data analysis as a true value to be originally acquired.
摘要翻译：本发明的目的是在电泳单元中扩展动态范围，同时增加多个样本之间的浓度差。在分析过程中调整样品的照射时间，而不改变采样时间。通过缩短照射时间，减少样品的荧光量，使得由检测器检测出的信号强度物理降低。如果照射时间非常短（几百毫秒），照射时间和荧光强度成正比关系。已知如果照射时间减少到1 / n，则荧光强度即被检测信号强度为1 / n。因此，对于在分析期间其照射时间减少到1 / n的数据，将通过将基本上测量的值乘以n获得的数据用作数据分析作为最初获取的真实值。

4. 发明申请

US20080217177A1 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US20080217177A1
公开(公告)日：2008-09-11
申请号：US12073296
申请日：2008-03-04
申请人： Ryoji Inaba , Motohiro Yamazaki , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Ryoji Inaba , Motohiro Yamazaki , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： G01N27/26
CPC分类号： G01N27/447
摘要： There is provided a capillary electrophoresis apparatus wherein coupling efficiency of exciting irradiation light to a capillary array does not decline even if any one capillary array of two capillary arrays is removed.Light emission generated by capillaries of each capillary array of 2n (n is a positive integer) capillary arrays radiating exciting light from one side is detected by one optical detection system.
摘要翻译：提供了一种毛细管电泳装置，其中激光照射光与毛细管阵列的耦合效率即使去除两个毛细管阵列的任何一个毛细管阵列也不会下降。通过一个光学检测系统检测由一个辐射来自一侧的激发光的2μs（n是正整数）毛细管阵列的毛细管阵列的毛细管产生的发光。

5. 发明授权

US08262888B2 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US08262888B2
公开(公告)日：2012-09-11
申请号：US12073296
申请日：2008-03-04
申请人： Ryoji Inaba , Motohiro Yamazaki , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Ryoji Inaba , Motohiro Yamazaki , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/447
摘要： There is provided a capillary electrophoresis apparatus wherein coupling efficiency of exciting irradiation light to a capillary array does not decline even if any one capillary array of two capillary arrays is removed.Light emission generated by capillaries of each capillary array of 2n (n is a positive integer) capillary arrays radiating exciting light from one side is detected by one optical detection system.
摘要翻译：提供了一种毛细管电泳装置，其中激光照射光与毛细管阵列的耦合效率即使去除两个毛细管阵列的任何一个毛细管阵列也不会下降。通过一个光学检测系统检测由辐射来自一侧的激发光的2n（n是正整数）毛细管阵列的毛细管阵列的毛细管产生的发光。

6. 发明申请

US20080110756A1 Electrophoresis unit and electrophoretic analysis method 有权
标题翻译：电泳单元和电泳分析方法
公开(公告)号：US20080110756A1
公开(公告)日：2008-05-15
申请号：US11979570
申请日：2007-11-06
申请人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
发明人： Motohiro Yamazaki , Ryoji Inaba , Satoshi Takahashi , Tomohiro Shoji , Takeshi Ohura , Takashi Gomi
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , C07K1/26 , G01N27/44721 , G01N27/44782
摘要： The object of the present invention is that a dynamic range is extended in an electrophoresis unit and concentration differences among a plurality of samples measured simultaneously are increased.An irradiation time to the samples is adjusted during analysis without changing a sampling time. By shortening the irradiation time, a fluorescence amount of the samples is reduced to cause signal intensity detected by a detector to physically decrease. If the irradiation time is very short (several 100 msec), the irradiation time and fluorescence intensity are in a direct proportional relationship. It is known that, if the irradiation time is reduced to 1/n, the fluorescence intensity, that is, signal intensity to be detected will be 1/n. Thus, for data whose irradiation time is reduced to 1/n during analysis, data obtained by multiplying a substantially measured value by n is used for data analysis as a true value to be originally acquired.
摘要翻译：本发明的目的是在电泳单元中扩展动态范围，同时增加多个样本之间的浓度差。在分析过程中调整样品的照射时间，而不改变采样时间。通过缩短照射时间，减少样品的荧光量，使得由检测器检测出的信号强度物理降低。如果照射时间非常短（几百毫秒），照射时间和荧光强度成正比关系。已知如果照射时间减少到1 / n，则荧光强度即被检测信号强度为1 / n。因此，对于在分析期间照射时间减少到1 / n的数据，将通过将基本上测量的值乘以n获得的数据用作数据分析，作为最初获取的真实值。

7. 发明授权

US08702949B2 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US08702949B2
公开(公告)日：2014-04-22
申请号：US13263040
申请日：2010-04-08
申请人： Takeshi Ohura , Ryoji Inaba , Manabu Akiba , Takashi Gomi , Mari Kotoura
发明人： Takeshi Ohura , Ryoji Inaba , Manabu Akiba , Takashi Gomi , Mari Kotoura
IPC分类号： G01N27/453
CPC分类号： G01N27/44743 , G01N27/44782
摘要： The solution reservoir apparatus of the capillary electrophoresis apparatus securely affixes an evaporation-preventing membrane to a container when a capillary is inserted or withdrawn, without extending the cathode end of the capillary. The solution reservoir apparatus comprises a container for reserving a sample or solution, a cover having a bore through which the capillary is passed and covering the container, an evaporation-preventing membrane having a capillary hole through which the capillary is passed, and a container holder for holding the container. The evaporation-preventing membrane has a projection provided at the periphery of the capillary hole, the projection of the evaporation-preventing membrane is engaged with the bore on the cover when the evaporation-preventing membrane is positioned on the cover, and the evaporation-preventing membrane is supported by the cover.
摘要翻译：当毛细管插入或取出时，毛细管电泳装置的溶液储存装置在不延长毛细管的阴极端的情况下，将防蒸发膜牢固地固定在容器上。溶液储存装置包括用于储存样品或溶液的容器，具有孔的盖，毛细管穿过孔覆盖容器，具有毛细孔通过的毛细孔的防蒸发膜和容器保持架用于拿着容器。防蒸发膜具有设置在毛细孔周边的突起，当防蒸发膜位于盖上时，防蒸发膜的突起与盖上的孔接合，并且防蒸发膜膜由盖支撑。

8. 发明申请

US20120031762A1 ELECTROPHORESIS DEVICE AND PUMP 有权
标题翻译：电泳装置和泵
公开(公告)号：US20120031762A1
公开(公告)日：2012-02-09
申请号：US13263304
申请日：2010-04-06
申请人： Takashi Gomi , Ryoji Inaba , Taro Nakazawa , Takeshi Ohura , Mari Kotoura
发明人： Takashi Gomi , Ryoji Inaba , Taro Nakazawa , Takeshi Ohura , Mari Kotoura
IPC分类号： F04B19/20 , G01N27/00
CPC分类号： F04B19/006 , B01D57/02 , G01N27/44704
摘要： Bubbles can be removed regardless of an individual difference of a pump to fill an electrophoresis medium into a capillary. Of flow passages formed between an inner side surface of a container for accommodating the electrophoresis medium and a side surface of a plunger, one of the flow passages causing an electrophoresis medium to be easily stagnant is formed to have the cross-sectional area larger than the cross-sectional area of the other flow passage on the opposite side. In other words, the flow passage portion causing the electrophoresis medium to be easily stagnant is formed in such a manner as to increase a flow amount of the electrophoresis medium. This can eliminate a region having an extremely small amount of electrophoresis medium flow in the pump.
摘要翻译：不管泵的个体差异，将电泳介质填充到毛细管中，都可以去除气泡。在容纳电泳介质的容器的内侧面和柱塞的侧面之间形成的流路之间形成有引起电泳介质容易停滞的流路之一，其横截面积大于另一个流动通道的相对侧的横截面面积。换句话说，导致电泳介质容易停滞的流通部分以增加电泳介质的流量的方式形成。这可以消除在泵中具有极少量的电泳介质流动的区域。

9. 发明授权

US07787120B2 Spectrophotometer and liquid chromatography system 失效
标题翻译：分光光度计和液相色谱系统
公开(公告)号：US07787120B2
公开(公告)日：2010-08-31
申请号：US12146920
申请日：2008-06-26
申请人： Motohiro Yamazaki , Ryoji Inaba , Kosaku Toyosaki , Shintaro Kubo , Takashi Gomi , Katsunobu Hama , Kiyotoshi Mori , Hideyuki Akiyama
发明人： Motohiro Yamazaki , Ryoji Inaba , Kosaku Toyosaki , Shintaro Kubo , Takashi Gomi , Katsunobu Hama , Kiyotoshi Mori , Hideyuki Akiyama
IPC分类号： G01J3/10 , G01J3/36 , G01N21/33
CPC分类号： G01J3/10 , G02B5/283 , G02B27/1006 , G02B27/1086 , G02B27/145 , G02B27/148
摘要： Detection sensitivity is improved by increasing the amount of light of beams that irradiate a sample cell without causing saturation of a detector with ultraviolet beams or visible beams. This spectrophotometer includes a sample cell, which stores a sample to be measured, a visible light source and an ultraviolet light source each for supplying an incident beam that enters the sample, a spectroscope, which disperses a beam that has passed through the sample, an optical detector, which detects beams dispersed from such beam (spectrum), and a dichroic element which reflects or transmits ultraviolet beams from the ultraviolet light source and which transmits or reflects visible beams from the visible light source. Optics are configured such that ultraviolet beams and visible beams that have passed through or have been reflected by the dichroic element enter the sample cell.
摘要翻译：通过增加照射样品池的光束的光量而不会使紫外线束或可见光束的检测器饱和而提高检测灵敏度。该分光光度计包括存储待测样品，可见光源和紫外光源的样品池，每个用于提供进入样品的入射光束，分散已经通过样品的光束的分光器，检测从这种光束（光谱）分散的光束的光检测器，以及从紫外光源反射或透射紫外光束并从可见光源透射或反射可见光束的二向色元件。光学构造使得已经通过或已被二色性元件反射的紫外光束和可见光束进入样品池。

10. 发明授权

US08349161B2 Electrophoresis device and pump 有权
标题翻译：电泳装置和泵
公开(公告)号：US08349161B2
公开(公告)日：2013-01-08
申请号：US13263304
申请日：2010-04-06
申请人： Takashi Gomi , Ryoji Inaba , Taro Nakazawa , Takeshi Ohura , Mari Kotoura
发明人： Takashi Gomi , Ryoji Inaba , Taro Nakazawa , Takeshi Ohura , Mari Kotoura
IPC分类号： G01N27/453
CPC分类号： F04B19/006 , B01D57/02 , G01N27/44704
摘要： Bubbles can be removed regardless of an individual difference of a pump to fill an electrophoresis medium into a capillary. Of flow passages formed between an inner side surface of a container for accommodating the electrophoresis medium and a side surface of a plunger, one of the flow passages causing an electrophoresis medium to be easily stagnant is formed to have the cross-sectional area larger than the cross-sectional area of the other flow passage on the opposite side. In other words, the flow passage portion causing the electrophoresis medium to be easily stagnant is formed in such a manner as to increase a flow amount of the electrophoresis medium. This can eliminate a region having an extremely small amount of electrophoresis medium flow in the pump.
摘要翻译：不管泵的个体差异，将电泳介质填充到毛细管中，都可以去除气泡。在容纳电泳介质的容器的内侧面和柱塞的侧面之间形成的流路之间形成有使电泳介质容易停滞的流路之一，其横截面积大于另一个流动通道的相对侧的横截面面积。换句话说，导致电泳介质容易停滞的流通部分以增加电泳介质的流量的方式形成。这可以消除在泵中具有极少量的电泳介质流动的区域。

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