专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20060196778A1 Tungsten electroprocessing 审中-公开
标题翻译：钨电加工
公开(公告)号：US20060196778A1
公开(公告)日：2006-09-07
申请号：US11342179
申请日：2006-01-27
申请人： Renhe Jia , Zhihong Wang , Yuan Tian , Huyen Tran , Daxin Mao , Stan Tsai , Lakshmanan Karuppiah , Liang-Yuh Chen
发明人： Renhe Jia , Zhihong Wang , Yuan Tian , Huyen Tran , Daxin Mao , Stan Tsai , Lakshmanan Karuppiah , Liang-Yuh Chen
IPC分类号： B23H9/00 , C25D17/00
CPC分类号： B23H5/08 , B24B37/042 , C25F3/08
摘要： Methods for polishing tungsten are provided. During ECMP, increasing the voltage to the pad is not always enough to increase the polishing rate. When polishing tungsten, simply increasing the applied voltage will, in some cases, actually decrease the removal rate. By increasing the down force pressure between the polishing pad and the substrate, the applied voltage, and the rotation speed of the substrate and the polishing pad, the tungsten removal rate will also increase.
摘要翻译：提供钨的抛光方法。在ECMP期间，增加焊盘的电压并不总是足以提高抛光速率。抛光钨时，简单地增加施加的电压将在某些情况下实际上降低去除率。通过增加抛光垫和基板之间的下压力，施加电压以及基板和抛光垫的旋转速度，钨去除率也将增加。

22. 发明申请

US20170114078A1 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA 审中-公开
公开(公告)号：US20170114078A1
公开(公告)日：2017-04-27
申请号：US15318483
申请日：2015-06-09
申请人： Meredeth Ann MCGOWAN , Kin Chiu FONG , Neville John ANTHONY , Hua ZHOU , Jason D. KATZ , Lihu YANG , Chaomin LI , Yuan TIAN , Changwei MU , Baijun YE , Feng SHI , Xiaoli ZHAO , Jianmin FU , Yabin LI , Merck Sharp & Dohme Corp.
发明人： Meredeth Ann McGowan , Kin Chiu Fong , Neville John Anthony , Hua Zhou , Jason D. Katz , Lihu Yang , Chaomin Li , Yuan Tian , Changwei Mu , Baijun Ye , Feng Shi , Xiaoli Zhao , Jianmin Fu , Yabin Li
IPC分类号： C07D519/00 , C07D473/30 , C07D473/34 , A61K31/52
CPC分类号： C07D519/00 , A61K31/52 , C07D473/30 , C07D473/34
摘要： The instant invention provides compounds of formula (I) which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

23. 发明申请

US20140106369A1 BIOMARKERS FOR AGGRESSIVE PROSTATE CANCER 有权
标题翻译：生物标志物用于肿瘤前列腺癌
公开(公告)号：US20140106369A1
公开(公告)日：2014-04-17
申请号：US14006503
申请日：2012-03-22
申请人： Hui Zhang , Yuan Tian , Daniel W. Chan , Jing Chen
发明人： Hui Zhang , Yuan Tian , Daniel W. Chan , Jing Chen
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/57434
摘要： The present invention relates to the field of biomarkers and, more specifically, to biomarkers useful in diagnosing aggressive prostate cancer. In specific embodiments, a method for diagnosing aggressive prostate cancer in a patient comprises (a) measuring the levels of one or more biomarkers in a sample collected from the patient; and (b) comparing the levels of the one or more biomarkers with predefined levels of the same biomarkers that correlate to a patient having aggressive prostate cancer and predefined levels of the same biomarkers that correlate to a patient not having aggressive prostate cancer, wherein a correlation to one of the predefined levels provides the diagnosis. In a specific embodiment, the one or more biomarkers may comprise cathepsin-L (CTSL), periostin, microfibrillar-associated protein 4 (MFAP4), collagen XII, neprilysin, clusterin, neutrophil gelatinase associated lipocalin (NGAL), epithelial cell activating molecule (EpCAM), prostate specific antigen (PSA), membrane metallo-endopeptidase (MME) and asporin (ASPN).
摘要翻译：本发明涉及生物标记领域，更具体地涉及可用于诊断侵略性前列腺癌的生物标志物。在具体实施方案中，用于诊断患者中侵袭性前列腺癌的方法包括（a）测量从患者收集的样品中的一种或多种生物标志物的水平; 和（b）将一种或多种生物标志物的水平与与具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平和与不具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平进行比较，其中相关性到其中一个预定义的级别提供诊断。在一个具体的实施方案中，一种或多种生物标志物可以包含组织蛋白酶-L（CTSL），骨膜素，微原纤维相关蛋白4（MFAP4），胶原XII，起泡蛋白，聚集蛋白，嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL），上皮细胞活化分子 EpCAM），前列腺特异性抗原（PSA），膜金属内肽酶（MME）和阿泊菌（ASPN）。

24. 发明申请

US20110028661A1 HYBRID POLYURETHANE BLOCK COPOLYMERS WITH THERMOPLASTIC PROCESSABILITY AND THERMOSET PROPERTIES 审中-公开
标题翻译：具有热塑性加工性和热稳定性的混合聚氨酯嵌段共聚物
公开(公告)号：US20110028661A1
公开(公告)日：2011-02-03
申请号：US12809212
申请日：2008-12-18
申请人： Robert S. Ward , Keith R. McCrea , Yuan Tian , Jim Yang
发明人： Robert S. Ward , Keith R. McCrea , Yuan Tian , Jim Yang
IPC分类号： C08F283/12
CPC分类号： C08G18/3228 , C08G18/4812 , C08G18/61 , C08G18/6611
摘要： Block copolymers are formulated with multifunctional chain extenders. The block copolymers include a soft segment and a hard segment made from a diisocyanate, an alkylene diamine chain extender, and a multifunctional chain extender which provides delayed crosslinking. The multifunctional chain extenders have a functionality and typically have at least one OH group. The multifunctional chain extenders may be aliphatic or aromatic triols or polyols, or may have other configurations, as described. The resulting block copolymers have improved mechanical properties such as compression set. They may be used in medical applications, or in industrial applications such as seal and gasket applications, including O-rings, window seals, and automotive gaskets. The initially-formed polyurethane resin behaves as a thermoplastic processable material, while the configured end-use product is thermoset.
摘要翻译：嵌段共聚物用多功能扩链剂配制。嵌段共聚物包括软链段和由二异氰酸酯制成的硬链段，亚烷基二胺扩链剂和提供延迟交联的多官能扩链剂。多功能扩链剂具有官能团并且通常具有至少一个OH基团。多官能增链剂可以是脂族或芳族三醇或多元醇，或者可以具有如所述的其它构型。所得的嵌段共聚物具有改进的机械性能，如压缩永久变形。它们可用于医疗应用或工业应用中，例如密封和垫片应用，包括O型圈，窗户密封件和汽车垫圈。初始形成的聚氨酯树脂表现为热塑性可加工材料，而配置的最终用途产品是热固性的。

25. 发明申请

US20100091756A1 METHOD OF USING ACKNOWLEDGMENT TONES FOR DATA CONSISTENCY IN INTRA-VEHICULAR WIRELESS NETWORKS 审中-公开
标题翻译：在无线网络中使用确认数据一致性的方法
公开(公告)号：US20100091756A1
公开(公告)日：2010-04-15
申请号：US12248311
申请日：2008-10-09
申请人： Thomas Alfons Hogenmueller , Vivek Jain , Lakshmi Venkatraman , Abtin Keshavarzian , Krishna Chintalapudi , Serbulent Tozlu , Yuan Tian
发明人： Thomas Alfons Hogenmueller , Vivek Jain , Lakshmi Venkatraman , Abtin Keshavarzian , Krishna Chintalapudi , Serbulent Tozlu , Yuan Tian
IPC分类号： H04J3/00 , H04B7/00
CPC分类号： H04L1/1692 , H04L2001/0097
摘要： A method for providing electronic communications between wireless nodes includes wirelessly transmitting data from a transmitting one of the nodes to a plurality of receiving ones of the nodes. A respective first acknowledgment tone is wirelessly transmitted from each of the receiving nodes to the transmitting node and to each other one of the receiving nodes. Each first acknowledgment tone is transmitted in response to the respective receiving node receiving the transmitted data. Each of the first acknowledgment tones is transmitted in a respective, unique time slot. At least one second acknowledgment tone is wirelessly transmitted from at least one of the nodes to each other one of the nodes. The second acknowledgment tone is transmitted dependent upon whether a group of received first acknowledgment tones matches a group of expected-to-be-received first acknowledgment tones.
摘要翻译：一种用于在无线节点之间提供电子通信的方法包括从节点中的发送节点之一向节点的多个接收节点无线地发送数据。相应的第一确认音从每个接收节点无线发送到发送节点，并且彼此相互接收节点之一。响应于相应的接收节点接收所发送的数据，发送每个第一确认音。每个第一确认音在相应的唯一时隙中发送。至少一个第二确认音从节点中的至少一个无线发送到彼此中的一个节点。第二确认音是根据一组接收到的第一确认音与一组预期接收的第一确认音匹配而发送的。

26. 发明申请

US20050218010A1 Process and composition for conductive material removal by electrochemical mechanical polishing 失效
标题翻译：通过电化学机械抛光去除导电材料的工艺和组成
公开(公告)号：US20050218010A1
公开(公告)日：2005-10-06
申请号：US11123274
申请日：2005-05-05
申请人： Zhihong Wang , You Wang , Daxin Mao , Renhe Jia , Stan Tsai , Yongqi Hu , Yuan Tian , Liang-Yuh Chen
发明人： Zhihong Wang , You Wang , Daxin Mao , Renhe Jia , Stan Tsai , Yongqi Hu , Yuan Tian , Liang-Yuh Chen
IPC分类号： B23H3/08 , B23H5/08 , C09G1/02 , C25F3/02 , H01L21/321 , H01L21/768
CPC分类号： C25F3/02 , B23H5/08 , C09G1/02 , H01L21/32125 , H01L21/7684
摘要： Compositions and methods for processing a substrate having a conductive material layer disposed thereon are provided. In one embodiment, a composition for processing a substrate having a conductive material layer disposed thereon is provided which composition includes an acid based electrolyte, a chelating agent, a corrosion inhibitor, a passivating polymeric material, a pH adjusting agent, a solvent, and a pH between about 3 and about 10. The composition is used in a method to form a passivation layer on the conductive material layer, abrading the passivation layer to expose a portion of the conductive material layer, applying a bias to the substrate, and removing the conductive material layer.
摘要翻译：提供了用于处理其上设置有导电材料层的基板的组合物和方法。在一个实施方案中，提供了一种用于处理其上设置导电材料层的基材的组合物，其组成包括酸性电解质，螯合剂，缓蚀剂，钝化聚合物材料，pH调节剂，溶剂和 pH为约3至约10.该组合物用于在导电材料层上形成钝化层的方法，研磨钝化层以暴露导电材料层的一部分，向衬底施加偏压，以及去除导电材料层。

27. 发明授权

US09594086B2 Biomarkers for aggressive prostate cancer 有权
标题翻译：用于侵略性前列腺癌的生物标志物
公开(公告)号：US09594086B2
公开(公告)日：2017-03-14
申请号：US14006503
申请日：2012-03-22
申请人： Hui Zhang , Yuan Tian , Daniel W. Chan , Jing Chen
发明人： Hui Zhang , Yuan Tian , Daniel W. Chan , Jing Chen
IPC分类号： G01N33/53 , G01N33/68 , G01N33/574
CPC分类号： G01N33/6893 , G01N33/57434
摘要： The present invention relates to the field of biomarkers and, more specifically, to biomarkers useful in diagnosing aggressive prostate cancer. In specific embodiments, a method for diagnosing aggressive prostate cancer in a patient comprises (a) measuring the levels of one or more biomarkers in a sample collected from the patient; and (b) comparing the levels of the one or more biomarkers with predefined levels of the same biomarkers that correlate to a patient having aggressive prostate cancer and predefined levels of the same biomarkers that correlate to a patient not having aggressive prostate cancer, wherein a correlation to one of the predefined levels provides the diagnosis. In a specific embodiment, the one or more biomarkers may comprise cathepsin-L (CTSL), periostin, microfibrillar-associated protein 4 (MFAP4), collagen XII, neprilysin, clusterin, neutrophil gelatinase associated lipocalin (NGAL), epithelial cell activating molecule (EpCAM), prostate specific antigen (PSA), membrane metallo-endopeptidase (MME) and asporin (ASPN).
摘要翻译：本发明涉及生物标记领域，更具体地涉及可用于诊断侵略性前列腺癌的生物标志物。在具体实施方案中，用于诊断患者中侵袭性前列腺癌的方法包括（a）测量从患者收集的样品中的一种或多种生物标志物的水平; 和（b）将一种或多种生物标志物的水平与与具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平和与不具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平进行比较，其中相关性到其中一个预定义的级别提供诊断。在一个具体的实施方案中，一种或多种生物标志物可以包含组织蛋白酶-L（CTSL），骨膜素，微原纤维相关蛋白4（MFAP4），胶原XII，起泡蛋白，聚集蛋白，嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL），上皮细胞活化分子 EpCAM），前列腺特异性抗原（PSA），膜金属内肽酶（MME）和阿泊菌（ASPN）。

28. 发明申请

US20120204971A1 SYSTEM AND METHOD FOR COMPRESSED GAS FUEL HANDLING 有权
标题翻译：压缩气体燃料处理系统与方法
公开(公告)号：US20120204971A1
公开(公告)日：2012-08-16
申请号：US13236510
申请日：2011-09-19
申请人： Wenjie Wu , Ping Yu , Yuan Tian , Zhiyong Chen
发明人： Wenjie Wu , Ping Yu , Yuan Tian , Zhiyong Chen
IPC分类号： F02B43/00
CPC分类号： F02C3/22 , F02C3/28 , F02C7/22 , F05D2220/722 , F05D2260/20 , F23K5/007 , F23K2401/10 , F23K2401/201 , F23K2900/05001 , Y02E20/16 , Y02E20/18 , Y02T50/675 , Y10T137/6416
摘要： A system includes a cooler configured to cool a first gas portion of a compressed gas fuel and discharge a cooled fluid. The cooled fluid comprises a cooled gas portion and a cooled liquid portion. The system also includes a separator configured to separate the cooled fluid into the cooled gas portion and the cooled liquid portion and a mixing tank configured to mix a second gas portion of the compressed gas fuel with the cooled gas portion in direct contact with one another to produce a superheated gas fuel. The superheated gas fuel comprises a degree of superheat above a lower threshold for a combustion system.
摘要翻译：系统包括冷却器，该冷却器构造成冷却压缩气体燃料的第一气体部分并排出冷却的流体。冷却的流体包括冷却的气体部分和冷却的液体部分。该系统还包括分离器，该分离器被构造成将冷却的流体分离成冷却的气体部分和冷却的液体部分;以及混合罐，其被配置成将压缩气体燃料的第二气体部分与冷却的气体部分彼此直接接触，产生过热气体燃料。过热气体燃料包括一个超过燃烧系统下限阈值的过热度。

29. 发明申请

US20110257027A2 GAMMA-SECRETASE SUBSTRATE AND METHODS OF USE 有权
公开(公告)号：US20110257027A2
公开(公告)日：2011-10-20
申请号：US12776141
申请日：2010-05-07
申请人： Christopher Shelton , Yuan Tian , Yueming Li
发明人： Christopher Shelton , Yuan Tian , Yueming Li
IPC分类号： G01N33/573 , C12P21/06 , C12N9/99 , C07H21/04 , C40B30/04 , C07K14/47 , C07K7/06 , C12Q1/37 , C12N5/02
CPC分类号： G01N33/573 , C07K14/4711 , G01N33/542 , G01N2333/4709 , G01N2333/948 , G01N2500/02 , G01N2800/2814 , G01N2800/2821
摘要： Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase.

30. 发明申请

US20110086077A1 SILICONE HYDROGELS FOR TISSUE ADHESIVES AND TISSUE DRESSING APPLICATIONS 审中-公开
标题翻译：用于组织粘合剂和组织粘合应用的硅胶水凝胶
公开(公告)号：US20110086077A1
公开(公告)日：2011-04-14
申请号：US12745509
申请日：2008-11-21
申请人： Keith R. McCrea , Robert S. Ward , Yuan Tian
发明人： Keith R. McCrea , Robert S. Ward , Yuan Tian
IPC分类号： A61L15/22 , A61K38/39 , A61P17/02
CPC分类号： A61L15/60 , A61L15/225 , A61L15/26 , A61L26/0019 , A61L26/0076 , A61L26/008 , C08L83/04
摘要： A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethyllacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).
摘要翻译：硅氧烷水凝胶制剂可以含有无规和/或嵌段共聚物或低聚物或大分子单体。硅氧烷共聚物与其它聚合物或单体或大分子单体共聚或共混以获得最终配方。硅氧烷水凝胶可以含有交联基团以提供完全或部分交联的最终结构。硅氧烷水凝胶制剂可以预先形成为膜或其它结构，或者可以在使用时聚合，如在粘合剂制剂的情况下。一种伤口敷料，其包含在施加到伤口之前或原位在伤口上形成的膜的硅酮水凝胶，该膜具有透气性，透湿性和高含水量，其中所述硅氧水凝胶由可聚合硅氧烷形成例如甲基丙烯酸二官能聚二甲基硅氧烷和N，N-二甲基丙烯酰胺（DMA），甲基丙烯酸2-羟乙酯（HEMA）和三甲基甲硅烷氧基硅烷（TRIS）等交联剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式