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21. 发明授权

US08702649B2 Multiple lumen diffusion catheter 有权
标题翻译：多腔扩散导管
公开(公告)号：US08702649B2
公开(公告)日：2014-04-22
申请号：US12515981
申请日：2007-11-28
申请人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Frederick W. Trombley, III , Arthur E. Uber, III
发明人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Frederick W. Trombley, III , Arthur E. Uber, III
IPC分类号： A61M29/00
CPC分类号： A61M25/007 , A61M25/003
摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.
摘要翻译：一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

22. 发明申请

US20120221042A1 Methods And Devices For Treating The Left Atrial Appendage 审中-公开
标题翻译：用于治疗左心耳的方法和装置
公开(公告)号：US20120221042A1
公开(公告)日：2012-08-30
申请号：US13361871
申请日：2012-01-30
申请人： Robert S. Schwartz , Robert A. Van Tassel , Gregg S. Sutton , Eric J. Simso
发明人： Robert S. Schwartz , Robert A. Van Tassel , Gregg S. Sutton , Eric J. Simso
IPC分类号： A61B17/08
CPC分类号： A61B17/12122 , A61B17/0218 , A61B17/12168 , A61B2017/00243 , A61B2017/00349 , A61B2017/00606 , A61B2017/0237 , A61B2017/12054 , A61B2017/12068 , A61B2017/12095 , A61B2017/22067
摘要： Methods and devices that treat the left atrial appendage by bringing the distal wall of the appendage to a position where the tissue of the wall blocks the ostium, thereby preventing blood from flowing into the appendage. The methods and devices are adapted to create a separation between the distal wall of the appendage and the adjacent pericardium such that the risk of rupturing the pericardium are minimized.
摘要翻译：通过使附肢的远侧壁到达壁的组织阻挡口的位置，从而防止血液流入附属物来治疗左心耳的方法和装置。所述方法和装置适于在附属物的远端壁和相邻的心包之间产生分离，使得将心包膜破裂的风险最小化。

23. 发明授权

US07618432B2 Valvuloplasty devices and methods 有权
标题翻译：瓣膜成形术装置及方法
公开(公告)号：US07618432B2
公开(公告)日：2009-11-17
申请号：US10856494
申请日：2004-05-27
申请人： Wesley Pedersen , Robert A. Van Tassel , Robert S. Schwartz , Gregory G. Brucker , Skott E. Greenhalgh
发明人： Wesley Pedersen , Robert A. Van Tassel , Robert S. Schwartz , Gregory G. Brucker , Skott E. Greenhalgh
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/22 , A61B17/3207 , A61B17/320725 , A61B2017/00783 , A61B2017/22051 , A61B2017/22061 , A61B2017/22098 , A61F2/013 , A61F2/2433 , A61M25/10 , A61M25/1002 , A61M25/104 , A61M29/02 , A61M2025/1059
摘要： The present invention provides an aortic valvuloplasty catheter which, in one preferred embodiment, has a tapered distal balloon segment that anchors within the left ventricle outflow track of the patient's heart and a rounded proximal segment which conforms to the aortic sinuses forcing the valve leaflets open. In addition, this embodiment of the valvuloplasty catheter includes a fiber-based balloon membrane, a distal pigtail end hole catheter tip, and a catheter sheath.
摘要翻译：本发明提供了一种主动脉瓣膜成形术导管，其在一个优选实施例中具有楔形的远侧气囊段，其锚定在患者心脏的左心室流出轨道内，并且圆形近端段符合主动脉窦，迫使瓣膜小叶开放。此外，瓣膜成形术导管的该实施例包括纤维基球囊膜，远端猪尾端孔导管末端和导管鞘。

24. 发明授权

US06193670B1 Hemostatic agent delivery device having built-in pressure sensor 失效
标题翻译：止血剂输送装置，内置压力传感器
公开(公告)号：US06193670B1
公开(公告)日：2001-02-27
申请号：US09218482
申请日：1998-12-22
申请人： Robert A. Van Tassel , Robert S. Schwartz , David Holmes , Mark A. Rydell
发明人： Robert A. Van Tassel , Robert S. Schwartz , David Holmes , Mark A. Rydell
IPC分类号： A61B500
CPC分类号： A61B17/00491 , A61B17/0057 , A61B2017/00495
摘要： An instrument for achieving rapid hemostasis at the conclusion of a catheterization procedure comprising a hemostatic agent injection device for use with a conventional introducer sheath used to gain access to the blood vessel. The injection device includes an elongated tubular member having ejection ports proximate its distal end. A hub member includes an elongated groove or track located in its surface with a transparent cover. The enclosed track is sealed from the lumen extending through the tubular member with a compliant membrane and filled with a predetermined amount of fluid. After the catheterization procedure, the device is inserted into the introducer sheath. Blood flows into the lumen of the device and pulsates against the compliant membrane. The fluid in the track pulsates within the enclosed track, clearly indicating that the ports are located in the blood vessel and subjected to variations in blood pressure. The instrument and introducer sheath are then slowly retracted as a unit in the puncture wound. The blood flow will stop pulsating against the compliant membrane when the ports have exited the blood vessel wall. A hemostatic agent is then injected by the instrument adjacent the vessel wall.
摘要翻译：一种用于在导尿术程序结束时实现快速止血的仪器，其包括用于与用于进入血管的通道的常规导引鞘一起使用的止血剂注射装置。注射装置包括细长管状构件，其具有靠近其远端的排出口。轮毂构件包括位于其表面上的具有透明盖的细长凹槽或轨道。封闭的轨道与通过管状构件延伸的管腔与柔性膜密封并填充预定量的流体。在导管插入术后，将装置插入导引鞘。血液流入装置的内腔并与柔顺膜搏动。轨道中的流体在封闭轨道内脉动，清楚地表明端口位于血管中并经受血压变化。然后将仪器和引导器护套作为穿刺伤口中的单元缓慢缩回。当端口离开血管壁时，血流将停止脉动抵抗柔顺膜。然后通过仪器在血管壁附近注射止血剂。

25. 发明授权

US06699280B2 Multi-section stent 有权
标题翻译：多段支架
公开(公告)号：US06699280B2
公开(公告)日：2004-03-02
申请号：US10282691
申请日：2002-10-29
申请人： Allan R. Camrud , David R. Holmes, Jr. , Robert S. Schwartz , Timothy D. Argo
发明人： Allan R. Camrud , David R. Holmes, Jr. , Robert S. Schwartz , Timothy D. Argo
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2002/826 , A61F2002/828 , A61F2210/0004 , A61F2250/0031 , A61F2250/0039 , A61F2250/0067 , A61F2250/0071 , A61F2250/0098
摘要： A stent includes a first stent section, a second stent section, and at least one connecting member. The connecting member has a first end attached to the first stent section, a second end attached to the second stent section and a physically separable portion.
摘要翻译：支架包括第一支架部分，第二支架部分和至少一个连接部件。连接构件具有附接到第一支架部分的第一端，附接到第二支架部分的第二端和物理上可分离的部分。

26. 发明授权

US06485510B1 Multi-section stent 有权
标题翻译：多段支架
公开(公告)号：US06485510B1
公开(公告)日：2002-11-26
申请号：US09549681
申请日：2000-04-14
申请人： Allan R. Camrud , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Allan R. Camrud , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2002/826 , A61F2002/828 , A61F2210/0004 , A61F2250/0031 , A61F2250/0039 , A61F2250/0067 , A61F2250/0071 , A61F2250/0098
摘要： A stent includes a first stent section, a second stent section, and at least one connecting member. The connecting member has a first end attached to the first stent section, a second end attached to the second stent section and a physically separable portion.
摘要翻译：支架包括第一支架部分，第二支架部分和至少一个连接部件。连接构件具有附接到第一支架部分的第一端，附接到第二支架部分的第二端和物理上可分离的部分。

27. 发明授权

US06258117B1 Multi-section stent 有权
标题翻译：多段支架
公开(公告)号：US06258117B1
公开(公告)日：2001-07-10
申请号：US09292558
申请日：1999-04-15
申请人： Allen R. Camrud , Robert S. Schwartz , David R. Holmes, Jr. , Timothy D. Argo , David Berry
发明人： Allen R. Camrud , Robert S. Schwartz , David R. Holmes, Jr. , Timothy D. Argo , David Berry
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2002/826 , A61F2002/828 , A61F2210/0004 , A61F2250/0031 , A61F2250/0039 , A61F2250/0067 , A61F2250/0071 , A61F2250/0098
摘要： A multi-section stent includes a connecting structure that allows the stent sections to move and flex relative to one another. For deployment and positioning, the connecting structure connects the multiple stent sections and holds the stent sections substantially stationary relative to one another. Following deployment, the connecting structure allows the multiple stent sections to move relative to one another. Movable stent sections enable flexure of the stent upon deployment within a body lumen. This flexing structure allows better conformance of the stent to the shape of the body lumen, and exerts less overall pressure against the lumen wall, reducing the potential for trauma. Upon deployment, the multiple stent sections may be completely detached from one another. Alternatively, the stent sections may remain partially connected in a manner that allows substantial independent movement. The connecting structure can be manufactured to separate upon deployment, for example, by breaking or degrading within the body lumen in which the stent is positioned.
摘要翻译：多部分支架包括允许支架部分相对于彼此移动和弯曲的连接结构。为了部署和定位，连接结构连接多个支架部分并且将支架部分相对于彼此基本上保持固定。在部署之后，连接结构允许多个支架部分相对于彼此移动。可移动支架部分能够在展开在体腔内时使支架挠曲。该弯曲结构允许支架更好地符合体腔的形状，并且对腔壁施加较小的整体压力，降低创伤的可能性。在部署时，多个支架部分可以彼此完全分离。或者，支架部分可以以允许基本独立运动的方式保持部分连接。连接结构可以被制造成在展开时分离，例如通过在支架所在的体腔内破碎或降解。

28. 发明授权

US07727184B2 Biological revascularization 有权
标题翻译：生物血运重建
公开(公告)号：US07727184B2
公开(公告)日：2010-06-01
申请号：US11750131
申请日：2007-05-17
申请人： David R. Holmes, Jr. , Robert S. Schwartz
发明人： David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M31/00
CPC分类号： A61B17/3207 , A61B17/22 , A61B18/1477 , A61B18/1492 , A61B2017/00252 , A61B2017/22044 , A61B2017/22067 , A61B2017/22077 , A61B2017/22082 , A61B2017/22084 , A61B2018/1425
摘要： A catheter delivery system for delivering a treatment substance to an occlusion in a lumen of a tubular vessel includes a tubular catheter and a treatment substance. The tubular catheter includes a central lumen passing between a proximal end and a distal end adjacent to an inflatable balloon. The treatment substance is in a form that is configured to be deliverable through the central lumen of the catheter into the lumen of the tubular vessel and to solidify in the vessel.
摘要翻译：用于将处理物质输送到管状容器的内腔中的闭塞的导管输送系统包括管状导管和处理物质。管状导管包括中心腔，其通过邻近可膨胀气囊的近端和远端之间。治疗物质是被构造成可以通过导管的中央腔输送到管状血管的腔中并在血管中固化的形式。

29. 发明授权

US06855132B2 Apparatus with weeping tip and method of use 失效
标题翻译：具有啜饮尖端和使用方法的设备
公开(公告)号：US06855132B2
公开(公告)日：2005-02-15
申请号：US10342023
申请日：2003-01-14
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61M5/158 , A61M5/32 , A61M25/00 , A61M31/00 , A61P43/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

30. 发明授权

US06569129B1 Biological revascularization 有权
标题翻译：生物血运重建
公开(公告)号：US06569129B1
公开(公告)日：2003-05-27
申请号：US09661439
申请日：2000-09-13
申请人： David R. Holmes, Jr. , Robert S. Schwartz
发明人： David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M2500
CPC分类号： A61B17/3207 , A61B17/22 , A61B18/1477 , A61B18/1492 , A61B2017/00252 , A61B2017/22044 , A61B2017/22067 , A61B2017/22077 , A61B2017/22082 , A61B2017/22084 , A61B2018/1425
摘要： A catheter delivery system for delivering a treatment substance to an occlusion in a lumen of a tubular vessel includes a tubular catheter and a treatment substance. The tubular catheter includes a central lumen passing between a proximal end and a distal end adjacent to an inflatable balloon. The treatment substance is in a form that is configured to be deliverable through the central lumen of the catheter into the lumen of the tubular vessel and to solidify in the vessel.
摘要翻译：用于将处理物质输送到管状容器的内腔中的闭塞的导管输送系统包括管状导管和处理物质。管状导管包括中心腔，其通过邻近可膨胀气囊的近端和远端之间。治疗物质是被构造成可以通过导管的中央腔输送到管状血管的腔中并在血管中固化的形式。

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