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1. 发明授权

US08702649B2 Multiple lumen diffusion catheter 有权
标题翻译：多腔扩散导管
公开(公告)号：US08702649B2
公开(公告)日：2014-04-22
申请号：US12515981
申请日：2007-11-28
申请人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Frederick W. Trombley, III , Arthur E. Uber, III
发明人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Frederick W. Trombley, III , Arthur E. Uber, III
IPC分类号： A61M29/00
CPC分类号： A61M25/007 , A61M25/003
摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.
摘要翻译：一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

2. 发明申请

US20100174183A1 MULTIPLE LUMEN DIFFUSION CATHETER 有权
标题翻译：多功能扩散吸管
公开(公告)号：US20100174183A1
公开(公告)日：2010-07-08
申请号：US12515981
申请日：2007-11-28
申请人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Edward J. Rhinehart , Frederick W. Trombley, III , Arthur E. Uber, III
发明人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Edward J. Rhinehart , Frederick W. Trombley, III , Arthur E. Uber, III
IPC分类号： A61B6/00 , A61M25/00
CPC分类号： A61M25/007 , A61M25/003
摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.
摘要翻译：一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

3. 发明授权

US09056200B2 Apparatus and methods for delivery of fluid injection boluses to patients and handling harmful fluids 有权
标题翻译：用于向患者输送流体注射剂并处理有害流体的装置和方法
公开(公告)号：US09056200B2
公开(公告)日：2015-06-16
申请号：US12996520
申请日：2009-06-05
申请人： Arthur E. Uber, III , Mark Trocki , Marc A. Mabie , Larry McCutchan , L. George Siddoway , Kevin P. Cowan , Lisa M. Coates , John F. Kalafut , Aaron Hughes , David M. Griffiths , Peter Twichell , Julie Gulick , Frederick W. Trombley, III
发明人： Arthur E. Uber, III , Mark Trocki , Marc A. Mabie , Larry McCutchan , L. George Siddoway , Kevin P. Cowan , Lisa M. Coates , John F. Kalafut , Aaron Hughes , David M. Griffiths , Peter Twichell , Julie Gulick , Frederick W. Trombley, III
IPC分类号： A61N5/00 , A61N5/10 , A61M5/00 , A61M5/168 , A61M5/178 , A61M5/14
CPC分类号： A61N5/1007 , A61M5/007 , A61M5/16827 , A61M5/1785 , A61M2005/1402 , A61M2202/0225 , A61M2202/049 , A61M2206/11 , A61M2206/18 , Y10T137/0318
摘要： A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.
摘要翻译：公开了一种危险流体输送容器和危险流体输送系统。危险流体输送容器包括封闭至少部分屏蔽的外壳的壳体。第一和第二流体通道元件设置在壳体内，第一流体路径元件和第二流体路径元件流体耦合在一起。可以提供泵单元，用于将流体从第一和第二流体路径元件任选地分配到第三流体路径元件中。此外，公开了用于引燃危险流体输送容器和减轻层流注射团块扩散的方法。此外，公开了一种用于注射器或其他容器的放射性流体输送容器。放射性流体输送容器允许注射器或容器在注射过程中使用而不从容器中取出。

4. 发明申请

US20100114064A1 MITIGATION OF CONTRAST-INDUCED NEPHROPATHY 有权
标题翻译：对比诱导性肾病的缓解
公开(公告)号：US20100114064A1
公开(公告)日：2010-05-06
申请号：US12611172
申请日：2009-11-03
申请人： John F. Kalafut , Alan D. Hirschman , David M. Griffiths , Thomas P. Joyce , Jerry A. Stokes , Gerald W. Callan , Dennis P. Hack , Julie Gulick , Andreas R. Maihoefer , Arthur E. Uber, III
发明人： John F. Kalafut , Alan D. Hirschman , David M. Griffiths , Thomas P. Joyce , Jerry A. Stokes , Gerald W. Callan , Dennis P. Hack , Julie Gulick , Andreas R. Maihoefer , Arthur E. Uber, III
IPC分类号： A61M31/00 , A61M5/14
CPC分类号： A61M5/1723 , A61B5/055 , A61B5/201 , A61B5/411 , A61B6/481 , A61B6/482 , A61B6/504 , A61M5/007 , A61M5/142 , A61M2210/1082 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system, includes a pressurizing mechanism to pressurize a fluid including a contrast enhancement agent for delivery to a patient; and a control system in operative connection with the pressurizing mechanism. The control system includes a system to adjust control of fluid injection based upon a measurement of renal function of the patient.
摘要翻译：一种系统，包括加压机构，用于对包括用于递送给患者的对比增强剂的流体加压; 以及与加压机构可操作地连接的控制系统。控制系统包括基于患者的肾功能的测量来调节流体注射的控制的系统。

5. 发明授权

US09421330B2 Mitigation of contrast-induced nephropathy 有权
标题翻译：对比剂诱导的肾病减轻
公开(公告)号：US09421330B2
公开(公告)日：2016-08-23
申请号：US12611172
申请日：2009-11-03
申请人： John F. Kalafut , Alan D. Hirschman , David M. Griffiths , Thomas P. Joyce , Jerry A. Stokes , Gerald W. Callan , Dennis P. Hack , Julie Gulick , Andreas R. Maihoefer , Arthur E. Uber, III
发明人： John F. Kalafut , Alan D. Hirschman , David M. Griffiths , Thomas P. Joyce , Jerry A. Stokes , Gerald W. Callan , Dennis P. Hack , Julie Gulick , Andreas R. Maihoefer , Arthur E. Uber, III
IPC分类号： A61M5/172 , G06F19/00 , A61B5/00 , A61B6/00 , A61M5/142 , A61B5/055 , A61B5/20 , A61M5/00
CPC分类号： A61M5/1723 , A61B5/055 , A61B5/201 , A61B5/411 , A61B6/481 , A61B6/482 , A61B6/504 , A61M5/007 , A61M5/142 , A61M2210/1082 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system which includes a pressurizing mechanism to pressurize a fluid including a contrast enhancement agent for delivery to a patient and a control system in operative connection with the pressurizing mechanism. The control system includes a system to adjust control of fluid injection based upon a measurement of renal function of the patient.
摘要翻译：一种系统，其包括加压机构，用于对包括用于输送给患者的造影剂的流体加压，以及与加压机构可操作地连接的控制系统。控制系统包括基于患者的肾功能的测量来调节流体注射的控制的系统。

6. 发明授权

US08197437B2 Systems and methods of modeling pharmaceutical propagation in a patient 有权
标题翻译：在患者体内药物传播建模的系统和方法
公开(公告)号：US08197437B2
公开(公告)日：2012-06-12
申请号：US11691748
申请日：2007-03-27
申请人： John F. Kalafut , Arthur E. Uber, III
发明人： John F. Kalafut , Arthur E. Uber, III
IPC分类号： A61M31/00
CPC分类号： A61M5/007 , A61B5/0044 , A61B5/02028 , A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/0295 , A61B5/055 , A61B5/7257 , A61B6/032 , A61B6/481 , A61B6/504 , A61B6/507 , A61B6/583 , A61B8/13 , A61B8/481 , A61K49/0002 , G01R33/5601 , G06F19/00 , G06F19/321 , G06F19/3468 , G16H50/50
摘要： An injection system includes an injector for injecting a fluid into a patient and a controller in operative communication with the injector for control thereof. The controller controls a diagnostic injection of the fluid based upon at least one mathematical model individualized to the patient. The model(s) are determined by collecting data corresponding to a time response curve resulting from at least one test injection of the fluid into the patient. The time response curve represents a response of a region of interest of the patient over time due to the fluid passing therethrough. An imaging system having such an injection system is also disclosed, as is a system for effecting a medical procedure. A method of delivering such a fluid to a patient using such an injection system is also disclosed, as is a method of modeling propagation of such a fluid in a patient.
摘要翻译：注射系统包括用于将流体注射到患者体内的注射器和与注射器可操作地连通以控制的控制器。控制器基于对患者个体化的至少一个数学模型来控制流体的诊断注射。模型通过收集对应于由流体进入至少一次试验注射到患者体内而产生的时间响应曲线的数据来确定。时间响应曲线表示由于流体通过其而使患者随时间变化的感兴趣区域的响应。还公开了具有这种注射系统的成像系统，以及用于实现医疗程序的系统。还公开了使用这种注射系统将这种流体递送到患者的方法，以及模拟患者体内这种流体的传播的方法。

7. 发明授权

US08295914B2 Systems and methods of determining patient transfer functions and modeling patient response to a pharmaceutical injection 有权
标题翻译：确定患者转移功能并建立患者对药物注射的反应的系统和方法
公开(公告)号：US08295914B2
公开(公告)日：2012-10-23
申请号：US11575846
申请日：2005-11-16
申请人： John F. Kalafut , Arthur E. Uber, III
发明人： John F. Kalafut , Arthur E. Uber, III
IPC分类号： A61B6/00
CPC分类号： A61M5/007 , A61B5/0044 , A61B5/02028 , A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/0295 , A61B5/055 , A61B5/7257 , A61B6/032 , A61B6/481 , A61B6/504 , A61B6/507 , A61B6/583 , A61B8/13 , A61B8/481 , A61K49/0002 , G01R33/5601 , G06F19/00 , G06F19/321 , G06F19/3468 , G16H50/50
摘要： A method of controlling an injector system for delivering a contrast enhancing fluid to a patient. The method includes the step of determining at least one patient transfer function for the patient based upon data specific to the patient, with the at least one patient transfer function providing a time enhancement output for a given input. The data specific to the patent may include at least one of an estimate of physiologic parameters of the patient, an estimate of anatomic parameters of the patient and an enhancement caused by an injection of the contrast enhancing fluid into the patient. Other steps involve: determining a desired time enhancement output; using the at least one patient transfer function to determine an injection procedure input; and controlling the injector system at least in part on the basis of the determined injection procedure input.
摘要翻译：一种控制用于将对比度增强流体输送给患者的注射器系统的方法。该方法包括基于患者特有的数据确定患者的至少一个患者传递功能的步骤，其中所述至少一个患者传递函数为给定输入提供时间增强输出。该专利特有的数据可以包括对患者的生理参数的估计，患者的解剖学参数的估计和通过将对比度增强流体注入患者而引起的增强中的至少一个。其他步骤包括：确定期望的时间增强输出; 使用所述至少一个患者传递函数来确定注射过程输入; 以及至少部分地基于所确定的喷射过程输入来控制喷射器系统。

8. 发明授权

US08608484B2 Dynamic anthropomorphic cardiovascular phantom 有权
标题翻译：动态拟人心血管虚拟
公开(公告)号：US08608484B2
公开(公告)日：2013-12-17
申请号：US12397713
申请日：2009-03-04
申请人： John F. Kalafut , David M. Reilly , Michael J. Yanniello
发明人： John F. Kalafut , David M. Reilly , Michael J. Yanniello
IPC分类号： G09B23/28
CPC分类号： G09B23/32
摘要： A cardiovascular flow system includes: a cardiovascular model system, a pump system in fluid connection with the cardiovascular model system, and an ECG simulator in communicative connection with the pump system. The ECG simulator system is adapted to create and transmit a simulated ECG signal. The ECG simulator system uses a signal received from the pump system to adjust the simulated ECG signal transmitted from the ECG simulator system. The cardiovascular flow system further includes an injection port adapted to be placed in fluid connection with an injector to inject at least one fluid into the system.
摘要翻译：心血管流量系统包括：心血管模型系统，与心血管模型系统流体连接的泵系统，以及与泵系统通信连接的ECG模拟器。 ECG模拟器系统适于创建和传输模拟的ECG信号。 ECG模拟器系统使用从泵系统接收的信号来调整从ECG模拟器系统发送的模拟ECG信号。心血管流量系统还包括注射口，其适于与注射器流体连接以将至少一种流体注入系统。

9. 发明授权

US08162903B2 System and method for proportional mixing and continuous delivery of fluids 有权
标题翻译：用于比例混合和连续输送流体的系统和方法
公开(公告)号：US08162903B2
公开(公告)日：2012-04-24
申请号：US12848570
申请日：2010-08-02
申请人： David M. Reilly , John F. Kalafut , Ralph H. Schriver
发明人： David M. Reilly , John F. Kalafut , Ralph H. Schriver
IPC分类号： A61M5/00
CPC分类号： A61M5/16827 , A61M5/007 , A61M5/1422
摘要： A system and method for mixing and delivering fluids such as contrast media and saline is disclosed including at least two fluid sources, a pump, a joining fluid path connecting the at least two fluid sources to an inlet to the pump, and a valve device in the fluid path upstream of the pump. The valve device includes an actuator adapted to restrict flow in at least one of respective fluid lines connecting the at least two fluid sources to the pump inlet. A patient interface device may be associated with an outlet of the pump. The valve device actuator is generally adapted to restrict the flow in at least one of the respective fluid lines such that a positional change in valve device actuator position provides a change in fluid mixture ratio of the fluids from the at least two fluid sources to the pump inlet.
摘要翻译：公开了用于混合和输送诸如造影剂和盐水的流体的系统和方法，其包括至少两个流体源，泵，将至少两个流体源连接到泵的入口的连接流体路径，以及将泵装置泵的上游的流体路径。阀装置包括致动器，其适于限制在将至少两个流体源连接到泵入口的各个流体管线中的至少一个中的流动。患者接口装置可以与泵的出口相关联。阀装置致动器通常适于限制相应流体管线中的至少一个中的流动，使得阀装置致动器位置的位置变化提供从至少两个流体源到泵的流体的流体混合比的变化进口。

10. 再颁专利

USRE45717E1 System and method for proportional mixing and continuous delivery of fluids 有权
标题翻译：用于比例混合和连续输送流体的系统和方法
公开(公告)号：USRE45717E1
公开(公告)日：2015-10-06
申请号：US14261028
申请日：2014-04-24
申请人： David M. Reilly , John F. Kalafut , Ralph H. Schriver
发明人： David M. Reilly , John F. Kalafut , Ralph H. Schriver
IPC分类号： A61M5/00 , A61M5/168 , A61M5/142
CPC分类号： A61M5/16827 , A61M5/007 , A61M5/1422
摘要： A system and method for mixing and delivering fluids such as contrast media and saline is disclosed including at least two fluid sources, a pump, a joining fluid path for connecting the at least two fluid sources to an inlet to of the pump, and a valve device in the fluid path upstream of the pump. The valve device includes an actuator adapted to restrict flow in at least one of the respective fluid lines connecting the at least two fluid sources to the pump inlet. A patient interface device may be associated with an outlet of the pump. The valve device actuator is generally adapted to restrict the flow in at least one of the respective fluid lines such that a positional change in valve device actuator position provides a change in fluid mixture ratio of the fluids from the at least two fluid sources to the pump inlet.
摘要翻译：公开了用于混合和输送诸如造影剂和盐水的流体的系统和方法，包括至少两个流体源，泵，用于将至少两个流体源连接到泵的入口的连接流体路径，以及阀在泵的上游的流体路径中的装置。阀装置包括致动器，其适于限制将至少两个流体源连接到泵入口的相应流体管线中的至少一个中的流动。患者接口装置可以与泵的出口相关联。阀装置致动器通常适于限制相应流体管线中的至少一个中的流动，使得阀装置致动器位置的位置变化提供了流体从至少两个流体源到泵的流体混合比的变化进口。

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