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    • 27. 发明申请
    • PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    • 生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法
    • US20140178943A9
    • 2014-06-26
    • US13980223
    • 2012-03-07
    • Takashi ShibuyaSeisuke IzawaTomoyuki NishimotoShigeharu FukudaToshio Miyake
    • Takashi ShibuyaSeisuke IzawaTomoyuki NishimotoShigeharu FukudaToshio Miyake
    • C12P19/18
    • A61K31/7048A61K9/16C07H17/04C12P19/18C12P19/60C12Y204/01019
    • The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
    • 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法,即使当抗坏血酸2-葡萄糖苷的产率不达到35重量%时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法,其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液,然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27%的溶液,纯化得到的溶液,将抗坏血酸2-葡萄糖苷含量提高至86重量%以上,将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法,收集沉淀的无水结晶抗坏血酸2-葡萄糖苷,并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。
    • 30. 发明申请
    • PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    • 生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法
    • US20130295618A1
    • 2013-11-07
    • US13980223
    • 2012-03-07
    • Takashi ShibuyaSeisuke IzawaTomoyuki NishimotoShigeharu FukudaToshio Miyake
    • Takashi ShibuyaSeisuke IzawaTomoyuki NishimotoShigeharu FukudaToshio Miyake
    • C12P19/18
    • A61K31/7048A61K9/16C07H17/04C12P19/18C12P19/60C12Y204/01019
    • The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
    • 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法,即使当抗坏血酸2-葡萄糖苷的产率不达到35重量%时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法,其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液,然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27%的溶液,纯化得到的溶液,将抗坏血酸2-葡萄糖苷含量提高至86重量%以上,将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法,收集沉淀的无水结晶抗坏血酸2-葡萄糖苷,并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。