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21. 发明申请

US20050004109A1 Methods and compositions for the treatment and prevention of tumors, tumor-related disorders and cachexia 审中-公开
公开(公告)号：US20050004109A1
公开(公告)日：2005-01-06
申请号：US10902249
申请日：2004-07-29
申请人： Shinichi Kurakata , Masaharu Hanai , Saori Kanai , Tomio Kimura
发明人： Shinichi Kurakata , Masaharu Hanai , Saori Kanai , Tomio Kimura
IPC分类号： A61K31/10 , A61K31/18 , A61K31/255 , A61K31/341 , A61K31/351 , A61K31/352 , A61K31/36 , A61K31/365 , A61K31/40 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/5415 , A61P3/00 , A61P35/00 , C07D20060101 , C07D207/325 , C07D207/333 , C07D405/10 , C07D405/12
CPC分类号： A61K31/541 , A61K31/10 , A61K31/18 , A61K31/255 , A61K31/341 , A61K31/351 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/5415
摘要： Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumors and tumor-related disorders and cachexia.

22. 发明授权

US06837199B2 Valve actuating apparatus for internal combustion engine 失效
标题翻译：内燃机气门执行装置
公开(公告)号：US06837199B2
公开(公告)日：2005-01-04
申请号：US10637007
申请日：2003-08-08
申请人： Katsuya Matsuura , Hitoshi Takahashi , Masaki Takayama , Mitsuru Sugimoto , Teruyoshi Morita , Tomio Kimura
发明人： Katsuya Matsuura , Hitoshi Takahashi , Masaki Takayama , Mitsuru Sugimoto , Teruyoshi Morita , Tomio Kimura
IPC分类号： F01L1/26 , F01L13/00 , F02D13/02 , F02D15/00 , F02D41/04 , F02D41/06 , F02D41/08 , F01L1/34
CPC分类号： F02D13/0207 , F01L1/022 , F01L1/267 , F01L13/0036 , F01L2800/00 , F02D13/0203 , F02D13/0234 , F02D13/0257 , F02D13/0269 , Y02T10/142
摘要： A valve actuating apparatus for an internal combustion engine selectively operating in the normal Otto cycle or the Miller cycle is provided which enables the engine to achieve stable combustion and improved fuel economy during cruising or in a low-load engine operating region. A delayed-closing cam for Miller cycle operation and a normal cam having a cam profile for earlier valve-closing timing of the intake valve than a cam profile of the delayed-closing cam are provided on a camshaft. A cam profile-switching mechanism switches between the delayed-closing cam and the normal cam, for opening and closing the intake valve. An ECU controls the switching mechanism such that when a detected operating condition of the engine indicates starting or idling, the intake valve is operated by the normal cam, and when the detected operating condition indicates cruising, the intake valve is operated by the delayed-closing cam.
摘要翻译：提供了一种用于在正常奥托循环或米勒循环中选择性操作的内燃机的阀致动装置，其使得发动机能够在巡航期间或在低负载发动机运行区域中实现稳定的燃烧和改善的燃料经济性。在凸轮轴上设置有用于米勒循环操作的延迟关闭凸轮和具有凸轮轮廓的普通凸轮，凸轮轮廓用于进气门的早期阀关闭正时，而不是延迟关闭凸轮的凸轮轮廓。凸轮轮廓切换机构在延迟关闭凸轮和正常凸轮之间切换，用于打开和关闭进气门。 ECU控制切换机构，使得当检测到的发动机的运转状况指示起动或空转时，进气门由正常凸轮操作，当检测到的运转状态表示巡航时，进气门由延迟关闭凸轮

23. 发明授权

US06673804B1 Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US06673804B1
公开(公告)日：2004-01-06
申请号：US09678294
申请日：2000-10-02
申请人： Tomio Kimura , Shoujiro Miyazaki , Keiji Ueda , Kazuhiko Tanzawa , Shigeru Ushiyama , Wataru Takasaki
发明人： Tomio Kimura , Shoujiro Miyazaki , Keiji Ueda , Kazuhiko Tanzawa , Shigeru Ushiyama , Wataru Takasaki
IPC分类号： C07D20946
CPC分类号： C07D209/48 , C07C311/29 , C07D209/66 , C07D233/78 , C07D239/54 , C07D239/70 , C07D239/96 , C07D275/06 , C07D277/34 , C07D401/12 , C07D401/14 , C07D471/04 , C07D473/04 , C07D475/02 , C07D495/04
摘要： A compound of the formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof: R1 is H or NHOH. R2 is H, optionally substituted alkyl, cycloalkyl or a group —AR6. A is an alkylene which may be optionally interrupted by O, —S(O)m— or —N(R9). R6 is a group (II), (III), (IV) X is O, S, —N(R10)—, —C(R11)(R12)—. Y is O, CO, —S(O)n—, —N(R10)—, —C(R11)(R12)—. Each of R7 and R8 is H, alkyl, COOH, optionally substituted alkyl, etc. Each of R9, R10, R11, and R12 is H, alkyl, etc. Each of m and n is 0 to 2. R3 is H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl. R4 is optionally substituted (hetero)arylene. R5 is optionally substituted alkyl, optionally substituted (hetero)aryl. These compounds have matrixmetalloproteinase—13 inhibitory activity and aglycanase inhibitory activity.
摘要翻译：式（I）的化合物或其药理学上可接受的盐，酯或其它衍生物：R 1是H或NHOH。 R 2是H，任选取代的烷基，环烷基或基团-AR 6 .A是可以任选被O，-S（O）m - 或-N（R 9）间隔的亚烷基。 R 6为（II），（III），（IV）X为O，S，-N（R 10） - ， - C（R 11）（R 12） Y是O，CO，-S（O）n - ， - N（R 10） - ， - C（R 11）（R 12） - 。 R 7和R 8中的每一个是H，烷基，COOH，任选取代的烷基等。R 9，R 10，R 11和R 12中的每一个是H，烷基等等。m和n各自为0至2.R 3为H，任选取代的烷基，任选取代的环烷基，任选取代的烯基，任选取代的炔基。 R 4是任选取代的（杂）亚芳基。 R 5是任选取代的烷基，任选取代的（杂）芳基。这些化合物具有基质金属蛋白酶-13抑制活性和糖苷连结酶抑制活性。

24. 发明授权

US4481362A Process for preparing optically active tryptophanes 失效
标题翻译：光学活性色氨酸的制备方法
公开(公告)号：US4481362A
公开(公告)日：1984-11-06
申请号：US494692
申请日：1983-05-17
申请人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
发明人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
IPC分类号： C12N9/80 , C12P13/04 , C12P13/22 , C12P41/00 , C12R1/025 , C12R1/05 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/145 , C12R1/20 , C12R1/225 , C12R1/265 , C12R1/32 , C12R1/365 , C12R1/38 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/65 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/78 , C12R1/80 , C12R1/84 , C12R1/845 , C12R1/85 , C12R1/88 , C12R1/885 , C07D209/20
CPC分类号： C12N9/80 , C12P13/04 , C12P13/227
摘要： Biochemical optical resolution of DL-tryptophanes in which DL-tryptophane amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-tryptophane amides in racemic DL-tryptophane amides are asymmetrically hydrolyzed to form optically active L-tryptophanes at a high yield and almost all D-tryptophane amides remain without being subjected to hydrolysis. The resultant D-tryptophane amides are readily hydrolyzed, after separating L-tryptophanes, to form optically active D-tryptophanes at a high yield.
摘要翻译：描述DL-色氨酰胺与能够产生酰胺酶的微生物或其处理产物相互作用的DL-色氨酸的生物化学光学拆分。外消旋的DL-色氨酰胺中的L-色氨酰胺不对称地水解，以高产率形成光学活性的L-色氨酸，并且几乎所有的D-色氨酸酰胺保持不被水解。得到的D-色氨酰胺在分离L-色氨酸后容易水解，以高产率形成光学活性的D-色氨酸。

25. 发明授权

US08344029B2 Substituted propanamide derivative and pharmaceutical composition containing the same 失效
标题翻译：取代丙酰胺衍生物和含有它们的药物组合物
公开(公告)号：US08344029B2
公开(公告)日：2013-01-01
申请号：US11996268
申请日：2006-07-18
申请人： Kazumasa Aoki , Koji Suda , Kentoku Gotanda , Tomio Kimura
发明人： Kazumasa Aoki , Koji Suda , Kentoku Gotanda , Tomio Kimura
IPC分类号： A01N37/18 , A01N33/02 , A01N33/18 , A01N33/24 , A61K31/165 , A61K31/135 , A61K31/04
CPC分类号： C07C237/22
摘要： It is an object of the present invention to provide a substituted propanamide derivative or a pharmacologically acceptable salt thereof that is useful as a prophylactic or therapeutic agent for a bone metabolic disease. The present invention relates to a pharmaceutical composition comprising a compound having General Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, R1 represents a C6-C10 aryl group that may be substituted by a group selected from Substituent Group α, for example; R2 represents a C6-C10 aryl group that may be substituted by a group selected from Substituent Group α, for example; and X represents a hydroxyl group or a C1-C6 alkoxy group, for example].
摘要翻译：本发明的目的是提供可用作骨代谢疾病的预防或治疗剂的取代丙酰胺衍生物或其药理学上可接受的盐。本发明涉及含有通式（I）的化合物或其药理学上可接受的盐作为活性成分的药物组合物[其中，R 1表示可以被选自取代基的基团取代的C6-C10芳基 α，例如; R2表示可以被选自取代基组α的基团取代的C6-C10芳基; X表示羟基或C 1 -C 6烷氧基。

26. 发明授权

US08170752B2 Parking assistance apparatus, vehicle-side apparatus of parking assistance apparatus, parking assist method, and parking assist program 失效
标题翻译：停车辅助装置，停车辅助装置的车辆侧装置，停车辅助方法和停车辅助程序
公开(公告)号：US08170752B2
公开(公告)日：2012-05-01
申请号：US12670713
申请日：2008-07-04
申请人： Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Masami Tomioka , Hideo Yanagisawa
发明人： Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Masami Tomioka , Hideo Yanagisawa
IPC分类号： A01B69/00 , B62D6/00 , B62D12/00 , G05D1/02
CPC分类号： G08G1/168 , B60R1/00 , B60R2300/108 , B60R2300/302 , B60R2300/50 , B60R2300/70 , B60R2300/8026 , B60R2300/806 , B60W30/095 , B60W40/02 , B60W2420/403 , B62D15/028
摘要： A parking assistance apparatus makes it easy for a driver to grasp a relative positional relation between a vehicle and a target parking position and makes it possible to park the vehicle at the target parking position in a parking space with accuracy.An image of a mark M in a parking space S is taken by a vehicle-side camera 7. A relative position calculation portion 8 calculates a relative positional relation between the vehicle and a target parking position T based on the taken image of the mark M. A backward locus calculation portion 9 calculates an expected locus when the vehicle moves based on the relative positional relation and based on a steering angle detected by a steering angle sensor 15. An image of the parking space S is taken by a parking-space-side camera 3 and transmitted to a vehicle-side apparatus 1. An image composition portion 12 composes the image of the parking space S from the parking-space-side camera 3 and the expected locus calculated by the backward locus calculation portion 9. The composed image is displayed on the monitor 14 located in the vicinity of a drivers seat of the vehicle.
摘要翻译：停车辅助装置使驾驶员容易掌握车辆与目标停车位置之间的相对位置关系，并且能够准确地将车辆停放在停车位置的目标停车位置。停车空间S中的标记M的图像由车辆侧照相机7拍摄。相对位置计算部8基于拍摄到的标记M的图像计算车辆与目标停车位置T之间的相对位置关系反向轨迹计算部9基于相对位置关系，基于由转向角传感器15检测到的转向角来计算车辆移动时的预期轨迹。停车位S的图像由停车位 - 图像合成部12从停车位侧摄像机3构成停车空间S的图像，由向后轨迹计算部9计算出的预期轨迹构成。图像显示在位于车辆驾驶员座位附近的监视器14上。

27. 发明授权

US07755511B2 Parking assistance apparatus 失效
标题翻译：停车辅助设备
公开(公告)号：US07755511B2
公开(公告)日：2010-07-13
申请号：US11885858
申请日：2006-02-28
申请人： Satoshi Yamamoto , Kazunori Shimazaki , Tomio Kimura
发明人： Satoshi Yamamoto , Kazunori Shimazaki , Tomio Kimura
IPC分类号： G08G1/14
CPC分类号： B62D15/028 , B62D15/0275
摘要： In a parking assistance apparatus disclosed herein, a position and a yaw angle of a vehicle are acquired continuously from an initial stop position A, and a vehicle mark C2′ in moving the vehicle backwards with a steering angle maintained during a backward movement operation from a backward movement start position B in parking the vehicle in a target parking space S is displayed on a display. The vehicle mark C2′ is displayed in a shifting manner on the display such that the target parking space S is traced based on a momentary steering angle and a momentary yaw angle of the vehicle, which result from backward movement of the vehicle. When the vehicle mark C2′ deviates from the target parking space S during the backward movement operation, a driver adjusts the steering angle. The vehicle mark C2′ is shifted on the display based on a change in the steering angle to be turned into a vehicle mark C4 at a suitable position corresponding to the target parking space S.
摘要翻译：在本文所公开的停车辅助装置中，从初始停止位置A连续地获取车辆的位置和偏航角，并且在向后移动操作期间保持的转向角从车辆向后移动的车辆标记C2' 将车辆停放在目标停车位S中的向后运动开始位置B显示在显示器上。车辆标记C2'以显示器的移动方式显示，使得基于车辆的后向移动导致的车辆的瞬时转向角和瞬时偏航角来追踪目标停车位S。当车辆标记C2'在向后移动操作期间偏离目标停车位S时，驾驶员调节转向角。基于在与目标停车空间S对应的适当位置处转向车辆标记C4的转向角的变化，车辆标记C2'在显示器上移动。

28. 发明申请

US20090233952A1 SUBSTITUTED CYCLOALKENE DERIVATIVE 有权
公开(公告)号：US20090233952A1
公开(公告)日：2009-09-17
申请号：US12066813
申请日：2006-09-13
申请人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
发明人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
IPC分类号： A61K31/443 , C07D317/72 , A61K31/357 , C07D405/08 , A61K31/4025 , C07D319/04 , C07D405/10
CPC分类号： C07C311/14 , C07C2601/16 , C07C2602/50 , C07D303/38 , C07D307/94 , C07D317/72 , C07D319/08 , C07D321/10 , C07D327/04 , C07D339/06 , C07D339/08 , C07D493/04 , C07D493/10
摘要： [Object] To provide a substituted cycloalkene derivative having an action to suppress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a medicament containing them as an active ingredient, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.[Solution] A compound represented by the general formula (I): {whereinX and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A (the ring is 3- to 7-membered heterocyclyl ring or 3- to 7-membered cycloalkyl ring), each represents a hydrogen atom, or X and Y together represent a substituent of ring B. l and m, independently from each other, represent an integer of 0 to 3, and l+m is 1 to 3. R1 is an aliphatic hydrocarbon group and the like which may be substituted with a group selected from Substituent group β and Substituent group γ. n represents an integer of 0 to 3. R2 is a C1-C6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. R3 is a phenyl group, 5- to 6-membered heteroaryl group and the like which may be substituted with a group selected from Substituent group ε. R5 is a C1-C6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. Provided that in the case where R3 is a phenyl group which may be substituted with a group selected from Substituent group ε, X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A, or X and Y together represent a substituent of ring B.

29. 发明申请

US20090118199A1 SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：取代的丙烯酰胺衍生物和药物组合物
公开(公告)号：US20090118199A1
公开(公告)日：2009-05-07
申请号：US11914209
申请日：2006-05-11
申请人： Kazumasa Aoki , Koji Suda , Toshio Kaneko , Tomio Kimura
发明人： Kazumasa Aoki , Koji Suda , Toshio Kaneko , Tomio Kimura
IPC分类号： A61K38/05 , C07D295/15 , A61K31/195 , C07C229/36 , C07C237/20 , A61K31/165 , A61P19/08
CPC分类号： A61K31/166 , C07C237/22 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2602/08 , C07D207/327 , C07D277/30 , C07D295/13 , C07D307/54 , C07D317/54 , C07D333/16 , C07D407/04 , C07D409/04 , Y02P20/55
摘要： A pharmaceutical composition comprising a compound having Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, R1 is, for example, a C6-C10 aryl group which may be substituted with one group or more than one group selected from substituent group α; R2 is, for example, a C6-C10 aryl group which may be substituted with one group or more than one group selected from substituent group α; and X is, for example, a hydroxyl group or a C1-C6 alkoxy group].
摘要翻译：一种药物组合物，其包含具有式（I）的化合物或其药理学上可接受的盐作为活性成分：[其中，R 1为例如可以被一个或多于一个基团取代的C 6 -C 10芳基来自取代基组α; R2是例如可以被一个或多于一个选自取代基组α的一个基团取代的C 6 -C 10芳基; X是例如羟基或C1-C6烷氧基]。

30. 发明申请

US20080174452A1 Parking Assistance Apparatus 失效
标题翻译：停车辅助设备
公开(公告)号：US20080174452A1
公开(公告)日：2008-07-24
申请号：US11885858
申请日：2006-02-28
申请人： Satoshi Yamamoto , Kazunori Shimazaki , Tomio Kimura
发明人： Satoshi Yamamoto , Kazunori Shimazaki , Tomio Kimura
IPC分类号： B60Q1/48
CPC分类号： B62D15/028 , B62D15/0275
摘要： In a parking assistance apparatus disclosed herein, a position and a yaw angle of a vehicle are acquired continuously from an initial stop position A, and a vehicle mark C2′ in moving the vehicle backwards with a steering angle maintained during a backward movement operation from a backward movement start position B in parking the vehicle in a target parking space S is displayed on a display. The vehicle mark C2′ is displayed in a shifting manner on the display such that the target parking space S is traced based on a momentary steering angle and a momentary yaw angle of the vehicle, which result from backward movement of the vehicle. When the vehicle mark C2′ deviates from the target parking space S during the backward movement operation, a driver adjusts the steering angle. The vehicle mark C2′ is shifted on the display based on a change in the steering angle to be turned into a vehicle mark C4 at a suitable position corresponding to the target parking space S.
摘要翻译：在本文公开的停车辅助装置中，从初始停止位置A连续地取得车辆的位置和偏航角，并且在向后移动操作期间保持的转向角向后移动车辆的车辆标记C 2' 将车辆停放在目标停车位S中的向后移动开始位置B显示在显示器上。车辆标记C 2'以显示器的移动方式显示，使得目标停车位S基于由车辆的后向运动引起的车辆的瞬时转向角和瞬时偏航角而被跟踪。当车辆标记C 2'在向后移动操作期间偏离目标停车位S时，驾驶员调节转向角。车辆标记C 2'基于在对应于目标停车空间S的适当位置处转向车辆标记C 4的转向角的变化而在显示器上移动。

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