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21. 发明申请

US20140281752A1 REDUNDANT BUS FAULT DETECTION 有权
标题翻译：冗余总线故障检测
公开(公告)号：US20140281752A1
公开(公告)日：2014-09-18
申请号：US13833021
申请日：2013-03-15
申请人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
发明人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
IPC分类号： G06F11/07
CPC分类号： G06F11/0757 , G06F11/0745 , G06F11/2007 , G06F11/325 , G06F11/327 , G08B29/123 , G08B29/16
摘要： A system and method for an approach of detecting faults in a redundant bus system based upon four timers.
摘要翻译：一种基于四个定时器检测冗余总线系统故障的方法的系统和方法。

22. 发明申请

US20100174343A1 APPARATUS AND METHODS FOR FACILITATING WOUND HEALING AND TREATING SKIN 审中-公开
标题翻译：促进创伤和治疗皮肤的装置和方法
公开(公告)号：US20100174343A1
公开(公告)日：2010-07-08
申请号：US12537670
申请日：2009-08-07
申请人： Rafael Victor Andino , Christopher J. Brooks , Michael J. Keating , Courtney F. Morgan , Donald Van Royen
发明人： Rafael Victor Andino , Christopher J. Brooks , Michael J. Keating , Courtney F. Morgan , Donald Van Royen
IPC分类号： A61N1/02
CPC分类号： A61N1/205 , A61N1/326
摘要： Electrode systems and methods are provided for applying electrical stimulation to a wound or skin. The electrode systems may include a feedback sensor configured to detect at least one wound healing factor or other treatment factors and may adjust the electrical stimulation based on feedback sensor measurements. The electrode systems may include multiple center electrodes for attachment to the wound. Multiple therapies may be stored on the electrode systems and a selected one of the stored therapies may be applied. A timer may be included to indicate the length of time a therapy has been applied. The electrode system may include a control module configured as a flexible circuit which conforms to the shape of the wound or the skin to which it is applied. In addition, a medical kit may be supplied for use in applying therapies, including multiple control modules and multiple electrodes.
摘要翻译：提供电极系统和方法以对伤口或皮肤施加电刺激。电极系统可以包括被配置为检测至少一个伤口愈合因子或其他治疗因素的反馈传感器，并且可以基于反馈传感器测量来调节电刺激。电极系统可以包括用于附接到伤口的多个中心电极。可以将多种疗法存储在电极系统上，并且可以应用所选存储的疗法。可以包括定时器以指示已经应用治疗的时间长度。电极系统可以包括配置为柔性电路的控制模块，其符合伤口或其所施加的皮肤的形状。此外，可以提供医疗套件用于应用治疗，包括多个控制模块和多个电极。

23. 发明授权

US06191497B1 Spirometer counter circuit 失效
标题翻译：脉搏计计数器电路
公开(公告)号：US06191497B1
公开(公告)日：2001-02-20
申请号：US09382441
申请日：1999-08-25
申请人： James C. Wickstead , Brian Forbes , Michael J. Keating
发明人： James C. Wickstead , Brian Forbes , Michael J. Keating
IPC分类号： H02J100
CPC分类号： A61B5/0875 , H02J1/14 , H02M2001/0006 , H02M2001/0032 , Y02B70/16 , Y10T307/25 , Y10T307/826
摘要： A single switch is utilized within a common ground line to control the current flow through a plurality of loads, whereby power to all of these loads may be interrupted by opening the system ground return so that power can be supplied to a particular component of the circuit, a microprocessor, to the exclusion of all remaining components by the operation of a single switch.
摘要翻译：在公共地线中使用单个开关来控制通过多个负载的电流，由此通过打开系统接地返回来中断所有这些负载的电力，使得功率可以被提供给电路的特定部件，微处理器，通过单个开关的操作来排除所有剩余部件。

24. 发明申请

US20140030260A1 METHODS AND COMPOSITIONS TO ELIMINATE CHRONIC LYMPHOCYTIC LEUKEMIA AND OTHER HEMATOLOGIC MALIGNANT CELLS IN STROMAL MICROENVIRONMENT FOR CANCER THERAPY 审中-公开
标题翻译：消除慢性淋巴细胞白血病和其他恶性肿瘤细胞的方法和组合物用于癌症治疗的结肠微环境
公开(公告)号：US20140030260A1
公开(公告)日：2014-01-30
申请号：US13989016
申请日：2011-11-22
申请人： Peng Huang , Wan Zhang , Michael J. Keating
发明人： Peng Huang , Wan Zhang , Michael J. Keating
IPC分类号： A61K31/195 , A61K33/20 , A61K45/06 , A61K31/095
CPC分类号： A61K31/195 , A61K31/095 , A61K31/21 , A61K33/20 , A61K45/06
摘要： The present invention regards compositions and methods for treating chronic lymphocytic leukemia in the in vivo tissue environment using selenium-containing compositions. In particular aspects, a selenium-comprising compound is administered to an individual wherein the CLL cells are in a stromal cell environment, wherein stromal factors modulate the selenium comprising compound to enhance its activity.
摘要翻译：本发明涉及使用含硒组合物在体内组织环境中治疗慢性淋巴细胞性白血病的组合物和方法。在具体方面，向个体施用含硒化合物，其中CLL细胞处于基质细胞环境中，其中基质因子调节含硒化合物以增强其活性。

25. 发明授权

US07443547B2 Portable electronic faxing, scanning, copying, and printing device 失效
标题翻译：便携式电子传真，扫描，复印和打印设备
公开(公告)号：US07443547B2
公开(公告)日：2008-10-28
申请号：US10884594
申请日：2004-07-03
申请人： Mario Moreno , Robert Cichielo , Michael J. Keating
发明人： Mario Moreno , Robert Cichielo , Michael J. Keating
IPC分类号： H04N1/024 , H04N1/40 , H04N1/00
CPC分类号： H04N1/00 , H04N2201/0081 , H04N2201/0082 , H04N2201/0093 , H04N2201/0096
摘要： A lightweight, battery operated, portable, personal electronic device capable of faxing, scanning, printing and copying media as a standalone device or in cooperation with other electronic devices including PCs, mobile telephones, PDAs, etc. is provided. The device automatically detects the presence of fax-capable devices and reconfigures the software for compatibility with the fax-capable device eliminating the need for user programming. The device's ergonomic design, intrinsic physical stability, and same side paper feeds and user interface provide use in work areas having limited space. The device includes unidirectional, independent pathways for original and recording media such that paper jams are minimized. Portability is maximized through innovative power management software and hardware.
摘要翻译：提供了一种轻巧的，电池供电的便携式个人电子设备，其能够传真，扫描，打印和复制作为独立设备的媒体或与包括PC，移动电话，PDA等其他电子设备的协作。该设备自动检测是否有传真功能的设备，并重新配置该软件以兼容具有传真功能的设备，从而无需用户编程。该设备的人体工程学设计，固有的物理稳定性以及相同的侧面进纸和用户界面可在具有有限空间的工作区域中使用。该装置包括用于原始和记录介质的单向独立通路，使卡纸最小化。通过创新的电源管理软件和硬件，可移植性最大化。

26. 发明申请

US20080027509A1 Apparatus and methods for facilitating wound healing and treating skin 审中-公开
标题翻译：用于促进伤口愈合和治疗皮肤的装置和方法
公开(公告)号：US20080027509A1
公开(公告)日：2008-01-31
申请号：US11494819
申请日：2006-07-28
申请人： Rafael Victor Andino , Christopher J. Brooks , Michael J. Keating , Courtney F. Morgan , Donald Van Royen
发明人： Rafael Victor Andino , Christopher J. Brooks , Michael J. Keating , Courtney F. Morgan , Donald Van Royen
IPC分类号： A61N1/18
CPC分类号： A61N1/205 , A61N1/326
摘要： Electrode systems and methods are provided for applying electrical stimulation to a wound or skin. The electrode systems may include a feedback sensor configured to detect at least one wound healing factor or other treatment factors and may adjust the electrical stimulation based on feedback sensor measurements. The electrode systems may include multiple center electrodes for attachment to the wound. Multiple therapies may be stored on the electrode systems and a selected one of the stored therapies may be applied. A timer may be included to indicate the length of time a therapy has been applied. The electrode system may include a control module configured as a flexible circuit which conforms to the shape of the wound or the skin to which it is applied. In addition, a medical kit may be supplied for use in applying therapies, including multiple control modules and multiple electrodes.
摘要翻译：提供电极系统和方法以对伤口或皮肤施加电刺激。电极系统可以包括被配置为检测至少一个伤口愈合因子或其他治疗因素的反馈传感器，并且可以基于反馈传感器测量来调节电刺激。电极系统可以包括用于附接到伤口的多个中心电极。可以将多种疗法存储在电极系统上，并且可以应用所选存储的疗法。可以包括定时器以指示已经应用治疗的时间长度。电极系统可以包括配置为柔性电路的控制模块，其符合伤口或其所施加的皮肤的形状。此外，可以提供医疗套件用于应用治疗，包括多个控制模块和多个电极。

27. 外观设计

USD532372S1 Portable battery charger 有权
公开(公告)号：USD532372S1
公开(公告)日：2006-11-21
申请号：US29244319
申请日：2005-12-07
申请人： Michael J. Keating
设计人： Michael J. Keating

28. 发明授权

US06663353B2 Fluid transfer system 有权
标题翻译：流体传输系统
公开(公告)号：US06663353B2
公开(公告)日：2003-12-16
申请号：US10214158
申请日：2002-08-08
申请人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
IPC分类号： G01F2202
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.
摘要翻译：用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极，与第一电极电隔离并设置在探针的远端。振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的次要冗余机构。

29. 发明授权

US06658946B2 Method of detecting fluid flow through a conduit 有权
标题翻译：检测流经管道的流体的方法
公开(公告)号：US06658946B2
公开(公告)日：2003-12-09
申请号：US10214161
申请日：2002-08-08
申请人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
IPC分类号： G01F2202
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant device for detecting fluid flow through the conduit.
摘要翻译：用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极，与第一电极电隔离并设置在探针的远端。振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的辅助冗余装置。

30. 发明授权

US07627381B2 Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy 有权
标题翻译：用于组合RF诱导的高热和放射免疫治疗的系统和方法
公开(公告)号：US07627381B2
公开(公告)日：2009-12-01
申请号：US11050478
申请日：2005-02-03
申请人： John Kanzius , William Harry Steinbrink , Robert J. McDonald , Michael J. Keating
发明人： John Kanzius , William Harry Steinbrink , Robert J. McDonald , Michael J. Keating
IPC分类号： A61F2/00
CPC分类号： A61K41/0052 , A61N1/403 , A61N1/406 , A61N5/1001 , B82Y5/00
摘要： A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells. Biomolecules labeled with at least one radionuclide suitable for radiotherapy may be used for both radiotherapy and as RF absorption enhancers for the hyperthermia generating RF signal.
摘要翻译：提供了联合放疗和高热疗法，包括在目标区域的至少一部分（例如肿瘤或部分肿瘤或靶向癌细胞）中诱导高热。提供用至少一种适用于放射治疗的放射性核素标记的生物分子并将其引入患者体内; 提供靶向RF吸收增强剂并将其引入患者体内; 并且通过朝向靶细胞引导产生高热的RF信号，从而加热与靶细胞结合的放射性核素标记的生物分子和靶向RF吸收增强剂。靶向RF吸收增强剂可以以说话的方式将一个或多个RF吸收频率添加到目标区域中的细胞，这将允许产生以该频率或频率的RF信号以加热靶细胞的热疗。用适合于放射治疗的至少一种放射性核素标记的生物分子可以用于放射治疗，也可以用作RF热吸收增强剂，用于产生高热的RF信号。

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