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1. 发明申请

US20140030260A1 METHODS AND COMPOSITIONS TO ELIMINATE CHRONIC LYMPHOCYTIC LEUKEMIA AND OTHER HEMATOLOGIC MALIGNANT CELLS IN STROMAL MICROENVIRONMENT FOR CANCER THERAPY 审中-公开
标题翻译：消除慢性淋巴细胞白血病和其他恶性肿瘤细胞的方法和组合物用于癌症治疗的结肠微环境
公开(公告)号：US20140030260A1
公开(公告)日：2014-01-30
申请号：US13989016
申请日：2011-11-22
申请人： Peng Huang , Wan Zhang , Michael J. Keating
发明人： Peng Huang , Wan Zhang , Michael J. Keating
IPC分类号： A61K31/195 , A61K33/20 , A61K45/06 , A61K31/095
CPC分类号： A61K31/195 , A61K31/095 , A61K31/21 , A61K33/20 , A61K45/06
摘要： The present invention regards compositions and methods for treating chronic lymphocytic leukemia in the in vivo tissue environment using selenium-containing compositions. In particular aspects, a selenium-comprising compound is administered to an individual wherein the CLL cells are in a stromal cell environment, wherein stromal factors modulate the selenium comprising compound to enhance its activity.
摘要翻译：本发明涉及使用含硒组合物在体内组织环境中治疗慢性淋巴细胞性白血病的组合物和方法。在具体方面，向个体施用含硒化合物，其中CLL细胞处于基质细胞环境中，其中基质因子调节含硒化合物以增强其活性。

2. 发明授权

US08463565B1 LED flashlight with battery life indicator 失效
标题翻译： LED手电筒，带电池寿命指示灯
公开(公告)号：US08463565B1
公开(公告)日：2013-06-11
申请号：US13336796
申请日：2011-12-23
申请人： Ralph Osterhout , Michael J. Keating , Antony Van der Mude
发明人： Ralph Osterhout , Michael J. Keating , Antony Van der Mude
IPC分类号： G01R31/36
CPC分类号： F21L4/005 , H01M10/443 , H02J7/0047
摘要： A flashlight includes a light powered by a battery, and a circuit having: a memory for storing a battery life information and voltage output information versus time for the battery to power the light, a controller operating a count down timer to accumulate an amount of time that the battery powers the light, a voltage measure circuit for monitoring the voltage output by the battery while the battery powers the light and supply the voltage output to the controller. The controller determines: a first remaining battery life by comparing the accumulated time to the battery life, a second remaining battery life by comparing the voltage output to the voltage output information, and the lesser of the first and second remaining battery lives. The flashlight includes a display for receiving a command from the controller to display the lesser of the first remaining battery life and the second remaining battery life.
摘要翻译：手电筒包括由电池供电的光，以及电路，具有：存储器，用于存储电池寿命信息和电压输出信息对电池供电的时间，控制器操作倒计时定时器以累积一定时间量电池为光源供电，一个电压测量电路，用于在电池供电并向控制器提供电压输出时监视电池输出的电压。所述控制器通过将所述累积时间与所述电池寿命进行比较来确定第一剩余电池寿命，通过将所述电压输出与所述电压输出信息进行比较来计算第二剩余电池寿命，以及所述第一和第二剩余电池寿命中的较小者。手电筒包括用于从控制器接收命令以显示第一剩余电池寿命和第二剩余电池寿命中的较小者的显示器。

3. 发明授权

US07816628B2 Heated garment 失效
标题翻译：加热服装
公开(公告)号：US07816628B2
公开(公告)日：2010-10-19
申请号：US11604182
申请日：2006-11-22
申请人： Juan Fernandez , Paul McGrath , Frank Cipolla , James Sabastian , Michael J. Keating
发明人： Juan Fernandez , Paul McGrath , Frank Cipolla , James Sabastian , Michael J. Keating
IPC分类号： H05B3/00 , H05B3/34
CPC分类号： H05B3/342 , A41D13/0051 , H05B2203/003 , H05B2203/014 , H05B2203/036
摘要： In an embodiment of the present invention, a garment includes a fabric having a channel, a heat conductive wire disposed in the channel, a power source coupled to the heat conductive wire and detachably attached to the garment, and a controller electrically coupled to the power source and detachably attached to the garment, wherein the controller is configured with a heat setting. In another embodiment of the present invention, a method of heating a garment includes providing a fabric, forming a channel, disposing a heat conductive wire within the channel, connecting the heat conductive wire with a power source, wherein the power source is a rechargeable battery, and adjusting the heating of the garment by operating the power source and the heat conductive wire using a controller.
摘要翻译：在本发明的一个实施例中，衣服包括具有通道的织物，设置在通道中的导热丝，耦合到导热丝并且可拆卸地附接到衣服的电源，以及电耦合到电源的控制器源和可拆卸地附接到衣服，其中控制器配置有热定形。在本发明的另一个实施例中，一种加热衣服的方法包括提供织物，形成通道，在通道内布置导热丝，将导热丝与电源连接，其中电源是可充电电池并且通过使用控制器操作电源和导热线来调节衣服的加热。

4. 发明授权

US07622306B2 Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy and clinical behavior, stratification of therapy, and monitoring disease in hematologic malignancies 有权
标题翻译：使用血浆蛋白质组学模式进行诊断，分类，对治疗反应的预测和临床行为，治疗分层和监测血液恶性肿瘤的疾病
公开(公告)号：US07622306B2
公开(公告)日：2009-11-24
申请号：US11110374
申请日：2005-04-20
申请人： Maher Albitar , Elihu H. Estey , Hagop M. Kantarjian , Francis J. Giles , Michael J. Keating
发明人： Maher Albitar , Elihu H. Estey , Hagop M. Kantarjian , Francis J. Giles , Michael J. Keating
IPC分类号： G01N24/00 , G01N1/00 , G01N1/10 , G01N33/48 , G01N33/00 , A61K49/00 , A01N61/00 , A61K31/00
CPC分类号： G01N33/6851 , G01N33/57426 , G01N33/6803 , G01N33/6848 , G01N2800/52 , Y10T436/24 , Y10T436/25 , Y10T436/25625
摘要： The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.
摘要翻译：本发明表明，可以通过分析存在于血浆样品中的蛋白质来完成血液恶性肿瘤患者（例如白血病）的临床行为的诊断和预测。因此，在具体实施方案中，本发明使用血浆来产生血液恶性肿瘤的诊断或预后蛋白质谱，包括从具有血液恶性肿瘤的患者群体收集血浆样品; 产生具有或不具有分级分离的血浆样品的蛋白质光谱; 将蛋白质谱与临床资料进行比较; 并鉴定与临床数据相关的血浆样品中的蛋白质标记。然后可以使用通过该方法鉴定的蛋白质标记产生可用于诊断血液恶性肿瘤或确定血液恶性肿瘤的预后的蛋白质谱。潜在地，这些特异性蛋白质可以在这些恶性肿瘤的治疗中被鉴定和靶向。

5. 发明授权

US07309247B1 Cable interconnect 有权
标题翻译：电缆互连
公开(公告)号：US07309247B1
公开(公告)日：2007-12-18
申请号：US11438987
申请日：2006-05-23
申请人： Michael J. Keating
发明人： Michael J. Keating
IPC分类号： H01R13/52
CPC分类号： H01R13/5219 , H01R13/5202 , H01R13/6471 , H01R13/6477 , H01R13/6584 , H01R13/6597 , H01R24/40 , H01R2103/00
摘要： A connection device comprises first and second connectors. The first connector has a sleeve having axially extending slots at a distal end to define tines yieldable resiliently inward, and a resilient seal encircling the sleeve proximally of the slots. The second connector has a shroud dimensioned to receive the distal end of the first connector sleeve within the shroud and to engage the first connector resilient seal when the sleeve is fully received within the shroud.
摘要翻译：连接装置包括第一和第二连接器。第一连接器具有套筒，其在远端具有轴向延伸的狭槽，以限定可弹性地向内屈曲的齿，以及围绕狭槽的近侧环绕套筒的弹性密封件。第二连接器具有尺寸适于接纳护罩内的第一连接器套筒的远端并且当套筒完全容纳在护罩内时与第一连接器弹性密封件接合的护罩。

6. 发明申请

US20090109461A1 Portable electronic faxing, scanning, copying, and printing device 审中-公开
标题翻译：便携式电子传真，扫描，复印和打印设备
公开(公告)号：US20090109461A1
公开(公告)日：2009-04-30
申请号：US12258546
申请日：2008-10-27
申请人： Mario Moreno , Robert Cichielo , Michael J. Keating
发明人： Mario Moreno , Robert Cichielo , Michael J. Keating
IPC分类号： G06K15/00 , H04N1/04
CPC分类号： H04N1/00 , H04N2201/0081 , H04N2201/0082 , H04N2201/0093 , H04N2201/0096
摘要： A lightweight, battery operated, portable, personal electronic device capable of faxing, scanning, printing and copying media as a standalone device or in cooperation with other electronic devices including PCs, mobile telephones, PDAs, etc. is provided. The device automatically detects the presence of fax-capable devices and reconfigures the software for compatibility with the fax-capable device eliminating the need for user programming. The device's ergonomic design, intrinsic physical stability, and same side paper feeds and user interface provide use in work areas having limited space. The device includes unidirectional, independent pathways for original and recording media such that paper jams are minimized. Portability is maximized through innovative power management software and hardware.
摘要翻译：提供了一种轻巧的，电池供电的便携式个人电子设备，其能够传真，扫描，打印和复制作为独立设备的媒体或与包括PC，移动电话，PDA等其他电子设备的协作。该设备自动检测是否有传真功能的设备，并重新配置该软件以兼容具有传真功能的设备，从而无需用户编程。该设备的人体工程学设计，固有的物理稳定性以及相同的侧面进纸和用户界面可在具有有限空间的工作区域中使用。该装置包括用于原始和记录介质的单向独立通路，使卡纸最小化。通过创新的电源管理软件和硬件，可移植性最大化。

7. 发明申请

US20080116189A1 Heated garment 失效
标题翻译：加热服装
公开(公告)号：US20080116189A1
公开(公告)日：2008-05-22
申请号：US11604182
申请日：2006-11-22
申请人： Juan Fernandez , Paul McGrath , Frank Cipolla , James Sabastian , Michael J. Keating
发明人： Juan Fernandez , Paul McGrath , Frank Cipolla , James Sabastian , Michael J. Keating
IPC分类号： H05B11/00
CPC分类号： H05B3/342 , A41D13/0051 , H05B2203/003 , H05B2203/014 , H05B2203/036
摘要： In an embodiment of the present invention, a garment includes a fabric having a channel, a heat conductive wire disposed in the channel, a power source coupled to the heat conductive wire and detachably attached to the garment, and a controller electrically coupled to the power source and detachably attached to the garment, wherein the controller is configured with a heat setting. In another embodiment of the present invention, a method of heating a garment includes providing a fabric, forming a channel, disposing a heat conductive wire within the channel, connecting the heat conductive wire with a power source, wherein the power source is a rechargeable battery, and adjusting the heating of the garment by operating the
摘要翻译：在本发明的一个实施例中，衣服包括具有通道的织物，设置在通道中的导热丝，耦合到导热丝并且可拆卸地附接到衣服的电源，以及电耦合到电源的控制器源和可拆卸地附接到衣服，其中控制器配置有热定形。在本发明的另一个实施例中，一种加热衣服的方法包括提供织物，形成通道，在通道内布置导热丝，将导热丝与电源连接，其中电源是可充电电池，并通过操作来调节衣服的加热

8. 发明授权

US09244753B2 Redundant bus fault detection 有权
标题翻译：冗余总线故障检测
公开(公告)号：US09244753B2
公开(公告)日：2016-01-26
申请号：US13833021
申请日：2013-03-15
申请人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
发明人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
IPC分类号： G08B21/00 , G06F11/07 , G08B29/12 , G08B29/16 , G06F11/20 , G06F11/32
CPC分类号： G06F11/0757 , G06F11/0745 , G06F11/2007 , G06F11/325 , G06F11/327 , G08B29/123 , G08B29/16
摘要： A system and method for an approach of detecting faults in a redundant bus system based upon four timers.
摘要翻译：一种基于四个定时器检测冗余总线系统故障的方法的系统和方法。

9. 发明申请

US20140281752A1 REDUNDANT BUS FAULT DETECTION 有权
标题翻译：冗余总线故障检测
公开(公告)号：US20140281752A1
公开(公告)日：2014-09-18
申请号：US13833021
申请日：2013-03-15
申请人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
发明人： Michael J. Keating , Harald Schermann , Paul Richard Strelecki , Vincent Baroncini , Pablo Torres
IPC分类号： G06F11/07
CPC分类号： G06F11/0757 , G06F11/0745 , G06F11/2007 , G06F11/325 , G06F11/327 , G08B29/123 , G08B29/16
摘要： A system and method for an approach of detecting faults in a redundant bus system based upon four timers.
摘要翻译：一种基于四个定时器检测冗余总线系统故障的方法的系统和方法。

10. 发明授权

US08501423B2 Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays 有权
公开(公告)号：US08501423B2
公开(公告)日：2013-08-06
申请号：US13543560
申请日：2012-07-06
申请人： Maher Albitar , Michael J. Keating , Taghi Manshouri
发明人： Maher Albitar , Michael J. Keating , Taghi Manshouri
IPC分类号： G01N31/00 , G01N33/53
CPC分类号： G01N33/6872 , C07K16/2887 , C07K2317/24 , C07K2317/76 , G01N33/564 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/70596 , G01N2800/52 , Y10S424/81 , Y10S436/809 , Y10T436/106664 , Y10T436/107497
摘要： The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.

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