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21. 发明申请

US20080019879A1 Method and apparatus for changing relative concentrations of gases present within a gaseous sample for mass spectrometry 有权
标题翻译：用于改变气相样品中存在的气体相对浓度的方法和装置用于质谱
公开(公告)号：US20080019879A1
公开(公告)日：2008-01-24
申请号：US11489150
申请日：2006-07-18
申请人： Arthur Schleifer
发明人： Arthur Schleifer
IPC分类号： B01L3/00
CPC分类号： G01N1/4005 , B01L3/5027
摘要： An apparatus for changing relative concentrations of first and second analyte substances in an analyte sample comprises a sample cell defining a sample chamber therewithin, and a semipermeable boundary member disposed in the sample chamber to define first and second sides of the sample chamber. Sample flow input and sample flow output ducts direct an analyte sample containing respective initial concentrations of the first and second analyte substances into the first side of the sample chamber. The semipermeable boundary member permits diffusion therethrough of the first and second analyte substances to the second side of the sample chamber at different rates. An analyte sample in the second side of the sample chamber, and an analyte sample exiting the first side via the sample flow output duct, have respective concentrations of the first and second analyte substances that are different from the initial concentrations.
摘要翻译：用于改变分析物样品中第一和第二分析物质的相对浓度的装置包括在其中限定样品室的样品池和设置在样品室中以限定样品室的第一和第二侧的半透性边界部件。样品流入口和样品流输出管道将含有相应初始浓度的第一和第二分析物质的分析物样品引导到样品室的第一侧。半透性边界构件允许第一和第二分析物质以不同的速率扩散到样品室的第二侧。样品室第二侧中的分析物样品和经由样品流量输出管道离开第一侧的分析物样品具有不同于初始浓度的第一和第二分析物质的相应浓度。

22. 发明申请

US20050214854A1 Testing multiple fluid samples with multiple biopolymer arrays 失效
标题翻译：用多个生物聚合物阵列测试多个流体样品
公开(公告)号：US20050214854A1
公开(公告)日：2005-09-29
申请号：US11136227
申请日：2005-05-23
申请人： SueAnn Dahm , Arthur Schleifer , Carol Schembri , Douglas Amorese
发明人： SueAnn Dahm , Arthur Schleifer , Carol Schembri , Douglas Amorese
IPC分类号： B01L3/00 , B01L7/00 , C12M1/34 , C12Q1/68
CPC分类号： B01L3/502 , B01L3/5025 , B01L7/00 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/0803 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , Y10T436/2575
摘要： A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
摘要翻译：用多个生物聚合物阵列测试多个流体样品的方法。将盖组装到承载在第一侧上的连续基底，多个阵列，每个阵列具有连接到基底的多个生物聚合区域，使得盖和基底一起形成多个腔室，每个腔室包含生物聚合物阵列，并且每个腔室可通过自己的港口多个流体样品通过各自的端口引入相应的室中，使得流体样品与相应的阵列接触。观察到阵列的绑定模式。还提供了一种在这些方法中有用的装置和试剂盒。

23. 发明授权

US06518556B2 Large dynamic range light detection 失效
公开(公告)号：US06518556B2
公开(公告)日：2003-02-11
申请号：US10068419
申请日：2002-02-04
申请人： Kenneth L. Staton , Andreas N. Dorsel , Arthur Schleifer
发明人： Kenneth L. Staton , Andreas N. Dorsel , Arthur Schleifer
IPC分类号： H01J4014
CPC分类号： G01J1/44 , G01N2021/6463 , H01J43/30
摘要： System for large dynamic range light detection. In one aspect, the system includes a hybrid counting/integrating system for processing a signal from a photomultiplier tube. In another aspect, large dynamic range is achieved in a cascaded detector system utilizing at least one asymmetric beam splitter for delivering a larger fraction of incident light to one photomultiplier tube and for delivering a smaller fraction of the incident light to another photomultiplier tube.

24. 发明授权

US06355921B1 Large dynamic range light detection 失效
标题翻译：大动态范围光检测
公开(公告)号：US06355921B1
公开(公告)日：2002-03-12
申请号：US09313102
申请日：1999-05-17
申请人： Kenneth L. Staton , Andreas N. Dorsel , Arthur Schleifer
发明人： Kenneth L. Staton , Andreas N. Dorsel , Arthur Schleifer
IPC分类号： H01J4014
CPC分类号： G01J1/44 , G01N2021/6463 , H01J43/30
摘要： System for large dynamic range light detection. In one aspect, the system includes a hybrid counting/integrating system for processing a signal from a photomultiplier tube. In another aspect, large dynamic range is achieved in a cascaded detector system utilizing at least one asymmetric beam splitter for delivering a larger fraction of incident light to one photomultiplier tube and for delivering a smaller fraction of the incident light to another photomultiplier tube.
摘要翻译：大动态范围光检测系统。一方面，该系统包括用于处理来自光电倍增管的信号的混合计数/积分系统。在另一方面，在级联检测器系统中实现了大的动态范围，该系统利用至少一个非对称分束器将较大部分的入射光传送到一个光电倍增管，并将较小部分的入射光传送到另一个光电倍增管。

25. 发明授权

US5239855A Positional calibration of robotic arm joints relative to the gravity vector 失效
标题翻译：相对于重力矢量的机械臂接头的位置校准
公开(公告)号：US5239855A
公开(公告)日：1993-08-31
申请号：US729748
申请日：1991-07-12
申请人： Arthur Schleifer , Philip B. Fuhrman , Mark E. Shuman
发明人： Arthur Schleifer , Philip B. Fuhrman , Mark E. Shuman
IPC分类号： B25J9/10 , B25J9/16 , B25J9/18 , B25J13/08 , B25J19/02 , G05B19/18 , G05B19/19 , G05D3/12
CPC分类号： B25J9/1692
摘要： Methods of calibrating robotic manipulators are disclosed. The present invention uses an inclinometer or a leveling device to provide a reference to calibrate each encoder for each joint of a robotic manipulator. The inclinometer or leveling device is most preferably an electronic protractor or similar device that is placed on a surface of one of the links and the joint is moved until the link is at a preselected angle. In certain embodiments an offset position between the level position and an index position for an absolute encoder is determined and absolute encoder data describing the offset position is recorded. Preferably, the inclinometer is capable of generating a signal that indicates the angle of the surface of the link with respect to the gravity vector. This signal can be used to control the joints and automatically calibrate the manipulator.

26. 发明授权

US07812307B2 Microplasma-based sample ionizing device and methods of use thereof 有权
标题翻译：基于微血管的样品离子化装置及其使用方法
公开(公告)号：US07812307B2
公开(公告)日：2010-10-12
申请号：US11485063
申请日：2006-07-11
申请人： David T. Dutton , Randall S. Urdahl , Arthur Schleifer , Karen L. Seward
发明人： David T. Dutton , Randall S. Urdahl , Arthur Schleifer , Karen L. Seward
IPC分类号： H01J49/00 , H01J27/00
CPC分类号： H01J37/32366
摘要： Aspects of the invention include sample ionizing devices and methods of use thereof. Embodiments of the sample ionizing devices include a microplasma generation source with a plasma generation region, a sample input port for delivering a sample to the plasma generation region, and a gas flow element configured to flow gas through the microplasma generation source independently of the sample input port. The devices and methods of the invention find use in a variety of different applications, including analyte detection applications.
摘要翻译：本发明的方面包括样品电离装置及其使用方法。样品离子化装置的实施例包括具有等离子体产生区域的微血浆发生源，用于将样品输送到等离子体产生区域的样品输入端口以及气体流动元件，其被配置成独立于样品输入流动气体通过微血浆发生源港口。本发明的装置和方法可用于各种不同的应用，包括分析物检测应用。

27. 发明授权

US07351379B2 Fluid containment structure 有权
标题翻译：流体遏制结构
公开(公告)号：US07351379B2
公开(公告)日：2008-04-01
申请号：US10172887
申请日：2002-06-14
申请人： Arthur Schleifer
发明人： Arthur Schleifer
IPC分类号： B01L3/00 , G01N1/28
CPC分类号： B01L3/50853 , B01L3/5025 , B01L3/5027 , B01L2300/0822 , B01L2300/0887 , B01L2400/0406 , G01N2035/00158 , G01N2035/00287
摘要： A fluid containment structure that includes a substrate with a gasket surface and a form-in-place gasket disposed on the gasket surface and a method for forming the fluid containment structure are described. The form-in-place gasket is disposed around and marks the perimeter of an interior area on the substrate. The interior area and the form-in-place gasket define a well that is adapted for retaining a fluid. The fluid containment structure may be associated with or form a portion of an analysis site where a sample fluid retained in the fluid containment structure may be analyzed.
摘要翻译：描述了一种流体容纳结构，其包括具有垫圈表面的基底和设置在垫圈表面上的就地形成垫圈以及用于形成流体容纳结构的方法。就地形成垫圈设置在衬底周围并标记衬底上的内部区域的周边。内部区域和就地形成垫圈限定适于保持流体的孔。流体容纳结构可以与可以分析流体容纳结构中保留的样品流体的分析位置相关联或形成一部分。

28. 发明申请

US20070170371A1 Microplasma-based sample ionizing device and methods of use thereof 有权
标题翻译：基于微血管的样品离子化装置及其使用方法
公开(公告)号：US20070170371A1
公开(公告)日：2007-07-26
申请号：US11485063
申请日：2006-07-11
申请人： David Dutton , Randall Urdahl , Arthur Schleifer , Karen Seward
发明人： David Dutton , Randall Urdahl , Arthur Schleifer , Karen Seward
IPC分类号： H01J27/00
CPC分类号： H01J37/32366
摘要： Aspects of the invention include sample ionizing devices and methods of use thereof. Embodiments of the sample ionizing devices include a microplasma generation source with a plasma generation region, a sample input port for delivering a sample to the plasma generation region, and a gas flow element configured to flow gas through the microplasma generation source independently of the sample input port. The devices and methods of the invention find use in a variety of different applications, including analyte detection applications.
摘要翻译：本发明的方面包括样品电离装置及其使用方法。样品离子化装置的实施例包括具有等离子体产生区域的微血浆发生源，用于将样品输送到等离子体产生区域的样品输入端口以及气体流动元件，其被配置成独立于样品输入流动气体通过微血浆发生源港口。本发明的装置和方法可用于各种不同的应用，包括分析物检测应用。

29. 发明申请

US20050272047A1 Automated process for washing array substrates 审中-公开
标题翻译：洗涤阵列基板的自动化过程
公开(公告)号：US20050272047A1
公开(公告)日：2005-12-08
申请号：US10864587
申请日：2004-06-08
申请人： Arthur Schleifer
发明人： Arthur Schleifer
IPC分类号： G01N33/53 , B01L99/00 , G01N1/00 , G01N1/31 , G01N1/34 , G01N35/00 , G01N37/00 , C12Q1/68 , C12M1/34
CPC分类号： G01N1/312 , B01L9/52 , B01L13/02 , B01L2300/0819 , G01N1/34 , G01N2035/00158
摘要： A method of washing an array substrate is disclosed. The method includes contacting the array substrate with a first wash solution and triggering an automatic wash process. The automatic wash process includes a) separating the array substrate from the first wash solution, b) contacting the array substrate with a second wash solution, c) incubating the array substrate in the second wash solution under controlled conditions, d) separating the array substrate from the second wash solution, e) contacting the array substrate with a third wash solution, and f) separating the array substrate from the third wash solution.
摘要翻译：公开了一种清洗阵列基板的方法。该方法包括使阵列基底与第一洗涤溶液接触并触发自动洗涤过程。自动洗涤过程包括：a）将阵列基板与第一洗涤溶液分离，b）使阵列基板与第二洗涤溶液接触，c）在受控条件下将阵列基板温育在第二洗涤溶液中，d）将阵列基板从第二洗涤溶液中，e）使阵列基底与第三洗涤溶液接触，以及f）将阵列基底与第三洗涤溶液分离。

30. 发明授权

US06329210B1 Method and apparatus for high volume polymer synthesis 失效
标题翻译：用于高体积聚合物合成的方法和装置
公开(公告)号：US06329210B1
公开(公告)日：2001-12-11
申请号：US09429055
申请日：1999-10-29
申请人： Arthur Schleifer
发明人： Arthur Schleifer
IPC分类号： G01N33543
CPC分类号： B01J19/0046 , B01J2219/00274
摘要： A scalable synthesis apparatus capable of rapid and efficient oligo synthesis. The apparatus includes a combination of dispensing elements, synthesis elements, and waste removal elements. More specifically, the synthesis elements are, in the preferred embodiment, a series of well-like synthesis locations on a continuous strip, where the strip is moving serially from one dispensing location to the next, and waste from each step is evacuated a vacuum egress element, until an entire oligo has been synthesized. Serial oligo synthesis increases the per hour productivity dramatically over batch synthesis apparatus currently used. The number of dispensing locations can be increased or decreased so that oligos of longer or shorter lengths may be synthesized. Moreover, a tremendous reduction of wasted reagents and oligo surplusage by providing serial synthesis.
摘要翻译：能够快速有效地进行寡聚合的可扩展合成装置。该装置包括分配元件，合成元件和废物移除元件的组合。更具体地说，在优选实施方案中，合成元件是在连续条带上的一系列类似的合成位置，其中条带从一个分配位置连续移动到下一个，并且每个步骤的废物被抽出真空出口元素，直到整个寡核苷酸被合成。串联低聚合成比目前使用的批量合成装置大大增加了每小时生产率。可以增加或减少分配位置的数量，从而可以合成更长或更短长度的寡核苷酸。此外，通过提供连续合成，大大减少了废弃的试剂和低聚物的剩余。

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