专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US5658673A Microwave-sensitive article 失效
标题翻译：微波敏感文章
公开(公告)号：US5658673A
公开(公告)日：1997-08-19
申请号：US504306
申请日：1995-07-20
申请人： Eric A. Holwitt , Johnathan L. Kiel , David N. Erwin
发明人： Eric A. Holwitt , Johnathan L. Kiel , David N. Erwin
IPC分类号： C03C17/34 , G01R29/08 , B32B27/08 , B32B27/34 , B32B27/38 , B32B27/40
CPC分类号： C03C17/3405 , G01R29/0857 , C03C2217/42 , C03C2217/475 , G01R29/0878 , Y10T428/31511 , Y10T428/31515 , Y10T428/31522 , Y10T428/31525 , Y10T428/31529 , Y10T428/31551 , Y10T428/31591 , Y10T428/31605 , Y10T428/31609 , Y10T428/31725 , Y10T428/31768 , Y10T428/31772 , Y10T428/31775 , Y10T428/31779 , Y10T428/31783 , Y10T428/31844 , Y10T428/31848
摘要： An article which is sensitive to non-ionizing electromagnetic radiation in the radiofrequency radiation range, consisting essentially of a substrate, a layer of a binder material and a layer of activated diazoluminomelanin. This article is prepared by coating at least one surface of a substrate with a binder, immersing the binder-coated substrate into a solution comprising luminol, 3AT and a soluble nitrite for a period of about 2 to 12 days to provide a layer of diazoluminomelanin (DALM) on the binder layer, removing the DALM-coated film from the solution and rinsing the same, activating the DALM with sodium bicarbonate and hydrogen peroxide for a period of about 2 to 12 days.
摘要翻译：在射频辐射范围内对非电离电磁辐射敏感的物品，其基本上由基底，粘合剂材料层和活化的二叠氮木兰素层组成。本文通过用粘合剂涂覆基材的至少一个表面来制备，将粘合剂涂覆的基材浸入包含鲁米诺3AT和可溶性亚硝酸盐的溶液中约2至12天的时间以提供一层二叠氮木兰宁（ DALM），从溶液中除去DALM涂膜并漂洗，用碳酸氢钠和过氧化氢活化DALM约2-12天。

22. 发明授权

US5003050A Diazoluminomelanin and a method for preparing same 失效
标题翻译：二氮芥菜素和其制备方法
公开(公告)号：US5003050A
公开(公告)日：1991-03-26
申请号：US489561
申请日：1990-03-07
申请人： Johnathan L. Kiel , Gerald J. O'Brien
发明人： Johnathan L. Kiel , Gerald J. O'Brien
IPC分类号： C07D403/12 , C12Q1/28 , G01N33/533
CPC分类号： C07D403/12 , C12Q1/28 , G01N33/533 , Y10S435/968 , Y10S436/805 , Y10S534/03
摘要： A water-soluble luminescent compound having repeating units of the formula: ##STR1## The product, which is a polymer having repeating units comprising diazo-linked luminol and hydroxyindole, is referred to as diazoluminomelanin (DALM), since one of the precursors to this product, 3-amino-L-tyrosine (3AT) is closely related to the biological substrates which are converted into melanin.Also provided is a method for preparing DALM which comprises reacting 3AT with an alkali metal nitrite, and reacting the resulting diazonium salt with luminol.DALM can be used for chemiluminescent immunoassays for biological and chemical agents; in radiofrequency and ionizing radiation dosimeters; and for RNA/DNA hybridization assays for viruses and genetic detection.
摘要翻译：具有下式重复单元的水溶性发光化合物：作为包含重氮连接的鲁米诺和羟基吲哚的重复单元的聚合物的产物被称为重氮基木兰素（DALM），因为其中一种前体产物，3-氨基-L-酪氨酸（3AT）与转化成黑色素的生物底物密切相关。还提供了一种制备DALM的方法，其包括使3AT与碱金属亚硝酸盐反应，并使得到的重氮盐与鲁米诺反应。 DALM可用于生物和化学试剂的化学发光免疫测定; 射频和电离辐射剂量计; 以及用于病毒和遗传检测的RNA / DNA杂交测定。

23. 发明授权

US08628955B2 Compositions, methods and uses for biosynthetic plasmid integrated capture elements 有权
标题翻译：生物合成质粒综合捕获元素的组成，方法和用途
公开(公告)号：US08628955B2
公开(公告)日：2014-01-14
申请号：US12792492
申请日：2010-06-02
申请人： Johnathan L. Kiel , Amanda Tijerina , Eric A. Holwitt , Jill Parker , Mark A. Sloan , Melanie Woitaske , Maomian Fan
发明人： Johnathan L. Kiel , Amanda Tijerina , Eric A. Holwitt , Jill Parker , Mark A. Sloan , Melanie Woitaske , Maomian Fan
IPC分类号： C12N15/63 , C07H21/04
CPC分类号： B82Y5/00 , C12N15/111 , C12N2320/32 , C12N2330/00 , C12P19/34
摘要： Embodiments herein report compositions, systems and methods for making and using plasmid vectors and nanotube complexes. In certain embodiments, compositions, systems and methods herein include making plasmid vectors having aptamer inserts. In some embodiments, methods disclosed herein may be used to rapidly generate large quantities of plasmid vectors having aptamer inserts directed to a particular target agent. Other aspects concern plasmid constructs associated with organic semiconductors. Yet other aspects concern complexes of nanotubes associated with dsDNA aptamers and tracking molecules.
摘要翻译：本文的实施方案报道了用于制备和使用质粒载体和纳米管复合物的组合物，系统和方法。在某些实施方案中，本文的组合物，系统和方法包括制备具有适体插入片段的质粒载体。在一些实施方案中，本文公开的方法可用于快速产生具有针对特定目标试剂的适配子插入物的大量质粒载体。其他方面涉及与有机半导体相关的质粒构建体。其他方面涉及与dsDNA适体和跟踪分子相关的纳米管的复合物。

24. 发明申请

US20120134877A1 METHODS FOR NEUTRALIZING ANTHRAX OR ANTHRAX SPORES 有权
标题翻译：用于中和ANTHRAX或ANTHRAX SPORES的方法
公开(公告)号：US20120134877A1
公开(公告)日：2012-05-31
申请号：US12973681
申请日：2010-12-20
申请人： Mark A. SLOAN , Jeevalatha Vivekananda , Eric A. Holwitt , Johnathan L. Kiel
发明人： Mark A. SLOAN , Jeevalatha Vivekananda , Eric A. Holwitt , Johnathan L. Kiel
IPC分类号： A61L2/12 , A61L2/14 , A61L2/08
CPC分类号： C12Q1/6825 , C12Q1/6837 , C12Q2565/607
摘要： The present invention concerns methods, compositions and apparatus for neutralizing bioagents, wherein bioagents comprise biowarfare agents, biohazardous agents, biological agents and/or infectious agents. The methods comprise exposing the bioagent to an organic semiconductor and exposing the bioagent and organic semiconductor to a source of energy. Although any source of energy is contemplated, in some embodiments the energy comprises visible light, ultraviolet, infrared, radiofrequency, microwave, laser radiation, pulsed corona discharge or electron beam radiation. Exemplary organic semiconductors include DAT and DALM. In certain embodiments, the organic semiconductor may be attached to one or more binding moieties, such as an antibody, antibody fragment, or nucleic acid ligand. Preferably, the binding moiety has a binding affinity for one or more bioagents to be neutralized. Other embodiments concern an apparatus comprising an organic semiconductor and an energy source. In preferred embodiments, the methods, compositions and apparatus are used for neutralizing anthrax spores.
摘要翻译：本发明涉及用于中和生物标签的方法，组合物和装置，其中生物制剂包括生物武器，生物危害剂，生物制剂和/或感染剂。所述方法包括将生物制剂暴露于有机半导体并将生物制剂和有机半导体暴露于能量源。尽管预期了任何能量源，但在一些实施例中，能量包括可见光，紫外线，红外线，射频，微波，激光辐射，脉冲电晕放电或电子束辐射。示例性有机半导体包括DAT和DALM。在某些实施方案中，有机半导体可以连接到一个或多个结合部分，例如抗体，抗体片段或核酸配体。优选地，结合部分对一种或多种待中和的生物剂具有结合亲和力。其他实施例涉及包括有机半导体和能量源的装置。在优选的实施方案中，所述方法，组合物和装置用于中和炭疽芽孢。

25. 发明申请

US20090004644A1 METHODS AND COMPOSITIONS FOR PROCESSES OF RAPID SELECTION AND PRODUCTION OF NUCLEIC ACID APTAMERS 有权
标题翻译：快速选择和生产核酸APTAMERS的方法和组合物
公开(公告)号：US20090004644A1
公开(公告)日：2009-01-01
申请号：US11965039
申请日：2007-12-27
申请人： Johnathan L. Kiel , Eric A. Holwitt , Michael (Maomian) Fan , Shelly D. Roper
发明人： Johnathan L. Kiel , Eric A. Holwitt , Michael (Maomian) Fan , Shelly D. Roper
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6811 , C12N15/115 , Y10T436/143333 , C12Q2525/205 , C12Q2565/101
摘要： Embodiments herein relate to compositions and methods for making and using aptamers, for example, DNA aptamers (DCEs) and/or RNA aptamers. In some embodiments, methods relate to making and amplifying target DCEs. In certain embodiments, methods for making capture elements or aptamers concern using a reporter moiety and signal reducing moiety prior to amplifying a target-specific capture element. In some embodiments, methods disclosed herein may be used to rapidly generate large quantities of aptamers such as DCEs directed to a particular target agent. Some embodiments relate to systems for performing automated generation of aptamers.
摘要翻译：本文的实施方案涉及用于制备和使用适体的组合物和方法，例如DNA适体（DCE）和/或RNA适体。在一些实施方案中，方法涉及制备和扩增目标DCE。在某些实施方案中，用于制备捕获元件或适体的方法在放大靶特异性捕获元件之前关注使用报道部分和信号降低部分。在一些实施方案中，本文公开的方法可用于快速产生大量适配体，例如针对特定目标试剂的DCE。一些实施例涉及用于执行适配体的自动生成的系统。

26. 发明授权

US06569630B1 Methods and compositions for aptamers against anthrax 有权
标题翻译：针对炭疽的适体的方法和组成
公开(公告)号：US06569630B1
公开(公告)日：2003-05-27
申请号：US09978753
申请日：2001-10-15
申请人： Jeevalatha Vivekananda , Johnathan L. Kiel
发明人： Jeevalatha Vivekananda , Johnathan L. Kiel
IPC分类号： C12Q168
CPC分类号： C12Q1/6825 , C12Q1/6837 , C12Q2565/607
摘要： The present invention concerns methods of preparing nucleic acid ligands against anthrax spores, compositions comprising anthrax specific nucleic acid ligands and methods of use of such ligands for detection and/or neutralization of anthrax spores.
摘要翻译：本发明涉及制备针对炭疽孢子的核酸配体的方法，包含炭疽特异性核酸配体的组合物和用于检测和/或中和炭疽孢子的这种配体的使用方法。

27. 发明授权

US5374811A Blood and tissue rewarming device 失效
标题翻译：血液和组织回暖装置
公开(公告)号：US5374811A
公开(公告)日：1994-12-20
申请号：US879015
申请日：1992-05-06
申请人： Johnathan L. Kiel , David N. Erwin , David M. Simmons , Christopher McQueen
发明人： Johnathan L. Kiel , David N. Erwin , David M. Simmons , Christopher McQueen
IPC分类号： A61M5/44 , H05B6/80 , H05B6/78
CPC分类号： H05B6/806 , A61M5/445 , H05B6/642 , H05B6/645 , A61M2205/362 , A61M2205/3686
摘要： An improved method and apparatus for safely and rapidly rewarming large quantities of frozen or refrigerated blood combines microwave, or radio frequency radiation, heating with a forced air system. Forced air is flowed over units of blood or tissue from those units that will absorb the most microwave energy, generally those units closest to the source of microwave energy, to those units that will absorb the least microwave energy, generally those units furthest from the source of microwave energy. The forced air initially thaws the closest units so that they begin to absorb significant microwave energy. The forced air, preferably chilled, then prevents overheating of those closest units by transferring heat to more distant units, beginning their thawing and contributing to their rewarming. The microwave energy source is turned off when the output temperature of the forced air reaches a preselected temperature and the flow of forced air continues until the output temperature stabilizes. The apparatus includes a separated stack of perforated plates, each plate holding two units, mounted inside a microwave oven. Forced air drives a turbine rotor which rotates the plates while the air leaving the turbine flows down among the stacked plates and out the microwave oven.
摘要翻译：一种用于安全和快速地重新加热大量冷冻或冷藏血液的改进方法和装置将微波或射频辐射，强制空气系统加热。强制空气从那些将吸收最微波能量的微波能量（通常是最接近微波能量源的单元）流向血液或组织的单位，到达吸收最少微波能量的那些单元，通常是离源最远的单元的微波能量。强制空气最初解冻最近的单位，以便它们开始吸收显着的微波能量。强制空气，优选冷冻，然后通过将热量传递到更远的单元，开始解冻并有助于它们的再温暖，从而防止最近的单元过热。当强制空气的输出温度达到预选温度并强制空气流持续直到输出温度稳定时，微波能量源关闭。该装置包括分开的多孔板堆叠，每个板保持两个单元，安装在微波炉内。强制空气驱动涡轮转子，涡轮转子旋转板，同时离开涡轮机的空气在堆叠的板之间向下流动并流出微波炉。

28. 发明授权

US4948975A Quantitative luminescence imaging system 失效
标题翻译：定量发光成像系统
公开(公告)号：US4948975A
公开(公告)日：1990-08-14
申请号：US241992
申请日：1988-09-08
申请人： David N. Erwin , Johnathan L. Kiel , Charles R. Batishko , Kurt A. Stahl
发明人： David N. Erwin , Johnathan L. Kiel , Charles R. Batishko , Kurt A. Stahl
IPC分类号： G01N21/76 , G01N22/00
CPC分类号： G01N21/76
摘要： The QLIS images and quantifies low-level chemiluminescent reactions in an electromagnetic field. It is capable of real time nonperturbing measurement and simultaneous recording of many biochemical and chemical reactions such as luminescent immunoassays or enzyme assays. The system comprises image transfer optics, a low-light level digitizing camera with image intensifying microchannel plates, an image process or, and a control computer. The image transfer optics may be a fiber image guide with a bend, or a microscope, to take the light outside of the RF field. Output of the camera is transformed into a localized rate of cumulative digitalized data or enhanced video display or hard-copy images. The system may be used as a luminescent microdosimetry device for radiofrequency or microwave radiation, as a thermal dosimeter, or in the dosimetry of ultra-sound (sonoluminescence) or ionizing radiation. It provides a near-real-time system capable of measuring the extremely low light levels from luminescent reactions in electromagnetic fields in the areas of chemiluminescence assays and thermal microdosimetry, and is capable of near-real-time imaging of the sample to allow spatial distribution analysis of the reaction. It can be used to instrument three distinctly different irradiation configurations, comprising (1) RF waveguide irradiation of a small Petri-dish-shaped sample cell, (2) RF irradiation of samples in a microscope for the microscopie imaging and measurement, and (3) RF irradiation of small to human body-sized samples in an anechoic chamber.
摘要翻译： QLIS图像和量化电磁场中的低水平化学发光反应。它能够进行实时的非干扰测量和同时记录许多生化和化学反应，如发光免疫测定或酶测定。该系统包括图像传输光学器件，具有图像增强微通道板的低光级数字化相机，图像处理或控制计算机。图像传输光学器件可以是具有弯曲或显微镜的光纤图像引导件，以将光照射到RF场外。相机的输出变换为累积数字化数据或增强型视频显示或硬拷贝图像的本地化速率。该系统可以用作射频或微波辐射的发光微量测量装置，作为热剂量计，或者用于超声（声发光）或电离辐射的剂量测定。它提供了一种近实时系统，能够在化学发光测定和热微量测定领域中测量电磁场中的发光反应的极低的光照水平，并且能够近似实时成像样品以允许空间分布分析反应。它可用于测量三种明显不同的照射配置，包括（1）小培养皿样品池的RF波导照射，（2）用于显微镜成像和测量的样品的RF照射，（3））在消声室中对人体大小的样品进行射频照射。

29. 发明授权

US4871770A Method of inhibiting the activity of peroxidases and stimulating tumor growth 失效
标题翻译：抑制过氧化物酶活性和刺激肿瘤生长的方法
公开(公告)号：US4871770A
公开(公告)日：1989-10-03
申请号：US133675
申请日：1987-12-16
申请人： Johnathan L. Kiel
发明人： Johnathan L. Kiel
IPC分类号： A61K38/44 , C12N11/18
CPC分类号： C12N11/18 , A61K31/198
摘要： A composition and process for suppressing the immune system of animals in which an effective amount of 3-aminotyrosine is administered which suppresses the endogeneous immune system of animals. In addition endogeneous peroxidase activity is inhibited and tumor growth is stimulated.
摘要翻译：用于抑制动物免疫系统的组合物和方法，其中施用有效量的3-氨基酪氨酸，其抑制动物的内在免疫系统。此外，内源性过氧化物酶活性受到抑制，肿瘤生长受到刺激。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式