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    • 24. 发明申请
    • Method For Detecting and/or Determining the Concentration of at Least One Ligand
    • 检测和/或确定最少一个配体浓度的方法
    • US20080138829A1
    • 2008-06-12
    • US11665169
    • 2005-10-12
    • Mirko LehmannIngo FreundHolger KlapprothSonja Mohry
    • Mirko LehmannIngo FreundHolger KlapprothSonja Mohry
    • G01N21/76G01N33/543G01N33/53
    • G01N33/54373
    • The invention relates to a method for detecting and/or determining the concentration of a ligand contained in a solution to be analyzed, during which a receptor, which can enter into a specific bond with the ligand, is immobilized on a semiconductor chip at a test location. In order to bind the ligand to the receptor, the solution is applied to the test location. A luminescence radiation or a color change is generated according to the binding of the ligand to the receptor. A radiation measurement signal is picked up with the aid of a radiation receiver integrated in the semiconductor chip, whereas the solution and/or an auxiliary liquid that does not contain the luminophore is in contact with the radiation receiver. While the generation of luminescence radiation is prevented and the radiation receiver is in contact with the auxiliary liquid and/or with a substitute liquid, a darkness measurement signal is measured for the radiation receiver. The radiation measurement signal is compensated for with the darkness measurement signal
    • 本发明涉及一种用于检测和/或确定待分析溶液中所含配体的浓度的方法,在该方法中,可以与配体进入特定键的受体在测试中固定在半导体芯片上 位置。 为了将配体结合到受体,将溶液施加到测试位置。 根据配体与受体的结合产生发光辐射或颜色变化。 借助于集成在半导体芯片中的辐射接收器拾取辐射测量信号,而不包含发光体的溶液和/或辅助液体与辐射接收器接触。 虽然防止了发光辐射的产生并且辐射接收器与辅助液体和/或替代液体接触,但是对辐射接收器测量了暗度测量信号。 用黑度测量信号补偿辐射测量信号
    • 26. 发明授权
    • Method for producing a solid body including a microstructure
    • 包括微结构的固体的制造方法
    • US07166232B2
    • 2007-01-23
    • US10433875
    • 2000-12-21
    • Guenter IgelMirko Lehmann
    • Guenter IgelMirko Lehmann
    • H01L21/033H01L21/768H01L21/60H01L21/308
    • H01L29/66719H01L21/0337H01L21/0338H01L21/3086H01L21/3088H01L21/76885H01L21/76897H01L29/1095H01L29/66712H01L29/7805Y10S438/947
    • According to a method for producing a solid body (1) including a microstructure (2), the surface of a substrate (3) is provided with a masking layer (6) that is impermeable to a substance to be applied. The substance is then incorporated into the substrate regions not covered by the masking layer (6). A heat treatment is used to diffuse the substance into a substrate region covered by the masking layer (6) such that a concentration gradient of the substance is created in the substrate region covered by the masking layer (6), proceeding from the edge of the masking layer (6) inward with increasing distance from the edge. The masking layer (6) is then removed to expose the substrate region under this layer, and a near-surface layer of the substrate (3) in the exposed substrate region is converted by a chemical conversion reaction into a coating (9) which has a layer thickness profile corresponding to the concentration gradient of the substance contained in this near-surface layer. A supplementary treatment is implemented in a subsection of the coating (9) in which the thickness of the coating (9) is reduced.
    • 根据包含微结构(2)的固体(1)的制造方法,在基材(3)的表面设置有对被涂物质不可渗透的掩模层(6)。 然后将该物质并入未被掩蔽层(6)覆盖的衬底区域中。 使用热处理将物质扩散到由掩模层(6)覆盖的衬底区域中,使得在由掩模层(6)覆盖的衬底区域中产生物质的浓度梯度,从 掩蔽层(6)随着与边缘的距离增加而向内。 然后去除掩模层(6)以暴露该层下的衬底区域,并且暴露的衬底区域中的衬底(3)的近表面层通过化学转化反应转化成具有 与该近表面层中所含的物质的浓度梯度对应的层厚度曲线。 在涂层(9)的分段中实施补充处理,其中涂层(9)的厚度减小。
    • 27. 发明申请
    • apparatus and method for determining a chemical element
    • 用于确定化学元素的装置和方法
    • US20060249401A1
    • 2006-11-09
    • US10867177
    • 2004-06-14
    • Mirko LehmannMaximilian Fleischer
    • Mirko LehmannMaximilian Fleischer
    • G01N27/26
    • G01N27/4143
    • Sensor for determining a chemical element and method for controlling such a sensor. The invention relates to a sensor (1) for determining a chemical element or a chemical compound (CO2) in a supplied gaseous medium with a reaction area (9), on and/or in which the element or the compound brings about a chemical reaction that changes a characteristic parameter (for example the work function), Version 3* of the reaction area (9), a sensor element (5) that is placed in the sensor (1) to detect the change in the characteristic parameter, a signal output (11) at which an output signal (UPS) corresponding to the chemical reaction detected by the sensor element can be detected as the measured variable, and a reaction control device (SC, 12) with an electrode system (10, 13) for applying a control voltage to affect a reaction in the reaction area (9). To be able to use the sensor more variably and more reliably, it is proposed to produce a surface topology of such dimensions that during operation, a moisture film (16) of deposited ambient moisture continuously coats the surface area of both the electrode system and the reaction area. Possibilities in particular are correction of long-term changes from the influence of surrounding gases, checking probe functionality, and selective adjustment to measure given chemical variables.
    • 用于确定化学元素的传感器和用于控制这种传感器的方法。 本发明涉及一种传感器(1),用于在所提供的具有反应区域(9)的气体介质中确定化学元素或化合物(CO 2),在该元件或/或其中元素 或该化合物引起改变反应区域(9)的特征参数(例如功函数)版本3 *的化学反应,放置在传感器(1)中的传感器元件(5),以检测 改变特性参数,可以检测与传感器元件检测到的与化学反应相对应的输出信号(U> PS )的信号输出(11)作为测量变量,反应控制 装置(SC,12),其具有用于施加控制电压以影响反应区域(9)中的反应的电极系统(10,13)。 为了能够更可变地和更可靠地使用传感器,提出了生产这样的尺寸的表面拓扑,即在操作期间,沉积的环境湿度的水分膜(16)连续地涂覆电极系统和 反应区域。 特别是可以纠正周围气体的长期变化,检查探测功能和选择性调整以测量给定的化学变量。
    • 28. 发明申请
    • Method for producing a sensor or actuator arrangement, and corresponding sensor or actuator arrangement
    • 用于制造传感器或致动器装置的方法以及相应的传感器或致动器装置
    • US20050155411A1
    • 2005-07-21
    • US10504738
    • 2003-02-07
    • Markus RogallaIngo FreundMirko Lehmann
    • Markus RogallaIngo FreundMirko Lehmann
    • G12B9/04B81B7/00G01N35/00H05K5/00H05K7/14G01N27/414
    • B81B7/0061
    • In a method for producing a sensor arrangement and the resulting sensor arrangement, a sensor is provided on or in a chip and the chip is covered with a protective cover, the cover being an interface between the sensor and the environment. An adhesive layer is provided between the chip and the protective cover, the adhesive layer alone or together with the protective cover being an interface between the sensor and the environment. The protective cover and/or the adhesive layer may have a channel formed therein, the channel functioning as the reception channel for a sensor. In an alternative embodiment, the protective cover placed on a wafer with several chips, and the wafer is cut up to produce the individual chips with the protective cover. Thus, a sensor arrangement may have the protective cover applied to the individual chip after the chip is cut from the wafer, or the protective cover may be applied to the wafer, and the wafer and cover are then cut up into the individual chips and corresponding covers. The channel leading from one side of the arrangement to the sensor may be taken through the adhesive layer, through the protective cover, or through both. A hole may be formed in the protective cover above the sensor, with the sensor lying loosely in the hole. The reaction volume may be determined by the dimensions of the hole.
    • 在用于制造传感器装置和所得到的传感器装置的方法中,传感器设置在芯片上或芯片中,并且芯片被保护盖覆盖,盖是传感器和环境之间的接口。 粘合剂层设置在芯片和保护盖之间,粘合剂层单独或与保护罩一起作为传感器和环境之间的界面。 保护盖和/或粘合剂层可以具有形成在其中的通道,该通道用作传感器的接收通道。 在替代实施例中,将保护盖放置在具有几个芯片的晶片上,并且切割晶片以用保护盖产生单独的芯片。 因此,在从晶片切割芯片之后,传感器装置可以具有施加到单个芯片的保护盖,或者可以将保护盖施加到晶片,然后将晶片和盖切割成各个芯片,并且对应于 盖子。 从布置的一侧引导到传感器的通道可以穿过粘合剂层,通过保护盖,或者通过两者。 可以在传感器上方的保护罩中形成孔,传感器松动地位于孔中。 反应体积可以由孔的尺寸确定。
    • 29. 发明授权
    • Measuring device and process for its manufacture
    • 测量装置及其制造工艺
    • US06471838B1
    • 2002-10-29
    • US09506646
    • 2000-02-18
    • Günter IgelHans-Jürgen GahleMirko Lehmann
    • Günter IgelHans-Jürgen GahleMirko Lehmann
    • G01N27327
    • G01N27/226G01N21/03G01N27/07
    • A measuring device (1), for examining a medium (2) that is liquid or free-flowing, has at least two electrically and/or optically conducting layers or layer areas (5a, 5b, 5c, 6a, 6b, 7a, 7b) located on a substrate layer (3), wherein these layers or layer areas are electrically and/or optically insulated from each other. At least one of these layers or layer areas (5a, 5b, 5c, 6a, 6b, 7a, 7b) is part of a layer stack (4), which has several layers arranged on top of each other on the substrate layer (3). The layer stack has, on its side facing away from the substrate layer (3), a recess that adjoins the electrically and/or optically conducting layers or layer areas (5a, 5b, 6a, 6b, 7a, 7b). At least one electrically and/or optically conducting layer or layer area (5a, 5b, 6a, 6b, 7a, 7b) located in the layer stack (4) is spaced at a distance from the bottom (11) of the recess (10).
    • 用于检查液体或自由流动的介质(2)的测量装置(1)具有至少两个电和/或光导电层或层区(5a,5b,5c,6a,6b,7a,7b) ),其中这些层或层区域彼此电隔离和/或光学绝缘。 这些层或层区域(5a,5b,5c,6a,6b,7a,7b)中的至少一个是层叠体(4)的一部分,其在基底层(3)上彼此顶部布置有多个层 )。 层叠体在其背离衬底层(3)的一侧具有邻接电和/或光传导层或层区(5a,5b,6a,6b,7a,7b)的凹部。 位于层叠体(4)中的至少一个电和/或光传导层或层区(5a,5b,6a,6b,7a,7b)与凹部(10)的底部(11) )。