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1. 发明授权

US08329104B2 Measurement device with at least one sensor 有权
标题翻译：至少有一个传感器的测量装置
公开(公告)号：US08329104B2
公开(公告)日：2012-12-11
申请号：US12146644
申请日：2008-06-26
申请人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
发明人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , C12Q1/00 , G01N33/53 , G01N33/566 , G01N33/543
CPC分类号： G01N33/54373 , G01D3/08 , G01N27/414 , G01N27/4163 , G01N33/0032
摘要： A measurement device has at least one sensor for detecting a parameter, a data storage unit, and a power supply for said sensor and data storage unit. In addition to the first sensor, the measurement device has at least one second sensor connected to the power supply and to the data storage unit. The second sensor is provided for detecting a physical quantity acting on the first sensor and is capable of permanently altering the measurement characteristic of the first sensor. An evaluator functions coactively with the second sensor and the data storage unit so that the permanent alteration of the measurement characteristic of the first sensor is recordable as a function of the measurement signal of the second sensor.
摘要翻译：测量装置具有用于检测参数的至少一个传感器，用于所述传感器和数据存储单元的数据存储单元和电源。除了第一传感器之外，测量装置具有连接到电源和数据存储单元的至少一个第二传感器。提供第二传感器用于检测作用在第一传感器上的物理量，并且能够永久地改变第一传感器的测量特性。评估器与第二传感器和数据存储单元共同作用，使得可以根据第二传感器的测量信号来记录第一传感器的测量特性的永久变化。

2. 发明申请

US20090175764A1 Measurement Device with At Least One Sensor 有权
标题翻译：具有至少一个传感器的测量装置
公开(公告)号：US20090175764A1
公开(公告)日：2009-07-09
申请号：US12146644
申请日：2008-06-26
申请人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
发明人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
IPC分类号： B01J19/00
CPC分类号： G01N33/54373 , G01D3/08 , G01N27/414 , G01N27/4163 , G01N33/0032
摘要： A measurement device has at least one sensor for detecting a parameter, a data storage unit, and a power supply for said sensor and data storage unit. In addition to the first sensor, the measurement device has at least one second sensor connected to the power supply and to the data storage unit. The second sensor is provided for detecting a physical quantity acting on the first sensor and is capable of permanently altering the measurement characteristic of the first sensor. An evaluator functions coactively with the second sensor and the data storage unit so that the permanent alteration of the measurement characteristic of the first sensor is recordable as a function of the measurement signal of the second sensor.
摘要翻译：测量装置具有用于检测参数的至少一个传感器，用于所述传感器和数据存储单元的数据存储单元和电源。除了第一传感器之外，测量装置具有连接到电源和数据存储单元的至少一个第二传感器。提供第二传感器用于检测作用在第一传感器上的物理量，并且能够永久地改变第一传感器的测量特性。评估器与第二传感器和数据存储单元共同作用，使得可以根据第二传感器的测量信号来记录第一传感器的测量特性的永久变化。

3. 发明申请

US20080138829A1 Method For Detecting and/or Determining the Concentration of at Least One Ligand 审中-公开
标题翻译：检测和/或确定最少一个配体浓度的方法
公开(公告)号：US20080138829A1
公开(公告)日：2008-06-12
申请号：US11665169
申请日：2005-10-12
申请人： Mirko Lehmann , Ingo Freund , Holger Klapproth , Sonja Mohry
发明人： Mirko Lehmann , Ingo Freund , Holger Klapproth , Sonja Mohry
IPC分类号： G01N21/76 , G01N33/543 , G01N33/53
CPC分类号： G01N33/54373
摘要： The invention relates to a method for detecting and/or determining the concentration of a ligand contained in a solution to be analyzed, during which a receptor, which can enter into a specific bond with the ligand, is immobilized on a semiconductor chip at a test location. In order to bind the ligand to the receptor, the solution is applied to the test location. A luminescence radiation or a color change is generated according to the binding of the ligand to the receptor. A radiation measurement signal is picked up with the aid of a radiation receiver integrated in the semiconductor chip, whereas the solution and/or an auxiliary liquid that does not contain the luminophore is in contact with the radiation receiver. While the generation of luminescence radiation is prevented and the radiation receiver is in contact with the auxiliary liquid and/or with a substitute liquid, a darkness measurement signal is measured for the radiation receiver. The radiation measurement signal is compensated for with the darkness measurement signal
摘要翻译：本发明涉及一种用于检测和/或确定待分析溶液中所含配体的浓度的方法，在该方法中，可以与配体进入特定键的受体在测试中固定在半导体芯片上位置。为了将配体结合到受体，将溶液施加到测试位置。根据配体与受体的结合产生发光辐射或颜色变化。借助于集成在半导体芯片中的辐射接收器拾取辐射测量信号，而不包含发光体的溶液和/或辅助液体与辐射接收器接触。虽然防止了发光辐射的产生并且辐射接收器与辅助液体和/或替代液体接触，但是对辐射接收器测量了暗度测量信号。用黑度测量信号补偿辐射测量信号

4. 发明申请

US20070243637A1 Process and device for determining the concentrations of ligands 审中-公开
标题翻译：用于测定配体浓度的方法和装置
公开(公告)号：US20070243637A1
公开(公告)日：2007-10-18
申请号：US11784768
申请日：2007-04-09
申请人： Sonja Mohry , Holger Klapproth , Mirko Lehmann , Ingo Freund
发明人： Sonja Mohry , Holger Klapproth , Mirko Lehmann , Ingo Freund
IPC分类号： G01N33/543 , C12M3/00
CPC分类号： G01N33/558 , G01N33/54306
摘要： In a process for determining the concentrations of ligands (9, 10) in a sample to be analyzed, ligands (9) of a first ligand type are bond-specific for receptors (6) of a first receptor type, and ligands (10) of a second ligand type are bond-specific for receptors (8) of a second receptor type. A first receptor (6) of the first receptor type is immobilized at least one first test site (5), and a second receptor (8) of the second receptor type is immobilized at a second test site (7) on a substrate (23). A third receptor (11) of the second receptor type is mixed with the sample in such a way that it is present in a specified concentration in the mixture that is obtained in this manner. The mixture is caused to contact the substrate in such a way that at least one ligand (9) of the first ligand type can bind to the first receptor (6) and ligands (10) of the second ligand type can bind to the second receptor (8) and to the third receptor (11). Thereupon components of the mixture that are not bound to an immobilized receptor (6, 8) are removed from the substrate. Thereupon a first measurement signal that is dependent on the concentration of the ligand (9) bound to the first receptor (6) and a second measurement signal that is dependent on the concentration of the ligand (10) bound to the second receptor (8) are generated. With the aid of the first measurement signal the concentration of the ligand (9) of the first ligand type in the sample is determined and, with the aid of the second measurement signal and of the concentration of the third receptor (11) in the mixture, the concentration of the ligands (10) of the second ligand type in the sample is determined.
摘要翻译：在用于测定待分析样品中配体（9,10）的浓度的方法中，第一配体类型的配体（9）对于第一受体类型的受体（6）是键特异性的，而配体（10）第二种配体类型是第二受体类型的受体（8）的键特异性。将第一受体类型的第一受体（6）固定在至少一个第一测试位点（5）上，并且将第二受体类型的第二受体（8）固定在基底（23）上的第二测试位点（7））。将第二受体类型的第三受体（11）与样品混合，使得其以以这种方式获得的混合物中以特定浓度存在。使混合物以这样的方式接触底物，使得第一配体型的至少一种配体（9）可以结合第一受体（6），并且第二配体型的配体（10）可以结合第二受体（8）和第三受体（11）。因此，从底物中除去不与固定化受体（6,8）结合的混合物的组分。因此，依赖于与第一受体（6）结合的配体（9）的浓度的第一测量信号和取决于与第二受体（8）结合的配体（10）的浓度的第二测量信号，被生成。借助于第一测量信号，测定样品中第一配体类型的配体（9）的浓度，借助于第二测量信号和混合物中第三受体（11）的浓度测定样品中第二配体类型的配体（10）的浓度。

5. 发明申请

US20060051244A1 Device for the detection of at least one ligand contained in a sample that is to be analyzed 有权
标题翻译：用于检测待分析样品中所含的至少一种配体的装置
公开(公告)号：US20060051244A1
公开(公告)日：2006-03-09
申请号：US10528954
申请日：2003-09-26
申请人： Mirko Lehmann , Claas Muller , Holger Klapproth , Ingo Freund
发明人： Mirko Lehmann , Claas Muller , Holger Klapproth , Ingo Freund
IPC分类号： G01N33/50
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/6454 , G01N33/54373
摘要： Disclosed is a device for detecting at least one ligand contained in a sample that is to be analyzed. Said device comprises an optical waveguide, on the surface of which at least one ligand-specific receptor is directly or indirectly immobilized. The ligand bonds to said receptor during contact therewith. The inventive device comprises at least one optical source of radiation for injecting excitation radiation into the waveguide, the radiation being used for exciting emission of luminescence radiation in accordance with the bonding of the ligand to the receptor. At least one radiation receiver is integrated into the semiconductor substrate of a semiconductor chip so as to detect the luminescence radiation. The waveguide is integrated in a monolithic manner into the semiconductor substrate or is applied thereupon as a wave-guiding layer.
摘要翻译：公开了一种用于检测待分析样品中所含的至少一种配体的装置。所述装置包括光波导，其表面上直接或间接固定至少一种配体特异性受体。配体在与其接触时与所述受体结合。本发明的装置包括至少一个用于将激发辐射注入到波导中的辐射光源，所述辐射用于根据配体与受体的结合激发发射辐射。至少一个辐射接收器被集成到半导体芯片的半导体衬底中，以便检测发光辐射。波导以单片方式集成到半导体衬底中或作为波导层施加在其上。

6. 发明授权

US07462326B2 Device for the detection of at least one ligand contained in a sample that is to be analyzed 有权
标题翻译：用于检测待分析样品中所含的至少一种配体的装置
公开(公告)号：US07462326B2
公开(公告)日：2008-12-09
申请号：US10528954
申请日：2003-09-26
申请人： Mirko Lehmann , Claas Müller , Holger Klapproth , Ingo Freund
发明人： Mirko Lehmann , Claas Müller , Holger Klapproth , Ingo Freund
IPC分类号： G01N21/76 , G01N21/00 , G01N33/543 , G01N21/41 , G02B6/12 , G02B6/00 , G02B6/10 , G01B9/02 , C12M1/34
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/6454 , G01N33/54373
摘要： Disclosed is a device for detecting at least one ligand contained in a sample that is to be analyzed. Said device comprises an optical waveguide, on the surface of which at least one ligand-specific receptor is directly or indirectly immobilized. The ligand bonds to said receptor during contact therewith. The inventive device comprises at least one optical source of radiation for injecting excitation radiation into the waveguide, the radiation being used for exciting emission of luminescence radiation in accordance with the bonding of the ligand to the receptor. At least one radiation receiver is integrated into the semiconductor substrate of a semiconductor chip so as to detect the luminescence radiation. The waveguide is integrated in a monolithic manner into the semiconductor substrate or is applied thereupon as a wave-guiding layer.
摘要翻译：公开了一种用于检测待分析样品中所含的至少一种配体的装置。所述装置包括光波导，其表面上直接或间接固定至少一种配体特异性受体。配体在与其接触时与所述受体结合。本发明的装置包括至少一个用于将激发辐射注入到波导中的辐射光源，所述辐射用于根据配体与受体的结合激发发射辐射。至少一个辐射接收器被集成到半导体芯片的半导体衬底中，以便检测发光辐射。波导以单片方式集成到半导体衬底中或作为波导层施加在其上。

7. 发明申请

US20050070009A1 Biopolymer synthesis substrate and method for producing biopolymers 审中-公开
标题翻译：生物聚合物合成底物和生物聚合物的生产方法
公开(公告)号：US20050070009A1
公开(公告)日：2005-03-31
申请号：US10495845
申请日：2002-11-12
申请人： Holger Klapproth , Mirko Lehmann , Ingo Freund , Joachim Sturken
发明人： Holger Klapproth , Mirko Lehmann , Ingo Freund , Joachim Sturken
IPC分类号： B01J19/00 , C12M1/34 , C08G63/48 , C08G63/91
CPC分类号： B01J19/0046
摘要： The invention concerns a biopolymer synthesis substrate, its use and a method for producing biopolymers
摘要翻译：本发明涉及生物聚合物合成底物，其用途和用于生产生物聚合物的方法

8. 发明授权

US07312867B2 Method and device for the detection of at least one luminescent substance 有权
标题翻译：用于检测至少一种发光物质的方法和装置
公开(公告)号：US07312867B2
公开(公告)日：2007-12-25
申请号：US10529048
申请日：2003-09-12
申请人： Holger Klapproth , Mirko Lehmann
发明人： Holger Klapproth , Mirko Lehmann
IPC分类号： G01J3/30
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/648 , H01L2924/0002 , H01L2924/00
摘要： Disclosed is a device for detecting at least one luminescent substance, comprising a radiation source for emitting excitation radiation to the at least one luminescent substance. The excitation radiation is provided with at least one excitation wavelength at which the luminescent substance is excited so as to emit luminescent radiation. At least one radiation receiver is provided, which detects the luminescent radiation and is configured regarding the spectral sensitivity thereof in such a way that said radiation receiver is insensitive to the radiation emitted by the radiation source. The luminescent substance is located inside a measuring chamber that is essentially impermeable to the luminescent radiation and comprises at least one wall area which is transparent to the excitation radiation emitted by the radiation source. The radiation source is placed outside the measuring chamber such that the excitation radiation emitted by the radiation source is coupled into the inside of the measuring chamber by penetrating said wall area.
摘要翻译：公开了一种用于检测至少一种发光物质的装置，包括用于向至少一种发光物质发射激发辐射的辐射源。激发辐射具有至少一个激发波长，在该激发波长处激发发光物质以发射发光辐射。提供至少一个辐射接收器，其检测发光辐射，并且被配置为关于其光谱灵敏度，使得所述辐射接收器对由辐射源发射的辐射不敏感。发光物质位于测量室内，其基本上不透气于发光辐射，并且包括对由辐射源发射的激发辐射透明的至少一个壁区域。辐射源被放置在测量室的外部，使得由辐射源发射的激发辐射通过穿透所述壁区域而耦合到测量室的内部。

9. 发明授权

US07416901B2 Method and coating apparatus for the manufacture of a microarray 失效
标题翻译：用于制造微阵列的方法和涂覆装置
公开(公告)号：US07416901B2
公开(公告)日：2008-08-26
申请号：US10876278
申请日：2004-06-24
申请人： Holger Klapproth , Mirko Lehmann
发明人： Holger Klapproth , Mirko Lehmann
IPC分类号： G01N35/08 , G01N1/00 , G01N33/53 , B01L3/00 , A61L2/00 , A61L9/00
CPC分类号： B01L3/0262 , B01J19/0046 , B01J2219/00382 , B01J2219/00385 , B01J2219/00527 , B01J2219/00585 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/0072 , B01L3/5025 , B01L3/50857 , B01L2300/069 , B01L2300/0819 , B01L2400/022 , B01L2400/0406 , C40B60/14 , Y10T436/117497 , Y10T436/25
摘要： In a method for the manufacture of a microarray, surface areas of a chip are brought into contact with different aqueous solutions that contain at least one coating substance. For each of the individual surface areas, an absorbent substrate is provided and is filled with the solution that is to be brought into contact with the surface area in question. Then, for the printing of the surface area with the at least one coating substance contained in the solution, each substrate is brought into contact with the surface area in question.
摘要翻译：在制造微阵列的方法中，芯片的表面积与含有至少一种涂层物质的不同水溶液接触。对于每个单独的表面区域，提供吸收性基材，并填充与所述表面区域接触的溶液。然后，为了用包含在溶液中的至少一种涂布物质印刷表面积，使每个基板与所讨论的表面区域接触。

10. 发明申请

US20050106587A1 Method for determining of nucleic acid analytes 审中-公开
标题翻译：核酸分析物测定方法
公开(公告)号：US20050106587A1
公开(公告)日：2005-05-19
申请号：US10870986
申请日：2004-06-21
申请人： Holger Klapproth , Mirko Lehmann
发明人： Holger Klapproth , Mirko Lehmann
IPC分类号： C12Q1/68 , C40B40/06 , C40B60/14 , G01N27/414
CPC分类号： C12Q1/6825 , B01J2219/00317 , B01J2219/00495 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , C40B40/06 , C40B60/14 , G01N27/414 , C12Q2563/167
摘要： The present invention concerns generally a method as well as an apparatus for the determination of nucleic acid analytes. In particular, the present invention concerns the detection of the presence of such analytes without the conventional use of optically detectable marker substances.
摘要翻译：本发明一般涉及一种用于测定核酸分析物的方法以及装置。特别地，本发明涉及检测这种分析物的存在，而不常规使用光学可检测的标记物质。

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