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21. 发明授权

US06999821B2 Body implantable lead including one or more conductive polymer electrodes and methods for fabricating same 失效
标题翻译：包括一个或多个导电聚合物电极的主体可植入引线及其制造方法
公开(公告)号：US06999821B2
公开(公告)日：2006-02-14
申请号：US10052776
申请日：2002-01-18
申请人： Christopher R. Jenney , Sheldon Williams
发明人： Christopher R. Jenney , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0563 , A61N2001/0585
摘要： A body implantable lead comprises a lead body including a conductive polymer electrode disposed along a distal end portion of the lead body for performing one or more of the functions consisting of pacing, sensing, cardioversion and defibrillation. An electrical conductor, preferably in the form of a multistrand cable conductor, couples the conductive polymer electrode with a proximal end of the lead body. The conductive polymer electrode encapsulates the conductor and is in electrical contact therewith along the length, and preferably along substantially the entire length, of the conductive polymer electrode. The lead body may comprise a multilumen polymer housing, the conductor being contained within one of the lumens of the housing. The conductive polymer electrode may be disposed within a window formed in the lead body. Alternatively, the conductive polymer electrode may comprise multiple electrode sections within a corresponding number of windows formed in the lead body and spaced apart along the length thereof. Further, the window and the conductive polymer electrode disposed therein may extend helically about the lead body. Because of its flexibility and because it can have a small diameter, the lead of the invention is particularly advantageous for implantation in the small, tortuous vessels of the coronary sinus region of the heart for left side stimulation and/or sensing.Methods of fabricating lead bodies incorporating conductive polymer electrodes are also disclosed.
摘要翻译：身体可植入引线包括引线主体，引线主体包括沿着引线主体的远端部分设置的导电聚合物电极，用于执行由起搏，感应，复律和除颤组成的一个或多个功能。优选以多股电缆导体形式的电导体将导电聚合物电极与引线主体的近端耦合。导电聚合物电极封装导体，并与导电聚合物电极的长度，优选沿着整个长度进行电接触。引线体可以包括多腔聚合物壳体，导体被容纳在壳体的一个腔内。导电聚合物电极可以设置在形成在引线体内的窗口内。或者，导电聚合物电极可以包括形成在引线主体中并沿着其长度间隔开的相应数量的窗口内的多个电极部分。此外，设置在其中的窗口和导电聚合物电极可以围绕引线体螺旋地延伸。由于其灵活性并且由于其可以具有小的直径，本发明的引线对于植入用于左侧刺激和/或感测的心脏的冠状窦区域的小的曲折血管中是特别有利的。

22. 发明申请

US20110202105A1 BIOELECTRIC BATTERY FOR IMPLANTABLE DEVICE APPLICATIONS 有权
标题翻译：用于可植入器件应用的BIOELECTRIC BATTERY
公开(公告)号：US20110202105A1
公开(公告)日：2011-08-18
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： A61N1/362 , H01M8/16
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

23. 发明授权

US07899555B2 Intrapericardial lead 有权
标题翻译：心包积液
公开(公告)号：US07899555B2
公开(公告)日：2011-03-01
申请号：US11691335
申请日：2007-03-26
申请人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
发明人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/059 , A61N1/057 , A61N1/0587 , A61N2001/058
摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the percaridal space to anchor the distal end portion of the lead body relative to the pericardial tissue.
摘要翻译：心包内引线包括具有近端部分和柔性的预弯曲远端部分的引线体。远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。导线部件在输送到大面积空间之后，再膨胀至其正常状态，以相对于心包组织锚固引线主体的远端部分。

24. 发明授权

US06968237B2 Implantable coronary sinus lead and lead system 失效
标题翻译：植入性冠状动脉窦引导系统
公开(公告)号：US06968237B2
公开(公告)日：2005-11-22
申请号：US10154893
申请日：2002-05-22
申请人： Phong D. Doan , Kevin L. Morgan , John R. Helland , Sheldon Williams , Kerwyn Schimke , Christopher R. Jenney
发明人： Phong D. Doan , Kevin L. Morgan , John R. Helland , Sheldon Williams , Kerwyn Schimke , Christopher R. Jenney
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An implantable stimulation lead is disclosed for placement in the coronary sinus region and its associated coronary vessels overlying the left side of a patient's heart. The lead comprises at least one proximal connector; at least one tissue stimulation electrode; at least one conductor coupled between the at least one proximal connector and the at least one stimulation electrode; and a lead body including a housing of insulating material enclosing the at least one conductor, the lead body having a relatively flexible distal portion of, for example, silicone rubber, having a length corresponding to the coronary sinus region of the heart, and a stiffer proximal portion of, for example, polyurethane. A robust transition joint comprising telescoped sections of the distal and proximal portions of the lead body couples the two portions of the lead body.Also provided is a versatile lead delivery system including a stylet stop disposed within the distal portion of the lead body. The stylet stop defines an aperture dimensioned to pass a guide wire but not the enlarged distal tip of a stylet. The lead includes a tip electrode having a longitudinally extending bore dimensioned to permit passage of the guide wire through the tip electrode.
摘要翻译：公开了一种植入式刺激引线，用于放置在冠状窦区及其相关联的冠状动脉血管，其覆盖在患者心脏的左侧。引线包括至少一个近端连接器; 至少一个组织刺激电极; 耦合在所述至少一个近端连接器和所述至少一个刺激电极之间的至少一个导体; 以及引线体，其包括围绕所述至少一个导体的绝缘材料的外壳，所述引线主体具有例如硅橡胶的相对柔性的远端部分，其长度对应于心脏的冠状窦区域，并且较硬例如聚氨酯的近端部分。包括引导体的远侧和近端部分的伸缩部分的鲁棒的过渡接头将引线体的两个部分相互连接。还提供了一种多功能引线输送系统，其包括设置在引线主体的远端部分内的探针止动器。探针止动器限定了通过导丝而不是通孔的扩大的远端的尺寸的孔。引线包括具有纵向延伸的孔的尖端电极，其尺寸允许引导线通过尖端电极。

25. 发明申请

US20050080471A1 Lead body construction 审中-公开
标题翻译：铅体结构
公开(公告)号：US20050080471A1
公开(公告)日：2005-04-14
申请号：US10652996
申请日：2003-08-28
申请人： Yougandh Chitre , Gene Bornzin , Sheldon Williams
发明人： Yougandh Chitre , Gene Bornzin , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An implantable cardiac stimulation lead system for use with a stimulation device includes a lead body preferably having an outer diameter of less than 4 French and formed of a biocompatible material having a Young's modulus of at least 20,000 pounds per square inch. In the lead body, an inner insulator is composed of a suitable polymer such as PTFE or ETFE with an outer peripheral surface formed with a helical groove containing a conductor extending between a proximal connector and a distal tip electrode, and an outer insulator composed of polyurethane or silicone rubber or a combination thereof is positioned around the inner insulator. The lead system may be formed with a lumen for receiving a guidewire longitudinally through the lead body. A pair of insulated conductors may be received in the helical groove, one extending to the distal tip electrode, the other extending to a ring electrode proximally spaced from the distal tip electrode.
摘要翻译：用于刺激装置的可植入心脏刺激引导系统包括优选具有小于4 French的外径的引线体，并且由具有至少20,000磅/平方英寸的杨氏模量的生物相容性材料形成。在引线体中，内绝缘体由诸如PTFE或ETFE的合适的聚合物构成，外周表面形成有包含在近端连接器和远端末端电极之间延伸的导体的螺旋槽，以及由聚氨酯或硅橡胶或其组合位于内绝缘体周围。引导系统可以形成有用于纵向地通过引线主体接收导丝的内腔。一对绝缘导体可以容纳在螺旋槽中，一个延伸到远端尖端电极，另一对延伸到与远侧末端电极间隔开的环状电极。

26. 发明授权

US08709631B1 Bioelectric battery for implantable device applications 有权
标题翻译：用于植入式设备应用的生物电池
公开(公告)号：US08709631B1
公开(公告)日：2014-04-29
申请号：US11737307
申请日：2007-04-19
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： H01M4/00 , H01M8/16
CPC分类号： A61N1/362 , A61N1/378 , H01M4/466 , H01M4/92 , H01M12/06 , H01M2220/30 , Y02E60/50
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

27. 发明授权

US08574737B2 Bioelectric battery for implantable device applications 有权
标题翻译：用于植入式设备应用的生物电池
公开(公告)号：US08574737B2
公开(公告)日：2013-11-05
申请号：US13018140
申请日：2011-01-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore , Sheldon Williams , Weiqun Yang , Taraneh Ghaffari Farazi
IPC分类号： H01M4/00 , H01M8/16 , H01M4/02 , H01M2/16
CPC分类号： A61N1/378 , H01M2/0275 , H01M2/1066 , H01M2/1653 , H01M2/18 , H01M2/361 , H01M4/12 , H01M4/366 , H01M4/48
摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.
摘要翻译：生物电池可用于为可植入装置供电。生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得管为阴极提供支撑。生物电池还可以具有围绕阴极的膜以减少组织包封。或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。电解质设置在可渗透膜内，并且网围绕可渗透膜。在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

28. 发明授权

US07949411B1 Epicardial lead 有权
标题翻译：心外膜导联
公开(公告)号：US07949411B1
公开(公告)日：2011-05-24
申请号：US11626132
申请日：2007-01-23
申请人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
发明人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/057
摘要： Embodiments include electrical leads and methods of using electrical leads that may be used for delivering both cardioversion/defibrillation signals and pacing signals and sensing to target tissue. Some of these embodiments may also be used to sense and transmit electrical signals from target tissue. Some electrical lead embodiments are configured to be delivered into a patient's intrapericardial space by non-invasive methods.
摘要翻译：实施例包括电引线和使用电引线的方法，其可以用于将心律转复/除颤信号和起搏信号以及感测传送到目标组织。这些实施例中的一些也可以用于感测和传输来自目标组织的电信号。一些电引线实施例被配置为通过非侵入性方法递送到患者的心包内空间。

29. 发明授权

US07881810B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US07881810B1
公开(公告)日：2011-02-01
申请号：US11753484
申请日：2007-05-24
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/05
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.
摘要翻译：可以通过心脏的心包空间访问心脏的腔室或脉管系统。最初，心包空间可以通过心肌的方法或亚型的方法进行。因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

30. 发明授权

US07231259B2 Body implantable lead comprising electrically conductive polymer conductors 有权
标题翻译：主体可植入引线包括导电聚合物导体
公开(公告)号：US07231259B2
公开(公告)日：2007-06-12
申请号：US10264687
申请日：2002-10-04
申请人： Christopher R. Jenney , Sheldon Williams
发明人： Christopher R. Jenney , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： A body implantable lead includes a lead body comprising an insulative housing containing at least one conductive polymer conductor terminating within a distal end portion of the lead body at an electrode structure carried by the distal end portion of the lead body. The electrode structure is positioned to contact body tissue to be electrically stimulated and/or sensed. The electrode structure electrically communicates with the at least one conductive polymer conductor by means of an electrically conductive interconnect penetrating the at least one conductive polymer conductor. The at least one conductive polymer conductor terminates within a proximal end portion of the lead body at a terminal contact adapted to be electrically connected to an electrically stimulating/sensing medical device.Also disclosed are connector assembly, tip electrode and ring electrode structures adapted to be coupled to an implantable lead body containing a conductive polymer conductor.
摘要翻译：主体可植入引线包括引线主体，引线主体包括绝缘壳体，该绝缘壳体包含至少一个导电聚合物导体，该导电聚合物导体在引线主体的远端部分承载的电极结构处终止于引线主体的远端部分内。电极结构定位成接触身体组织以进行电刺激和/或感测。电极结构通过穿透至少一个导电聚合物导体的导电互连与至少一个导电聚合物导体电连通。所述至少一个导电聚合物导体在适于电连接到电刺激/感测医疗装置的端子触头处终止于引线主体的近端部分内。还公开了连接器组件，尖端电极和环形电极结构，其适于耦合到包含导电聚合物导体的可植入引线体。

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