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1. 发明授权

US06999821B2 Body implantable lead including one or more conductive polymer electrodes and methods for fabricating same 失效
标题翻译：包括一个或多个导电聚合物电极的主体可植入引线及其制造方法
公开(公告)号：US06999821B2
公开(公告)日：2006-02-14
申请号：US10052776
申请日：2002-01-18
申请人： Christopher R. Jenney , Sheldon Williams
发明人： Christopher R. Jenney , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0563 , A61N2001/0585
摘要： A body implantable lead comprises a lead body including a conductive polymer electrode disposed along a distal end portion of the lead body for performing one or more of the functions consisting of pacing, sensing, cardioversion and defibrillation. An electrical conductor, preferably in the form of a multistrand cable conductor, couples the conductive polymer electrode with a proximal end of the lead body. The conductive polymer electrode encapsulates the conductor and is in electrical contact therewith along the length, and preferably along substantially the entire length, of the conductive polymer electrode. The lead body may comprise a multilumen polymer housing, the conductor being contained within one of the lumens of the housing. The conductive polymer electrode may be disposed within a window formed in the lead body. Alternatively, the conductive polymer electrode may comprise multiple electrode sections within a corresponding number of windows formed in the lead body and spaced apart along the length thereof. Further, the window and the conductive polymer electrode disposed therein may extend helically about the lead body. Because of its flexibility and because it can have a small diameter, the lead of the invention is particularly advantageous for implantation in the small, tortuous vessels of the coronary sinus region of the heart for left side stimulation and/or sensing.Methods of fabricating lead bodies incorporating conductive polymer electrodes are also disclosed.
摘要翻译：身体可植入引线包括引线主体，引线主体包括沿着引线主体的远端部分设置的导电聚合物电极，用于执行由起搏，感应，复律和除颤组成的一个或多个功能。优选以多股电缆导体形式的电导体将导电聚合物电极与引线主体的近端耦合。导电聚合物电极封装导体，并与导电聚合物电极的长度，优选沿着整个长度进行电接触。引线体可以包括多腔聚合物壳体，导体被容纳在壳体的一个腔内。导电聚合物电极可以设置在形成在引线体内的窗口内。或者，导电聚合物电极可以包括形成在引线主体中并沿着其长度间隔开的相应数量的窗口内的多个电极部分。此外，设置在其中的窗口和导电聚合物电极可以围绕引线体螺旋地延伸。由于其灵活性并且由于其可以具有小的直径，本发明的引线对于植入用于左侧刺激和/或感测的心脏的冠状窦区域的小的曲折血管中是特别有利的。

2. 发明授权

US06968237B2 Implantable coronary sinus lead and lead system 失效
标题翻译：植入性冠状动脉窦引导系统
公开(公告)号：US06968237B2
公开(公告)日：2005-11-22
申请号：US10154893
申请日：2002-05-22
申请人： Phong D. Doan , Kevin L. Morgan , John R. Helland , Sheldon Williams , Kerwyn Schimke , Christopher R. Jenney
发明人： Phong D. Doan , Kevin L. Morgan , John R. Helland , Sheldon Williams , Kerwyn Schimke , Christopher R. Jenney
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An implantable stimulation lead is disclosed for placement in the coronary sinus region and its associated coronary vessels overlying the left side of a patient's heart. The lead comprises at least one proximal connector; at least one tissue stimulation electrode; at least one conductor coupled between the at least one proximal connector and the at least one stimulation electrode; and a lead body including a housing of insulating material enclosing the at least one conductor, the lead body having a relatively flexible distal portion of, for example, silicone rubber, having a length corresponding to the coronary sinus region of the heart, and a stiffer proximal portion of, for example, polyurethane. A robust transition joint comprising telescoped sections of the distal and proximal portions of the lead body couples the two portions of the lead body.Also provided is a versatile lead delivery system including a stylet stop disposed within the distal portion of the lead body. The stylet stop defines an aperture dimensioned to pass a guide wire but not the enlarged distal tip of a stylet. The lead includes a tip electrode having a longitudinally extending bore dimensioned to permit passage of the guide wire through the tip electrode.
摘要翻译：公开了一种植入式刺激引线，用于放置在冠状窦区及其相关联的冠状动脉血管，其覆盖在患者心脏的左侧。引线包括至少一个近端连接器; 至少一个组织刺激电极; 耦合在所述至少一个近端连接器和所述至少一个刺激电极之间的至少一个导体; 以及引线体，其包括围绕所述至少一个导体的绝缘材料的外壳，所述引线主体具有例如硅橡胶的相对柔性的远端部分，其长度对应于心脏的冠状窦区域，并且较硬例如聚氨酯的近端部分。包括引导体的远侧和近端部分的伸缩部分的鲁棒的过渡接头将引线体的两个部分相互连接。还提供了一种多功能引线输送系统，其包括设置在引线主体的远端部分内的探针止动器。探针止动器限定了通过导丝而不是通孔的扩大的远端的尺寸的孔。引线包括具有纵向延伸的孔的尖端电极，其尺寸允许引导线通过尖端电极。

3. 发明授权

US07231259B2 Body implantable lead comprising electrically conductive polymer conductors 有权
标题翻译：主体可植入引线包括导电聚合物导体
公开(公告)号：US07231259B2
公开(公告)日：2007-06-12
申请号：US10264687
申请日：2002-10-04
申请人： Christopher R. Jenney , Sheldon Williams
发明人： Christopher R. Jenney , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： A body implantable lead includes a lead body comprising an insulative housing containing at least one conductive polymer conductor terminating within a distal end portion of the lead body at an electrode structure carried by the distal end portion of the lead body. The electrode structure is positioned to contact body tissue to be electrically stimulated and/or sensed. The electrode structure electrically communicates with the at least one conductive polymer conductor by means of an electrically conductive interconnect penetrating the at least one conductive polymer conductor. The at least one conductive polymer conductor terminates within a proximal end portion of the lead body at a terminal contact adapted to be electrically connected to an electrically stimulating/sensing medical device.Also disclosed are connector assembly, tip electrode and ring electrode structures adapted to be coupled to an implantable lead body containing a conductive polymer conductor.
摘要翻译：主体可植入引线包括引线主体，引线主体包括绝缘壳体，该绝缘壳体包含至少一个导电聚合物导体，该导电聚合物导体在引线主体的远端部分承载的电极结构处终止于引线主体的远端部分内。电极结构定位成接触身体组织以进行电刺激和/或感测。电极结构通过穿透至少一个导电聚合物导体的导电互连与至少一个导电聚合物导体电连通。所述至少一个导电聚合物导体在适于电连接到电刺激/感测医疗装置的端子触头处终止于引线主体的近端部分内。还公开了连接器组件，尖端电极和环形电极结构，其适于耦合到包含导电聚合物导体的可植入引线体。

4. 发明授权

US06456890B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456890B2
公开(公告)日：2002-09-24
申请号：US09797531
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N100
CPC分类号： A61N1/056
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multi-lumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多腔管沿着导丝线前进，直到达到所需的位置，导线从主体和多管腔管中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

5. 发明授权

US06456889B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456889B2
公开(公告)日：2002-09-24
申请号：US09797281
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N1100
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multilumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多根管沿引导线前进，直到达到所需的位置，导线从主体和多管腔中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

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