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21. 发明授权

US06322965B1 Chimera antigen peptide 失效
标题翻译：嵌合抗原肽
公开(公告)号：US06322965B1
公开(公告)日：2001-11-27
申请号：US09020846
申请日：1998-02-09
申请人： Kenjiro Yamaguchi , Tomiko Kashiwakuma , Yukie Chiba , Shintaro Yagi , Akira Hasegawa
发明人： Kenjiro Yamaguchi , Tomiko Kashiwakuma , Yukie Chiba , Shintaro Yagi , Akira Hasegawa
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2770/24222 , Y10S436/811 , Y10S436/82 , Y10S530/806 , Y10S530/826
摘要： A chimera antigen peptide containing the epitope regions in the core region, the NS3 region, and the NS4 region of the HCV polypeptide. A sensitive detection of a wide range of infection by hepatitis C virus (HCV) can be carried out.
摘要翻译：含有HCV多核苷酸核心区域，NS3区域和NS4区域中的表位区域的嵌合抗原肽。可以进行丙型肝炎病毒（HCV）的广泛感染的敏感检测。

22. 发明授权

US5871904A Immunassay of non-A, non-B hepatitis virus-related antigens, monoclonal antibodies for use therein, and hybridomas producing the antibodies 失效
标题翻译：非A型非乙型肝炎病毒相关抗原的免疫测定，用于其中的单克隆抗体和产生抗体的杂交瘤
公开(公告)号：US5871904A
公开(公告)日：1999-02-16
申请号：US501195
申请日：1995-07-11
申请人： Tomiko Kashiwakuma , Shintaro Yagi , Akira Hasegawa , Tadahiro Kajita , Yohsuke Ohta , Hiroyuki Mori
发明人： Tomiko Kashiwakuma , Shintaro Yagi , Akira Hasegawa , Tadahiro Kajita , Yohsuke Ohta , Hiroyuki Mori
IPC分类号： G01N33/53 , C07K14/18 , C07K16/10 , C12N5/10 , C12N5/20 , C12P21/08 , G01N33/576 , G01N33/577 , C12Q1/70 , C07K16/08 , C12N5/12
CPC分类号： C07K14/005 , C07K16/10 , C12N2770/24222
摘要： This invention concerns a monoclonal antibody having binding specificity for an antigenic determinant site on core structural protein from Non-A,Non-B hepatitis virus (NANBV); a hybridoma cell line capable of producing the monoclonal antibody; a process for the preparation of the monoclonal antibody; an immunoassay of NANBV-related antigens by use of the monoclonal antibody; and a test kit for use in the immunoassay. The preferred monoclonal antibody is 5E3, 5F11, 515S or 1080S. The monoclonal antibody can specifically recognize the NANBV core structural protein in sera from patients with Non-A,Non-B hepatitis thereby being served extensively as an antibody in various immunological reagents for definitive diagnosis of Non-A, Non-B hepatitis.
摘要翻译：本发明涉及对来自非A非乙型肝炎病毒（NANBV）的核心结构蛋白上的抗原决定簇位点具有结合特异性的单克隆抗体; 能够产生单克隆抗体的杂交瘤细胞系; 一种制备单克隆抗体的方法; 通过使用单克隆抗体对NANBV相关抗原的免疫测定; 和用于免疫测定的测试试剂盒。优选的单克隆抗体是5E3,5F11,515S或1080S。单克隆抗体可以特异性识别来自非A型非乙型肝炎患者的血清中的NANBV核心结构蛋白，从而作为用于非A型非乙型肝炎确定诊断的各种免疫试剂中的抗体作为抗体。

23. 发明授权

US5567684A Synthetic ganglioside derivatives 失效
标题翻译：合成神经节苷脂衍生物
公开(公告)号：US5567684A
公开(公告)日：1996-10-22
申请号：US305832
申请日：1994-09-14
申请人： Stephan Ladisch , Akira Hasegawa
发明人： Stephan Ladisch , Akira Hasegawa
IPC分类号： A61K31/70 , A61K31/7028 , A61P37/06 , C07H3/06 , C07H15/10 , C08B37/00
CPC分类号： C07H15/10 , C07H3/06
摘要： Synthetic compounds which are useful for suppressing an immune response are disclosed. The synthetic compounds have the formula ##STR1## wherein A is a carbohydrate moiety which corresponds to the carbohydrate moiety of a naturally occurring ganglioside, n is 5 to 20 and m is to 20. Also presented are methods for suppressing an immune response in an animal and compositions of matter employing the compounds as shown above.
摘要翻译：公开了可用于抑制免疫应答的合成化合物。合成化合物具有式“IMAGE”，其中A是对应于天然存在的神经节苷脂的碳水化合物部分的碳水化合物部分，n为5至20，m为20.还提供了抑制动物免疫应答的方法和使用上述化合物的物质组成。

24. 发明授权

US5371202A Processes of preparing sialoglycosyl compounds 失效
标题翻译：制备唾液酸糖基化合物的方法
公开(公告)号：US5371202A
公开(公告)日：1994-12-06
申请号：US833794
申请日：1992-02-12
申请人： Akira Hasegawa
发明人： Akira Hasegawa
IPC分类号： C07H1/00 , C07H3/06 , C07H5/10 , C07H13/04 , C07H13/08 , C07H15/18 , C07H23/00
CPC分类号： C07H13/04 , C07H13/08 , C07H15/18 , C07H23/00 , C07H3/06
摘要： An improved process for the preparation of O-glycosyl compounds of sialic acid, which are useful as intermediates in the synthesis of sialoconjugated glycosides. This process comprises effecting condensation reaction between thioglycosides of sialic acid and sugar derivatives in the presence of N-iodosuccinimide and trifluoromethanesulfonic acid. O-glycosyl compounds of sialic acid are prepared in high resio- and stereo-selectivity and in high yields.
摘要翻译：一种用于制备唾液酸O-糖基化合物的改进方法，其可用作合成唾液酸糖苷的中间体。该方法包括在N-碘代琥珀酰亚胺和三氟甲磺酸的存在下进行唾液酸的硫代糖苷与糖衍生物之间的缩合反应。唾液酸的O-糖基化合物以高回收率和立体选择性和高产率制备。

25. 发明授权

US5280151A Method and apparatus for drying beltlike article, and induction heater having rotary drums 失效
标题翻译：用于干燥带状制品的方法和装置，以及具有旋转鼓的感应加热器
公开(公告)号：US5280151A
公开(公告)日：1994-01-18
申请号：US666379
申请日：1991-03-08
申请人： Tetsuo Matsunaga , Shunji Miyamoto , Tadahiro Takamatsu , Akira Hasegawa
发明人： Tetsuo Matsunaga , Shunji Miyamoto , Tadahiro Takamatsu , Akira Hasegawa
IPC分类号： F26B13/08 , F26B3/347 , F26B13/00 , F26B13/18 , F26B23/08 , H05B6/14 , H05B6/64
CPC分类号： F26B13/004 , F26B13/183 , F26B3/347
摘要： In drying a beltlike article such as a slide fastener tape by high-frequency induction heating, the tape is wound on the outer circumferential surface of a rotary drum heated from inside while rotating. An induction heating coil is mounted on the outer circumferential surface of a stationary drum, as an inner drum, with a gap with the inner circumferential surface of the rotary drum. The rotary drum is supported at one end by a rotary shaft via an adiabatic material. The stationary inner drum is made of a metal plate having a high heat conductivity for facilitating heat radiation of the heating coil, while the rotary drum is made of a cladding plate including iron and copper plates in combination.
摘要翻译：在通过高频感应加热干燥诸如拉链带的带状制品时，将带卷绕在从内部加热旋转的滚筒的外周表面上，同时旋转。感应加热线圈安装在作为内滚筒的固定滚筒的外圆周表面上，与旋转滚筒的内圆周表面间隙。旋转鼓通过绝热材料由旋转轴在一端支撑。固定内筒由具有高导热性的金属板制成，用于促进加热线圈的热辐射，同时旋转鼓由包括铁和铜板的包层板组合而成。

26. 发明授权

US5254604A Light polymerizable resin compositions for the preparation of clasp patterns 失效
标题翻译：用于制备扣钩图案的光聚合树脂组合物
公开(公告)号：US5254604A
公开(公告)日：1993-10-19
申请号：US807655
申请日：1991-12-16
申请人： Hiroshi Mori , Tatsuhiko Takahashi , Akira Hasegawa
发明人： Hiroshi Mori , Tatsuhiko Takahashi , Akira Hasegawa
IPC分类号： A61K6/083 , C08F2/46 , C08F2/48 , G08F2/46
CPC分类号： A61K6/083 , C08F2/48 , Y10S522/908
摘要： A light-polymerizable resin composition for the preparation of clasp patterns comprises (a) a light-polymerizable compound having at least one ethylenically unsaturated double bond, (b) an organic filler material, (c) a light polymerization initiator and (d) a reducing agent. The light-polymerizable compound is solid at normal temperature, and may be a mono- or polyfunctional acrylate or methacrylate.
摘要翻译：用于制备钩扣图案的可光聚合树脂组合物包括（a）具有至少一个烯键式不饱和双键的可光聚合化合物，（b）有机填料，（c）光聚合引发剂和（d）还原剂。光聚合性化合物在常温下为固体，可以是单官能或多官能的丙烯酸酯或甲基丙烯酸酯。

27. 发明授权

US5250641A Curing of dental resin 失效
标题翻译：牙科树脂固化
公开(公告)号：US5250641A
公开(公告)日：1993-10-05
申请号：US863416
申请日：1992-04-03
申请人： Tomohiro Kumagai , Akira Hasegawa
发明人： Tomohiro Kumagai , Akira Hasegawa
IPC分类号： A61K6/083 , C08F2/44 , C08F4/00 , C08F4/42 , C08F4/44 , C08F120/18
CPC分类号： A61K6/083 , C08F4/00
摘要： A method of curing dental resin according to this invention is characterized by adding a morpholine derivative to a conventional curing process, more particularly, the dental resin is cured by polymerizing (1) a polymerizable compound having at least one ethylenically unsaturated double bond in the presence of (2) a morpholine derivative, (3) 1-cyclohexyl-5-ethylpyrimidinetrione, (4) an organometal compound and (5) an organohalogen compound, in which the self-polymerizing dental resin is polymerized or cured more rapidly than is possible with the conventional process and without detriment to its transparency, color tone stability and physical properties.
摘要翻译：根据本发明的固化牙科用树脂的方法的特征在于向常规固化方法中加入吗啉衍生物，更具体地说，通过在（1）具有至少一个烯属不饱和双键的聚合性化合物的存在的（2）吗啉衍生物，（3）1-环己基-5-乙基嘧啶四酮，（4）有机金属化合物和（5）有机卤素化合物，其中自聚合牙科树脂比可能的更快地聚合或固化具有常规方法，并且不损害其透明度，色调稳定性和物理性质。

28. 发明授权

US5246360A Green tire charging apparatus for a tire vulcanizing machine 失效
标题翻译：轮胎硫化机的绿色轮胎充气装置
公开(公告)号：US5246360A
公开(公告)日：1993-09-21
申请号：US987566
申请日：1992-12-08
申请人： Toshifumi Murakami , Akira Hasegawa
发明人： Toshifumi Murakami , Akira Hasegawa
IPC分类号： B29D30/06
CPC分类号： B29D30/0603
摘要： In a green tire charging apparatus for a tire vulcanizing machine according to the present invention, provision is made such that a vertically movable chuck body is inserted into a tire, chuck segments which are synchronously slidable in the radial direction are expanded to concentrically hold an upper bead portion by upper projections of centering rods, the chuck body is raised to insert the upper bead portion into an upper bead ring of a metal mold, subsequently the upper bead portion is held by holder arms of holders, the chuck body is lowered to hold a lower bead portion of the tire by lower projections of the centering rods, and the lower bead portion is inserted into a lower bead ring of the metal mold. Owing to the above-mentioned the upper and lower bead portion of provision, even a deformed green tire can be surely set on the upper and lower bead rings, respectively, of the metal mold.
摘要翻译：在本发明的轮胎硫化机的生轮胎充气装置中，设置将可升降的卡盘体插入轮胎中，将沿径向同步滑动的卡盘片段扩大成同心地保持上部胎圈部分通过定中心杆的上突起，卡盘体被升起以将上胎圈部分插入到金属模具的上胎圈环中，随后上胎圈部分由保持器的保持臂保持，卡盘体下降以保持轮胎的下部胎圈部分通过定心杆的下突出部分，并且下胎圈部分插入到金属模具的下胎圈环中。由于上述设置的上胎圈部分和下胎圈部分，即使变形的生胎也可以分别设置在金属模具的上和下胎圈环上。

29. 发明授权

US5191072A Lipid A monosaccharide analogues 失效
标题翻译：脂肪单糖类似物
公开(公告)号：US5191072A
公开(公告)日：1993-03-02
申请号：US689770
申请日：1991-07-17
申请人： Akira Hasegawa , Makoto Kiso , Shinichi Uesato , Masanobu Suzuki , Tomio Ishida , Yutaka Saito
发明人： Akira Hasegawa , Makoto Kiso , Shinichi Uesato , Masanobu Suzuki , Tomio Ishida , Yutaka Saito
IPC分类号： A61K31/665 , A61K31/70 , A61K31/7024 , A61P35/00 , A61P37/04 , C07F9/655 , C07H13/06
CPC分类号： C07H13/06 , C07F9/6552 , Y02P20/55
摘要： Lipid A monosaccharide analogues of the following general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a hydroxyl group, 1 is an integer of 8-14, m is an integer of 11-17 integer, and n is 8-14 integer.

30. 发明授权

US5175650A Objective lens system for endoscopes 失效
标题翻译：内窥镜物镜系统
公开(公告)号：US5175650A
公开(公告)日：1992-12-29
申请号：US520501
申请日：1990-05-08
申请人： Toshikazu Takayama , Akira Hasegawa , Hiroyuki Fukuda
发明人： Toshikazu Takayama , Akira Hasegawa , Hiroyuki Fukuda
IPC分类号： G02B23/24
CPC分类号： G02B23/243
摘要： An objective optical system for endoscopes comprising, in the order from the object side, a front negative lens unit, an aperture stop, a positive lens unit comprising at least one positive lens component, and an infrared cut filter arranged immediately before said aperture stop, said objective optical system being adapted so as to allow rays to be incident on said filter at heights lower than the outside circumference of said filter.
摘要翻译：一种用于内窥镜的物镜光学系统，包括从物体侧开始的顺序为前置负透镜单元，孔径光阑，包括至少一个正透镜部件的正透镜单元和紧邻所述孔径光阑的红外截止滤光器，所述物镜光学系统被适配成允许射线在高于所述过滤器外周的高度入射到所述过滤器上。

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