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1. 发明授权

US5871904A Immunassay of non-A, non-B hepatitis virus-related antigens, monoclonal antibodies for use therein, and hybridomas producing the antibodies 失效
标题翻译：非A型非乙型肝炎病毒相关抗原的免疫测定，用于其中的单克隆抗体和产生抗体的杂交瘤
公开(公告)号：US5871904A
公开(公告)日：1999-02-16
申请号：US501195
申请日：1995-07-11
申请人： Tomiko Kashiwakuma , Shintaro Yagi , Akira Hasegawa , Tadahiro Kajita , Yohsuke Ohta , Hiroyuki Mori
发明人： Tomiko Kashiwakuma , Shintaro Yagi , Akira Hasegawa , Tadahiro Kajita , Yohsuke Ohta , Hiroyuki Mori
IPC分类号： G01N33/53 , C07K14/18 , C07K16/10 , C12N5/10 , C12N5/20 , C12P21/08 , G01N33/576 , G01N33/577 , C12Q1/70 , C07K16/08 , C12N5/12
CPC分类号： C07K14/005 , C07K16/10 , C12N2770/24222
摘要： This invention concerns a monoclonal antibody having binding specificity for an antigenic determinant site on core structural protein from Non-A,Non-B hepatitis virus (NANBV); a hybridoma cell line capable of producing the monoclonal antibody; a process for the preparation of the monoclonal antibody; an immunoassay of NANBV-related antigens by use of the monoclonal antibody; and a test kit for use in the immunoassay. The preferred monoclonal antibody is 5E3, 5F11, 515S or 1080S. The monoclonal antibody can specifically recognize the NANBV core structural protein in sera from patients with Non-A,Non-B hepatitis thereby being served extensively as an antibody in various immunological reagents for definitive diagnosis of Non-A, Non-B hepatitis.
摘要翻译：本发明涉及对来自非A非乙型肝炎病毒（NANBV）的核心结构蛋白上的抗原决定簇位点具有结合特异性的单克隆抗体; 能够产生单克隆抗体的杂交瘤细胞系; 一种制备单克隆抗体的方法; 通过使用单克隆抗体对NANBV相关抗原的免疫测定; 和用于免疫测定的测试试剂盒。优选的单克隆抗体是5E3,5F11,515S或1080S。单克隆抗体可以特异性识别来自非A型非乙型肝炎患者的血清中的NANBV核心结构蛋白，从而作为用于非A型非乙型肝炎确定诊断的各种免疫试剂中的抗体作为抗体。

2. 发明授权

US5767247A Anti-annexin-V monoclonal antibodies, and preparation and use thereof 失效
标题翻译：抗 - 膜联蛋白-V单克隆抗体及其制备和应用
公开(公告)号：US5767247A
公开(公告)日：1998-06-16
申请号：US669509
申请日：1996-10-22
申请人： Noboru Kaneko , Ryuko Matsuda , Tadahiro Kajita , Yohsuke Ohta
发明人： Noboru Kaneko , Ryuko Matsuda , Tadahiro Kajita , Yohsuke Ohta
IPC分类号： C07K16/18 , C12N15/06 , C12P21/08 , C07K16/28 , G01N33/53
CPC分类号： C07K16/18 , G01N2333/4718
摘要： Using human annexin-V or human annexin-V plus dog annexin-V as antigen(s), hybridoma cell lines are prepared which are capable of producing anti-annexin-V monoclonal antibodies having a binding specificity to antigenic determinant site on annexin-V as antigenic protein and belonging to immunoglobulin G class. By the hybridoma cell lines are produced the anti-annexin-V monoclonal antibodies, with which a diagnostic agent is provided for diagnosis of myocardial infarction and angina pectoris. There is also provided diagnosis of myocardial infarction and angina pectoris using a first and a second monoclonal antibodies produced by the hybridoma cell lines to quantitate human annexin-V in a sample, in which an antigen-antibody reaction on annexin-V in the sample is caused with the first anti-annexin-V monoclonal antibody to form an annexin-V antigen/anti-annexin-V monoclonal antibody complex, the antigenic site of annexin-V of the formed annexin-V antigen/annexin-V monoclonal antibody complex is allowed to be bound with a labeled anti-annexin-V polyclonal or second monoclonal antibody so as to form a labeled form of said annexin-V antigen/anti-annexin-V monoclonal antibody complex bound with the polyclonal or the second monoclonal antibody, and the labeled form of the complex is quantitatively analyzed.
摘要翻译： PCT No.PCT / JP95 / 02305 Sec。 371日期1996年10月22日第 102（e）日期1996年10月22日PCT 1995年11月10日PCT PCT。出版物WO96 / 15152 日期1996年5月23日使用人膜联蛋白-V或人膜联蛋白-V加狗膜联蛋白-V作为抗原，制备能够产生对抗原决定簇位点具有结合特异性的抗叶绿体-V单克隆抗体的杂交瘤细胞系对膜联蛋白-V作为抗原蛋白，属于免疫球蛋白G类。通过杂交瘤细胞系产生抗膜联蛋白-V单克隆抗体，通过该单克隆抗体提供用于诊断心肌梗塞和心绞痛的诊断剂。还提供使用由杂交瘤细胞系产生的第一和第二单克隆抗体来定量样品中的人膜联蛋白-V的心肌梗塞和心绞痛的诊断，其中样品中对膜联蛋白-V的抗原 - 抗体反应是由第一抗膜联蛋白-V单克隆抗体形成膜联蛋白-V抗原/抗 - 膜联蛋白-V单克隆抗体复合物，形成的膜联蛋白-V抗原/膜联蛋白-V单克隆抗体复合物的膜联蛋白-V的抗原位点是允许与标记的抗 - 膜联蛋白-V多克隆或第二单克隆抗体结合，以形成与多克隆或第二单克隆抗体结合的所述膜联蛋白-V抗原/抗 - 膜联蛋白-V单克隆抗体复合物的标记形式，以及定量分析复合物的标记形式。

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