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1. 发明授权

US07776542B1 Methods for the detection of hepatitis B and C viruses 有权
标题翻译：检测乙型和丙型肝炎病毒的方法
公开(公告)号：US07776542B1
公开(公告)日：2010-08-17
申请号：US09269897
申请日：1998-08-04
申请人： Katsumi Aoyagi , Chiharu Ohue , Kumiko Iida , Tatsuji Kimura , Shintaro Yagi
发明人： Katsumi Aoyagi , Chiharu Ohue , Kumiko Iida , Tatsuji Kimura , Shintaro Yagi
IPC分类号： G01N33/53 , G01N33/569 , G01N33/576
CPC分类号： G01N33/5767 , G01N33/56983 , G01N2333/02 , G01N2333/18
摘要： A method for treating a virus-containing sample, characterized by treatment of a virus-containing sample with a treatment solution containing (1) an anionic surfactant and (2) an amphoteric surfactant, nonionic surfactant or protein denaturant; a virus assay method using said treating method; a method for treating a virus-containing sample, characterized by treatment of a virus-containing sample with a treatment solution containing (1) a chaotropic ion and (2) an acidifying agent; a virus assay method using said treating method; a virus assay method, characterized in that a virus antigen and a virus antibody are measured based on their binding to their probe in the presence of a surfactant with an alkyl group of 10 or more carbon atoms and a secondary, tertiary or quaternary amine, or a nonionic surfactant, or of both of them; and a monoclonal antibody and a hybridoma producing the same for carrying out said method.
摘要翻译：一种治疗含病毒样品的方法，其特征在于用含有（1）阴离子表面活性剂和（2）两性表面活性剂，非离子表面活性剂或蛋白质变性剂的处理溶液处理病毒样品; 使用所述处理方法的病毒测定方法; 一种用于处理含病毒样品的方法，其特征在于用含有（1）离液序列离子的处理溶液和（2）酸化剂处理含有病毒的样品; 使用所述处理方法的病毒测定方法; 一种病毒测定方法，其特征在于，在具有10个或更多个碳原子的烷基和二级，三级或季胺的表面活性剂存在下，基于它们与它们的探针的结合来测量病毒抗原和病毒抗体，或非离子表面活性剂，或它们两者; 以及用于实施所述方法的单克隆抗体和产生其的杂交瘤。

2. 发明授权

US07323331B2 Method for detecting or assaying HBV 有权
标题翻译： HBV检测方法
公开(公告)号：US07323331B2
公开(公告)日：2008-01-29
申请号：US10343324
申请日：2001-08-10
申请人： Noboru Maki , Tatsuji Kimura , Yoko Oda , Shintaro Yagi
发明人： Noboru Maki , Tatsuji Kimura , Yoko Oda , Shintaro Yagi
IPC分类号： C12N5/00 , C12N5/06 , C12N5/12 , C12N5/18 , C12N5/20 , C12Q1/00 , C12Q1/70 , G01N33/53 , C07K16/08
CPC分类号： G01N33/5762 , C07K16/082
摘要： A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody that specifically binds to a specific site of core-related protein of hepatitis B virus.
摘要翻译：一种检测乙型肝炎病毒的方法以及试剂盒及其试剂，其包括使用特异性结合乙型肝炎病毒的磷酸盐缓冲液，例如特异性结合乙型肝炎核心相关蛋白质的特定位点的单克隆抗体病毒。

3. 发明授权

US06623921B2 Method for measurement of hepatitis C virus 有权
公开(公告)号：US06623921B2
公开(公告)日：2003-09-23
申请号：US10133007
申请日：2002-04-26
申请人： Katsumi Aoyagi , Chiharu Ohue , Kumiko Iida , Shintaro Yagi
发明人： Katsumi Aoyagi , Chiharu Ohue , Kumiko Iida , Shintaro Yagi
IPC分类号： C12Q170
CPC分类号： G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20 , Y10S435/962 , Y10T436/108331
摘要： A method for measurement of the hepatitis C virus (HCV) characterized by measuring HCV core antigen and HCV core antibody by their binding with probes in the presence of an anionic surfactant or a non-ionic surfactant, or both.

4. 发明授权

US08987232B2 Agent for ameliorating brain hypofunction 有权
标题翻译：改善脑功能减退症的药剂
公开(公告)号：US08987232B2
公开(公告)日：2015-03-24
申请号：US13035717
申请日：2011-02-25
申请人： Kunio Shiota , Masayoshi Kuwahara , Takefumi Kikusui , Shintaro Yagi
发明人： Kunio Shiota , Masayoshi Kuwahara , Takefumi Kikusui , Shintaro Yagi
IPC分类号： A61K31/7008 , C08B37/00 , A61P25/00 , A61P25/28
CPC分类号： A61K31/7008
摘要： Provided are effective and highly safe agents, medicaments and the like for ameliorating various disorders caused by brain hypofunction. Also provided is a preventing or ameliorating agent for brain hypofunction containing N-acetyl-D-mannosamine, a pharmaceutical composition for preventing, ameliorating or treating disorders due to brain hypofunction, containing an effective amount of N-acetyl-D-mannosamine and a pharmaceutically acceptable carrier, and a food comprising N-acetyl-D-mannosamine added thereto.
摘要翻译：提供了用于改善由脑功能不全引起的各种疾病的有效且高度安全的药剂，药物等。还提供了含有N-乙酰基-D-甘露糖胺的预防或改善剂，其用于预防，改善或治疗由于脑功能不全引起的疾病的药物组合物，其含有有效量的N-乙酰基-D-甘露糖胺和药学上可接受的载体和包含N-乙酰-D-甘露糖胺的食品。

5. 发明授权

US08893680B2 Intake valve of internal combustion engine 有权
标题翻译：内燃机进气阀
公开(公告)号：US08893680B2
公开(公告)日：2014-11-25
申请号：US13358048
申请日：2012-01-25
申请人： Shintaro Yagi
发明人： Shintaro Yagi
IPC分类号： F16K31/00
CPC分类号： F01L3/02 , B23P15/002 , F01L3/14 , Y10T29/49313
摘要： An intake valve of an internal combustion engine includes a valve body and a valve stem extending from a central portion of the valve body. The valve body includes a valve body framework portion and a valve body thick portion provided on an outer side of the valve body framework portion. The valve body framework portion and the valve stem are made of iron material and the valve body thick portion is made of aluminum alloy.
摘要翻译：内燃机的进气阀包括阀体和从阀体的中心部分延伸的阀杆。阀体包括阀体框架部分和设置在阀体框架部分的外侧上的阀体厚部。阀体框架部分和阀杆由铁材料制成，阀体厚部由铝合金制成。

6. 发明申请

US20110262892A1 METHODS FOR DETECTION OR MEASUREMENT OF VIRUSES 审中-公开
标题翻译：检测或测量病毒的方法
公开(公告)号：US20110262892A1
公开(公告)日：2011-10-27
申请号：US12349928
申请日：2009-01-07
申请人： Katsumi Aoyagi , Chiharu Ohue , Kumiko Iida , Tatsuji Kimura , Shintaro Yagi
发明人： Katsumi Aoyagi , Chiharu Ohue , Kumiko Iida , Tatsuji Kimura , Shintaro Yagi
IPC分类号： C12Q1/70 , C07K16/08
CPC分类号： G01N33/5767 , G01N33/56983 , G01N2333/02 , G01N2333/18
摘要： A method for treating a virus-containing sample, characterized by treatment of a virus-containing sample with a treatment solution containing (1) an anionic surfactant and (2) an amphoteric surfactant, nonionic surfactant or protein denaturant; a virus assay method using said treating method; a method for treating a virus-containing sample, characterized by treatment of a virus-containing sample with a treatment solution containing (1) a chaotropic ion and (2) an acidifying agent; a virus assay method using said treating method; a virus assay method, characterized in that a virus antigen and a virus antibody are measured based on their binding to their probe in the presence of a surfactant with an alkyl group of 10 or more carbon atoms and a secondary, tertiary or quaternary amine, or a nonionic surfactant, or of both of them; and a monoclonal antibody and a hybridoma producing the same for carrying out said method.
摘要翻译：一种治疗含病毒样品的方法，其特征在于用含有（1）阴离子表面活性剂和（2）两性表面活性剂，非离子表面活性剂或蛋白质变性剂的处理溶液处理含病毒样品; 使用所述处理方法的病毒测定方法; 一种用于处理含病毒样品的方法，其特征在于用含有（1）离液序列离子的处理溶液和（2）酸化剂处理含有病毒的样品; 使用所述处理方法的病毒测定方法; 一种病毒测定方法，其特征在于，在具有10个或更多个碳原子的烷基和二级，三级或季胺的表面活性剂存在下，基于它们与其探针的结合度来测量病毒抗原和病毒抗体，或非离子表面活性剂，或它们两者; 以及用于实施所述方法的单克隆抗体和产生其的杂交瘤。

7. 发明申请

US20110212917A1 AGENT FOR AMELIORATING BRAIN HYPOFUNCTION 有权
标题翻译：改善脑血压功能的药剂
公开(公告)号：US20110212917A1
公开(公告)日：2011-09-01
申请号：US13035717
申请日：2011-02-25
申请人： Kunio SHIOTA , Masayoshi KUWAHARA , Takefumi KIKUSUI , Shintaro YAGI
发明人： Kunio SHIOTA , Masayoshi KUWAHARA , Takefumi KIKUSUI , Shintaro YAGI
IPC分类号： A61K31/7008 , C08B37/00 , A61P25/00 , A61P25/28
CPC分类号： A61K31/7008
摘要： Provided are effective and highly safe agents, medicaments and the like for ameliorating various disorders caused by brain hypofunction. Also provided is a preventing or ameliorating agent for brain hypofunction containing N-acetyl-D-mannosamine, a pharmaceutical composition for preventing, ameliorating or treating disorders due to brain hypofunction, containing an effective amount of N-acetyl-D-mannosamine and a pharmaceutically acceptable carrier, and a food comprising N-acetyl-D-mannosamine added thereto.
摘要翻译：提供了用于改善由脑功能不全引起的各种疾病的有效且高度安全的药剂，药物等。还提供了含有N-乙酰基-D-甘露糖胺的预防或改善剂，其用于预防，改善或治疗由于脑功能不全引起的疾病的药物组合物，其含有有效量的N-乙酰基-D-甘露糖胺和药学上可接受的载体和包含N-乙酰-D-甘露糖胺的食品。

8. 发明授权

US07713532B2 HBV precore protein capable of forming particles 有权
标题翻译： HBV前蛋白能够形成颗粒
公开(公告)号：US07713532B2
公开(公告)日：2010-05-11
申请号：US10526744
申请日：2003-09-05
申请人： Noboru Maki , Tatsuji Kimura , Shintaro Yagi
发明人： Noboru Maki , Tatsuji Kimura , Shintaro Yagi
IPC分类号： A61K38/00
CPC分类号： C07K14/005 , A61K2039/5258 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , G01N33/5761
摘要： There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and virus-like particles formed by this HBV precore protein. These virus-like particles can be used for vaccines and therapeutic agents. The present invention also provides a method of determining the HBV precore protein and a method of determining the anti-HBV precore protein antibody.
摘要翻译：提供了具有形成颗粒的能力的HBV前核蛋白，以及用于确定它的手段。鉴定出形成HBV病毒（如）颗粒的新型HBV前核蛋白。本发明提供了这种新型HBV前核蛋白。此外，还提供了由该HBV前核蛋白形成的核心状颗粒和病毒样颗粒。这些病毒样颗粒可用于疫苗和治疗剂。本发明还提供了确定HBV前核蛋白的方法以及确定抗HBV前蛋白抗体的方法。

9. 发明申请

US20090221066A1 Anti-Methylated Dna Antibody and Method for Production Thereof 审中-公开
标题翻译：抗甲基化Dna抗体及其生产方法
公开(公告)号：US20090221066A1
公开(公告)日：2009-09-03
申请号：US12225675
申请日：2007-03-27
申请人： Kunio Shiota , Shintaro Yagi , Fumiko Sunaga , Keiji Hirabayashi
发明人： Kunio Shiota , Shintaro Yagi , Fumiko Sunaga , Keiji Hirabayashi
IPC分类号： C12N5/22 , C07K16/00
CPC分类号： C07K16/18 , C07K16/44
摘要： The present invention provides a method of preparing an anti-methylated DNA antibody, comprising a step of administering to an animal an oligodeoxyribonucleotide containing a methylated cytosine(s) and an oligodeoxyribonucleotide containing no methylated cytosine. The antibody prepared by this method is capable of detecting a DNA containing a methylated cytosine(s) in a state close to the state of a biological component.
摘要翻译：本发明提供了制备抗甲基化DNA抗体的方法，包括向动物施用含有甲基化胞嘧啶的寡脱氧核糖核苷酸和不含甲基化胞嘧啶的寡脱氧核糖核苷酸的步骤。通过该方法制备的抗体能够检测到接近生物成分状态的甲基化胞嘧啶的DNA。

10. 发明申请

US20090170063A1 Hcv rna having novel sequence 审中-公开
标题翻译： Hcv rna具有新颖的序列
公开(公告)号：US20090170063A1
公开(公告)日：2009-07-02
申请号：US11630374
申请日：2005-06-24
申请人： Shintaro Yagi , Kenjiro Yamaguchi , Kenichi Mori , Eiji Tanaka , Kendo Kiyosawa , Noboru Maki
发明人： Shintaro Yagi , Kenjiro Yamaguchi , Kenichi Mori , Eiji Tanaka , Kendo Kiyosawa , Noboru Maki
IPC分类号： C12Q1/70 , C07H21/00 , C12N5/10 , C12N7/00 , C07K14/005 , C07K16/08
CPC分类号： C07K14/005 , C07K16/109 , C12N15/70 , C12N2770/24222
摘要： A truncated form hepatitis C virus gene wherein part of the gene region encoding from the core protein to the NS2 protein of hepatitis C virus has been deleted while retaining the translation frame. In particular, the gene according to claim 1 wherein said part of the gene region is present in a region encoding at least the E1 protein and the E2 protein.
摘要翻译：其截断形式的丙型肝炎病毒基因，其中编码从核心蛋白到丙型肝炎病毒的NS2蛋白的基因区域的一部分已被删除，同时保持翻译框架。特别地，根据权利要求1的基因，其中所述部分基因区域存在于编码至少E1蛋白和E2蛋白的区域中。

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