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21. 发明申请

US20080051418A1 Arylalkanoic Acid Derivative 审中-公开
标题翻译：芳基链烷酸衍生物
公开(公告)号：US20080051418A1
公开(公告)日：2008-02-28
申请号：US11791374
申请日：2005-11-25
申请人： Tsuyoshi Maekawa , Osamu Ujikawa , Hidenori Abe , Izumi Nomura
发明人： Tsuyoshi Maekawa , Osamu Ujikawa , Hidenori Abe , Izumi Nomura
IPC分类号： A61K31/501 , A61K31/415 , A61K31/422 , A61K31/427 , A61P3/06 , C07D213/00 , C07D263/02 , C07D401/02 , C07D413/02 , C07D417/02 , C07D401/14 , C07D277/02 , C07D231/12 , A61P3/10 , A61K31/44 , A61K31/4439 , A61K31/4709
CPC分类号： C07D401/06 , C07D213/30 , C07D213/50 , C07D213/64 , C07D213/69 , C07D231/20 , C07D231/22 , C07D277/20 , C07D277/56
摘要： A compound represented by the formula (I): wherein Ar is an optionally substituted aromatic ring; Xa, Xc, Ya, Yc, Z1 and Z2 are each a bond, O, S, —CO—, —CS—, —CR3(OR4)—, —NR5—, —SO—, —SO2—, —CONR6— or —NR6CO— (wherein R3, R4, R5 and R6 are as defined in the specification); Xb and Yb are each a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R1 is an optionally substituted hydrocarbon group; ring A is an optionally further substituted aromatic ring, provided that the ring should not be benzimidazole; n is an integer of 1 to 8; ring B is an optionally further substituted aromatic ring, provided that the ring should not be oxazole; W is a divalent saturated hydrocarbon group having 1 to 20 carbon atoms; and R2 is —OR8 or —NR9R10 (wherein R8, R9 and R10 are as defined in the specification) or a salt thereof, is useful as an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译：由式（I）表示的化合物：其中Ar为任选取代的芳环; Xa，Xc，Ya，Yc，Z 1和Z 2各自为键，O，S，-CO-，-CS-，-CR 3 （OR 4） - ， - -NR 5 - ， - SO - ， - SO 2 - ， - CONR 6 - 或-NR 6 CO-（其中R 3，R 4，R 4，R 5，和R 6如说明书中所定义）; Xb和Yb各自为键或碳原子数为1〜20的二价烃基; R 1是任选取代的烃基; 环A是任选进一步取代的芳环，条件是该环不应为苯并咪唑; n为1〜8的整数，环B是任选进一步取代的芳环，条件是该环不应为恶唑; W是碳原子数为1〜20的二价饱和烃基; 和R 2是-OR 8或-NR 9 R 10（其中R 8）其中R 9，R 9和R 10如说明书中所定义）或其盐可用作预防或治疗糖尿病等的药剂。

22. 发明申请

US20060135578A1 Five-membered heterocyclic compounds 失效
标题翻译：五元杂环化合物
公开(公告)号：US20060135578A1
公开(公告)日：2006-06-22
申请号：US10527426
申请日：2003-09-09
申请人： Yu Momose , Nobuyuki Takakura , Tsuyoshi Maekawa , Hiroyuki Odaka , Hiroyuki Kimura
发明人： Yu Momose , Nobuyuki Takakura , Tsuyoshi Maekawa , Hiroyuki Odaka , Hiroyuki Kimura
IPC分类号： A61K31/422 , C07D413/14
CPC分类号： C07D263/32 , C07F9/6558 , C07F9/65583
摘要： The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1- or -Z1-(CH2)n— (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, —PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.
摘要翻译：本发明提供由下式表示的化合物：其中R 1是任选取代的5元杂环基; X，Y和V相同或不同，各自为键，氧原子，硫原子等; Q为碳原子数为1〜20的二价烃基; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - - - - - - - - 1 - （CH 2）（n为0〜8的整数，Z 1为键，氧原子，硫原子等）; n为0〜8的整数。环B是任选进一步具有1至3个取代基的含氮杂环; W是碳原子数为1〜20的键或二价烃基; R 2是氢原子，氰基，-PO（OR 9）（OR 10）（R 10） SUP＆gt;和R 10相同或不同，各自为氢原子或任选取代的烃基，R 9和R 10为任选地键合以形成任选取代的环）等，或其盐，其具有优异的脂肪组织重量减少作用，降血糖作用和降血脂作用，并且其可用作预防或治疗肥胖症，糖尿病，高脂血症，葡萄糖耐量降低，高血压等。

23. 发明授权

US08921379B2 Fused ring compound and use thereof 有权
标题翻译：熔融环化合物及其用途
公开(公告)号：US08921379B2
公开(公告)日：2014-12-30
申请号：US13205967
申请日：2011-08-09
申请人： Tsuyoshi Maekawa , Hideyuki Igawa
发明人： Tsuyoshi Maekawa , Hideyuki Igawa
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： Provided is a novel compound represented by the following formula Wherein each symbol is as defined in the specification, or a salt thereof, which has an angiotensin II receptor antagonistic activity and a peroxisome proliferator-activated receptor γ agonistic activity, and is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and/or metabolic diseases such as diabetes and the like, and the like.
摘要翻译：提供了由下式表示的新化合物，其中每个符号如说明书中所定义，或其盐，其具有血管紧张素II受体拮抗活性和过氧化物酶体增殖物激活受体γ激动活性，并且可用作试剂用于预防或治疗诸如高血压等循环系统疾病和/或代谢疾病如糖尿病等。

24. 发明授权

US08328973B2 Method of manufacturing radial tire for construction vehicle 失效
标题翻译：制造车辆子午线轮胎的方法
公开(公告)号：US08328973B2
公开(公告)日：2012-12-11
申请号：US10573450
申请日：2004-10-01
申请人： Ken Takahashi , Kazuo Teramoto , Tsuyoshi Maekawa
发明人： Ken Takahashi , Kazuo Teramoto , Tsuyoshi Maekawa
IPC分类号： B60C9/08 , B29D30/20
CPC分类号： B60C9/08 , B29D30/20 , Y10T152/10873
摘要： Disclosed is a method of manufacturing a radial tire for a construction vehicle, wherein when a cylindrical band is formed by using one layer of carcass layer formed of steel cords in a band making step, a shape retaining layer formed of at least one layer of organic fiber cords is wrapped on the outer peripheral surface of the carcass layer so that the organic fiber cords cross the steel cords of the carcass layer. The radial tire having excellent uniformity without any uneven widening between the steel cords can be provided without using a shape retaining auxiliary apparatus.
摘要翻译：公开了一种制造用于建筑车辆的子午线轮胎的方法，其中当在带制造步骤中通过使用由钢丝帘线形成的一层胎体层形成圆柱形带时，由至少一层有机物形成的形状保持层纤维帘线被包裹在胎体层的外周表面上，使得有机纤维帘线穿过胎体层的钢丝帘线。在不使用形状保持辅助装置的情况下，可以提供具有优异的均匀性而不会在钢丝帘线之间发生不均匀加宽的子午线轮胎。

25. 发明申请

US20110288087A1 FUSED RING COMPOUND AND USE THEREOF 有权
标题翻译：熔化环化合物及其用途
公开(公告)号：US20110288087A1
公开(公告)日：2011-11-24
申请号：US13146989
申请日：2010-01-29
申请人： Tsuyoshi Maekawa , Hideyuki Igawa
发明人： Tsuyoshi Maekawa , Hideyuki Igawa
IPC分类号： A61K31/5377 , A61K31/519 , C07D413/14 , A61P9/12 , A61P9/00 , A61P3/10 , A61P13/12 , A61P27/02 , A61P1/16 , A61P25/00 , A61P3/06 , A61P3/04 , C07D487/04 , A61P9/10
CPC分类号： C07D487/04 , A61K31/519
摘要： Provided is a novel compound represented by the following formula Wherein each symbol is as defined in the specification, or a salt thereof, which has an angiotensin II receptor antagonistic activity and a peroxisome proliferator-activated receptor γ agonistic activity, and is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and/or metabolic diseases such as diabetes and the like, and the like.
摘要翻译：提供了由下式表示的新化合物，其中每个符号如说明书中所定义，或其盐，其具有血管紧张素II受体拮抗活性和过氧化物酶体增殖物激活受体γ激动活性，并且可用作试剂用于预防或治疗诸如高血压等循环系统疾病和/或代谢疾病如糖尿病等。

26. 发明申请

US20110112120A9 HETEROMONOCYCLIC COMPOUND AND USE THEREOF 失效
标题翻译：异环化合物及其用途
公开(公告)号：US20110112120A9
公开(公告)日：2011-05-12
申请号：US12625622
申请日：2009-11-25
申请人： Takanobu Kuroita , Hiroki Sakamoto , Hideyuki Igawa , Minoru Sasaki , Kouhei Asano , Tsuyoshi Maekawa , Koji Fuji
发明人： Takanobu Kuroita , Hiroki Sakamoto , Hideyuki Igawa , Minoru Sasaki , Kouhei Asano , Tsuyoshi Maekawa , Koji Fuji
IPC分类号： A61K31/506 , C07D413/10 , C07D413/14 , A61P25/00 , A61P9/00 , A61P3/00
CPC分类号： C07D413/10 , C07D413/14 , C07D417/14
摘要： A compound represented by the formula (I): wherein R1 is an oxo group, ═N—R or the like; a group represented by the formula: is a group represented by the formula: R2 is a group represented by the formula: R3 and R4 are each H, or C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, di(C1-C6)alkylamino or C1-C6 alkylthio, each of which is optionally substituted; and R5 is H, or C1-C6 alkyl, C2-C6 alkenyl, cyclic group, each of which is optionally substituted, —CO—R8 or —O—R8′, or a salt thereof. The compound of the present invention is useful as a drug for the prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases.
摘要翻译：由式（I）表示的化合物：其中R 1是氧代基，或= N-R等; 由下式表示的基团是由下式表示的基团：R 2是由下式表示的基团：R 3和R 4各自为H或C 1 -C 6烷基，C 3 -C 6环烷基，C 1 -C 6烷氧基，C 1 -C 6 烷基氨基，二（C 1 -C 6）烷基氨基或C 1 -C 6烷硫基，其各自任选被取代; 和R 5为H或C 1 -C 6烷基，C 2 -C 6烯基，环状基团，各自为任选取代的-CO-R 8或-O-R 8'或其盐。本发明的化合物可用作预防或治疗心血管疾病，代谢疾病和/或中枢神经系统疾病的药物。

27. 发明申请

US20100056526A1 HETEROMONOCYCLIC COMPOUND AND USE THEREOF 审中-公开
标题翻译：异环化合物及其用途
公开(公告)号：US20100056526A1
公开(公告)日：2010-03-04
申请号：US12516099
申请日：2007-11-21
申请人： Takanobu Kuroita , Hiroki Sakamoto , Hideyuki Igawa , Minoru Sasaki , Kouhei Asano , Tsuyoshi Maekawa
发明人： Takanobu Kuroita , Hiroki Sakamoto , Hideyuki Igawa , Minoru Sasaki , Kouhei Asano , Tsuyoshi Maekawa
IPC分类号： C07D413/14 , C07D413/08 , C07D239/02 , A61K31/506 , A61K31/5377 , A61K31/4245 , C07D249/12 , A61K31/4196
CPC分类号： C07D413/14 , C07D413/10 , C07D417/14
摘要： A compound represented by the formula (I): wherein R1 is an oxo group, ═N—R or the like; a group represented by the formula: is a group represented by the formula: R2 is a group represented by the formula: or a salt thereof. The compound of the present invention is useful as a drug for the prophylaxis or treatment of circulatory diseases, metabolic diseases and/or central nervous system diseases.
摘要翻译：由式（I）表示的化合物：其中R 1是氧代基，或= N-R等; 由下式表示的基团是由下式表示的基团：R 2是由下式表示的基团：或其盐。本发明的化合物可用作预防或治疗循环系统疾病，代谢疾病和/或中枢神经系统疾病的药物。

28. 发明授权

US07241785B2 Five-membered heterocyclic alkanoic acid derivative 失效
标题翻译：五元杂环烷酸衍生物
公开(公告)号：US07241785B2
公开(公告)日：2007-07-10
申请号：US10472159
申请日：2002-03-22
申请人： Yu Momose , Tsuyoshi Maekawa , Hiroshi Imoto , Hiroyuki Odaka , Hiroyuki Kimura
发明人： Yu Momose , Tsuyoshi Maekawa , Hiroshi Imoto , Hiroyuki Odaka , Hiroyuki Kimura
IPC分类号： C07D413/10 , C07D413/12 , A61K31/422
CPC分类号： C07D413/12 , C07D263/32 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to a compound represented by the formula wherein R1 is an optionally substituted 5-membered heterocyclic group; X is a bond etc.; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond etc.; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n—Z1— (n is an integer of 0 to 8 and Z1 is a bond etc.) and the like; ring B is a 5-membered heterocycle optionally further having 1 to 3 substituents; W is a divalent saturated hydrocarbon group having 1 to 20 carbon atoms; R2 is —OH etc., or a salt thereof. A pharmaceutical composition containing this compound is useful as a prophylactic or therapeutic agent of diseases such as diabetes mellitus and the like.
摘要翻译：本发明涉及由下式表示的化合物：其中R 1是任选取代的5元杂环基; X是债券等; Q为碳原子数为1〜20的二价烃基; Y是债券等; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - n 1 - （n是0至8的整数，Z <1） SUP>是债券等）等; 环B是任选进一步具有1至3个取代基的5元杂环; W是碳原子数为1〜20的二价饱和烃基; R 2是-OH等，或其盐。含有该化合物的药物组合物可用作糖尿病等疾病的预防或治疗剂。

29. 发明授权

US07238716B2 Alkanoic acid derivatives process for their production and use thereof 失效
标题翻译：用于其生产和使用的烷酸衍生物方法
公开(公告)号：US07238716B2
公开(公告)日：2007-07-03
申请号：US10465938
申请日：2001-12-28
申请人： Yu Momose , Tsuyoshi Maekawa , Nobuyuki Takakura , Hiroyuki Odaka , Hiroyuki Kimura , Tatsuya Ito
发明人： Yu Momose , Tsuyoshi Maekawa , Nobuyuki Takakura , Hiroyuki Odaka , Hiroyuki Kimura , Tatsuya Ito
IPC分类号： A61K31/4439 , C07D413/12
CPC分类号： C07D403/04 , C07D263/32 , C07D277/24 , C07D277/42 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： An alkanoic acid derivative useful as a prophylactic or therapeutic agent of diabetes mellitus, hyperlipidemia, impaired glucose tolerance and the like can be provided by a compound represented by the formula wherein R1 is an optionally substituted 5-membered aromatic heterocyclic group; X is a bond and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond and the like; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1-(n is an integer of 1 to 8 and Z1 is an oxygen atom and the like) and the like; ring B is a pyridine ring optionally further having 1 to 3 substituents, and the like; U is a bond and the like; W is a divalent hydrocarbon group having 1 to 20 carbon atoms; and R3 is —OH and the like, provided that, when ring B is a benzene ring optionally further having 1 to 3 substituents, U should be a bond, or a salt thereof.
摘要翻译：可用作糖尿病，高脂血症，葡萄糖耐量异常等的预防或治疗剂的链烷酸衍生物可由下式表示的化合物提供：其中R 1为任选取代的5元芳香族杂环基; X是一个键等; Q为碳原子数为1〜20的二价烃基; Y是一个债券等; 环A是任选进一步具有1至3个取代基的芳环; Z是 - （CH 2）n - n 1 - （n是1至8的整数，Z <1） SUP>是氧原子等）等; 环B是任选还含有1至3个取代基的吡啶环等; U是一个债券等; W是碳原子数为1〜20的二价烃基; 且R 3为-OH等，条件是当环B为任选还含有1至3个取代基的苯环时，U应为键或其盐。

30. 发明授权

US5891895A Hydroxypyridine derivatives their production and use 失效
标题翻译：羟基吡啶衍生物的生产和使用
公开(公告)号：US5891895A
公开(公告)日：1999-04-06
申请号：US834123
申请日：1997-04-14
申请人： Mitsuru Shiraishi , Tsuyoshi Maekawa , Toshifumi Watanabe
发明人： Mitsuru Shiraishi , Tsuyoshi Maekawa , Toshifumi Watanabe
IPC分类号： C07D213/65 , C07D213/89 , A61K31/44 , C07D213/53
CPC分类号： C07D213/89 , C07D213/65
摘要： Hydroxypyridine derivatives of the formula ##STR1## wherein R.sup.1 is a branched C.sub.3-8 alkyl group or a C.sub.3-8 cycloalkyl group, each of which may be substituted;R.sup.2 is a halogen atom, a C.sub.1-4 alkyl group or a C.sub.1-4 alkoxy group;X is an oxygen atom or NR.sup.3 in which R.sup.3 is a hydrogen atom or a C.sub.1-4 alkyl group;R.sup.4, R.sup.5 and R.sup.6 are independently (1) a hydrogen atom, (2) a halogen atom, (3) a cyano group, (4) a nitro group, (5) a C.sub.1-4 acyl group, (6) a C.sub.1-4 alkoxy group which may be substituted with halogen, (7) a C.sub.1-4 alkyl group which may be substituted with halogen or (8) a mercapto group which may be substituted with a C.sub.1-4 alkyl group;m is 0 to 3; andn is 0 or 1;provided that all of R.sup.4, R.sup.5 and R.sup.6 are not hydrogen atom, or a salt thereof, which have potassium channel opening activity and are useful as therapeutic agents of cardiovascular diseases such as angina pectoris, hypertension, etc.
摘要翻译：其中R 1是支链C 3-8烷基或C 3-8环烷基，其中每一个可以被取代; R2是卤素原子，C1-4烷基或C1-4烷氧基; X是氧原子或NR 3，其中R 3是氢原子或C 1-4烷基; R4，R5和R6独立地为（1）氢原子，（2）卤素原子，（3）氰基，（4）硝基，（5）C1-4酰基，（6）C1 -4-烷氧基，（7）可被卤素取代的C 1-4烷基或（8）可被C 1-4烷基取代的巯基; m为0〜3; 并且n为0或1; 条件是所有R4，R5和R6不是氢原子，或其盐，其具有钾通道开放活性，并且可用作心血管疾病如心绞痛，高血压等的治疗剂。

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