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1. 发明授权

US08960808B2 Underwater miner cutter head, underwater miner, and underwater mining system 有权
标题翻译：水下矿工刀头，水下矿工和水下采矿系统
公开(公告)号：US08960808B2
公开(公告)日：2015-02-24
申请号：US13635492
申请日：2011-05-09
申请人： Norihide Wakita , Futoshi Sameshima , Hiroyuki Odaka
发明人： Norihide Wakita , Futoshi Sameshima , Hiroyuki Odaka
IPC分类号： E02F3/92 , E02F3/24 , E02F3/88 , E02F3/20 , E21C50/00
CPC分类号： E02F3/246 , E02F3/205 , E02F3/8866 , E02F3/9237 , E02F3/9268 , E21C50/00
摘要： Provided is an underwater miner cutter head (20) attached to an underwater miner disposed on a seabed and configured to excavate the seabed, the cutter head including cylindrical cutter drums (21) disposed on respective sides defining a regular polygon in plan view, having bits (26) on the outer circumferential surfaces thereof, and configured to rotate around corresponding first rotational axes by first driving sources; and an intake (28) disposed at a center part of the regular polygon and configured to receive muck excavated with the bits (26), wherein rotating directions of the cutter drums (21) are set such that the bits (26) sequentially move toward the intake (28).
摘要翻译：本发明提供了一种安装在海床上并被构造成挖掘海底的水下矿工的水下矿工切割头（20），该切割头包括设置在平面图中限定正多边形的相应侧上的圆柱形切割滚筒（21）（26），并且构造成通过第一驱动源围绕对应的第一旋转轴线旋转; 以及设置在所述正多边形的中心部分并且被配置为接收用所述钻头（26）挖掘的钻屑的进气口（28），其中所述切割器滚筒（21）的旋转方向被设定为使得所述钻头（26）顺序地朝向摄入量（28）。

2. 发明申请

US20090246232A1 Pharmaceutical composition 有权
公开(公告)号：US20090246232A1
公开(公告)日：2009-10-01
申请号：US12382691
申请日：2009-03-20
申请人： Hitoshi Ikeda , Takashi Sohada , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohada , Hiroyuki Odaka
IPC分类号： A61K9/00 , A61K31/4439 , A61K31/426 , A61K31/155
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

3. 发明授权

US07538125B2 Pharmaceutical composition 失效
公开(公告)号：US07538125B2
公开(公告)日：2009-05-26
申请号：US11523771
申请日：2006-09-20
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

4. 发明授权

US07179823B1 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity 有权
标题翻译：具有低血糖和降血脂活性的5元正构杂环化合物
公开(公告)号：US07179823B1
公开(公告)日：2007-02-20
申请号：US10129702
申请日：2000-11-09
申请人： Yu Momose , Tsuyoshi Maekawa , Hiroyuki Odaka , Hiroyuki Kimura
发明人： Yu Momose , Tsuyoshi Maekawa , Hiroyuki Odaka , Hiroyuki Kimura
IPC分类号： C07D263/32 , C07D277/24 , C07D401/04 , A61K31/422 , A61K31/4439
CPC分类号： C07D231/12 , A61K31/501 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14 , Y02P20/55
摘要： A compound of formula (I) F wherein R1 represents a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; x represents a bond, an oxygen atom, a sulfur atom, or a group of the formula: —CO—, —CS—, —CR4(OR5)— or —NR6— wherein each of R4 and R6 represents a hydrogen atom or a hydrocarbon group which may be stubstituted, R5 represents a hydrogen atom or a protective group for a hydroxyl group; m represents an integer of 0 to 3; Y represents an oxygen atom, a sulfur atom, or a group of the formula: —SO—, —SO2—, —NR7—, —CONR7— or —NR7CO— wherein R7 represents a hydrogen atom or a hydrocarbon group which may be substituted; ring A represents an aromatic ring which may further have 1 to 3 substituents; n represents an integer of 1 to 8; ring B represents a nitrogen-containing 5-membered hetero ring which may further be substituted by an alkyl group.
摘要翻译：式（I）F化合物，其中R 1表示可被取代的烃基或可被取代的杂环基; X表示键，氧原子，硫原子或下式基团：-CO-，-CS-，-CR 4（OR 5） - 或-NR 6 - ，其中R 4和R 6各自表示氢原子或可以被取代的烃基，R SUP > 5表示氢原子或羟基的保护基; m表示0〜3的整数， Y表示氧原子，硫原子或下式的基团：-SO - ， - SO 2 - ， - NR 7 - ， - CONR 7 - 或-NR 7 CO-，其中R 7表示氢原子或可被取代的烃基; 环A表示可以进一步具有1至3个取代基的芳环; n表示1〜8的整数，环B表示可以进一步被烷基取代的含氮5元杂环。

5. 发明授权

US06924300B2 Oxyiminoalkanoic acid derivatives 失效
公开(公告)号：US06924300B2
公开(公告)日：2005-08-02
申请号：US10331056
申请日：2002-12-27
申请人： Yu Momose , Hiroyuki Odaka , Hiroshi Imoto , Hiroyuki Kimura , Junichi Sakamoto
发明人： Yu Momose , Hiroyuki Odaka , Hiroshi Imoto , Hiroyuki Kimura , Junichi Sakamoto
IPC分类号： A61K31/195 , A61K31/235 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4439 , A61K31/47 , A61K31/4704 , A61K31/4745 , A61K31/496 , A61K31/505 , A61P3/06 , A61P3/10 , A61P9/10 , A61P29/00 , A61P43/00 , C07D213/74 , C07D215/14 , C07D239/42 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D413/04 , C07D413/12 , C07D471/04 , C07D263/30 , C07D277/20
CPC分类号： C07D213/74 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/47 , A61K31/4745 , A61K31/505 , C07D215/14 , C07D239/42 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D413/12 , C07D471/04
摘要： To provide a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the prevention or treatment of diabetes mellitus, hyperlipemia, insulin insensitivity, insulin resistance and impaired glucose tolerance.A compound represented by the formula: wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond, —CO—, —CH(OH)— or a group represented by —NR6— wherein R6 is a hydrogen atom or an optionally substituted alkyl group; n is an integer of 1 to 3; Y is an oxygen atom, a sulfur atom, —SO—, —SO2— or a group represented by —NR7— wherein R7 is a hydrogen atom or an optionally alkyl group; ring A is a benzene ring optionally having additional one to three substituents; p is an integer of 1 to 8; R2 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; q is an integer of 0 to 6; m is 0 or 1; R3 is a hydroxy group, OR8 (R8 is an optionally substituted hydrocarbon group.) or NR9R10 (R9 and R10 are the same or different groups which are selected from a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group or R9 and R10 combine together to form a ring); R4 and R5 are the same or different groups which are selected from a hydrogen atom or an optionally substituted hydrocarbon group wherein R4 may form a ring with R2; provided that when R1 is a ethoxymethyl, a C1-3 alkyl, phenyl or p-methoxyphenyl and q=m=0, R3 is NR9R10; and provided that O-[2-chloro-4-(2-quinolylmethoxy)phenylmethyl]oxime and a methyl pyruvate of [2-chloro-4-(2-quinolylmethoxy)phenylmethyl]-2-iminoxypropionic acid are excluded; or a salt thereof.

6. 发明授权

US06677363B1 Agent for improving ketosis 失效
标题翻译：改善酮症的药剂
公开(公告)号：US06677363B1
公开(公告)日：2004-01-13
申请号：US09937447
申请日：2001-09-26
申请人： Hiroyuki Odaka , Masami Suzuki
发明人： Hiroyuki Odaka , Masami Suzuki
IPC分类号： A61K31425
CPC分类号： A61K31/427 , A61K31/422 , A61K31/426 , A61K31/4439 , Y10S514/866
摘要： An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.
摘要翻译：用于改善酮症的药剂，其包含胰岛素敏化剂，其具有优异的作用和低毒性。

7. 发明授权

US06495581B1 Oxyiminoalkanoic acid derivatives 失效
标题翻译：氧亚氨基链烷酸衍生物
公开(公告)号：US06495581B1
公开(公告)日：2002-12-17
申请号：US09714699
申请日：2000-11-16
申请人： Yu Momose , Hiroyuki Odaka , Hiroshi Imoto , Hiroyuki Kimura , Junichi Sakamoto
发明人： Yu Momose , Hiroyuki Odaka , Hiroshi Imoto , Hiroyuki Kimura , Junichi Sakamoto
IPC分类号： A61K31425
CPC分类号： C07D213/74 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/47 , A61K31/4745 , A61K31/505 , C07D215/14 , C07D239/42 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/24 , C07D413/12 , C07D471/04
摘要： A compound represented by the formula: wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond, —CO—, —CH(OH)— or a group represented by —NR6— wherein R6 is a hydrogen atom or an optionally substituted alkyl group; n is an integer of 1 to 3; Y is an oxygen atom, a sulfur atom, —SO—, —SO2— or a group represented by —NR7— wherein R7 is a hydrogen atom or an optionally alkyl group; ring A is a benzene ring optionally having additional one to three substituents; p is an integer of 1 to 8; R2 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; q is an integer of 0 to 6; m is 0 or 1; R3 is a hydroxy group, OR8 (R8 is an optionally substituted hydrocarbon group.) or NR9R10 (R9 and R10 are the same or different groups which are selected from a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group or R9 and R10 combine together to form a ring); R4 and R5 are the same or different groups which are selected from a hydrogen atom or an optionally substituted hydrocarbon group wherein R4 may form a ring with R2; provided that when R1 is a ethoxymethyl, a C1-3 alkyl, phenyl or p-methoxyphenyl and q=m=0, R3 is NR9R10; and provided that O-[2-chloro-4-(2-quinolylmethoxy)phenylmethyl]oxime and a methyl pyruvate of [2-chloro-4-(2-quinolylmethoxy)phenylmethyl]-2-iminoxypropionic acid are excluded; or a salt thereof which has excellent hypoglycemic and hypolipidemic actions.
摘要翻译：由下式表示的化合物：其中R1是任选取代的烃基或任选取代的杂环基; X是键，-CO - ， - CH（OH） - 或-NR 6 - 表示的基团，其中R 6是氢原子或任选取代的烷基; n为1〜3的整数。 Y是氧原子，硫原子，-SO-，-SO 2 - 或-NR 7 - 表示的基团，其中R 7是氢原子或任意烷基; 环A是任选具有另外一个至三个取代基的苯环; p为1〜8的整数， R2是氢原子，任选取代的烃基或任选取代的杂环基; q为0〜6的整数; m为0或1; R3是羟基，OR8（R8是任选取代的烃基）或NR9R10（R9和R10是相同或不同的基团，其选自氢原子，任选取代的烃基，任选取代的杂环基或任选取代的酰基或R 9和R 10结合在一起形成环）; R4和R5是选自氢原子或任选取代的烃基的相同或不同的基团，其中R 4可以与R 2形成环; 条件是当R1是乙氧基甲基，C1-3烷基，苯基或对甲氧基苯基且q = m = 0时，R3是NR9R10; 并且排除了[2-氯-4-（2-喹啉基甲氧基）苯基甲基] -2-亚氨基丙酸的O- [2-氯-4-（2-喹啉基甲氧基）苯甲基]肟和丙酮酸甲酯。或其盐，其具有优异的降血糖和降血脂作用。

8. 发明授权

US06288090B1 Pharmaceutical composition 有权
公开(公告)号：US06288090B1
公开(公告)日：2001-09-11
申请号：US09610992
申请日：2000-07-06
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： C07D4002
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

9. 发明授权

US06232330B1 Pharmaceutical composition 有权
公开(公告)号：US06232330B1
公开(公告)日：2001-05-15
申请号：US09610993
申请日：2000-07-06
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： C07D40102
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

10. 发明授权

US06211207B1 Pharmaceutical composition 有权
公开(公告)号：US06211207B1
公开(公告)日：2001-04-03
申请号：US09619641
申请日：2000-07-19
申请人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
发明人： Hitoshi Ikeda , Takashi Sohda , Hiroyuki Odaka
IPC分类号： C07D40102
CPC分类号： A61K9/2018 , A61K9/2054 , A61K9/4858 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/50 , A61K31/52 , A61K31/535 , A61K31/64 , A61K31/70 , A61K45/06 , Y10S514/866 , A61K2300/00 , A61K31/21 , A61K31/155 , A61K31/405 , A61K31/40 , A61K31/365 , A61K31/22
摘要： Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis and treatment of diabetes.

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