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    • 25. 发明申请
    • DUAL INJECTION TUBE CRYOCATHETER AND METHOD FOR USING SAME
    • 双注射管结晶器及其使用方法
    • US20120029493A1
    • 2012-02-02
    • US12844388
    • 2010-07-27
    • Dan WITTENBERGERClaudia LUECKGEMiriam LANE
    • Dan WITTENBERGERClaudia LUECKGEMiriam LANE
    • A61B18/02
    • A61B18/02A61B2018/00166A61B2018/0022A61B2018/00642A61B2018/0212A61B2090/064
    • A medical device includes a catheter body having a first injection lumen, a second injection lumen, and an exhaust lumen, where the first injection lumen provides a fluid flow rate greater than a fluid flow rate provided by the second injection lumen; an expandable element coupled to the catheter body in fluid communication with the first and second injection lumens; a cryogenic fluid source in fluid communication with the first and second injection lumens; a valve in fluid communication with the first and second injection lumens to selectively allow fluid flow to at least one of the first and second injection lumens; a pressure sensor in fluid communication with an interior defined by the expandable element; and a controller in communication with the pressure sensor programmed to regulate fluid flow through the first injection lumen based at least in part on a signal from the pressure sensor.
    • 医疗装置包括具有第一注射腔,第二注射内腔和排气腔的导管主体,其中第一注射腔提供大于由第二注射腔提供的流体流速的流体流速; 耦合到所述导管主体的可扩张元件,其与所述第一和第二注射腔流体连通; 与所述第一和第二注射腔流体连通的低温流体源; 与所述第一和第二注射腔流体连通的阀,以选择性地允许流体流向所述第一和第二注射腔中的至少一个; 与由可膨胀元件限定的内部流体连通的压力传感器; 以及与所述压力传感器通信的控制器,其被编程为至少部分地基于来自所述压力传感器的信号来调节通过所述第一喷射腔的流体流动。
    • 28. 发明申请
    • CATHETER WITH CRYOGENIC AND ELECTRICAL HEATING ABLATION
    • 具有低温和电加热的导管
    • US20070299432A1
    • 2007-12-27
    • US11768259
    • 2007-09-10
    • Steven ArlessFredric MilderMarwan AbboudDan WittenbergerSean Carroll
    • Steven ArlessFredric MilderMarwan AbboudDan WittenbergerSean Carroll
    • A61B18/18
    • A61B18/02A61B18/1492A61B18/18A61B2017/00243A61B2018/0212A61B2018/0268
    • A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion re-treatment cycles. In one embodiment a microwave energy source operates at a frequency to extend beyond the thermal conduction depth, or to penetrate the cryogenic ice ball and be absorbed in tissue beyond an ice boundary, thus extending the depth and/or width of a single treatment locus. In another embodiment, the cooling and the application of RF energy are both controlled to position the ablation region away from the surface contacted by the electrode, for example to leave surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth. The driver or RF energy source may supply microwave energy at a frequency effective to penetrate the ice ball which develops on a cryocatheter, and different frequencies may be selected for preferential absorption in a layer of defined thickness at depth in the nearby tissue. The catheter may operate between 70 and minus 70 degrees Celsius for different tissue applications, such as angioplasty, cardiac ablation and tissue remodeling, and may preset the temperature of the tip or adjacent tissue, and otherwise overlay or delay the two different profiles to tailor the shape or position where ablation occurs or to speed up a treatment cycle.
    • 导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。 冷冻消融尖端可以用冷却室来实现,通过该冷却室可控制地注入的冷却剂循环以降低尖端温度,并且在其远端具有RF电极。 RF电极可以被操作以加热低温冷却的组织,或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织,从而允许操作的更大的通用性和增强病变大小,速度或放置多病变 治疗或单次病变再治疗周期。 在一个实施例中,微波能量源的频率以超出热传导深度的频率运行,或者穿透低温冰球并被吸收在超过冰界的组织中,从而延长单个处理轨迹的深度和/或宽度。 在另一个实施例中,RF能量的冷却和应用都被控制以将消融区域远离与电极接触的表面,例如在深度消融时留下表面组织而不受伤害,或者提供具有更大均匀性的消融带, 增加深度。 驱动器或RF能源可以以有效穿透在低温导管上形成的冰球的频率提供微波能量,并且可以选择不同的频率用于在附近组织的深度处的限定厚度的层中的优先吸收。 对于不同的组织应用(例如血管成形术,心脏消融和组织重建),导管可以在70摄氏度和零下70度之间运行,并且可以预设尖端或相邻组织的温度,否则叠加或延迟两个不同的轮廓以定制 消融发生的形状或位置或加速治疗周期。