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1. 发明授权

US09220556B2 Balloon design to enhance cooling uniformity 有权
标题翻译：气球设计，以提高冷却均匀性
公开(公告)号：US09220556B2
公开(公告)日：2015-12-29
申请号：US13360430
申请日：2012-01-27
申请人： Jean-Pierre Lalonde , Scott W. Davie , Dan Wittenberger
发明人： Jean-Pierre Lalonde , Scott W. Davie , Dan Wittenberger
IPC分类号： A61B18/00 , A61B18/02 , A61B18/14 , A61B19/00
CPC分类号： A61B18/02 , A61B18/1492 , A61B2018/0022 , A61B2018/00255 , A61B2018/00375 , A61B2018/00577 , A61B2018/00648 , A61B2018/00791 , A61B2018/00994 , A61B2018/0212 , A61B2018/0268 , A61B2018/0275 , A61B2090/064
摘要： A device, system, and method for enhancing cooling uniformity and efficiency of cryogenic fluids and providing a treatment element the shape of which can be adjusted for multiple purposes. The device may include a balloon catheter and fluid dispersion element, the fluid dispersion element directing the flow of coolant from a fluid injection element the interior wall of the balloon. The method of changing the shape of the treatment element may include retracting and extending a shaft to which the distal neck of a balloon is coupled, so that the balloon goes from a first shape to a second shape.
摘要翻译：一种用于增强低温流体的冷却均匀性和效率的装置，系统和方法，并提供一种处理元件，其形状可以被调整用于多种目的。该装置可以包括球囊导管和流体分散元件，流体分散元件将来自流体注射元件的冷却剂流引导到气囊的内壁。改变处理元件的形状的方法可以包括缩回和延伸气球的远端颈部所连接的轴，使得气球从第一形状变为第二形状。

2. 发明授权

US09168080B2 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US09168080B2
公开(公告)日：2015-10-27
申请号：US13360092
申请日：2012-01-27
申请人： Dan Wittenberger , Claudia Lueckge , Réal Ste-Marie
发明人： Dan Wittenberger , Claudia Lueckge , Réal Ste-Marie
IPC分类号： A61B18/02 , A61B18/14 , A61B18/00
CPC分类号： A61B18/02 , A61B18/1492 , A61B2018/0016 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device including a catheter body defining a proximal portion and a distal portion. An expandable element is included defining a proximal end and a distal end, the proximal end being coupled to the distal portion of the catheter body. A tip element coupled to the distal end of the expandable element is included, the tip element including a shaft slideably receivable within a portion of the catheter body. A tensioning element coupled to the shaft and disposed within the expandable element is included, the tensioning element being engageable with the distal end of the catheter body and biasing the expandable element toward a pre-determined longitudinal position. An electrode array defining a substantially closed loop affixed to and extending from the tip element is also included.
摘要翻译：一种医疗装置，包括限定近端部分和远端部分的导管主体。包括可扩张元件，其限定近端和远端，近端联接到导管主体的远端部分。包括联接到可扩张元件的远端的尖端元件，末端元件包括可滑动地容纳在导管主体的一部分内的轴。包括联接到轴并且设置在可扩张元件内的张紧元件，张紧元件可与导管主体的远端接合并且朝向预定的纵向位置偏压可扩张元件。还包括限定固定到尖端元件并从尖端元件延伸的基本上闭合回路的电极阵列。

3. 发明授权

US09089314B2 Partially compliant balloon device 有权
标题翻译：部分兼容球囊装置
公开(公告)号：US09089314B2
公开(公告)日：2015-07-28
申请号：US12694938
申请日：2010-01-27
申请人： Dan Wittenberger
发明人： Dan Wittenberger
IPC分类号： A61B18/02 , A61B18/00
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/00255 , A61B2018/00375 , A61B2018/0212
摘要： A medical device is provided, having an elongate body defining a distal portion and a proximal portion; a first expandable member disposed on the distal portion of the elongate body and defining a cooling chamber therein, the first expandable member having a first rigidity; a second expandable member disposed around the first expandable member to define an interstitial region therebetween, where the second expandable member has a second rigidity less than the first rigidity; a gel disposed within the interstitial region; a coolant flow path in fluid communication with the cooling chamber; and a cryogenic coolant source in fluid communication with the coolant flow path.
摘要翻译：提供了一种医疗装置，其具有限定远侧部分和近端部分的细长主体; 第一可膨胀构件，其设置在细长主体的远端部分上并且在其中限定冷却室，第一可膨胀构件具有第一刚性; 第二可膨胀构件，其围绕所述第一可膨胀构件设置以在其间限定间隙区域，其中所述第二可膨胀构件具有小于所述第一刚性的第二刚性; 布置在间隙区内的凝胶; 与冷却室流体连通的冷却剂流动路径; 以及与冷却剂流动路径流体连通的低温冷却剂源。

4. 发明授权

US09039712B2 Shape modification system for a cooling chamber of a medical device 有权
标题翻译：用于医疗器械冷却室的形状修改系统
公开(公告)号：US09039712B2
公开(公告)日：2015-05-26
申请号：US11476408
申请日：2006-06-28
申请人： Marwan Abboud , Dan Wittenberger
发明人： Marwan Abboud , Dan Wittenberger
IPC分类号： A61F11/00 , A61M25/10
CPC分类号： A61M25/10181 , A61B2018/0212 , A61M2025/1068
摘要： The present invention provides a medical device having an catheter body defining proximal and distal portions, and a guidewire lumen at least partially disposed within and movable within the catheter body. The medical device may include an expandable element defining a proximal end and a distal end, wherein the proximal end is coupled to the distal portion of the catheter body and the distal end is coupled to the guidewire lumen. In addition, an actuator element may be coupled to the guidewire lumen for longitudinal movement thereof, and a tensioning element may further be coupled to the guidewire lumen to bias the guidewire lumen and/or the expandable element towards a particular geometric configuration.
摘要翻译：本发明提供一种医疗装置，其具有限定近端部分和远端部分的导管主体，以及至少部分地设置在导管主体内并在导管主体内可移动的导丝管腔。医疗装置可以包括限定近端和远端的可扩张元件，其中近端联接到导管主体的远端部分，并且远端联接到导丝管腔。此外，致动器元件可以联接到导丝管腔以用于其纵向运动，并且张紧元件可以进一步联接到导丝管腔，以将导丝管腔和/或可扩张元件朝向特定的几何构型偏置。

5. 发明授权

US08911434B2 Balloon catheter with deformable fluid delivery conduit 有权
标题翻译：具有可变形流体输送导管的气球导管
公开(公告)号：US08911434B2
公开(公告)日：2014-12-16
申请号：US12910492
申请日：2010-10-22
申请人： Dan Wittenberger
发明人： Dan Wittenberger
IPC分类号： A61B18/02 , A61B18/00
CPC分类号： A61B18/02 , A61B2018/00214 , A61B2018/0022 , A61B2018/00345 , A61B2018/00375 , A61B2018/00577 , A61B2018/0212 , A61B2018/0268 , A61M25/0147
摘要： A medical device, including an elongate body having a proximal portion and a distal portion; a shaft at least partially disposed within the elongate body; an expandable element at the distal portion of the elongate body; and a fluid delivery conduit defining a deflectable segment movably coupled to the shaft, the deflectable segment being transitionable from a substantially linear configuration to a substantially curvilinear configuration.
摘要翻译：一种医疗装置，包括具有近端部分和远端部分的细长体; 至少部分地设置在所述细长主体内的轴; 在所述细长体的远端部分处的可膨胀元件; 以及流体输送导管，其限定可移动地联接到所述轴的可偏转段，所述可偏转段可从基本线性构型转变到基本上曲线形状。

6. 发明申请

US20130104993A1 SYSTEMS AND METHODS FOR VARIABLE INJECTION FLOW 审中-公开
公开(公告)号：US20130104993A1
公开(公告)日：2013-05-02
申请号：US13409875
申请日：2012-03-01
申请人： Regina E. GROVES , Jean-Pierre LALONDE , Timothy G. LASKE , Claudia LUECKGE , Dan WITTENBERGER , Ramin SABBAGHE-KERMANI , Mahmoud KABIR-SERAJ
发明人： Regina E. GROVES , Jean-Pierre LALONDE , Timothy G. LASKE , Claudia LUECKGE , Dan WITTENBERGER , Ramin SABBAGHE-KERMANI , Mahmoud KABIR-SERAJ
IPC分类号： F17D3/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

7. 发明申请

US20120029494A1 DEVICE AND METHOD FOR PULMONARY VEIN ISOLATION 有权
标题翻译：脉搏血管分离装置及方法
公开(公告)号：US20120029494A1
公开(公告)日：2012-02-02
申请号：US12845312
申请日：2010-07-28
申请人： Dan WITTENBERGER , Ioana Alina DEAC , Jean-Pierre LALONDE , Deborah A. DE ROY
发明人： Dan WITTENBERGER , Ioana Alina DEAC , Jean-Pierre LALONDE , Deborah A. DE ROY
IPC分类号： A61B18/02 , A61F7/12
CPC分类号： A61B18/02 , A61B18/1492 , A61B2018/00255 , A61B2018/00285 , A61B2018/00375 , A61B2018/00577 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262
摘要： An intravascular catheter is provided, including a flexible elongate body; an expandable element positioned on the elongate body; a substantially linear thermal segment located distally of the expandable element; a first fluid flow path in fluid communication with the expandable element; and a second fluid flow path in fluid communication with the substantially linear thermal segment.
摘要翻译：提供血管内导管，包括柔性细长体; 定位在细长体上的可扩张元件; 位于所述可扩张元件的远端的基本线性的热段; 与可膨胀元件流体连通的第一流体流动路径; 以及与所述基本上线性的热段流体连通的第二流体流动路径。

8. 发明授权

US07955298B2 Defined deflection structure 有权
标题翻译：定义偏转结构
公开(公告)号：US07955298B2
公开(公告)日：2011-06-07
申请号：US11112100
申请日：2005-05-09
申请人： Sean Carroll , Domenic Santoianni , Benoit Thibault , Dan Wittenberger , Mathieu-Philippe Aubert , Marc-André Marcotte
发明人： Sean Carroll , Domenic Santoianni , Benoit Thibault , Dan Wittenberger , Mathieu-Philippe Aubert , Marc-André Marcotte
IPC分类号： A61M31/00
CPC分类号： A61M25/0105 , A61B1/0051 , A61B18/1492 , A61B2018/00214 , A61B2018/00898 , A61M25/0041 , A61M25/0043 , A61M25/005 , A61M25/0054 , A61M25/0116 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M25/0155 , A61M25/0662 , A61M25/10 , A61M2025/0161 , A61M2025/0163 , A61M2025/09141
摘要： Deflection mechanisms are disclosed that are positionable to deflecting portions of a flexible body, such as a catheter, in more than one direction in a single plane, as well as in more than one plane. The invention allows a distal portion of a catheter to be deflected more than 360 degrees to provide a loop.
摘要翻译：公开了一种偏转机构，其可定位成在单个平面中以及多于一个平面中在多于一个方向上偏转诸如导管的柔性体的部分。本发明允许导管的远端部分被偏转超过360度以提供环路。

9. 发明授权

US07914524B2 Surgical clamp having trasmurality assessment capabilities 有权
标题翻译：手术夹具具有纹理评估能力
公开(公告)号：US07914524B2
公开(公告)日：2011-03-29
申请号：US11709040
申请日：2007-02-21
申请人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
发明人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00026 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/1465
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.
摘要翻译：提供了具有用于致动一对相对的钳口构件的装置的医疗装置。钳口构件可从第一位置相对于彼此移动，其中钳口构件相对于彼此以间隔开的关系设置到第二位置，其中钳口构件协作以在其间抓握组织。消融机构连接到至少一个夹爪构件，使得钳口构件能够通过夹在其间夹持的组织进行消融能量。

10. 发明授权

US07896870B2 Catheter with cryogenic and electrical heating ablation 有权
标题翻译：导管用低温和电加热消融
公开(公告)号：US07896870B2
公开(公告)日：2011-03-01
申请号：US11768259
申请日：2007-09-10
申请人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
发明人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
IPC分类号： A61B18/02 , A61B18/12 , A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B18/18 , A61B2017/00243 , A61B2018/0212 , A61B2018/0268
摘要： A catheter includes a cryoablation tip with an ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber and have an RF electrode at its distal end. The electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled in combination with an RF treatment regimen to enhance the lesion size, speed or placement of multi-lesion or single lesion cycles. In one embodiment a microwave energy source operates to extend beyond the thermal conduction depth, or penetrate the ice ball and be absorbed in tissue beyond an ice boundary, thus extending a dimension of treatment. Also, the cooling and application of RF energy can be controlled to position the ablation region away from the surface contacted by the electrode thereby leaving surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth.
摘要翻译：导管包括具有用于加热组织的消融组件的冷冻消融尖端。冷冻消融尖端可以用冷却室实现，并且在其远端具有RF电极。可以操作电极以温热低温冷却的组织，或者可以与RF治疗方案结合控制冷却剂，以增强病变大小，速度或多损伤或单个病变周期的放置。在一个实施例中，微波能量源的作用是延伸超过热传导深度，或者穿透冰球并被吸收在超过冰界的组织中，从而延伸处理的尺寸。此外，可以控制RF能量的冷却和施加，以使消融区域远离与电极接触的表面，从而在深度消融时使表面组织不受伤害，或者提供具有更高均匀度的消融带，并且随着深度增加。

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