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1. 发明授权

US07648497B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US07648497B2
公开(公告)日：2010-01-19
申请号：US11244710
申请日：2005-10-06
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

2. 发明授权

US06280439B1 Adjustable position injection tubing 有权
标题翻译：可调节位置注射管
公开(公告)号：US06280439B1
公开(公告)日：2001-08-28
申请号：US09352021
申请日：1999-07-12
申请人： Robert Martin , Claudia Lueckge , Leonilda Capuano , Miriam Lane
发明人： Robert Martin , Claudia Lueckge , Leonilda Capuano , Miriam Lane
IPC分类号： A61B1802
CPC分类号： A61B18/02 , A61B2017/00092 , A61B2018/00196 , A61B2018/0212 , A61B2018/0262
摘要： A cryogenic catheter includes an outer flexible member having a cryogenic fluid path defined by an injection tube disposed in the outer flexible member. The injection tube is slidably disposed within the outer flexible member. A guide member may be provided to support the injection tube within the outer flexible member. A wire is attached to the injection tube at one end and further attached to a spool to provide for take-up of the wire.
摘要翻译：低温导管包括具有由设置在外部柔性构件中的注射管限定的低温流体路径的外部柔性构件。注射管可滑动地设置在外部柔性构件内。可以设置引导构件以将注射管支撑在外部柔性构件内。电线在一端连接到注射管，并进一步连接到线轴以提供线的卷绕。

3. 发明授权

US08298217B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US08298217B2
公开(公告)日：2012-10-30
申请号：US12410835
申请日：2009-03-25
申请人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik
发明人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

4. 发明申请

US20090182319A1 ENDOVASCULAR CRYOTREATMENT CATHETER 有权
标题翻译：内膜切开导管
公开(公告)号：US20090182319A1
公开(公告)日：2009-07-16
申请号：US12410835
申请日：2009-03-25
申请人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Mihalik
发明人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Mihalik
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

5. 发明申请

US20080312643A1 TISSUE ABLATION SYSTEM INCLUDING GUIDEWIRE WITH SENSING ELEMENT 审中-公开
标题翻译：组织吸收系统，包括带传感元件的指南
公开(公告)号：US20080312643A1
公开(公告)日：2008-12-18
申请号：US12199255
申请日：2008-08-27
申请人： Wlodzimierz KANIA , Miriam LANE , Sean CARROLL , Allan SKANES
发明人： Wlodzimierz KANIA , Miriam LANE , Sean CARROLL , Allan SKANES
IPC分类号： A61B18/02 , A61B18/12 , A61N7/02
CPC分类号： A61B5/6851 , A61B5/6856 , A61B18/02 , A61B18/04 , A61B18/1492 , A61B18/18 , A61B2017/00026 , A61B2017/00044 , A61B2017/00084 , A61B2017/00243 , A61B2017/00292 , A61B2017/00867 , A61B2018/00214 , A61B2018/0212 , A61B2018/1407
摘要： A tissue ablation system for ablating tissue is presented having independent sensing and ablation capabilities. A sensing wire is positioned distally to the ablation region and passed through the ablation device allowing independent movement. The ablation device can ablate a substantial portion of a circumferential region of tissue. The tissue ablation system comprises an ablation device comprised of an elongated catheter with a proximal region and a distal region and an ablation element located proximate the distal region of the catheter. A sensing device having an elongated body with a proximal portion and a distal portion is adapted to be positioned within a vessel at or near a vessel ostium, wherein the sensing device is adapted to be slidably received within a lumen of the ablation device. The sensing device may be shaped in various configurations.
摘要翻译：具有消融组织的组织消融系统具有独立的感测和消融能力。传感线位于切除区域的远侧并通过消融装置，允许独立的移动。消融装置可消融组织的圆周区域的大部分。组织消融系统包括消融装置，其包括具有近端区域和远侧区域的细长导管和位于导管远侧区域附近的消融元件。具有具有近端部分和远端部分的细长主体的感测装置适于被定位在容器内或容器口附近，其中感测装置适于可滑动地容纳在消融装置的内腔内。感测装置可以以各种构造成形。

6. 发明授权

US07300433B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US07300433B2
公开(公告)日：2007-11-27
申请号：US10397619
申请日：2003-03-26
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

7. 发明授权

US09211393B2 Distal cooling distribution system for a medical device 有权
标题翻译：用于医疗设备的远端冷却分配系统
公开(公告)号：US09211393B2
公开(公告)日：2015-12-15
申请号：US11476416
申请日：2006-06-28
申请人： Yixin Hu , Vladimir Tzonev , Teresa Ann Mihalik , Benoit Thibault , Dan Wittenberger , Miriam Lane , Cristian Petre
发明人： Yixin Hu , Vladimir Tzonev , Teresa Ann Mihalik , Benoit Thibault , Dan Wittenberger , Miriam Lane , Cristian Petre
IPC分类号： A61M25/10 , A61M25/00 , A61M25/01 , A61B18/02 , A61B17/22 , A61B18/00
CPC分类号： A61M25/1025 , A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61M2025/0004 , A61M2025/0175 , A61M2025/1061
摘要： The present invention may include a medical device having a handle, a catheter coupled to the handle, and an expandable element coupled to the catheter. The medical device may also include first and second elongate bodies that traverse a length of the handle and the catheter. A housing may be disposed within the handle, with the housing defining a first opening able to receive a portion of the first elongate body, a second opening able to receive a portion of the second elongate body, and a third opening opposite the first and second openings able to receive a portion of both the first and second elongate bodies. A separation element may be disposed within the housing, with the separation element defining a path able to receive a portion of the second elongate body, and whereby a portion of the first elongate body forms a loop around the separation element.
摘要翻译：本发明可以包括具有手柄，耦合到手柄的导管和联接到导管的可扩张元件的医疗装置。医疗装置还可以包括穿过手柄和导管的一段长度的第一和第二细长体。壳体可以设置在手柄内，其中壳体限定能够容纳第一细长主体的一部分的第一开口，能够容纳第二细长主体的一部分的第二开口，以及与第一和第二开口能够容纳第一和第二细长体的一部分。分离元件可以设置在壳体内，其中分离元件限定能够接收第二细长主体的一部分的路径，并且由此第一细长主体的一部分围绕分离元件形成环。

8. 发明申请

US20120029493A1 DUAL INJECTION TUBE CRYOCATHETER AND METHOD FOR USING SAME 有权
标题翻译：双注射管结晶器及其使用方法
公开(公告)号：US20120029493A1
公开(公告)日：2012-02-02
申请号：US12844388
申请日：2010-07-27
申请人： Dan WITTENBERGER , Claudia LUECKGE , Miriam LANE
发明人： Dan WITTENBERGER , Claudia LUECKGE , Miriam LANE
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00166 , A61B2018/0022 , A61B2018/00642 , A61B2018/0212 , A61B2090/064
摘要： A medical device includes a catheter body having a first injection lumen, a second injection lumen, and an exhaust lumen, where the first injection lumen provides a fluid flow rate greater than a fluid flow rate provided by the second injection lumen; an expandable element coupled to the catheter body in fluid communication with the first and second injection lumens; a cryogenic fluid source in fluid communication with the first and second injection lumens; a valve in fluid communication with the first and second injection lumens to selectively allow fluid flow to at least one of the first and second injection lumens; a pressure sensor in fluid communication with an interior defined by the expandable element; and a controller in communication with the pressure sensor programmed to regulate fluid flow through the first injection lumen based at least in part on a signal from the pressure sensor.
摘要翻译：医疗装置包括具有第一注射腔，第二注射内腔和排气腔的导管主体，其中第一注射腔提供大于由第二注射腔提供的流体流速的流体流速; 耦合到所述导管主体的可扩张元件，其与所述第一和第二注射腔流体连通; 与所述第一和第二注射腔流体连通的低温流体源; 与所述第一和第二注射腔流体连通的阀，以选择性地允许流体流向所述第一和第二注射腔中的至少一个; 与由可膨胀元件限定的内部流体连通的压力传感器; 以及与所述压力传感器通信的控制器，其被编程为至少部分地基于来自所述压力传感器的信号来调节通过所述第一喷射腔的流体流动。

9. 发明授权

US07527622B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US07527622B2
公开(公告)日：2009-05-05
申请号：US10887271
申请日：2004-07-08
申请人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Mihalik
发明人： Miriam Lane , Marwan Abboud , Rachid Mahrouche , Teresa Mihalik
IPC分类号： A61B18/18 , A61M29/00
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. One or more sensors may be disposed between the balloons or the vacuum return lumen, to detect leaks and control the flow of fluid through the device. Examples of sensors include pressure and temperature sensors, optical sensors, magnetic flow switches and flow meters.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。一个或多个传感器可以设置在气球或真空返回腔之间，以检测泄漏并控制通过装置的流体的流动。传感器的示例包括压力和温度传感器，光学传感器，磁流量开关和流量计。

10. 发明申请

US20080312642A1 TISSUE ABLATION SYSTEM INCLUDING GUIDEWIRE WITH SENSING ELEMENT 审中-公开
公开(公告)号：US20080312642A1
公开(公告)日：2008-12-18
申请号：US12199016
申请日：2008-08-27
申请人： Wlodzimierz KANIA , Miriam LANE , Sean CARROLL , Allan SKANES
发明人： Wlodzimierz KANIA , Miriam LANE , Sean CARROLL , Allan SKANES
IPC分类号： A61B18/02 , A61B18/18 , A61B18/04 , A61N7/02
CPC分类号： A61B5/6851 , A61B5/6856 , A61B18/02 , A61B18/04 , A61B18/1492 , A61B18/18 , A61B2017/00026 , A61B2017/00044 , A61B2017/00084 , A61B2017/00243 , A61B2017/00292 , A61B2017/00867 , A61B2018/00214 , A61B2018/0212 , A61B2018/1407
摘要： A tissue ablation system for ablating tissue is presented having independent sensing and ablation capabilities. A sensing wire is positioned distally to the ablation region and passed through the ablation device allowing independent movement. The ablation device can ablate a substantial portion of a circumferential region of tissue. The tissue ablation system comprises an ablation device comprised of an elongated catheter with a proximal region and a distal region and an ablation element located proximate the distal region of the catheter. A sensing device having an elongated body with a proximal portion and a distal portion is adapted to be positioned within a vessel at or near a vessel ostium, wherein the sensing device is adapted to be slidably received within a lumen of the ablation device. The sensing device may be shaped in various configurations.

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