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1. 发明授权

US08297108B2 Mesh leak detection system for a medical device 有权
标题翻译：用于医疗设备的网孔泄漏检测系统
公开(公告)号：US08297108B2
公开(公告)日：2012-10-30
申请号：US12767012
申请日：2010-04-26
申请人： Marwan Abboud , Dan Wittenberger
发明人： Marwan Abboud , Dan Wittenberger
IPC分类号： G01M3/00
CPC分类号： G01M3/02 , A61B18/02 , A61B2017/00119 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/0147 , A61M25/10 , A61M2205/15
摘要： The present invention provides a surgical device including an elongate body defining a fluid flow path therethrough. An expandable element may be coupled to the elongate body and placed in fluid communication with the fluid flow path. Moreover, the surgical device may include a first leak detection element at least partially surrounding a portion of the expandable element, and a second leak detection element may be provided in fluid communication with the fluid flow path. In addition, a console may be provided, where the console may be in communication with the first and second leak detection elements. Further, a supply of cryogenic fluid as well as a vacuum source may be provided in fluid communication with the fluid flow path.
摘要翻译：本发明提供一种手术装置，其包括限定通过其中的流体流动通道的细长主体。可膨胀元件可以联接到细长主体并且被放置成与流体流动路径流体连通。此外，手术装置可以包括至少部分地围绕可膨胀元件的一部分的第一泄漏检测元件，并且第二泄漏检测元件可以设置成与流体流动路径流体连通。此外，可以提供控制台，其中控制台可以与第一和第二泄漏检测元件通信。此外，可以提供与流体流动路径流体连通的低温流体以及真空源的供应。

2. 发明授权

US08287526B2 Method of simultaneously freezing and heating tissue for ablation 有权
标题翻译：同时冷冻和加热组织消融的方法
公开(公告)号：US08287526B2
公开(公告)日：2012-10-16
申请号：US13301978
申请日：2011-11-22
申请人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
发明人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/1492 , A61B18/18 , A61B2017/00243 , A61B2018/0212 , A61B2018/0268
摘要： A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen.
摘要翻译：导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。可以操作RF电极以温热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织。

3. 发明申请

US20070299432A1 CATHETER WITH CRYOGENIC AND ELECTRICAL HEATING ABLATION 有权
标题翻译：具有低温和电加热的导管
公开(公告)号：US20070299432A1
公开(公告)日：2007-12-27
申请号：US11768259
申请日：2007-09-10
申请人： Steven Arless , Fredric Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
发明人： Steven Arless , Fredric Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B18/18 , A61B2017/00243 , A61B2018/0212 , A61B2018/0268
摘要： A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion re-treatment cycles. In one embodiment a microwave energy source operates at a frequency to extend beyond the thermal conduction depth, or to penetrate the cryogenic ice ball and be absorbed in tissue beyond an ice boundary, thus extending the depth and/or width of a single treatment locus. In another embodiment, the cooling and the application of RF energy are both controlled to position the ablation region away from the surface contacted by the electrode, for example to leave surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth. The driver or RF energy source may supply microwave energy at a frequency effective to penetrate the ice ball which develops on a cryocatheter, and different frequencies may be selected for preferential absorption in a layer of defined thickness at depth in the nearby tissue. The catheter may operate between 70 and minus 70 degrees Celsius for different tissue applications, such as angioplasty, cardiac ablation and tissue remodeling, and may preset the temperature of the tip or adjacent tissue, and otherwise overlay or delay the two different profiles to tailor the shape or position where ablation occurs or to speed up a treatment cycle.
摘要翻译：导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。 RF电极可以被操作以加热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织，从而允许操作的更大的通用性和增强病变大小，速度或放置多病变治疗或单次病变再治疗周期。在一个实施例中，微波能量源的频率以超出热传导深度的频率运行，或者穿透低温冰球并被吸收在超过冰界的组织中，从而延长单个处理轨迹的深度和/或宽度。在另一个实施例中，RF能量的冷却和应用都被控制以将消融区域远离与电极接触的表面，例如在深度消融时留下表面组织而不受伤害，或者提供具有更大均匀性的消融带，增加深度。驱动器或RF能源可以以有效穿透在低温导管上形成的冰球的频率提供微波能量，并且可以选择不同的频率用于在附近组织的深度处的限定厚度的层中的优先吸收。对于不同的组织应用（例如血管成形术，心脏消融和组织重建），导管可以在70摄氏度和零下70度之间运行，并且可以预设尖端或相邻组织的温度，否则叠加或延迟两个不同的轮廓以定制消融发生的形状或位置或加速治疗周期。

4. 发明申请

US20070149969A1 Surgical clamp having transmurality assessment capabilities 有权
公开(公告)号：US20070149969A1
公开(公告)日：2007-06-28
申请号：US11708927
申请日：2007-02-21
申请人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean Lalonde , Cristian Petre , Real Ste-Marie , Sean Carroll , Allan Skanes , Alan Menkis
发明人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean Lalonde , Cristian Petre , Real Ste-Marie , Sean Carroll , Allan Skanes , Alan Menkis
IPC分类号： A61B18/18
CPC分类号： A61B17/2812 , A61B5/0408 , A61B17/122 , A61B17/282 , A61B17/29 , A61B18/02 , A61B18/0218 , A61B2017/00026 , A61B2017/00084 , A61B2017/00243 , A61B2017/00738 , A61B2017/2905 , A61B2017/2931 , A61B2017/2944 , A61B2018/00011 , A61B2018/00577 , A61B2018/00744 , A61B2018/00791 , A61B2018/00839 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/145
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.

5. 发明授权

US06635053B1 Cooling system 有权
标题翻译：冷却系统
公开(公告)号：US06635053B1
公开(公告)日：2003-10-21
申请号：US09638208
申请日：2000-08-11
申请人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche , Dan Wittenberger
发明人： Jean-Pierre Lalonde , Marwan Abboud , Rachid Mahrouche , Dan Wittenberger
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00092 , A61B2017/00119 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： A cryogenic medical system includes a medical device and a console connectable to the medical device at a connection point. The console controls the temperature of the medical device. The console includes a first cooling system directing coolant to the medical device at a first temperature along a coolant supply line and a second cooling system chilling the coolant within the coolant supply line to a temperature below the first temperature before the coolant reaches the connection point.
摘要翻译：低温医疗系统包括在连接点处可连接到医疗装置的医疗装置和控制台。控制台控制医疗设备的温度。所述控制台包括第一冷却系统，所述第一冷却系统沿着冷却剂供应管线在第一温度下将冷却剂引导至所述医疗设备;以及第二冷却系统，在所述冷却剂到达所述连接点之前将所述冷却剂供应管线内的冷却剂冷却至低于所述第一温度的温

6. 发明授权

US06546932B1 Cryogenic method and apparatus for promoting angiogenesis 有权
标题翻译：用于促进血管发生的低温方法和装置
公开(公告)号：US06546932B1
公开(公告)日：2003-04-15
申请号：US09543108
申请日：2000-04-05
申请人： Daniel Nahon , Mathieu-Philippe Aubert , Philippe Marchand , Marwan Abboud , Steven G. Arless , Richard Gallo , Marc Dubuc , Sean Carroll , Dan Wittenberger , John W. Lehmann
发明人： Daniel Nahon , Mathieu-Philippe Aubert , Philippe Marchand , Marwan Abboud , Steven G. Arless , Richard Gallo , Marc Dubuc , Sean Carroll , Dan Wittenberger , John W. Lehmann
IPC分类号： A61B1900
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F2250/0067
摘要： A method of promoting blood vessel growth includes the steps of providing a cryocatheter having a thermally transmission region; placing the cryocatheter proximate an area of tissue to be treated; cooling the thermally transmissive region of the cryocatheter proximate the area of tissue to a temperature sufficient to injure the area of tissue; allowing the area of tissue to warm; and removing the cryocatheter from the area of tissue. Prior, during or after the cooling step, the area of tissue can be mechanically traumatized, and drugs can be injected into the tissue.
摘要翻译：促进血管生长的方法包括以下步骤：提供具有热传递区域的低温容器; 将低温套管放置在待处理组织的一个区域附近; 将靠近组织区域的低温热管的热传导区域冷却到足以损伤组织面积的温度; 允许组织的面积温暖; 并从组织区域移除低温切片机。之前，在冷却步骤期间或之后，组织的面积可以被机械地创伤，药物可以被注射到组织中。

7. 发明授权

US09039712B2 Shape modification system for a cooling chamber of a medical device 有权
标题翻译：用于医疗器械冷却室的形状修改系统
公开(公告)号：US09039712B2
公开(公告)日：2015-05-26
申请号：US11476408
申请日：2006-06-28
申请人： Marwan Abboud , Dan Wittenberger
发明人： Marwan Abboud , Dan Wittenberger
IPC分类号： A61F11/00 , A61M25/10
CPC分类号： A61M25/10181 , A61B2018/0212 , A61M2025/1068
摘要： The present invention provides a medical device having an catheter body defining proximal and distal portions, and a guidewire lumen at least partially disposed within and movable within the catheter body. The medical device may include an expandable element defining a proximal end and a distal end, wherein the proximal end is coupled to the distal portion of the catheter body and the distal end is coupled to the guidewire lumen. In addition, an actuator element may be coupled to the guidewire lumen for longitudinal movement thereof, and a tensioning element may further be coupled to the guidewire lumen to bias the guidewire lumen and/or the expandable element towards a particular geometric configuration.
摘要翻译：本发明提供一种医疗装置，其具有限定近端部分和远端部分的导管主体，以及至少部分地设置在导管主体内并在导管主体内可移动的导丝管腔。医疗装置可以包括限定近端和远端的可扩张元件，其中近端联接到导管主体的远端部分，并且远端联接到导丝管腔。此外，致动器元件可以联接到导丝管腔以用于其纵向运动，并且张紧元件可以进一步联接到导丝管腔，以将导丝管腔和/或可扩张元件朝向特定的几何构型偏置。

8. 发明授权

US07914524B2 Surgical clamp having trasmurality assessment capabilities 有权
标题翻译：手术夹具具有纹理评估能力
公开(公告)号：US07914524B2
公开(公告)日：2011-03-29
申请号：US11709040
申请日：2007-02-21
申请人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
发明人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00026 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/1465
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.
摘要翻译：提供了具有用于致动一对相对的钳口构件的装置的医疗装置。钳口构件可从第一位置相对于彼此移动，其中钳口构件相对于彼此以间隔开的关系设置到第二位置，其中钳口构件协作以在其间抓握组织。消融机构连接到至少一个夹爪构件，使得钳口构件能够通过夹在其间夹持的组织进行消融能量。

9. 发明授权

US07896870B2 Catheter with cryogenic and electrical heating ablation 有权
标题翻译：导管用低温和电加热消融
公开(公告)号：US07896870B2
公开(公告)日：2011-03-01
申请号：US11768259
申请日：2007-09-10
申请人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
发明人： Steven G. Arless , Fredric L. Milder , Marwan Abboud , Dan Wittenberger , Sean Carroll
IPC分类号： A61B18/02 , A61B18/12 , A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B18/18 , A61B2017/00243 , A61B2018/0212 , A61B2018/0268
摘要： A catheter includes a cryoablation tip with an ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber and have an RF electrode at its distal end. The electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled in combination with an RF treatment regimen to enhance the lesion size, speed or placement of multi-lesion or single lesion cycles. In one embodiment a microwave energy source operates to extend beyond the thermal conduction depth, or penetrate the ice ball and be absorbed in tissue beyond an ice boundary, thus extending a dimension of treatment. Also, the cooling and application of RF energy can be controlled to position the ablation region away from the surface contacted by the electrode thereby leaving surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth.
摘要翻译：导管包括具有用于加热组织的消融组件的冷冻消融尖端。冷冻消融尖端可以用冷却室实现，并且在其远端具有RF电极。可以操作电极以温热低温冷却的组织，或者可以与RF治疗方案结合控制冷却剂，以增强病变大小，速度或多损伤或单个病变周期的放置。在一个实施例中，微波能量源的作用是延伸超过热传导深度，或者穿透冰球并被吸收在超过冰界的组织中，从而延伸处理的尺寸。此外，可以控制RF能量的冷却和施加，以使消融区域远离与电极接触的表面，从而在深度消融时使表面组织不受伤害，或者提供具有更高均匀度的消融带，并且随着深度增加。

10. 发明授权

US07819860B2 Surgical clamp having trasmurality assessment capabilities 有权
标题翻译：手术夹具具有纹理评估能力
公开(公告)号：US07819860B2
公开(公告)日：2010-10-26
申请号：US10841955
申请日：2004-05-07
申请人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
发明人： Dan Wittenberger , Daniel Nahon , Marwan Abboud , Jean-Pierre Lalonde , Cristian Petre , Réal Ste-Marie , Sean Carroll , Allan Skanes , Alan H. Menkis
IPC分类号： A61B18/02
CPC分类号： A61B17/2812 , A61B5/0408 , A61B17/122 , A61B17/282 , A61B17/29 , A61B18/02 , A61B18/0218 , A61B2017/00026 , A61B2017/00084 , A61B2017/00243 , A61B2017/00738 , A61B2017/2905 , A61B2017/2931 , A61B2017/2944 , A61B2018/00011 , A61B2018/00577 , A61B2018/00744 , A61B2018/00791 , A61B2018/00839 , A61B2018/0212 , A61B2018/0225 , A61B2018/0262 , A61B2018/145
摘要： A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.
摘要翻译：提供了具有用于致动一对相对的钳口构件的装置的医疗装置。钳口构件可从第一位置相对于彼此移动，其中钳口构件相对于彼此以间隔开的关系设置到第二位置，其中钳口构件协作以在其间抓握组织。消融机构连接到至少一个夹爪构件，使得钳口构件能够通过夹在其间夹持的组织进行消融能量。

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