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21. 发明授权

US07145134B2 Multi-anode detector with increased dynamic range for time-of-flight mass spectrometers with counting data acquisitions 有权
标题翻译：多阳极检测器具有增加的飞行时间质谱仪的动态范围，具有计数数据采集功能
公开(公告)号：US07145134B2
公开(公告)日：2006-12-05
申请号：US10856397
申请日：2004-05-28
申请人： Marc Gonin , Valeri Raznikov , Katrin Fuhrer , J. Albert Schultz , Michael I. McCully
发明人： Marc Gonin , Valeri Raznikov , Katrin Fuhrer , J. Albert Schultz , Michael I. McCully
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/40 , H01J49/025
摘要： A detection scheme for time-of-flight mass spectrometers is described that extends the dynamic range of spectrometers that use counting techniques while avoiding the problems of crosstalk. It is well known that a multiple anode detector capable of detecting different fractions of the incoming particles may be used to increase the dynamic range of a TOFMS system. However, crosstalk between the anodes limits the amount by which the dynamic range may be increased. The present invention overcomes limitations imposed by crosstalk by using either a secondary amplification stage or by using different primary amplification stages.
摘要翻译：描述了用于飞行时间质谱仪的检测方案，其扩展了使用计数技术的光谱仪的动态范围，同时避免串扰问题。众所周知，可以使用能够检测进入颗粒的不同分数的多重阳极检测器来增加TOFMS系统的动态范围。然而，阳极之间的串扰限制了动态范围可能增加的量。本发明通过使用二级放大级或通过使用不同的初级放大级来克服串扰所引起的限制。

22. 发明申请

US20060192104A1 Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions 有权
公开(公告)号：US20060192104A1
公开(公告)日：2006-08-31
申请号：US11342716
申请日：2006-01-30
申请人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
发明人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： G01N27/622 , H01J49/0045
摘要： Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.

23. 发明授权

US07084395B2 Time-of-flight mass spectrometer for monitoring of fast processes 有权
公开(公告)号：US07084395B2
公开(公告)日：2006-08-01
申请号：US10967715
申请日：2004-10-18
申请人： Katrin Fuhrer , Marc Gonin , Kent J. Gillig , Thomas F. Egan , Michael I. McCully , J. Albert Schultz
发明人： Katrin Fuhrer , Marc Gonin , Kent J. Gillig , Thomas F. Egan , Michael I. McCully , J. Albert Schultz
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/0059 , H01J49/025
摘要： Time-of-flight mass spectrometer instruments for monitoring fast processes using an interleaved timing scheme and a position sensitive detector are described. The combination of both methods is also described.

24. 发明授权

US06909090B2 Multi-anode detector with increased dynamic range for time-of-flight mass spectrometers with counting data acquisitions 有权
标题翻译：多阳极检测器具有增加的飞行时间质谱仪的动态范围，具有计数数据采集功能
公开(公告)号：US06909090B2
公开(公告)日：2005-06-21
申请号：US10638799
申请日：2003-08-11
申请人： Marc Gonin , Valeri Raznikov , Katrin Fuhrer , J. Albert Schultz , Michael I. McCully
发明人： Marc Gonin , Valeri Raznikov , Katrin Fuhrer , J. Albert Schultz , Michael I. McCully
IPC分类号： H01J49/02 , H01J49/40
CPC分类号： H01J49/40 , H01J49/025
摘要： A detection scheme for time-of-flight mass spectrometers is described that extends the dynamic range of spectrometers that use counting techniques while avoiding the problems of crosstalk. It is well known that a multiple anode detector capable of detecting different fractions of the incoming particles may be used to increase the dynamic range of a TOFMS system. However, crosstalk between the anodes limits the amount by which the dynamic range may be increased. The present invention overcomes limitations imposed by crosstalk by using either a secondary amplification stage or by using different primary amplification stages.
摘要翻译：描述了用于飞行时间质谱仪的检测方案，其扩展了使用计数技术的光谱仪的动态范围，同时避免串扰问题。众所周知，可以使用能够检测进入颗粒的不同分数的多重阳极检测器来增加TOFMS系统的动态范围。然而，阳极之间的串扰限制了动态范围可能增加的量。本发明通过使用二级放大级或通过使用不同的初级放大级来克服串扰所引起的限制。

25. 发明申请

US20030111597A1 Multi-anode detector with increased dynamic range for time-of-flight mass spectrometers with counting data acquisition 有权
标题翻译：多阳极检测器具有增加的飞行时间质谱仪的动态范围，具有计数数据采集功能
公开(公告)号：US20030111597A1
公开(公告)日：2003-06-19
申请号：US10025508
申请日：2001-12-19
申请人： Ionwerks, Inc.
发明人： Marc Gonin , Valeri Raznikov , Katrin Fuhrer , J. Albert Schultz , Michael I. McCully
IPC分类号： H01J049/40
CPC分类号： H01J49/40 , H01J49/025
摘要： A detection scheme for time-of-flight mass spectrometers is described that extends the dynamic range of spectrometers that use counting techniques while avoiding the problems of crosstalk. It is well known that a multiple anode detector capable of detecting different fractions of the incoming particles may be used to increase the dynamic range of a TOFMS system. However, crosstalk between the anodes limits the amount by which the dynamic range may be increased. The present invention overcomes limitations imposed by crosstalk by using either a secondary amplification stage or by using different primary amplification stages.
摘要翻译：描述了用于飞行时间质谱仪的检测方案，其扩展了使用计数技术的光谱仪的动态范围，同时避免串扰问题。众所周知，可以使用能够检测进入颗粒的不同分数的多重阳极检测器来增加TOFMS系统的动态范围。然而，阳极之间的串扰限制了动态范围可能增加的量。本发明通过使用二级放大级或通过使用不同的初级放大级来克服串扰所引起的限制。

26. 发明授权

US10191028B1 Inorganic nanoparticle matrices for sample analysis 有权
公开(公告)号：US10191028B1
公开(公告)日：2019-01-29
申请号：US10861970
申请日：2004-06-04
申请人： John Albert Schultz , Michael V. Ugarov
发明人： John Albert Schultz , Michael V. Ugarov
IPC分类号： G01N33/483 , H01J49/16
摘要： A new type of matrices for Matrix Assisted Laser Desorption and Ionization technique based on derivatized carbon clusters, which will be suitable for the analysis of peptides, proteins and other biomolecules by mass spectrometry which has several advantages over conventional matrices, such as optical sensitivity in a broad spectrum, low interference in the wide mass range and high analyte ionization efficiency.

27. 发明授权

US08614416B2 Nonoparticulate assisted nanoscale molecular imaging by mass spectrometery 有权
标题翻译：通过质谱法测定无微粒辅助纳米级分子成像
公开(公告)号：US08614416B2
公开(公告)日：2013-12-24
申请号：US13156111
申请日：2011-06-08
申请人： J. Albert Schultz , Thomas F. Egan , Ernest K. Lewis , Steven Ulrich , Kelley L. Waters
发明人： J. Albert Schultz , Thomas F. Egan , Ernest K. Lewis , Steven Ulrich , Kelley L. Waters
IPC分类号： H01J49/40 , H01J49/26 , H01J37/26 , G01N21/64
CPC分类号： H01J49/10 , G01N21/64 , G01N21/6458 , G01N21/65 , G01N21/658 , G01N23/2258 , G01N2021/6417 , H01J49/0004 , H01J49/0422 , H01J49/0463 , H01J49/142 , H01J49/164 , H01J49/26 , H01J49/40
摘要： Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.
摘要翻译：描述了用于质谱的方法和装置，具体地，使用纳米颗粒注入作为二次离子的基质，更一般地说是二次粒子。光子束源或纳米颗粒束源可用于解吸源或初级离子/一次粒子源。

28. 发明申请

US20130134305A1 POST-IONIZATION OF NEUTRALS FOR ION MOBILITY oTOFMS IDENTIFICATION OF MOLECULES AND ELEMENTS DESORBED FROM SURFACES 有权
标题翻译：离子移动物质的中和离子化表征从表面脱落的分子和元素的鉴定
公开(公告)号：US20130134305A1
公开(公告)日：2013-05-30
申请号：US13746704
申请日：2013-01-22
申请人： Ionwerks, Inc.
发明人： J. Albert Schultz , Thomas F. Egan , Kelley L. Waters , Ernest K. Lewis
IPC分类号： H01J49/40 , H01J49/00
CPC分类号： H01J49/40 , G01N27/622 , H01J49/0027 , H01J49/0045 , H01J49/107
摘要： The present invention relates to a method and apparatus for ionizing a neutral MALDI desorption plume, and in particular, for efficiently measuring the ionized MALDI desorption plume when post-ionization techniques are combined with a medium pressure MALDI-IM-oTOFMS instrument. Additionally, the present disclosure provides a method and apparatus that simultaneously separates tissue-sample MALDI ions by IM-oTOFMS according to their chemical family. After separation, the MALDI ions are directly compared to the ions created by post-ionizing the co-desorbed neutral molecules with a second laser wherein the second laser is delayed by a few hundred microseconds. The present disclosure further provides novel approaches that enhance the analysis of ions, including the use of giant fullerene internal standards to enhance mass accuracy, and ultraviolet (UV) declustering lasers to generate intact peptides and proteins, either of which may be followed by VUV post-ionization which generates identifiable structural fragments.
摘要翻译：本发明涉及一种用于离子化中性MALDI解吸羽流的方法和装置，特别是当电离后技术与中压MALDI-IM-OTOFMS仪器结合时，用于有效测量电离的MALDI解吸羽流。此外，本公开提供了一种方法和装置，其通过IM-oTOFMS根据其化学族同时分离组织样品MALDI离子。分离后，将MALDI离子直接与通过用第二激光离子化共解吸的中性分子产生的离子进行比较，其中第二激光器延迟几百微秒。本公开进一步提供了增强离子分析的新方法，包括使用巨富勒烯内标来提高质量精度，以及紫外（UV）去聚簇激光以产生完整的肽和蛋白质，其中之一可以是VUV柱产生可识别的结构碎片。

29. 发明申请

US20110049355A1 FAST TIME-OF-FLIGHT MASS SPECTROMETER WITH IMPROVED DATA ACQUISITION SYSTEM 有权
标题翻译：具有改进的数据采集系统的快速飞行时间质谱仪
公开(公告)号：US20110049355A1
公开(公告)日：2011-03-03
申请号：US12885064
申请日：2010-09-17
申请人： Katrin Fuhrer , Marc Gonin , Thomas F. Egan , William Burton , J. Albert Schultz , Valerie E. Vaughn , Steven Ulrich
发明人： Katrin Fuhrer , Marc Gonin , Thomas F. Egan , William Burton , J. Albert Schultz , Valerie E. Vaughn , Steven Ulrich
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , H01J49/0036 , H01J49/025
摘要： Time-of-flight mass spectrometer instruments are disclosed for monitoring fast processes with large dynamic range using a multi-threshold TDC data acquisition method or a threshold ADC data acquisition method. Embodiments using a combination of both methods are also disclosed.
摘要翻译：公开了飞行时间质谱仪仪器，用于使用多阈值TDC数据采集方法或阈值ADC数据采集方法监测具有大动态范围的快速过程。还公开了使用两种方法的组合的实施方案。

30. 发明授权

US07800054B2 Fast time-of-flight mass spectrometer with improved dynamic range 有权
标题翻译：快速飞行时间质谱仪具有改进的动态范围
公开(公告)号：US07800054B2
公开(公告)日：2010-09-21
申请号：US12110037
申请日：2008-04-25
申请人： Katrin Fuhrer , Marc Gonin , Thomas F. Egan , William Burton , J. Albert Schultz , Valerie E. Vaughn , Steven R. Ulrich
发明人： Katrin Fuhrer , Marc Gonin , Thomas F. Egan , William Burton , J. Albert Schultz , Valerie E. Vaughn , Steven R. Ulrich
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , H01J49/0036 , H01J49/025
摘要： Time-of-flight mass spectrometer instruments are disclosed for monitoring fast processes with large dynamic range using a multi-threshold TDC data acquisition method or a threshold ADC data acquisition method. Embodiments using a combination of both methods are also disclosed.
摘要翻译：公开了飞行时间质谱仪仪器，用于使用多阈值TDC数据采集方法或阈值ADC数据采集方法监测具有大动态范围的快速过程。还公开了使用两种方法的组合的实施方案。

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