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1. 发明申请

US20060289746A1 Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording 有权
公开(公告)号：US20060289746A1
公开(公告)日：2006-12-28
申请号：US11441766
申请日：2006-05-26
申请人： Valeri Raznikov , J. Schultz , Thomas Egan , Michael Ugarov , Agnes Tempez , Gennadiy Savenkov , Vladislav Zelenov
发明人： Valeri Raznikov , J. Schultz , Thomas Egan , Michael Ugarov , Agnes Tempez , Gennadiy Savenkov , Vladislav Zelenov
IPC分类号： H01J49/00
CPC分类号： H01J49/009 , G01N27/622 , H01J49/40
摘要： The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.

2. 发明申请

US20060138317A1 Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues 有权
公开(公告)号：US20060138317A1
公开(公告)日：2006-06-29
申请号：US11231448
申请日：2005-09-21
申请人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le bayec , Serge Negra
发明人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le bayec , Serge Negra
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/0031 , H01J49/0418
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.

3. 发明授权

US07019286B2 Time-of-flight mass spectrometer for monitoring of fast processes 有权
公开(公告)号：US07019286B2
公开(公告)日：2006-03-28
申请号：US10689173
申请日：2003-10-20
申请人： Katrin Fuhrer , Marc Gonin , Kent J. Gillig , Thomas Egan , Michael I. McCully , John A. Schultz
发明人： Katrin Fuhrer , Marc Gonin , Kent J. Gillig , Thomas Egan , Michael I. McCully , John A. Schultz
IPC分类号： H01J49/40
CPC分类号： H01J49/025 , G01N27/622 , H01J49/40
摘要： Time-of-flight mass spectrometer instruments for monitoring fast processes using an interleaved timing scheme and a position sensitive detector are described. The combination of both methods is also described.

4. 发明申请

US20050109931A1 Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions 有权
标题翻译：离子迁移率TOF / MALDI / MS使用漂移电池交替高低电场区域
公开(公告)号：US20050109931A1
公开(公告)日：2005-05-26
申请号：US10969643
申请日：2004-10-20
申请人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
发明人： J. Schultz , Valeri Raznikov , Thomas Egan , Michael Ugarov , Agnes Tempez
IPC分类号： G01N20060101 , G01N27/64 , H01J49/00 , H01J49/40
CPC分类号： G01N27/622 , H01J49/0045
摘要： Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.
摘要翻译：用于离子迁移率漂移池的改进的离子聚焦允许用于后续检测（例如质量检测）的提高的生产量。通过在离子迁移率漂移池中使用高电场和低电场的交替区域来实现改进的聚焦。

5. 发明申请

US20050035284A1 Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues 有权
标题翻译：金子植入/沉积生物样品用于激光解吸三维组织的深度剖析
公开(公告)号：US20050035284A1
公开(公告)日：2005-02-17
申请号：US10861962
申请日：2004-06-04
申请人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le Bayec , Serge Della-Negra
发明人： J. Schultz , Michael Ugarov , Thomas Egan , Agnes Tempez , Yvon Le Bayec , Serge Della-Negra
IPC分类号： B01D59/44 , H01J20060101 , H01J49/00 , H01J49/04 , H01J49/16 , H01J49/40
CPC分类号： H01J49/164 , H01J49/0031 , H01J49/0418
摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.
摘要翻译：本发明通过将低能离子簇（金，铝等）或化学衍生的簇离子注入到样品的近表面区域中，形成表面定位的MALDI粒子基质来增强生物分子离子从表面的激光解吸附。然后可以通过激光解吸到质谱仪中或者在优选的实施方式中将离子迁移正交时间合并在离子迁移正交时间内的表面上或在由离子的注入范围限定的窄地下区域内的完整生物分子的MALDI分析质谱仪

6. 发明授权

US07640409B1 Method and apparatus for data migration and failover 失效
标题翻译：用于数据迁移和故障转移的方法和设备
公开(公告)号：US07640409B1
公开(公告)日：2009-12-29
申请号：US11193166
申请日：2005-07-29
申请人： Anthony Arthur Stafford , Norman Allen Abramovitz , Thomas Egan , Jenlong Wang , Cheng-Mu Wen , Juntse Chen , Thomas Rex Bosworth , Steven Bundy Wahl , Bradley David Musolff
发明人： Anthony Arthur Stafford , Norman Allen Abramovitz , Thomas Egan , Jenlong Wang , Cheng-Mu Wen , Juntse Chen , Thomas Rex Bosworth , Steven Bundy Wahl , Bradley David Musolff
IPC分类号： G06F12/00
CPC分类号： G06F3/0647 , G06F3/0605 , G06F3/0614 , G06F3/0689 , G06F11/142 , Y10S707/99953
摘要： Method and apparatus for data migration are described herein. In one embodiment, in response to data received from an application to be written to a first storage volume, the data is written to the first storage volume and a second storage volume substantially concurrently. When the first and second storage volumes are synchronized, a switchover is performed from the first storage volume to the second storage volume, such that subsequent data received from the application is written to the second storage volume, where writing the data to the first and second storage volumes and the switchover are performed without knowledge of the application. Other methods and apparatuses are also described.
摘要翻译：本文描述了用于数据迁移的方法和装置。在一个实施例中，响应于从要写入第一存储卷的应用程序接收的数据，数据基本上同时写入第一存储卷和第二存储卷。当同步第一和第二存储卷时，从第一存储卷到第二存储卷执行切换，使得从应用接收到的后续数据被写入第二存储卷，其中将数据写入第一和第二存储卷存储卷和切换在不了解应用程序的情况下执行。还描述了其它方法和装置。

7. 发明申请

US20060192111A1 Fast time-of-flight mass spectrometer with improved data acquisition system 有权
公开(公告)号：US20060192111A1
公开(公告)日：2006-08-31
申请号：US11368639
申请日：2006-03-06
申请人： Katrin Fuhrer , Marc Gonin , Thomas Egan , William Burton , J. Schultz , Valerie Vaughn , Steven Ulrich
发明人： Katrin Fuhrer , Marc Gonin , Thomas Egan , William Burton , J. Schultz , Valerie Vaughn , Steven Ulrich
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , H01J49/0036 , H01J49/025
摘要： Time-of-flight mass spectrometer instruments are disclosed for monitoring fast processes with large dynamic range using a multi-threshold TDC data acquisition method or a threshold ADC data acquisition method. Embodiments using a combination of both methods are also disclosed.

8. 发明申请

US20060024720A1 Multiplex data acquisition modes for ion mobility-mass spectrometry 有权
标题翻译：用于离子迁移率 - 质谱的多重数据采集模式
公开(公告)号：US20060024720A1
公开(公告)日：2006-02-02
申请号：US11191666
申请日：2005-07-27
申请人： John McLean , David Russell , Thomas Egan , Michael Ugarov , J. Schultz
发明人： John McLean , David Russell , Thomas Egan , Michael Ugarov , J. Schultz
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/48
CPC分类号： G01N33/6851 , B82Y30/00 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms.
摘要翻译：描述了一种与质谱耦合的气相离子迁移多路复用数据采集方法和装置。离子包以比离子迁移率分离到达时间分布更快的速率注入离子迁移率漂移室。由此产生的复杂到达时间分布由质谱仪和后处理算法解卷积。

9. 发明申请

US20050264020A1 Multi-motion lifting and transferring apparatus and method 有权
标题翻译：多动提升和传送装置及方法
公开(公告)号：US20050264020A1
公开(公告)日：2005-12-01
申请号：US11104672
申请日：2005-04-13
申请人： Thomas Egan
发明人： Thomas Egan
IPC分类号： B60N2/00 , B60N2/02 , B60N2/14 , B60N2/24 , B60N2/50
CPC分类号： B60N2/14 , B60N2/245 , Y10S414/134
摘要： A multi-motion lifting and transferring apparatus and method are disclosed. The multi-motion lifting and transferring apparatus and method may be realized in primarily two versions, the first being referred to as the single linkage arm version, and the second being referred to as the dual linkage arm version. In one particular exemplary embodiment, a multi-motion lifting and transferring apparatus in accordance with the single linkage arm version may be realized as having a first pivot point for rotating an intermediary support member about a first substantially vertical axis, a second pivot point for rotating an electrically or hydraulically powered up/down extension arm about a second substantially vertical axis, and a seat support member for supporting a seat for accommodating at least one person.
摘要翻译：公开了一种多动式提升和转移装置和方法。多动式提升和传送装置和方法可以主要实现两个版本，第一个称为单个联动臂版本，第二个被称为双联动臂版本。在一个具体的示例性实施例中，可以实现根据单个联动臂版本的多运动提升和传送装置，具有用于围绕第一基本垂直的轴线旋转中间支撑构件的第一枢转点，用于旋转的第二枢转点围绕第二基本垂直轴线的电动或液压动力上/下延伸臂，以及用于支撑用于容纳至少一个人的座椅的座椅支撑构件。

10. 发明申请

US20050217920A1 Technique for controlling vehicle functions 有权
标题翻译：控制车辆功能的技术
公开(公告)号：US20050217920A1
公开(公告)日：2005-10-06
申请号：US11067493
申请日：2005-02-28
申请人： Thomas Egan
发明人： Thomas Egan
IPC分类号： B62D1/04 , B62D6/00
CPC分类号： B62D1/046 , B62D1/043 , Y10T74/20834
摘要： A technique for controlling vehicle functions is disclosed. In one particular exemplary embodiment, the technique may be realized as an apparatus for controlling vehicle functions. Such an apparatus may comprise a support member configured to attach to a steering wheel of a vehicle, a switch assembly fixedly attached to the support member for electrically controlling functions of the vehicle, and a prosthetic steering device rotatably attached to the support member for manually controlling steering of the vehicle. In an alternative exemplary embodiment, such an apparatus may comprise a support member configured to attach to a steering wheel of a vehicle, and a prosthetic device rotatably attached to the support member for manually controlling steering of the vehicle, wherein the prosthetic device has a switch assembly for electrically controlling functions of the vehicle.
摘要翻译：公开了一种用于控制车辆功能的技术。在一个特定的示例性实施例中，该技术可以被实现为用于控制车辆功能的装置。这样的装置可以包括构造成附接到车辆的方向盘的支撑构件，固定地附接到支撑构件以用于电控制车辆的功能的开关组件，以及可旋转地附接到支撑构件的手动控制的假体转向装置转向车辆。在替代的示例性实施例中，这种装置可以包括构造成附接到车辆的方向盘的支撑构件和可旋转地附接到支撑构件的手动控制车辆的转向的假肢装置，其中假肢装置具有开关用于电控制车辆功能的组件。

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