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11. 发明申请

US20130319086A1 HIGH PURITY CHROMATOGRAPHIC MATERIALS COMPRISING AN IONIZABLE MODIFIER 审中-公开
标题翻译：包含可离子改性剂的高纯度色谱材料
公开(公告)号：US20130319086A1
公开(公告)日：2013-12-05
申请号：US13750511
申请日：2013-01-25
申请人： Waters Technologies Corporation
发明人： Kevin Daniel Wyndham , Pamela C. Iraneta , Thomas H. Walter
IPC分类号： B01D15/36 , G01N30/90
CPC分类号： B01D15/36 , B01D15/1871 , B01D15/327 , B01D15/3833 , B01D15/3847 , B01J20/286 , B01J20/29 , B01J20/3204 , B01J20/3236 , B01J20/3257 , B01J20/3285 , B01J2220/52 , B01J2220/54 , B01J2220/58 , G01N30/90
摘要： The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.
摘要翻译：本发明提供了新颖的色谱材料，例如用于色谱分离，其制备方法和含有色谱材料的分离装置; 分离装置，色谱柱和包含它们的试剂盒; 及其制备方法。本发明的色谱材料是包含色谱表面的高纯度色谱材料，其中色谱表面包含疏水表面基团和一种或多种可离子化的改性剂。

12. 发明申请

US20130040829A1 IN VITRO MODEL OF LATENT MYCOBACTERIAL INFECTION 失效
标题翻译：真菌感染的体外模型
公开(公告)号：US20130040829A1
公开(公告)日：2013-02-14
申请号：US13572888
申请日：2012-08-13
申请人： Pappachan E. Kolattukudy , Tatiana Sirakova , Jaiyanth Daniel , Chirajoti Deb
发明人： Pappachan E. Kolattukudy , Tatiana Sirakova , Jaiyanth Daniel , Chirajoti Deb
IPC分类号： C12N5/0786 , C12Q1/18 , G01N21/64 , C40B30/00 , G01N30/90 , C12N1/20 , C12Q1/68
CPC分类号： C12N1/36 , C12N1/20
摘要： A method of inducing latency in Mycobacterium permits preparation of an in vitro model system of latent mycobacterial infection. Latency is induced in a pure culture of Mycobacterium by exposing it to multiple stress conditions, including a low nutrient culture medium without glycerol, a low pH, a relatively high level of carbon dioxide and a relatively low gas phase oxygen level. An in vitro model of mycobacterial infection employs macrophages induced from THP1 cells which are then infected with Mycobacterium. The infected macrophages are grown under hypoxic conditions to induce latency in the mycobacteria. The in vitro model of infection is useful in evaluating compounds for activity against latent mycobacteria.
摘要翻译：在分枝杆菌中诱导潜伏期的方法允许制备潜在分枝杆菌感染的体外模型系统。通过将其暴露于多种胁迫条件，包括不含甘油的低营养培养基，低pH值，较高水平的二氧化碳和相对低的气相氧水平，在纯分枝杆菌的纯培养物中诱导潜伏期。分支杆菌感染的体外模型使用由THP1细胞诱导的巨噬细胞，然后用分枝杆菌感染。感染的巨噬细胞在缺氧条件下生长以在分枝杆菌中诱导潜伏期。感染的体外模型可用于评价化合物对潜在分枝杆菌的活性。

13. 发明申请

US20120149124A1 DEVICE FOR COLLECTION AND ASSAY OF ORAL FLUIDS 审中-公开
标题翻译：口服液的收集和测定装置
公开(公告)号：US20120149124A1
公开(公告)日：2012-06-14
申请号：US13301067
申请日：2011-11-21
申请人： Ronald W. MINK , Andrew S. GOLDSTEIN , Robert C. BOHANNON
发明人： Ronald W. MINK , Andrew S. GOLDSTEIN , Robert C. BOHANNON
IPC分类号： G01N30/90
CPC分类号： A61B10/0051 , A61B2010/0006 , G01N30/90 , Y10S435/974 , Y10S436/81
摘要： A method and a device for collection and assay of oral fluids are disclosed. The method places an assay device into an oral cavity, removes the device, and determines the presence or absence of an analyte. The assay device comprises an assay portion housing a lateral flow assay strip, a neck portion extending from the assay portion and forming a channel for fluid delivery to the assay strip; a collection strip in fluid communication with the lateral flow assay strip; and a blocking strip coupled between and in flow communication with the lateral flow assay strip and the collection strip. The channel is defined by a narrow part proximal to the assay portion and a part which receives oral fluid and has a substantially wider channel width. The collection strip has a first portion disposed within the channel and a second portion protruding outwardly from the neck opening.
摘要翻译：公开了用于收集和测定口腔液体的方法和装置。该方法将测定装置放入口腔，去除装置，并确定分析物的存在或不存在。测定装置包括容纳侧流测定条的测定部分，从测定部分延伸的颈部，并形成用于流体输送到测定条的通道; 与侧流测定条流体连通的收集条; 以及连接在侧流测定条和收集条之间并与其流动连通的阻挡条。通道由靠近测定部分的狭窄部分和接收口腔液体的部分限定，并且具有基本更宽的通道宽度。收集带具有设置在通道内的第一部分和从颈部开口向外突出的第二部分。

14. 发明申请

US20090253213A1 DEVICE AND PROCESS FOR THE CHROMATOGRAPHIC DETECTION OF A SUBSTANCE 有权
标题翻译：用于物质色谱检测的装置和方法
公开(公告)号：US20090253213A1
公开(公告)日：2009-10-08
申请号：US12370862
申请日：2009-02-13
申请人： Ingo KANEBLEI
发明人： Ingo KANEBLEI
IPC分类号： G01N30/90 , G01N21/00
CPC分类号： G01N30/95 , G01N21/8483 , G01N30/94
摘要： A device for the chromatographic detection of a substance provides an improved reproducible measuring process. A monitoring indicator (6) is provided, which is designed to detect the relative position of a test strip (13) in relation to the direction of the force of gravity, wherein a processor unit (8) generates a shut-off signal or interruption signal for the process control system (7) if a limit value is exceeded.
摘要翻译：用于色谱检测物质的装置提供了改进的可再现的测量过程。提供监测指示器（6），其被设计成检测测试条（13）相对于重力方向的相对位置，其中处理器单元（8）产生切断信号或中断如果超过极限值，则用于过程控制系统（7）的信号。

15. 发明授权

US07029918B2 Water-soluble derivatives of lipophilic drugs 失效
标题翻译：亲脂性药物的水溶性衍生物
公开(公告)号：US07029918B2
公开(公告)日：2006-04-18
申请号：US10057762
申请日：2002-01-25
申请人： Min Li , Robert S. Wu , Jane S. C. Tsai
发明人： Min Li , Robert S. Wu , Jane S. C. Tsai
IPC分类号： G01N33/548 , G01N30/90 , C07D243/24
CPC分类号： G01N33/9473 , A61K47/643 , A61K47/646 , C07D243/24 , G01N33/5306 , G01N33/948 , Y10S436/815 , Y10T436/10
摘要： A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I): G-(L)n—Y; (I) where G is a lipophilic drug; L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms; n is 0 or 1; and Y is a water-solubilizing group such as —SO3−, —NR—SO3−, —P(═O)(OH)(O−), or —O—P(═O)(OH)(O−); where R is H or an alkyl group of 1 to 10 carbon atoms.
摘要翻译：水溶性参考标准对亲脂性药物的免疫测定是有用的。参考标准是式（I）的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> G-（L）（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中G是亲脂性药物; L是含有1至20个碳原子的烷基或杂烷基的连接体; n为0或1; Y是水溶性基团，例如-SO 3 - ， - SO 2 SO 3 - ， - SO 2 - -P（-O）（OH）（O-O）或-OP（-O）（OH）（O-O）其中R是H或1-10个碳原子的烷基。

16. 发明申请

US20050244985A1 Chromatographic Assay Device and Methods 有权
标题翻译：色谱测定装置和方法
公开(公告)号：US20050244985A1
公开(公告)日：2005-11-03
申请号：US10711408
申请日：2004-09-16
申请人： Helmut Freitag , Qinwei Shi
发明人： Helmut Freitag , Qinwei Shi
IPC分类号： B01L3/00 , G01N30/90 , G01N33/543 , G01N33/546 , G01N33/558
CPC分类号： B01L3/5023 , B01L2200/0621 , B01L2200/16 , G01N30/90 , G01N33/54366 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S435/975 , Y10S436/81 , Y10S436/814 , Y10S436/818
摘要： A chromatographic assay device for the analysis of an analyte in a liquid sample has a proximal sample application zone and a distal test zone. The test zone contains a first ligand capable of binding with the analyte to form an analyte-ligand complex. The device also includes a spatially distinct reservoir containing a labeled reagent capable of binding to the analyte-ligand complex; an absorbent sink which is positioned to be capable of drawing the contents of the spatially distinct reservoir through the test zone; and structures for contacting the spatially distinct reservoir with the chromatographic medium so that the labeled reagent migrates from the reservoir to the absorbent sink, and thereby through the test zone to determine the presence or absence of the analyte. The device is used in a method for detecting analyte.
摘要翻译：用于分析液体样品中的分析物的色谱分析装置具有近端样品施加区域和远端测试区域。测试区包含能够与分析物结合以形成分析物 - 配体复合物的第一配体。该装置还包括含有能够结合分析物 - 配体复合物的标记试剂的空间不同的储存器; 吸收槽，其被定位成能够通过测试区域抽取空间不同的储存器的内容物; 以及用于使空间不同的储存器与色谱介质接触的结构，使得标记的试剂从储存器迁移到吸收剂槽，从而通过测试区域来确定分析物的存在或不存在。该装置用于检测分析物的方法。

17. 发明申请

US20050042308A1 Pharmaceutical composition having cholagogic and litholytic effect and its preparation method 审中-公开
标题翻译：具有胆酸和岩石效应的药物组合物及其制备方法
公开(公告)号：US20050042308A1
公开(公告)日：2005-02-24
申请号：US10494143
申请日：2002-09-05
申请人： Wei Xiao , Yin Yang , Ya Ling , Minghui Li , Zhenggen Liao , Chenfeng Zhang , Shubo Cao
发明人： Wei Xiao , Yin Yang , Ya Ling , Minghui Li , Zhenggen Liao , Chenfeng Zhang , Shubo Cao
IPC分类号： G01N33/15 , A61K36/00 , A61K36/185 , A61K36/315 , A61K36/355 , A61K36/534 , A61K36/539 , A61K36/87 , A61P1/16 , A61P21/00 , A61P21/02 , A61P25/04 , A61P29/00 , A61P31/00 , A61P31/04 , G01N30/88 , G01N30/90 , A61K35/78
CPC分类号： A61K36/185 , A61K36/315 , A61K36/355 , A61K36/534 , A61K36/539 , A61K2300/00
摘要： The invention publishes a kind of drug complex with cholagogue and lithontriptic effect and its preparation method; the invention also publishes a kind of quality-control method of a kind of drug complex soft capsule. The invention drug complex is composed by the main materials of mint oil and herit oil. The aforementioned drug is mixed uniformly according to certain proportion, and can be added into conventional accessories to prepare into clinically accepted forms of drug, such as pill, tablet, orally-taken liquid preparation, capsule, granule et al. To control the drug quality according to the quality-control method of the soft-capsule-form drug publicized in the invention, good product stability and high repeatability can be acquired; The invention drug complex has distinct cholagogue, lithontriptic, anti-inflammation, analgesic effect through the pharmacological experiment.
摘要翻译：本发明公开了一种具有胆碱和药物作用的药物复合物及其制备方法; 本发明还公开了一种药物复合软胶囊的一种质量控制方法。本发明药物复合体由薄荷油和乳酸油的主要成分组成。上述药物按一定比例均匀混合，可加入常规配件中，制备成临床接受的药物，如丸剂，片剂，口服液制剂，胶囊剂，颗粒剂等。根据本发明公开的软胶囊形式药物的质量控制方法控制药物质量，可以获得良好的产品稳定性和高重复性; 本发明药物复合物通过药理实验具有明显的胆碱，溶栓，抗炎，镇痛作用。

18. 发明授权

US6435012B2 Method for determination of chromatographic media parameters in packed beds of hydrophobic polymer particles 有权
公开(公告)号：US6435012B2
公开(公告)日：2002-08-20
申请号：US92408401
申请日：2001-08-07
申请人： ROHM & HAAS
发明人： MAIKNER JOHN JOSEPH
IPC分类号： G01N30/00 , B01D15/08 , B01D15/16 , B01D15/20 , B01D15/32 , B01D15/34 , B01J20/26 , B01J20/28 , B01J20/281 , B01J20/285 , G01N30/88 , G01N30/89 , G01N30/90
CPC分类号： G01N30/482 , B01D15/166 , B01D15/20 , B01D15/325 , B01D15/327 , B01D15/34 , B01J20/26 , B01J20/285 , B01J2220/54 , G01N30/02 , G01N30/89
摘要： An improved method for measuring the chromatographic properties, such as excluded volume, of hydrophobic polymer substrates is disclosed. Use of 0.05-1 micron sized crosslinked ionically-charged polymer particles, especially emulsion-form or ground polymer particles, as a large-molecule probe, allows environmentally friendly aqueous-based solvent systems to be used as mobile phases to characterize hydrophobic polymer supports for use in analytical or preparative scale chromatographic applications. This method eliminates the use of non-polar organic solvents that is required when conventional non-polar large-molecule probes (such as polystyrene) are used to characterize chromatographic media.

19. 发明授权

US6030621A Ginkgo biloba composition, method to prepare the same and uses thereof 失效
公开(公告)号：US6030621A
公开(公告)日：2000-02-29
申请号：US44551
申请日：1998-03-19
申请人： Xie De Long , Wang Ning , Gao Qi , Zhang Guo An , Shao Bao Ping , Jin Xiao Wu , Huang Xin Sheng
发明人： Xie De Long , Wang Ning , Gao Qi , Zhang Guo An , Shao Bao Ping , Jin Xiao Wu , Huang Xin Sheng
IPC分类号： A01N43/04 , A61K31/70 , A61K36/16 , A61P3/06 , A61P9/10 , C12Q1/00 , G01N30/90 , A61K35/78
CPC分类号： A61K36/16 , Y10S435/967
摘要： This invention provides different compositions extracted from Ginkgo biloba leaves. Said compositions comprise new active components. This invention also provides a method of preparation of the compositions and individual components of said compositions. Finally, this invention provides various uses of this composition.

20. 发明授权

US5882939A Separating materials for linking TLC and FTIR 失效
标题翻译：分离用于连接TLC和FTIR的材料
公开(公告)号：US5882939A
公开(公告)日：1999-03-16
申请号：US913469
申请日：1997-09-18
申请人： Karl Artur Kovar , Walter Fischer , Heinz Emil Hauck
发明人： Karl Artur Kovar , Walter Fischer , Heinz Emil Hauck
IPC分类号： G01N30/74 , G01N30/93 , G01N30/90
CPC分类号： G01N30/93 , G01N2030/743 , Y10T436/255
摘要： The invention concerns separating materials for thin-layer chromatography, the materials having a sorbent layer formed from sorbent particles and disposed on a carrier. A reflection intensifier, preferably magnesium tungstate and/or Bi.sub.2 O.sub.3, is added to the sorbent layer. This addition comprises at least 10 wt % relative to the amount of sorbent. In preferred embodiments, the particle size of the reflection intensifier is 3 to 5 .mu.m and the amount of the reflection intensifier is 0.6 to 15 times the amount of sorbent. These separating materials are particularly suitable for the in-situ measurement of FTIR spectra. The invention also concerns the use of these separating materials for the in-situ measurement of FTIR spectra.
摘要翻译： PCT No.PCT / EP96 / 00965 Sec。 371日期：1997年9月18日 102（e）1997年9月18日PCT PCT 1996年3月7日PCT公布。公开号WO96 / 29596 日期1996年9月26日本发明涉及薄层色谱分离材料，该材料具有由吸附剂颗粒形成并设置在载体上的吸附剂层。在吸附剂层中加入反射增强剂，优选钨酸镁和/或Bi 2 O 3。该添加量相对于吸附剂的量至少为10重量％。在优选的实施方式中，反射增强器的粒径为3〜5μm，反射增强剂的量为吸附剂的0.6〜15倍。这些分离材料特别适用于FTIR光谱的原位测量。本发明还涉及这些分离材料用于原位测量FTIR光谱的用途。

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