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1. 发明授权

US11959891B2 Proteomics reactor, protein chromatographic separation platform and use thereof 有权
公开(公告)号：US11959891B2
公开(公告)日：2024-04-16
申请号：US16089503
申请日：2017-01-05
申请人： Shenzhen SheenviOmics Biotechnology Co., Ltd.
发明人： Ruijun Tian , Wendong Chen
IPC分类号： C07K1/36 , G01N30/06 , G01N30/60 , G01N30/89
CPC分类号： G01N30/06 , C07K1/36 , G01N30/6078 , G01N30/89 , G01N2030/065
摘要： Disclosed is a proteomics sample preparation device, comprising a pipette tip, an ion exchange resin filler and a solid-phase extraction membrane. The solid-phase extraction membrane is filled into the lower end of the pipette tip, and the ion exchange resin filler is filled into the lower end of the pipette tip and is located above the solid-phase extraction membrane. The ion exchange resin filler is a strong cation exchange resin filler or a strong anion exchange resin filler. Disclosed is a protein chromatographic separation platform comprising the proteomic reactor and a liquid chromatography-mass spectrometer. Disclosed is the use of the proteomics reactor and protein chromatographic separation platform in the protein identification and protein quantitative analysis of a cell, a tissue or a blood sample.

2. 发明公开

US20230152280A1 ANALYSIS METHOD FOR IMPURITY MOLECULES IN COMPOSITION CONTAINING MULTI-SPECIFIC ANTIGEN-BINDING MOLECULES 审中-公开
公开(公告)号：US20230152280A1
公开(公告)日：2023-05-18
申请号：US17915834
申请日：2021-04-01
申请人： Chugai Seiyaku Kabushiki Kaisha
发明人： Motohiko Sato , Hiroko Murata
IPC分类号： G01N30/02 , G01N30/89
CPC分类号： G01N30/02 , G01N30/89
摘要： The present disclosure provides an analysis method for measuring the content of light chain-exchanged molecules in a composition containing a multi-specific antigen-binding molecule. The analysis method of the present disclosure includes the steps of: treating a composition comprising a multi-specific antigen-binding molecule and preparing a plurality of types of F(ab) fragments; and measuring the F(ab) fragments by a separation method based on electric charge or hydrophobic interactions and determining the content (content ratio) of each fragment.

3. 发明申请

US20220229029A1 CHROMATOGRAPHY METHOD, METHOD OF DETERMINING THE CONCENTRATION OF AT LEAST ONE COMPOUND IN A CHROMATOGRAPHY METHOD, METHOD OF OBTAINING AN ADSORPTION ISOTHERM, METHOD OF OBTAINING AT LEAST ONE STATIONARY PHASE AND METHOD OF EVALUATING THE ACCURACY OF A PREDETERMINED ADSORPTION ISOTHERM 有权
公开(公告)号：US20220229029A1
公开(公告)日：2022-07-21
申请号：US17613701
申请日：2020-05-08
申请人： Sartorius Stedim Biotech GmbH
发明人： Dominik Stein , Jan Schwellenbach
IPC分类号： G01N30/89 , G01N30/86
摘要： The present invention relates to a chromatography method, a method of determining the concentration of at least one compound in a chromatography method, a method of obtaining an adsorption isotherm, a method of obtaining at least one stationary phase and a method of evaluating the accuracy of a predetermined adsorption isotherm.

4. 发明申请

US20190017974A1 UNIT FOR NON-CONTINUOUS SAMPLE FRACTIONATION AND INTEGRATION, AND DUAL ONLINE MULTIFUNCTIONAL LIQUID CHROMATOGRAPHY DEVICE HAVING SAME 审中-公开
公开(公告)号：US20190017974A1
公开(公告)日：2019-01-17
申请号：US16070100
申请日：2016-10-31
申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
发明人： Sang-Won LEE , Hangyeore LEE
IPC分类号： G01N30/34 , G01N30/82 , G01N30/89 , B01D15/08
摘要： Disclosed are non-continuous sample fractionating and concatenating device and a dual online multidimensional liquid chromatography system having the same. The non-continuous sample fractionating and concatenating device according to an embodiment of the present disclosure includes a sample supply module which supplies a sample to be analyzed, and a sample fractionation module connected to the sample supply module, and which is continuously supplied with the sample, sets a plurality of unit sample supply times obtained by equally dividing a total sample supply time during which the sample is supplied from the sample supply module, sets a plurality of unit fractionation intervals obtained by equally dividing each of the plurality of unit sample supply times, and concatenates and stores the sample supplied during corresponding unit fractionation intervals within each unit sample supply time to acquire a plurality of fractions.

5. 发明申请

US20170267934A1 Process for Evaluating The Catalytic Performance of A Porous Solid 审中-公开
公开(公告)号：US20170267934A1
公开(公告)日：2017-09-21
申请号：US15532426
申请日：2015-12-01
申请人： W. R. Grace & Co,-Conn
发明人： Dieter Wallenstein , Stefan Brandt
IPC分类号： C10G11/18 , G01N15/08 , G01N30/89 , G01N13/00
CPC分类号： C10G11/187 , C10G2300/708 , G01N13/00 , G01N15/082 , G01N30/89 , G01N2013/003
摘要： Process for evaluating the catalytic performance of a porous solid using a vapor diffusion technique, where a probe molecule and a molecule for dead-time determination is injected into a carrier gas that is then contacted with the porous solid in a vessel, where a detector analyzes the peak width and retention time of a probe molecule and the retention time of the molecule for dead-time determination in the gas exiting the vessel.

6. 发明申请

US20120231532A1 OPTICAL SCANNING SYSTEM 审中-公开
标题翻译：光学扫描系统
公开(公告)号：US20120231532A1
公开(公告)日：2012-09-13
申请号：US13474130
申请日：2012-05-17
申请人： Reuven Duer
发明人： Reuven Duer
IPC分类号： G01N21/41 , G01N21/64 , G01N30/89 , C12M1/34
CPC分类号： G01N21/7703 , G01N21/253 , G01N21/553 , G01N2021/7786
摘要： An optical scanning system including a switchable light source, a detector, a substrate and a plurality of optical sensing sites, as well as methods and kits for use thereof are provided. The substrate is coupled to and in optical communication with the switchable light source and the detector. Additionally, the substrate includes a plurality of substantially parallel excitation waveguides, and a plurality of substantially parallel collection waveguides, the excitation waveguides and collection waveguides crossing to form a two-dimensional array of intersection regions where an excitation waveguide and a collection waveguide cross and provide optical communication with the intersection region at each crossing. The plurality of optical sensing sites are each in optical communication with an intersection region.
摘要翻译：提供了包括可切换光源，检测器，基板和多个光学感测位置的光学扫描系统，以及用于其的方法和套件。衬底耦合到可切换光源和检测器的光通信中。另外，衬底包括多个基本上平行的激励波导和多个基本上平行的收集波导，激励波导和收集波导交叉以形成二维阵列的交叉区域，其中激发波导和收集波导交叉并提供在每个交叉口与交叉路口区域进行光通信。多个光学感测位置各自与交叉区域光学连通。

7. 发明公开

US20240385153A1 METHOD FOR ANALYZING REACTIVE LOW-MOLECULAR-WEIGHT COMPOUND CONTAINED IN POLYOXYETHYLENE DERIVATIVE 审中-公开
公开(公告)号：US20240385153A1
公开(公告)日：2024-11-21
申请号：US18578893
申请日：2022-06-30
申请人： NOF CORPORATION
发明人： Masaki KAMIYA , Akira SUZUKI , Hiroki YOSHIOKA
IPC分类号： G01N30/74 , G01N30/88 , G01N30/89
CPC分类号： G01N30/74 , G01N30/88 , G01N30/89 , G01N2030/884
摘要： The present invention provides an analysis method including separating a compound of the formula (1):

contained in a polyoxyethylene derivative by reversed-phase chromatography, and detecting the compound with an ultraviolet visible spectrometer detector, in which ultraviolet light with a wavelength shorter than 200 nm as the detection wavelength is used, and an acidic substance with a maximum molar absorption coefficient of not more than 20 M−1cm−1 at 190 to 200 nm and a pKa of not more than 4 is used as an additive to the mobile phase for analysis.

8. 发明授权

US11946911B2 Analysis system and method for rapidly detecting vitamin d in an oil or fat, or a biological sample 有权
公开(公告)号：US11946911B2
公开(公告)日：2024-04-02
申请号：US17049249
申请日：2019-01-25
申请人： SHIMADZU CORPORATION
发明人： Yanli Guo , Naoki Hamada , Yuki Hashi
IPC分类号： G01N30/46 , G01N30/06 , G01N30/88 , G01N30/89
CPC分类号： G01N30/06 , G01N30/46 , G01N30/88 , G01N2030/065 , G01N30/89
摘要： The present invention relates to an analysis system that is applied to rapid automatic analysis and detection of highly lipophilic components and a method for rapidly detecting vitamin D in an oil or fat, or a biological sample. In the present invention, online pretreatment and separation of a sample containing highly lipophilic components in a sample to be analyzed are performed by a multidimensional chromatography system. The multidimensional chromatography system includes a supercritical chromatography part and a reverse phase liquid chromatography part sequentially connected, the reverse phase liquid chromatography part including one or more reverse phase liquid chromatography columns, and the supercritical chromatography part including a supercritical mobile phase, a modifier, and a supercritical packed column.

9. 发明授权

US10077404B2 Process for evaluating the catalytic performance of a porous solid 有权
公开(公告)号：US10077404B2
公开(公告)日：2018-09-18
申请号：US15532426
申请日：2015-12-01
申请人： W. R. Grace & Co.-Conn.
发明人： Dieter Wallenstein , Stefan Brandt
IPC分类号： C10G11/18 , G01N13/00 , G01N15/08 , G01N30/89
CPC分类号： C10G11/187 , C10G2300/708 , G01N13/00 , G01N15/082 , G01N30/89 , G01N2013/003
摘要： Process for evaluating the catalytic performance of a porous solid using a vapor diffusion technique, where a probe molecule and a molecule for dead-time determination is injected into a carrier gas that is then contacted with the porous solid in a vessel, where a detector analyzes the peak width and retention time of a probe molecule and the retention time of the molecule for dead-time determination in the gas exiting the vessel.

10. 发明申请

US20050193802A1 Methods and systems for characterizing a sorbent tube 有权
标题翻译：用于表征吸附剂管的方法和系统
公开(公告)号：US20050193802A1
公开(公告)日：2005-09-08
申请号：US11072829
申请日：2005-03-04
申请人： Andrew Tipler
发明人： Andrew Tipler
IPC分类号： B01D46/46 , G01B13/00 , G01B13/08 , G01N15/08 , G01N30/08 , G01N30/32 , G01N30/52 , G01N30/54 , G01N30/60 , G01N30/62 , G01N30/86 , G01N30/89
CPC分类号： G01N30/89 , G01N15/0826 , G01N30/32 , G01N30/60 , G01N2030/324 , G01N2030/524 , G01N2030/626 , G01N2030/525
摘要： Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.
摘要翻译：公开了包括提供其中设置有吸附剂的容器的系统和方法，所述容器具有用于使载气通过容器连通的入口和出口; 确定出口处的已知流速的入口和出口之间的压差; 并且基于已知流量和压差的比率确定容器的几何度量。在一些实施方案中，方法和系统可以包括该比例的粘度，使用基于输出处的气体压力和环境压力的比率的因子确定环境压力下的流速，和/或确定使用基于输出温度和环境温度的比率的因子的环境温度。

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