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11. 发明授权

US08993759B2 Transamination of nitrogen-containing compounds to make cyclic and cyclic/acyclic polyamine mixtures 有权
标题翻译：含氮化合物的转氨酶制备环状和环状/非环状多胺混合物
公开(公告)号：US08993759B2
公开(公告)日：2015-03-31
申请号：US13884430
申请日：2011-10-20
申请人： Stephen W. King
发明人： Stephen W. King
IPC分类号： C07D241/04 , C07D243/08 , C07D295/023 , C07D295/13 , C07C209/02 , C07C209/48 , C07C209/60
CPC分类号： C07D295/023 , C07D243/08 , C07D295/13
摘要： A transamination process is described to prepare polyamine product mixtures from reactants comprising mixed nitrogen-containing compounds with binary carbon spacing between nitrogen-containing groups (a binary component). A second nitrogen-containing component with a second carbon atom spacing between nitrogen-containing groups may also be employed. The molar ratio between the binary and second components can be adjusted to customize the product composition for desired end uses.
摘要翻译：描述了一种转氨过程，以从包含含氮基团（二元组分）之间的二元碳间隔的混合含氮化合物的反应物制备多胺产物混合物。也可以使用在含氮基团之间具有第二碳原子间隔的第二含氮组分。可以调整二元和第二成分之间的摩尔比以定制所需最终用途的产品组成。

12. 发明申请

US20140046054A1 PROCESS FOR PREPARING AMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION IN THE PRESENCE OF A COMPLEX CATALYST COMPRISING IRIDIUM AND AN AMINO ACID 审中-公开
标题翻译：在含有IRIDI和氨基酸的复合催化剂存在下通过均相催化的乙醇胺化制备胺的方法
公开(公告)号：US20140046054A1
公开(公告)日：2014-02-13
申请号：US13961345
申请日：2013-08-07
申请人： BASF SE
发明人： Alexander WETZEL , Michael Limbach , Marion Brinks , Mathias Schelwies
IPC分类号： C07C209/16 , C07C227/18 , C07D295/023 , C07C209/18
CPC分类号： C07C209/16 , C07C209/18 , C07C227/18 , C07C2601/14 , C07D295/023 , C07D295/03 , C07C211/48 , C07C211/08 , C07C211/27 , C07C211/35
摘要： The invention relates to a process for preparing amines (A) by alcohol amination of alcohols (Al) by means of an aminating agent (Am) with elimination of water, wherein the alcohol amination is carried out in the presence of a complex catalyst comprising iridium and an amino acid.
摘要翻译：本发明涉及通过胺化剂（Am）通过醇的胺化来制备胺（A）的方法，其中除去水，其中醇胺化在包含铱的复合催化剂存在下进行和氨基酸。

13. 发明申请

US20130281700A1 PALLADIUM CATALYST, METHOD FOR ITS PREPARATION AND ITS USE 有权
标题翻译：钯催化剂，其制备方法及其用途
公开(公告)号：US20130281700A1
公开(公告)日：2013-10-24
申请号：US13918735
申请日：2013-06-14
申请人： Zoltán DALICZEK , Tibor SOÓS , Zoltán FINTA , Géza Timári , Gábor Vlád
发明人： Zoltán DALICZEK , Tibor SOÓS , Zoltán FINTA , Géza Timári , Gábor Vlád
IPC分类号： B01J31/24 , C07C17/26 , C07C201/12 , C07C41/30 , C07C2/88 , C07D217/18 , C07D209/08 , C07D217/02 , C07D213/127 , C07D213/30 , C07D295/023 , C07D217/20
CPC分类号： B01J31/2404 , B01J31/2409 , B01J31/2447 , C07B35/02 , C07B37/04 , C07C2/66 , C07C2/88 , C07C15/52 , C07C15/54 , C07C17/26 , C07C41/30 , C07C201/12 , C07C205/06 , C07D209/08 , C07D213/127 , C07D213/14 , C07D213/26 , C07D213/30 , C07D215/06 , C07D215/12 , C07D215/14 , C07D217/02 , C07D217/16 , C07D217/18 , C07D217/20 , C07D295/023
摘要： The invention relates to palladium(0)-tris{tri-[3,5-bis(trifluoromethyl)-phenyl]-phosphine} complex of formula (I), as well as to its preparation and use. This compound is outstandingly stable, and can be used as catalyst with excellent results.
摘要翻译：本发明涉及式（I）的钯（0） - 三（三 - [3,5-双（三氟甲基） - 苯基] - 膦}络合物，以及其制备和用途。该化合物稳定，可用作催化剂，效果优异。

14. 发明申请

US20120010403A1 FLUOROBORON COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RING MADE OF THE SAME, AND PRODUCTION METHOD OF COMPOUND CONTAINING AMINOMETHYL AROMATIC RING USING AMINOMETHYLATING AGENT 有权
标题翻译：氟化硼化合物，其芳族化合物的氨基甲酸酯化剂以及使用氨基甲酸酯化剂的含有氨基甲酸芳香环的化合物的生产方法
公开(公告)号：US20120010403A1
公开(公告)日：2012-01-12
申请号：US13238571
申请日：2011-09-21
申请人： Keigo TANAKA
发明人： Keigo TANAKA
IPC分类号： C07F5/02 , C07C213/02 , C07D295/023 , C07C231/10 , C07C269/00 , C07C209/66 , C07D209/48
CPC分类号： C07F5/02
摘要： A production method of a compound containing a primary, secondary, or tertiary aminomethyl aromatic ring of the present invention includes: using a fluoroboron compound or a dimer thereof, or solvates thereof, which are represented by a formula (I): Ra(Rb)N—CH2—BF3M (I) as an aminomethylating agent for an aromatic ring; and reacting the aminomethylating agent with an aromatic ring-containing compound, which can react with the aminomethylating agent, under the presence of a metal catalyst such as a palladium compound so as to perform the direct aminomethylation of the aromatic ring.
摘要翻译：含有本发明的伯，仲或叔氨基甲基芳香环的化合物的制备方法包括：使用由式（I）表示的氟硼化合物或其二聚体或其溶剂合物：Ra（Rb）作为芳环的氨基甲基化剂的N-CH2-BF3M（I）并使氨基甲基化试剂与可与氨基甲基化试剂反应的含芳香环的化合物在金属催化剂如钯化合物的存在下反应，以进行芳环的直接氨基甲基化。

15. 发明申请

US20110144337A1 PROCESSES FOR THE PREPARATION OF 2,5-DIHYDROXYBENZENESULFONIC ACID SALTS 有权
标题翻译：制备2,5-二羟基苯甲酸酯钠盐的方法
公开(公告)号：US20110144337A1
公开(公告)日：2011-06-16
申请号：US12811621
申请日：2009-01-02
申请人： Unni Santhosh , Annadurai Marimuthu Senthilkumar , Bodireddy Mohan Reddy , Rajendran Kamala , Mahender Rao Siripragada
发明人： Unni Santhosh , Annadurai Marimuthu Senthilkumar , Bodireddy Mohan Reddy , Rajendran Kamala , Mahender Rao Siripragada
IPC分类号： C07C303/20 , C07C309/42 , C07D295/023 , C07D213/20
CPC分类号： A61K31/185 , C07C303/06 , C07C303/22 , C07C309/42
摘要： Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts of formula (I) and a crystalline form of potassium 2,5 2,5-dihydroxybenzenesulfonic acid are provided.
摘要翻译：提供了制备式（I）的2,5-二羟基苯磺酸盐和2,5,5-二羟基苯磺酸钾的结晶形式的方法。

16. 发明授权

US07732451B2 Naphthalene-containing melanocortin receptor-specific small molecule 有权
标题翻译：含萘的黑皮质素受体特异性小分子
公开(公告)号：US07732451B2
公开(公告)日：2010-06-08
申请号：US11036282
申请日：2005-01-14
申请人： Shubh D. Sharma , Annette M. Shadiack , Yiqun Shi , Zhijun Wu , Ramesh Rajpurohit , Kevin D. Burris , Papireddy Purma
发明人： Shubh D. Sharma , Annette M. Shadiack , Yiqun Shi , Zhijun Wu , Ramesh Rajpurohit , Kevin D. Burris , Papireddy Purma
IPC分类号： A61K31/4965 , C07D295/023
CPC分类号： A61K31/495 , A61K31/496
摘要： A method of modulating energy homeostasis in a mammal without eliciting a sexual response by administration of a therapeutically effective amount of a pharmaceutical composition including a melanocortin receptor compound of the formula: where R1 is a bond or a linker unit including from one to six backbone atoms and an unsubstituted naphthalene group, and L, R2, R3 and Rx are as defined in the specification.
摘要翻译：一种通过施用治疗有效量的药物组合物调节哺乳动物体内能量稳态的方法，其不引起性反应，所述药物组合物包括下式的黑皮质素受体化合物：其中R 1是键或包含一至六个骨架原子的连接体单元和未取代的萘基，L，R2，R3和Rx如说明书中所定义。

17. 发明授权

US07718802B2 Substituted melanocortin receptor-specific piperazine compounds 有权
标题翻译：取代的黑皮质素受体特异性哌嗪化合物
公开(公告)号：US07718802B2
公开(公告)日：2010-05-18
申请号：US11099814
申请日：2005-04-05
申请人： Shubh D. Sharma , Yi-Qun Shi , Ramesh Rajpurohit , Zhijun Wu
发明人： Shubh D. Sharma , Yi-Qun Shi , Ramesh Rajpurohit , Zhijun Wu
IPC分类号： C07D241/04 , C07D403/06 , C07D295/023
CPC分类号： C07D241/04 , C07D403/06
摘要： Melanocortin receptor-specific compounds of the general formulas and pharmaceutically acceptable salts thereof, where J is a substituted or unsubstituted monocyclic or bicyclic ring structure, L is a linker, W is a heteroatom unit with at least one cationic center, hydrogen bond donor or hydrogen bond acceptor, Q includes a substituted or unsubstituted aromatic carbocyclic ring, R6, R7, y and z are as defined in the specification, and the carbon atom marked with an asterisk can have any stereochemical configuration, and optionally with one or two additional ring substituents as defined, which compounds bind to one or more melanocortin receptors and are optionally an agonist, a partial agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist, and may be employed for treatment of one or more melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.
摘要翻译：其中J为取代或未取代的单环或双环结构的黑皮质素受体特异性化合物及其药学上可接受的盐，L为连接基，W为至少一个阳离子中心，氢键供体或氢的杂原子单元键接受体，Q包括取代或未取代的芳族碳环，R6，R7，y和z如说明书中所定义，并且具有星号的碳原子可以具有任何立体化学构型，并且任选具有一个或两个另外的环取代基定义为哪些化合物结合一种或多种黑皮质素受体，并且任选地是激动剂，部分激动剂，拮抗剂，反向激动剂的反向激动剂或拮抗剂，并且可用于治疗一种或多种黑皮质素受体相关条件或障碍，以及使用本发明化合物的方法。

18. 发明申请

US20080255360A1 Process for Producing Ethyleneamines 有权
标题翻译：生产乙烯胺的方法
公开(公告)号：US20080255360A1
公开(公告)日：2008-10-16
申请号：US12088715
申请日：2006-09-25
申请人： Gunther van Cauwenberge , Johann-Peter Melder , Holger Evers , Till Gerlach , Frank Kiesslich , Ekkehard Schwab , Bram Willem Hoffer
发明人： Gunther van Cauwenberge , Johann-Peter Melder , Holger Evers , Till Gerlach , Frank Kiesslich , Ekkehard Schwab , Bram Willem Hoffer
IPC分类号： C07C209/14 , C07D295/023 , C07D241/04
CPC分类号： C07C209/16 , B01J21/04 , B01J23/755 , B01J35/023 , B01J37/0201 , B01J37/18 , C07D295/02 , C07D295/13 , C07C211/10 , C07C211/14
摘要： Processes comprising: providing a starting material comprising monoethanolamine; and reacting the starting material with ammonia in the presence of a heterogeneous transition metal catalyst to form a reaction product comprising one or more ethylene amines; wherein the catalyst comprises a catalytically active composition, which prior to treatment with hydrogen, comprises a mixture of oxygen-containing compounds of aluminum, copper, nickel and cobalt; and wherein the catalyst is present as one or more shaped catalyst particles selected from spheres, extrudates, pellets and other geometries, wherein the sphere or extrudate has a diameter of
摘要翻译：方法包括：提供包含单乙醇胺的原料; 并在非均相过渡金属催化剂的存在下使原料与氨反应形成包含一种或多种亚乙基胺的反应产物; 其中所述催化剂包含催化活性组合物，其在用氢处理之前包括铝，铜，镍和钴的含氧化合物的混合物; 并且其中所述催化剂作为选自球体，挤出物，丸粒和其它几何形状的一种或多种成型催化剂颗粒存在，其中所述球体或挤出物的直径<3mm，所述颗粒具有<3mm的高度，而另一种几何形状具有等效直径L = 1 / a'<0.70mm，其中a'是每单位体积的外表面积（mm×s×2 / 由 ${定义的}^{3 MI> a =A/ MSUB>Vp其中A < SUB>是催化剂颗粒的外表面积（mm 2），V p是催化剂颗粒的体积（mm 3） 3＆lt; 3＆gt; 3＆lt; 3＆gt;）。}$

19. 发明申请

US20050215825A1 Hydroaminomethylation of olefins 有权
标题翻译：烯烃的氢氨基甲基化
公开(公告)号：US20050215825A1
公开(公告)日：2005-09-29
申请号：US11040762
申请日：2005-01-21
申请人： John Briggs , Gregory Whiteker , Jerzy Klosin
发明人： John Briggs , Gregory Whiteker , Jerzy Klosin
IPC分类号： C07C29/60 , C07C33/30 , C07C69/732 , C07C209/26 , C07C209/60 , C07C211/03 , C07C211/17 , C07C231/12 , C07C237/08 , C07C311/08 , C07D211/22 , C07D215/22 , C07D215/227 , C07D295/023
CPC分类号： C07C209/60 , C07C33/30 , C07C69/732 , C07C231/12 , C07C311/08 , C07D211/22 , C07D215/227 , C07D295/023 , C07C211/17 , C07C237/08
摘要： The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.
摘要翻译：本发明涉及包括在氢氨基甲基化条件下接触烯烃，胺，铑 - 磷配体和合成气（合成气）的步骤的方法。特别地，已经发现，在某些情况下，规定了中性铑 - 单齿亚磷酸酯配体。本发明提供了以高产率和区域特异性制备各种产品，包括药理活性产品如伊布利特，特非那定和非索非那定及其衍生物的简单方法。

20. 发明授权

US06946560B2 Ligands for metals and improved metal-catalyzed processes based thereon 有权
标题翻译：金属配体和基于其的改进的金属催化方法
公开(公告)号：US06946560B2
公开(公告)日：2005-09-20
申请号：US10420950
申请日：2003-04-22
申请人： Stephen L. Buchwald , David W. Old , John P. Wolfe , Michael Palucki , Ken Kamikawa
发明人： Stephen L. Buchwald , David W. Old , John P. Wolfe , Michael Palucki , Ken Kamikawa
IPC分类号： C07C1/26 , C07C17/26 , C07C41/16 , C07C45/68 , C07C45/71 , C07C67/31 , C07C205/04 , C07C205/06 , C07C209/10 , C07C209/18 , C07C211/48 , C07C211/55 , C07C211/59 , C07C213/02 , C07C213/08 , C07C217/40 , C07C217/84 , C07C217/92 , C07C221/00 , C07C225/12 , C07C225/22 , C07C227/08 , C07C227/18 , C07C229/36 , C07C229/60 , C07C231/12 , C07C233/07 , C07C235/46 , C07C249/02 , C07C249/16 , C07C251/24 , C07C251/86 , C07C253/30 , C07C255/33 , C07C255/50 , C07C255/54 , C07C255/56 , C07C255/58 , C07D209/08 , C07D213/50 , C07D213/72 , C07D213/74 , C07D295/02 , C07D295/023 , C07D295/033 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/155 , C07D307/33 , C07D317/22 , C07D317/26 , C07D317/66 , C07D333/08 , C07D333/66 , C07D401/04 , C07F7/18 , C07F9/48 , C07F9/50 , C07F9/572 , C07F9/653 , C07F9/6547 , C07F9/6571 , C07F15/00 , C07D211/70 , C07C209/00 , C07D207/04
CPC分类号： C07C1/26 , C07C1/321 , C07C17/16 , C07C17/263 , C07C29/32 , C07C29/38 , C07C37/18 , C07C41/30 , C07C45/68 , C07C45/71 , C07C49/675 , C07C67/31 , C07C201/12 , C07C209/10 , C07C209/18 , C07C211/59 , C07C213/02 , C07C213/08 , C07C221/00 , C07C225/12 , C07C227/08 , C07C227/18 , C07C231/08 , C07C231/12 , C07C249/02 , C07C249/16 , C07C251/24 , C07C253/30 , C07C2531/24 , C07C2531/26 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D213/50 , C07D213/72 , C07D213/74 , C07D295/023 , C07D295/033 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/155 , C07D307/33 , C07D317/22 , C07D317/26 , C07D317/66 , C07D333/08 , C07D333/66 , C07D401/04 , C07F7/1892 , C07F9/4875 , C07F9/5022 , C07F9/5027 , C07F9/5728 , C07F9/653 , C07F9/6547 , C07F9/65719 , C07F15/0066 , C07C25/18 , C07C49/255 , C07C49/213 , C07C49/657 , C07C49/67 , C07C49/84 , C07C49/245 , C07C49/755 , C07C49/215 , C07C49/683 , C07C47/575 , C07C49/782 , C07C69/92 , C07C211/48 , C07C211/55 , C07C217/40 , C07C217/84 , C07C217/92 , C07C225/22 , C07C229/36 , C07C229/60 , C07C233/07 , C07C235/46 , C07C251/86 , C07C255/33 , C07C255/50 , C07C255/54 , C07C255/56 , C07C255/58 , C07C15/14 , C07C35/21 , C07C33/24 , C07C205/04 , C07C205/06 , C07C43/205 , C07C43/225 , C07C39/15 , C07C35/08
摘要： One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.
摘要翻译：本发明的一个方面涉及用于过渡金属的新配体。本发明的第二方面涉及包含这些配体的催化剂在过渡金属催化的碳 - 杂原子和碳 - 碳键形成反应中的用途。本发明方法提供了过渡金属催化反应的许多特征的改进，包括合适底物的范围，反应条件和效率。

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