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1. 发明授权

US09695110B2 Reductive preparation of tertiary dimethylamines from nitriles 有权
公开(公告)号：US09695110B2
公开(公告)日：2017-07-04
申请号：US14745508
申请日：2015-06-22
申请人： Eastman Chemical Company
发明人： Neil Warren Boaz
IPC分类号： C07C209/48 , C07C213/02
CPC分类号： C07C209/48 , C07C213/02 , C07C211/27 , C07C211/08 , C07C215/08 , C07C211/09
摘要： This disclosure describes a low temperature process for the preparation of dimethyl amines from nitriles via reductive amination. In some embodiments, the process proceeds under mild conditions with aqeuous dimethylamine and show an unexpected rate acceleration by the inclusion of an acid addition salt of the dimethylamine.

2. 发明授权

US09340489B2 Process for the preparation of deuterated compounds containing N-alkyl groups 有权
标题翻译：制备含有N-烷基的氘代化合物的方法
公开(公告)号：US09340489B2
公开(公告)日：2016-05-17
申请号：US14118705
申请日：2012-05-21
申请人： Jens Atzrodt , Volker Derdau , Wolfgang Holla , Matthias Beller , Lorenz Neubert , Dirk Michalik
发明人： Jens Atzrodt , Volker Derdau , Wolfgang Holla , Matthias Beller , Lorenz Neubert , Dirk Michalik
IPC分类号： C07C217/28 , C07B59/00 , C07C211/07 , C07C211/08 , C07C211/27 , C07D207/06 , C07D211/14 , C07D223/04 , C07D241/04 , C07D401/04
CPC分类号： C07C217/28 , C07B59/00 , C07C211/07 , C07C211/08 , C07C211/27 , C07D207/06 , C07D211/14 , C07D223/04 , C07D241/04 , C07D401/04
摘要： The present invention relates to a process for deuteration of amines in the alpha and/or beta position of the N-atom by using a deuterium source and a Ruthenium(II) based catalyst.
摘要翻译：本发明涉及通过使用氘源和基于钌（II）的催化剂，在N-原子的α和/或β位上氘化胺的方法。

3. 发明申请

US20160108062A1 NOVEL TETRAARYL BORATE COMPOUND AND METHOD FOR PRODUCING SAME 有权
标题翻译：新型四硼酸盐化合物及其生产方法
公开(公告)号：US20160108062A1
公开(公告)日：2016-04-21
申请号：US14890519
申请日：2014-04-24
申请人： KOEI CHEMICAL COMPANY, LIMITED
发明人： Satoshi TAKAISHI , Hang JIANG
IPC分类号： C07F5/02
CPC分类号： C07F5/02 , C07C209/68 , C07C211/08
摘要： The present invention relates to a novel tetraaryl borate compound and a method for producing the same, and a method for producing a tetraaryl borate compound using the tetraaryl borate compound as an intermediate. According to the present invention, it is possible to provide a tetraaryl borate compound which has high thermal stability and can be safely handled industrially and a method for producing the same. It is also possible to provide a method for producing a tetraaryl borate compound used as a co-catalyst for a polymerization reaction using a metallocene catalyst by further reacting the tetraaryl borate compound with an amine compound.
摘要翻译：本发明涉及一种新的四芳基硼酸盐化合物及其制备方法，以及使用四芳基硼酸盐化合物作为中间体制备四芳基硼酸盐化合物的方法。根据本发明，可以提供热稳定性高且可以在工业上安全处理的硼酸四芳酯化合物及其制造方法。还可以提供一种通过使四芳基硼酸盐化合物与胺化合物进一步反应，使用茂金属催化剂制备用作聚合反应助催化剂的四芳基硼酸盐化合物的方法。

4. 发明授权

US08969608B2 Organometallic compound preparation 有权
标题翻译：有机金属化合物制剂
公开(公告)号：US08969608B2
公开(公告)日：2015-03-03
申请号：US13586679
申请日：2012-08-15
申请人： Curtis D. Modtland
发明人： Curtis D. Modtland
IPC分类号： C07F7/00 , C07F5/00 , B01J14/00 , C07C209/68
CPC分类号： C07F7/003 , B01J14/00 , C07C209/68 , C07F5/00 , C07F5/003 , C07F7/00 , C07C211/04 , C07C211/08
摘要： A method of continuously manufacturing an organometallic compound is provided where two or more reactants are conveyed to a contacting zone of a reactor in a manner so as to maintain a laminar flow of the reactants; and causing the reactants to form the organometallic compound.
摘要翻译：提供连续制造有机金属化合物的方法，其中两种或多种反应物以保持反应物的层流的方式输送到反应器的接触区; 并使反应物形成有机金属化合物。

5. 发明申请

US20140046054A1 PROCESS FOR PREPARING AMINES BY HOMOGENEOUSLY CATALYZED ALCOHOL AMINATION IN THE PRESENCE OF A COMPLEX CATALYST COMPRISING IRIDIUM AND AN AMINO ACID 审中-公开
标题翻译：在含有IRIDI和氨基酸的复合催化剂存在下通过均相催化的乙醇胺化制备胺的方法
公开(公告)号：US20140046054A1
公开(公告)日：2014-02-13
申请号：US13961345
申请日：2013-08-07
申请人： BASF SE
发明人： Alexander WETZEL , Michael Limbach , Marion Brinks , Mathias Schelwies
IPC分类号： C07C209/16 , C07C227/18 , C07D295/023 , C07C209/18
CPC分类号： C07C209/16 , C07C209/18 , C07C227/18 , C07C2601/14 , C07D295/023 , C07D295/03 , C07C211/48 , C07C211/08 , C07C211/27 , C07C211/35
摘要： The invention relates to a process for preparing amines (A) by alcohol amination of alcohols (Al) by means of an aminating agent (Am) with elimination of water, wherein the alcohol amination is carried out in the presence of a complex catalyst comprising iridium and an amino acid.
摘要翻译：本发明涉及通过胺化剂（Am）通过醇的胺化来制备胺（A）的方法，其中除去水，其中醇胺化在包含铱的复合催化剂存在下进行和氨基酸。

6. 发明申请

US20130296323A1 GGA AND GGA DERIVATIVES COMPOSITIONS THEREOF AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES INCLUDING PARALYSIS INCLUDING THEM 有权
公开(公告)号：US20130296323A1
公开(公告)日：2013-11-07
申请号：US13779568
申请日：2013-02-27
申请人： COYOTE PHARMACEUTICALS, INC.
发明人： Hiroaki Serizawa , Ankush B. Argade , Akash Datwani , Natalie Spencer , Yonghua Pan , Florian Ermini
IPC分类号： C07C49/203 , C07C69/02 , C07C69/24 , C07C69/743 , C07C69/74 , C07D295/13 , C07C309/66 , C07C309/73 , C07C333/04 , C07C333/06 , C07C333/08 , C07D211/26 , C07C69/145 , C07C69/75
CPC分类号： C07C49/203 , C07C33/02 , C07C33/14 , C07C47/21 , C07C49/21 , C07C49/255 , C07C49/557 , C07C49/647 , C07C57/03 , C07C57/66 , C07C69/007 , C07C69/02 , C07C69/145 , C07C69/24 , C07C69/587 , C07C69/608 , C07C69/738 , C07C69/74 , C07C69/743 , C07C69/75 , C07C69/757 , C07C69/76 , C07C69/92 , C07C205/57 , C07C211/08 , C07C211/35 , C07C211/38 , C07C217/08 , C07C251/40 , C07C251/60 , C07C271/12 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/30 , C07C309/66 , C07C309/73 , C07C333/04 , C07C333/06 , C07C333/08 , C07C333/10 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D211/26 , C07D213/75 , C07D263/32 , C07D263/38 , C07D271/10 , C07D295/13 , C07D307/46 , C07D307/52 , C07D413/04
摘要： This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and increasing the survival rate of subjects administered the GGA or GGA derivatives.

7. 发明授权

US08519199B2 Process for the manufacture of nitropropanes 有权
标题翻译：硝基丙烷生产工艺
公开(公告)号：US08519199B2
公开(公告)日：2013-08-27
申请号：US12934810
申请日：2009-04-08
申请人： Daniel M Trauth , Richard L James
发明人： Daniel M Trauth , Richard L James
IPC分类号： C07C201/16
CPC分类号： C07C201/08 , C07C201/12 , C07C209/34 , C07C239/10 , C07D263/04 , Y02P20/582 , C07C205/02 , C07C205/15 , C07C211/08
摘要： Provided is a process for the formation of 2-nitropropane and/or 2,2-dinitropropane by the nitration of propane with dilute nitric acid.
摘要翻译：提供了通过用稀硝酸硝化丙烷来形成2-硝基丙烷和/或2,2-二硝基丙烷的方法。

8. 发明申请

US20130204037A1 Catalytic alkylation of alcohols to liquid ethers and organic compounds to alkylated products 审中-公开
标题翻译：将醇与液体醚和有机化合物催化烷基化成烷基化产物
公开(公告)号：US20130204037A1
公开(公告)日：2013-08-08
申请号：US13385192
申请日：2012-02-07
申请人： Melvin Keith Carter
发明人： Melvin Keith Carter
IPC分类号： C07C41/09 , C07C45/68 , C07C51/367 , C07C209/02
CPC分类号： C07C41/09 , B01J31/2239 , B01J2231/44 , B01J2531/16 , B01J2531/56 , B01J2531/845 , C07C45/68 , C07C51/367 , C07C209/16 , C07C211/08 , C07C43/04 , C07C43/164 , C07C65/21 , C07C49/04
摘要： A catalytic process is taught for non-oxidative alkylation of organic compounds, comprising alcohols, alkanes, glycols, ethers, aldehydes, ketones, carboxylic acids, esters, amines, thiols or phosphines, by alkyl groups produced from alcohols or glycols, forming products comprising ethers and other higher molecular weight alkylated compounds. The process is conducted at a reflux temperature below 200° C. in the presence of an acid, alkali or neutral salt dehydrating agent comprising sulfuric acid, phosphoric acid or their salts, lime or anhydrous calcium sulfate in the absence of zero valent metals and air. Specifically, this catalytic process converts ethanol to ethyl butyl ethers, ethyl hexyl ethers and dibutyl ethers or oxygenated gasoline as well as amines comprising n-butyl amine plus butanol to dibutyl amine and butyl hexyl amines at ambient pressure. This same catalytic alkylation chemistry, which does not constitute a condensation reaction, alkylates 4-hydroxybenzoic acid using ethanol to 4-ethoxyethylbenzoic acid products.
摘要翻译：教导了通过由醇或二醇生产的烷基对有机化合物（包括醇，烷烃，二醇，醚，醛，酮，羧酸，酯，胺，硫醇或膦）进行非氧化烷基化的催化方法，醚和其他较高分子量的烷基化化合物。在不存在零价金属和空气的情况下，在含有硫酸，磷酸或其盐，石灰或无水硫酸钙的酸，碱或中性盐脱水剂的存在下，在低于200℃的回流温度下进行该方法。具体地说，该催化方法在环境压力下将乙醇转化为乙基丁基醚，乙基己基醚和二丁基醚或含氧汽油以及包含正丁胺加丁醇的胺至二丁基胺和丁基己基胺。这种不构成缩合反应的催化烷基化化学反应使用乙醇将4-羟基苯甲酸烷基化成4-乙氧基乙基苯甲酸产物。

9. 发明申请

US20130178541A1 NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY 有权
标题翻译：用于寡核苷酸交付的新型低分子量阳离子脂肪
公开(公告)号：US20130178541A1
公开(公告)日：2013-07-11
申请号：US13823830
申请日：2011-09-20
申请人： Matthew G. Stanton , Brian W. Budzik , Gregory L. Beutner , Hongbiao Liao
发明人： Matthew G. Stanton , Brian W. Budzik , Gregory L. Beutner , Hongbiao Liao
IPC分类号： A61K47/18 , C07D207/06 , C07C211/17 , C07C211/21
CPC分类号： A61K47/18 , A61K45/00 , A61K48/00 , C07C211/04 , C07C211/08 , C07C211/17 , C07C211/21 , C07D207/06 , C12N15/88
摘要： The instant invention provides for novel catiomc lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
摘要翻译：本发明提供了可以与其它脂质成分如胆固醇和PEG-脂质组合使用以与寡核苷酸形成脂质纳米颗粒的新型细胞脂质。本发明的目的是提供一种阳离子脂质支架，由于肝中脂质水平降低，其表现出增强的功效以及较低的肝毒性。本发明使用具有一个短脂链的低分子量阳离子脂质以增强siRNA的体内递送的效率和耐受性。

10. 发明申请

US20120123167A1 REACTION APPARATUS 有权
标题翻译：反应装置
公开(公告)号：US20120123167A1
公开(公告)日：2012-05-17
申请号：US13353359
申请日：2012-01-19
申请人： Atsushi Hirota , Toru Nishimura
发明人： Atsushi Hirota , Toru Nishimura
IPC分类号： C07C209/00
CPC分类号： B01F7/00341 , B01F3/04531 , B01F7/00241 , B01F7/00466 , B01F2003/0456 , B01F2003/04673 , B01J10/007 , B01J19/0066 , B01J2219/32296 , B01J2219/32466 , C07C209/16 , C07C211/08
摘要： A reaction apparatus which is used for conducting a gas-liquid chemical reaction in a state that a liquid is in a continuous phase, wherein its reactor has therein a shear type stirring impeller for dispersing a raw reaction gas or a carrier gas and a film-formed catalyst, which apparatus is capable of producing a target reaction product; and a process for producing a tertiary amine in such reaction apparatus.
摘要翻译：一种用于在液体处于连续相的状态下进行气液化学反应的反应装置，其中反应器具有分散原料反应气体或载气的剪切式搅拌叶轮，形成的催化剂，该装置能够产生目标反应产物; 以及在该反应装置中生产叔胺的方法。

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