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11. 发明申请

US20050203578A1 Process and apparatus for treating biological organisms 审中-公开
标题翻译：用于处理生物体的方法和装置
公开(公告)号：US20050203578A1
公开(公告)日：2005-09-15
申请号：US11066418
申请日：2005-02-25
申请人： Michael Weiner , Robert Gray , Stuart MacDonald , Jack Tuszynski , Kendrick Goss , Amara Angelica
发明人： Michael Weiner , Robert Gray , Stuart MacDonald , Jack Tuszynski , Kendrick Goss , Amara Angelica
IPC分类号： A61N5/00 , A61N1/00 , H03C3/06 , H03C3/09
CPC分类号： A61N5/00
摘要： An apparatus for treating a biological organism comprising a device for emitting and delivering energy to the biological organism, a programmable controller for varying the type and amount of energy emitted, and apparatus for sensing a condition of the biological organism.
摘要翻译：一种用于治疗生物体的装置，包括用于向生物体生物发射和输送能量的装置，用于改变发射的能量的类型和量的可编程控制器以及用于感测生物体的状况的装置。

12. 发明申请

US20050167595A1 Digital imaging assembly and methods thereof 失效
标题翻译：数字成像组件及其方法
公开(公告)号：US20050167595A1
公开(公告)日：2005-08-04
申请号：US10983053
申请日：2004-11-05
申请人： David Prelewitz , Robert Gray , Rolf Gerchberg , Michael Weiner
发明人： David Prelewitz , Robert Gray , Rolf Gerchberg , Michael Weiner
IPC分类号： G01J5/02 , G02B27/48 , G06K9/00 , G06K9/40
CPC分类号： G02B27/48
摘要： A coherent radiation imaging system that produces digital images with a reduced amount of speckle. Radiation from a long coherence length source is used to form an image of a sample. The output coherent wave is temporally divided into a plurality of wavelets. The spatial phase of each wavelet is then modulated a known and different amount. Each phase modulated wavelet illuminates the sample and is perturbed by its interaction with the sample. A spatial phase map of each perturbed wavelet is then created and converted to a sample image with an image reconstruction program. The plurality of sample images thus formed is statistically averaged to form a final averaged image. The high frequency speckle that is not optically resolvable tends to average to zero with continual statistical averaging, leaving only the optically resolvable lower frequency phase information.
摘要翻译：相干辐射成像系统，产生数量少的斑点数字图像。来自长相干长度源的辐射用于形成样品的图像。输出相干波在时间上分为多个小波。然后将每个小波的空间相位调制为已知且不同的量。每个相位调制小波照亮样品，并受到与样品的相互作用的干扰。然后创建每个扰动小波的空间相位图，并将其转换为具有图像重建程序的样本图像。如此形成的多个样本图像被统计学地平均以形成最终平均图像。不能光学解析的高频散斑趋向于平均为零，并且连续的统计平均，仅留下光学可分辨的较低频率相位信息。

13. 发明授权

US07282716B2 Digital imaging assembly and methods thereof 失效
标题翻译：数字成像组件及其方法
公开(公告)号：US07282716B2
公开(公告)日：2007-10-16
申请号：US10983053
申请日：2004-11-05
申请人： David Prelewitz , Robert Gray , Rolf Gerchberg , Michael Weiner
发明人： David Prelewitz , Robert Gray , Rolf Gerchberg , Michael Weiner
IPC分类号： G01J5/02 , G02B21/06 , G01B9/02 , G01B11/02
CPC分类号： G02B27/48
摘要： A coherent radiation imaging system that produces digital images with a reduced amount of speckle. Radiation from a long coherence length source is used to form an image of a sample. The output coherent wave is temporally divided into a plurality of wavelets. The spatial phase of each wavelet is then modulated a known and different amount. Each phase modulated wavelet illuminates the sample and is perturbed by its interaction with the sample. A spatial phase map of each perturbed wavelet is then created and converted to a sample image with an image reconstruction program. The plurality of sample images thus formed is statistically averaged to form a final averaged image. The high frequency speckle that is not optically resolvable tends to average to zero with continual statistical averaging, leaving only the optically resolvable lower frequency phase information.
摘要翻译：相干辐射成像系统，产生数量少的斑点数字图像。来自长相干长度源的辐射用于形成样品的图像。输出相干波在时间上分为多个小波。然后将每个小波的空间相位调制为已知且不同的量。每个相位调制小波照亮样品，并受到与样品的相互作用的干扰。然后创建每个扰动小波的空间相位图，并将其转换为具有图像重建程序的样本图像。如此形成的多个样本图像被统计学地平均以形成最终平均图像。不能光学解析的高频散斑趋向于平均为零，并且连续的统计平均，仅留下光学可分辨的较低频率相位信息。

14. 发明申请

US20080003142A1 Microfluidic devices 审中-公开
标题翻译：微流体装置
公开(公告)号：US20080003142A1
公开(公告)日：2008-01-03
申请号：US11803104
申请日：2007-05-11
申请人： Darren Link , Michael Weiner , David Marran , Jonathan Rothberg
发明人： Darren Link , Michael Weiner , David Marran , Jonathan Rothberg
IPC分类号： G01N21/64 , B01L3/00 , B29C33/38
CPC分类号： B01F3/0807 , B01F13/0062 , B01J19/0093 , B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/565 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/086 , B03C5/005 , B03C5/026 , C12N15/1068 , C12N15/1086 , C12Q1/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6844 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/628 , C12Q2565/629 , G01N15/147 , G01N21/05 , G01N21/64 , G01N27/3275 , G01N35/08 , G01N2021/0346 , G01N2035/00237 , G01N2035/00326 , G01N2201/024 , Y10T137/87571 , Y10T137/87619 , Y10T137/87652 , C12Q2525/191 , C12Q2563/159 , C12Q2535/101 , C12Q2563/149 , C12Q2531/113
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了可用于进行生物学，化学和诊断测定的新型微流体底物和方法。基板可以包括多个可电寻址的通道支承流体模块，其一体地布置成使得提供用于不混溶流体流动的连续通道。

15. 发明申请

US20060163160A1 Halloysite microtubule processes, structures, and compositions 审中-公开
标题翻译：高岭土微管过程，结构和组成
公开(公告)号：US20060163160A1
公开(公告)日：2006-07-27
申请号：US11042219
申请日：2005-01-25
申请人： Michael Weiner , John Lanzafame , John Hammond
发明人： Michael Weiner , John Lanzafame , John Hammond
IPC分类号： B01D61/00
CPC分类号： B01D63/08 , B01D61/20 , B01D63/06 , B01D63/088 , B01D2315/04
摘要： A processes for the separation and purification of microtubules of halloysite clay by separating an inlet stream of a liquid slurry of suspended clay particles flowing into a cross-flow filter into a decantate stream and a filtrate stream, the filtrate stream having a higher concentration of microtubular particles than the inlet stream. Also disclosed are subsequent preparations of novel structures and compositions of matter that include microtubules of halloysite clay.
摘要翻译：通过将流入交叉流过滤器的悬浮粘土颗粒的液体浆料的入口流分离成倾析物流和滤液流来分离和纯化多层高岭土粘土的微管的方法，所述滤液流具有较高浓度的微管颗粒比入口流。还公开了随后的包括多水高岭土粘土的微管的物质结构和组成的制备。

16. 发明申请

US20060160178A1 Methods of generating antibody diversity in vitro 审中-公开
标题翻译：体外产生抗体多样性的方法
公开(公告)号：US20060160178A1
公开(公告)日：2006-07-20
申请号：US10991309
申请日：2004-11-17
申请人： Jonathan Rothberg , Michael Weiner
发明人： Jonathan Rothberg , Michael Weiner
IPC分类号： C12P21/06 , C07K16/18 , C12N1/21 , C07H21/04 , C12N5/06 , C12N1/18 , C12N15/74
CPC分类号： C07K16/2803 , C07K16/241 , C07K2317/34 , C07K2317/622
摘要： The present invention provides a high throughput method for generating fully human monoclonal antibodies.
摘要翻译：本发明提供了用于产生完全人单克隆抗体的高通量方法。

17. 发明申请

US20050043761A1 MRI-compatible implantable device 有权
标题翻译： MRI兼容的植入式装置
公开(公告)号：US20050043761A1
公开(公告)日：2005-02-24
申请号：US10946026
申请日：2004-09-21
申请人： Patrick Connelly , Michael Weiner , Thomas Foster
发明人： Patrick Connelly , Michael Weiner , Thomas Foster
IPC分类号： A61N1/16 , A61N1/375 , A61N1/00
CPC分类号： A61N1/08 , A61N1/37 , A61N1/3718 , A61N1/375
摘要： A medical device containing a device for connecting the medical device to a substrate, for furnishing electrical impulses from the medical device to the substrate, for ceasing the furnishing of electrical impulses to the substrate, for receiving pulsed radio frequency fields, for transmitting and receiving optical signals, and for protecting the substrate and the medical device from currents induced by the pulsed radio frequency fields. The medical device contains a control circuit comprised of a parallel resonant frequency circuit.
摘要翻译：一种医疗装置，包括用于将医疗装置连接到基板的装置，用于从医疗装置向基板提供电脉冲，用于停止向基板提供电脉冲，用于接收脉冲射频场，用于发射和接收光学信号，并且用于保护衬底和医疗装置免受由脉冲射频场引起的电流。医疗装置包含由并联谐振频率电路构成的控制电路。

18. 发明授权

US09588756B2 Updating software components in a program 有权
标题翻译：在程序中更新软件组件
公开(公告)号：US09588756B2
公开(公告)日：2017-03-07
申请号：US14387215
申请日：2012-03-22
申请人： Clifford Liem , Hongrui Dong , Sam Martin , Yuan Xiang Gu , Michael Weiner
发明人： Clifford Liem , Hongrui Dong , Sam Martin , Yuan Xiang Gu , Michael Weiner
IPC分类号： G06F9/44 , G06F9/445 , G06F21/57
CPC分类号： G06F8/65 , G06F8/656 , G06F8/658 , G06F9/44521 , G06F21/57 , G06F21/572
摘要： A method and system for renewing software at the component-level is provided. A client program includes a base component for loading a software component into at least one loadable region of the program to update the program. Code in the software component is for writing state data associating the state of the update in storage, upon execution of the software component, and testing the state data to verify condition of the updated program and disallowing rollback and roll-forward attacks, the state data comprising hash chain values. The state data for verifying the correctness of the updated program is entangled with application data used for the program functionality. A server includes: an update pool having a plurality of software updates deployed in each client, and a policy control for monitoring and controlling at least one of: the length of time the client runs until the software update is invoked, a chain of the updates; and the granularity of the update.
摘要翻译：提供了一种在组件级更新软件的方法和系统。客户端程序包括用于将软件组件加载到程序的至少一个可加载区域中以更新程序的基础组件。软件组件中的代码用于写入状态数据，将存储器中的更新状态与执行软件组件相关联，并测试状态数据以验证更新程序的状态，并禁止回滚和前滚攻击，状态数据包括哈希链值。用于验证更新的程序的正确性的状态数据与用于程序功能的应用程序数据相互纠缠。服务器包括：具有部署在每个客户端中的多个软件更新的更新池，以及用于监视和控制以下至少之一的策略控制：客户端运行到软件更新被调用的时间长短，更新链 ; 和更新的粒度。

19. 发明申请

US20130183659A1 MICROFLUIDIC DEVICES 审中-公开
公开(公告)号：US20130183659A1
公开(公告)日：2013-07-18
申请号：US13772002
申请日：2013-02-20
申请人： Darren R. Link , Michael Weiner , David Marran , Jonathan M. Rothberg
发明人： Darren R. Link , Michael Weiner , David Marran , Jonathan M. Rothberg
IPC分类号： G01N27/327
CPC分类号： B01F3/0807 , B01F13/0062 , B01J19/0093 , B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/565 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/086 , B03C5/005 , B03C5/026 , C12N15/1068 , C12N15/1086 , C12Q1/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6844 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/628 , C12Q2565/629 , G01N15/147 , G01N21/05 , G01N21/64 , G01N27/3275 , G01N35/08 , G01N2021/0346 , G01N2035/00237 , G01N2035/00326 , G01N2201/024 , Y10T137/87571 , Y10T137/87619 , Y10T137/87652 , C12Q2525/191 , C12Q2563/159 , C12Q2535/101 , C12Q2563/149 , C12Q2531/113
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

20. 发明申请

US20060135374A1 Indicating lubricant additive 审中-公开
标题翻译：指示润滑剂添加剂
公开(公告)号：US20060135374A1
公开(公告)日：2006-06-22
申请号：US11013821
申请日：2004-12-16
申请人： Sarah Cooper , Michael Weiner , Stuart MacDonald
发明人： Sarah Cooper , Michael Weiner , Stuart MacDonald
IPC分类号： C10M125/04
CPC分类号： C10M169/044 , C10M171/007 , C10M2201/05 , C10M2215/08 , C10M2215/16 , C10M2217/044 , C10N2210/01 , C10N2210/02 , C10N2210/08 , C10N2220/03 , C10N2240/56 , C10N2250/16 , F16C33/106 , F16C33/109
摘要： An indicating lubricant additive comprising a color-changable polymer having an outer layer of a first color, and an intermediate layer of a second color; and a lubricant sensing dipstick comprising a circuit housing, an elongated body having a proximal end and a distal end, and lubricant sensing means disposed at said distal end, wherein in one embodiment, the sensing means detects a change in the indicating lubricant additive that is. present in a lubricant.
摘要翻译：一种显示润滑剂添加剂，其包含具有第一颜色的外层的颜色变化的聚合物和第二颜色的中间层; 以及润滑剂感测量尺，其包括电路壳体，具有近端和远端的细长体，以及设置在所述远端处的润滑剂感测装置，其中在一个实施例中，感测装置检测指示润滑剂添加剂的变化，。存在润滑剂。

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