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    • 3. 发明申请
    • Halloysite microtubule processes, structures, and compositions
    • 高岭土微管过程,结构和组成
    • US20070292459A1
    • 2007-12-20
    • US11183417
    • 2005-07-18
    • Sarah CooperAmara Angelica
    • Sarah CooperAmara Angelica
    • A61K9/14A61K8/02
    • A61K9/0092A61K8/02A61K8/26A61Q11/00A61Q19/00
    • A composition for use in the delivery of a first active agent and a second active agent, the first active agent being sequentially deliverable after the second active agent, the composition comprising hollow mineral microtubules, each of the hollow mineral microtubules having a length, and opposing ends; and including a cylindrical wall, and a hollow lumen; and a central region, an intermediate region, and an outer region along the length; and within the microtubules, the first active agent disposed within the lumen in the central region of the microtubules, and the second active agent disposed within the lumen in the intermediate region of the microtubules. The composition may also be provided for the delivery of three or more active agents in sequence. There is further provided methods for making the compositions of the present invention.
    • 一种用于递送第一活性剂和第二活性剂的组合物,所述第一活性剂在所述第二活性剂之后可顺序递送,所述组合物包含中空矿物质微管,每个所述中空矿物质微管具有长度,并且相对 结束 并且包括圆柱形壁和中空管腔; 以及沿该长度的中心区域,中间区域和外部区域; 并且在所述微管内,所述第一活性剂设置在所述微管的中心区域内的所述内腔内,所述第二活性剂设置在所述微管的中间区域的内腔内。 还可以提供组合物以顺序递送三种或更多种活性剂。 还提供了制备本发明组合物的方法。