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11. 发明授权

US06855291B2 Method of blood oxygenation 失效
标题翻译：血氧合法
公开(公告)号：US06855291B2
公开(公告)日：2005-02-15
申请号：US10384301
申请日：2003-03-07
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M1/16 , A61M1/36 , A61M1/14 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membranes(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了一种用于血氧的装置和方法。该装置包括具有第一入口以容纳气体过饱和流体例如生理盐水的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。联接到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到其中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其他类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成含氧血液，再次输送到患者或其他部位。

12. 发明授权

US06602467B1 Apparatus and method for blood oxygenation 失效
标题翻译：用于血氧的设备和方法
公开(公告)号：US06602467B1
公开(公告)日：2003-08-05
申请号：US09410344
申请日：1999-09-30
申请人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
发明人： Vincent Divino, Jr. , William R. Patterson , Jeffrey L. Creech , Stephen E. Myrick
IPC分类号： A61M114
CPC分类号： A61M1/3626 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M25/0028 , A61M25/0029 , A61M2025/0031 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , B01F3/04758 , C01B13/02 , Y10S261/28 , A61M2202/0007
摘要： An apparatus and method for blood oxygenation are provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly. The liquid-to-liquid oxygenation assembly includes a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The mixed fluid exits the chamber via an outlet for delivery to a patient.
摘要翻译：提供了一种用于血氧的装置和方法。该装置有利地包括液体 - 液体氧合装置。液体 - 液体氧合组件包括具有用于第一气体过饱和流体和第二流体（例如血液）的入口的可加压室。入口有利地位于混合室中，使得第一流体和第二流体通常彼此进入混合室，以促进混合和液体 - 液体气体的转移。混合流体通过出口离开室以输送给患者。

13. 发明申请

US20120065482A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20120065482A1
公开(公告)日：2012-03-15
申请号：US13193602
申请日：2011-07-29
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Dan Welsh , Steve Bernard , John O'Mahony , Dave McMahon , Victor Gerald Grafe , Dave Tobler , William R. Patterson , Donald W. Landry , James H. Macemon , Russell Abbink
IPC分类号： A61B5/145
CPC分类号： A61B5/150221 , A61B5/0215 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61M2005/1588 , A61M2039/0009
摘要： The present invention provides methods and apparatuses related to measurement of analytes, including measurements of analytes in samples withdrawn from a patient.
摘要翻译：本发明提供了与分析物的测量相关的方法和装置，包括从患者抽出的样品中的分析物的测量。

14. 发明授权

US07820102B2 Disposable cartridge for producing gas-enriched fluids 有权
标题翻译：用于生产富含气体的流体的一次性筒
公开(公告)号：US07820102B2
公开(公告)日：2010-10-26
申请号：US10402463
申请日：2003-03-28
申请人： Stephen E. Myrick , Gregory P. Watson , William R. Patterson , Paul J. Zalesky
发明人： Stephen E. Myrick , Gregory P. Watson , William R. Patterson , Paul J. Zalesky
IPC分类号： A61M1/00 , A61M37/00
CPC分类号： A61M1/3621 , A61M1/32 , A61M1/3626 , A61M2202/0208 , A61M2202/0476 , B01F3/04758
摘要： A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiologic fluid under pressure to an atomizer. The atomizer delivers fluid droplets into a gas-pressurized atomization chamber to enrich the physiologic fluid with the gas. The gas-enriched physiologic fluid is delivered to a mixing chamber in the cartridge where the gas-enriched physiologic fluid is mixed with a bodily fluid, such as blood, to create a gas-enriched bodily fluid.
摘要翻译：装置产生气体富集的生理流体并将其与体液结合以产生富含气体的体液。该装置可以采取一次性盒式的形式。药筒可以包括用于将生理液体在压力下输送到雾化器的流体供应室。雾化器将流体液滴输送到气体加压的雾化室中以与气体一起富集生理液体。将气体富集的生理液体输送到药筒中的混合室，其中富含气体的生理液体与诸如血液的体液混合，以产生富含气体的体液。

15. 发明授权

US06387324B1 Apparatus and method for blood oxygenation 有权
公开(公告)号：US06387324B1
公开(公告)日：2002-05-14
申请号：US09409952
申请日：1999-09-30
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M114
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.

16. 发明申请

US20100168535A1 METHODS AND APPARATUSES RELATED TO BLOOD ANALYTE MEASUREMENT SYSTEM 审中-公开
标题翻译：与血液分析仪测量系统相关的方法和装置
公开(公告)号：US20100168535A1
公开(公告)日：2010-07-01
申请号：US12714100
申请日：2010-02-26
申请人： Mark Ries Robinson , William R. Patterson , Richard P. Thompson , Shonn Hendee , James H. Macemon
发明人： Mark Ries Robinson , William R. Patterson , Richard P. Thompson , Shonn Hendee , James H. Macemon
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2230/201
摘要： The present invention relates to a blood analyte measurement system for the procurement of blood samples for measurement of blood properties such as analyte concentration or analyte presence. A blood access system can be coupled with a measurement system such as an electrochemical sensor, and can also be used with other measurement modalities. Embodiments of the present invention can facilitate accurate measurement of blood glucose by the clinician in a sterile manner. Embodiments of the present invention can also enable the calibration of the sensor at one or more calibration points. One desired analyte of measurement is glucose for the effective implementation of glycemic control protocols. Embodiments of the present invention can also be used for the measurement of other analytes such as arterial blood gases, lactate, hemoglobin, potassium and urea. Additionally, embodiments of the present invention can function effectively on a variety of blood access points and specifically enables glucose monitoring in an existing arterial line that is already in place for hemodynamic monitoring. The present invention does not consume a significant amount of blood. Some embodiments of the present invention can re-infuse the blood into the patient, which can facilitate operation of the system in a sterile manner.
摘要翻译：本发明涉及一种用于血液分析物测量系统，用于采血用于测量血液特性如分析物浓度或分析物存在。血液存取系统可以与诸如电化学传感器的测量系统耦合，并且还可以与其它测量模式一起使用。本发明的实施方案可以促进临床医生以无菌方式精确测量血糖。本发明的实施例还可以实现在一个或多个校准点处的传感器的校准。一个期望的测量分析物是用于有效实施血糖控制方案的葡萄糖。本发明的实施方案也可用于测量其它分析物，例如动脉血气，乳酸，血红蛋白，钾和尿素。此外，本发明的实施例可以有效地在各种血液接入点上起作用，并且具体地实现已经存在于用于血液动力学监测的现有动脉管线中的葡萄糖监测。本发明不消耗大量的血液。本发明的一些实施例可以将血液重新注入患者体内，这可以以无菌的方式促进系统的操作。

17. 外观设计

USD497989S1 Cartridge for generating gas-enriched fluids 失效
标题翻译：用于产生富含气体的流体的墨盒
公开(公告)号：USD497989S1
公开(公告)日：2004-11-02
申请号：US29156499
申请日：2002-03-01
申请人： Stephen E. Myrick , Mark S. Buhr , William R. Patterson , Gregory P. Watson
设计人： Stephen E. Myrick , Mark S. Buhr , William R. Patterson , Gregory P. Watson

18. 发明授权

US06622542B2 Bubble detector and method of use thereof 有权
标题翻译：气泡检测器及其使用方法
公开(公告)号：US06622542B2
公开(公告)日：2003-09-23
申请号：US09813072
申请日：2001-03-20
申请人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
发明人： Daw J. Derek , Jeffrey L. Creech , William R. Patterson
IPC分类号： G01N2900
CPC分类号： G01N35/08 , A61M1/32 , A61M1/3626 , A61M2202/0476 , A61M2209/02 , G01N2291/015 , G01N2291/02433 , G01N2291/02466
摘要： A bubble detector utilizes an ultrasonic transducer to sample bubbles as they pass the transducer. The envelope of the return signal is analyzed to determine the volume of each sampled bubble. If the total volume of bubbles sampled within a certain period of time exceeds a desired maximum volume, the bubble detector may initiate a system shut down. A bubble detector can be evaluated or calibrated by introducing bubbles into a conduit, detecting the bubbles introduced into the conduit using visual inspection or a bubble detector of known resolution and comparing the results with the examination of a bubble detector under evaluation.
摘要翻译：气泡检测器利用超声波换能器在气泡通过传感器时进行取样。分析返回信号的包络线以确定每个采样气泡的体积。如果在一定时间内采样的气泡的总体积超过所需的最大体积，则气泡检测器可能会启动系统关闭。气泡检测器可以通过将气泡引入管道中进行评估或校准，使用目视检查或者已知分辨率的气泡检测器检测导入导管的气泡，并将结果与正在评估的气泡检测器进行比较。

19. 发明授权

US06613280B2 Disposable cartridge for producing gas-enriched fluids 有权
公开(公告)号：US06613280B2
公开(公告)日：2003-09-02
申请号：US09813062
申请日：2001-03-20
申请人： Stephen E. Myrick , Gregory P. Watson , William R. Patterson , Paul J. Zalesky
发明人： Stephen E. Myrick , Gregory P. Watson , William R. Patterson , Paul J. Zalesky
IPC分类号： A61M114
CPC分类号： A61M1/3621 , A61M1/32 , A61M1/3626 , A61M2202/0208 , A61M2202/0476 , B01F3/04758
摘要： A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiologic fluid under pressure to an atomizer. The atomizer delivers fluid droplets into a gas-pressurized atomization chamber to enrich the physiologic fluid with the gas. The gas-enriched physiologic fluid is delivered to a mixing chamber in the cartridge where the gas-enriched physiologic fluid is mixed with a bodily fluid, such as blood, to create a gas-enriched bodily fluid.

20. 发明授权

US06533766B1 Coating medical device surfaces for delivering gas-supersaturated fluids 有权
标题翻译：涂覆医疗器械表面，用于输送气体过饱和流体
公开(公告)号：US06533766B1
公开(公告)日：2003-03-18
申请号：US09466626
申请日：1999-12-17
申请人： William R. Patterson , Jeffrey L. Creech
发明人： William R. Patterson , Jeffrey L. Creech
IPC分类号： A61M3100
CPC分类号： A61M1/1698 , A61L29/08 , A61L33/0011 , A61L33/0017 , A61M1/3613 , A61M1/3621 , A61M1/3626 , A61M25/0029 , A61M2025/0031 , A61M2025/0037 , A61M2202/0476
摘要： A method is provided of using biocompatible surface-active agents to impart improved characteristics to a surface contacting a gas-supersaturated fluid, advantageously by forming on the surface a coating including an adsorbed biocompatible surface-active agent promoting surface charge neutralization or surface energy reduction, and of providing a surface contacting a gas-supersaturated fluid, the surface having such improved characteristics.
摘要翻译：提供了使用生物相容性表面活性剂赋予与气体过饱和流体接触的表面改进特性的方法，有利地通过在表面上形成包含促进表面电荷中和或表面能降低的吸附的生物相容性表面活性剂的涂层，并且提供与气体过饱和流体接触的表面，该表面具有这样改进的特性。

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