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11. 发明申请

US20110298926A1 PARKING ASSISTANCE APPARATUS AND PARKING ASSISTANCE METHOD 审中-公开
标题翻译：停车辅助设备和停车辅助方法
公开(公告)号：US20110298926A1
公开(公告)日：2011-12-08
申请号：US13202004
申请日：2010-02-25
申请人： Hiroshi Katsunaga , Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Koji Hika , Keisuke Inoue
发明人： Hiroshi Katsunaga , Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Koji Hika , Keisuke Inoue
IPC分类号： H04N7/18
CPC分类号： B62D15/027 , G06K9/00798 , G06K9/00912 , G06T7/73 , G06T2207/30208 , G06T2207/30264 , G08G1/16 , G08G1/168
摘要： Provided is a parking assistance apparatus utilizing a fixed target by taking an image thereof, the parking assistance apparatus being capable of recognizing the fixed target with high recognition accuracy while using simple image recognition processing. A mark (M) includes a plurality of illuminators (1). Sets of the plurality of illuminators (1) form characteristic points C1 to C4. Turn-ON request generation means (36) of a vehicle-side device (20) sequentially generates turn-ON requests for each characteristic point and transmits the generated turn-ON requests to a parking-lot-side device (10). A display control unit (11) of the parking-lot-side device (10) turns ON the characteristic points based on the turn-ON requests. An image recognition unit (31) of the vehicle-side device (20) performs image recognition for the characteristic points sequentially. Using the recognition result, positional parameter calculation means (34) of the vehicle-side device (20) calculates positional parameters of a camera with respect to the mark (M).
摘要翻译：提供一种通过拍摄图像来利用固定目标的停车辅助装置，在使用简单的图像识别处理的同时，能够以高识别精度识别固定目标的停车辅助装置。标记（M）包括多个照明器（1）。多个照明器（1）的组合形成特征点C1〜C4。车辆侧设备（20）的接通请求产生装置（36）顺序地产生每个特征点的接通请求，并将生成的接通请求发送到停车场侧设备（10）。停车场侧装置（10）的显示控制单元（11）基于接通请求接通特征点。车辆侧装置（20）的图像识别单元（31）依次对特征点进行图像识别。使用识别结果，车辆侧装置（20）的位置参数计算装置（34）计算相机相对于标记（M）的位置参数。

12. 发明申请

US20090306059A1 CYCLIC AMINE DERIVATIVE HAVING SUBSTITUTED ALKYL GROUP 审中-公开
标题翻译：具有取代的烷基的环胺衍生物
公开(公告)号：US20090306059A1
公开(公告)日：2009-12-10
申请号：US11915522
申请日：2006-05-26
申请人： Tomio Kimura , Naoki Tanaka , Hiroyuki Kobayashi , Atsuhiro Sugidachi
发明人： Tomio Kimura , Naoki Tanaka , Hiroyuki Kobayashi , Atsuhiro Sugidachi
IPC分类号： A61K31/541 , C07D413/06 , A61K31/5377 , C07D417/06 , C07D401/06 , A61K31/4545 , A61P7/02
CPC分类号： F16D3/2233 , F16D2003/22309 , Y10T403/32655
摘要： A compound having the general formula (I), pharmacologically acceptable salts thereof or prodrugs thereof: [wherein R1 represents a hydrogen atom, a C1-C6 alkyl group which may be substituted, a C3-C6 cycloalkyl group which may be substituted, a C1-C6 alkoxy group which may be substituted or a C6-C10 aryl group which may be substituted; R2 represents a hydrogen atom, a halogen atom, a carboxy group, a C2-C7 alkoxycarbonyl group, a carbamoyl group, a cyano group, a C1-C6 alkyl group, a halogeno C1-C6 alkyl group, a C1-C6 alkyl group substituted by a heteroaryl group, a C1-C6 alkoxy group, a halogeno C1-C6 alkoxy group, a hydroxy C1-C6 alkyl group, a C2-C12 alkoxyalkyl group, a formyl group, a C2-C7 alkanoyl group, a C4-C7 cycloalkylcarbonyl group, a C2-C7 alkylcarbamoyl group, a di(C1-C6 alkyl)carbamoyl group, a group of formula R4—CO—CR5R6—(CH2)m—, a group of formula R7—CO—(CH2)l—N(R8)— or a sulfamoyl C1-C6 alkyl group; R3 represents a substituted C1-C6 alkyl group, a heterocyclyl group or a heterocyclyl group substituted with 1 to 5 substituents; X1, X2, X3, X4 and X5 each independently represents a hydrogen atom, a halogen atom, an amino group, a carboxy group, a carbamoyl group, a cyano group, a nitro group, a C1-C6 alkyl group, a halogeno C1-C6 alkyl group, a C1-C6 alkoxy group, or a halogeno C1-C6 alkoxy group; and n represents an integer of 0 to 2].
摘要翻译：具有通式（I）的化合物，其药学上可接受的盐或其前药：其中R1表示氢原子，可被取代的C1-C6烷基，可被取代的C3-C6环烷基，C1 可被取代的-C6烷氧基或可被取代的C6-C10芳基; R2表示氢原子，卤素原子，羧基，C2-C7烷氧基羰基，氨基甲酰基，氰基，C1-C6烷基，卤代C1-C6烷基，C1-C6烷基被杂芳基，C 1 -C 6烷氧基，卤代C 1 -C 6烷氧基，羟基C 1 -C 6烷基，C 2 -C 12烷氧基烷基，甲酰基，C 2 -C 7烷酰基， C7环烷基羰基，C2-C7烷基氨基甲酰基，二（C1-C6烷基）氨基甲酰基，式R4-CO-CR5R6-（CH2）m-的基团，式R7-CO-（CH2）（R8） - 或氨磺酰基C1-C6烷基; R 3表示取代的C 1 -C 6烷基，杂环基或被1至5个取代基取代的杂环基; X1，X2，X3，X4和X5各自独立地表示氢原子，卤素原子，氨基，羧基，氨基甲酰基，氰基，硝基，C1-C6烷基，卤代C1 C 1-6烷基，C 1 -C 6烷氧基或卤代C 1 -C 6烷氧基; n表示0〜2的整数]。

13. 发明授权

US07295227B1 Apparatus for assisting steering of vehicle when backing 有权
标题翻译：用于辅助车辆转向的装置
公开(公告)号：US07295227B1
公开(公告)日：2007-11-13
申请号：US09484316
申请日：2000-01-18
申请人： Goro Asahi , Hisashi Kuriya , Masashi Ushino , Tomio Kimura , Kousuke Teramura , Kazunori Shimazaki , Kanji Hattori , Satoshi Yamada
发明人： Goro Asahi , Hisashi Kuriya , Masashi Ushino , Tomio Kimura , Kousuke Teramura , Kazunori Shimazaki , Kanji Hattori , Satoshi Yamada
IPC分类号： H04N7/00 , H04N7/18
CPC分类号： G01S15/931 , B60R1/00 , B60R2300/301 , B60R2300/302 , B60R2300/305 , B60R2300/806 , B60R2300/8093 , B62D15/0275 , B62D15/028 , G01S15/025 , G01S2015/935 , H04N7/183
摘要： A steering assist apparatus that assists a driver when backing a vehicle in an S-shaped path or parallel parking. The apparatus displays guidance marking on a monitor screen and the driver refers to the guidance marking, which permits the driver to easily back the vehicle to a desired position. The apparatus includes a camera, a monitor, an angle sensor, obstacle sensors, an image processing unit, a controller and a monitor controller. The image processing unit computes the predicted path of the vehicle at the current wheel angle. The monitor shows an image captured by the camera. The image processing unit generates data representing a guidance marking based on the predicted path and superimposes the marking on the monitor screen. The location of the marking on the screen is determined based on the current wheel angle. The marking represents part of the predicted path. Specifically, the marking matches the width of the vehicle. In the monitor screen, a marking is separated from the rear bumper of the vehicle by a distance corresponding to the wheelbase of the vehicle.
摘要翻译：一种辅助驾驶员在将车辆背置在S形路径或平行停车场时的转向辅助装置。该装置在监视器屏幕上显示引导标记，并且驾驶员参考引导标记，其允许驾驶员容易地将车辆返回到期望的位置。该装置包括照相机，监视器，角度传感器，障碍传感器，图像处理单元，控制器和监视器控制器。图像处理单元以当前车轮角度计算车辆的预测路径。显示器显示相机拍摄的图像。图像处理单元基于预测路径产生表示引导标记的数据，并将标记叠加在监视器屏幕上。基于当前车轮角度确定屏幕上的标记位置。标记代表预测路径的一部分。具体地，该标记与车辆的宽度相匹配。在监视器屏幕中，标记与车辆的后保险杠分开与车辆的轴距相对应的距离。

14. 发明授权

US07122666B2 Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses 失效
标题翻译：杂芳基取代的吡咯衍生物，其制备及其治疗用途
公开(公告)号：US07122666B2
公开(公告)日：2006-10-17
申请号：US10354648
申请日：2003-01-30
申请人： Tomio Kimura , Akira Nakao , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
发明人： Tomio Kimura , Akira Nakao , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
IPC分类号： C07D207/00 , C07D209/00
CPC分类号： C07D451/02 , C07D401/04 , C07D401/14 , C07D453/02 , C07D455/02 , C07D471/04 , C07D487/04
摘要： Compounds having activity against production of an inflammatory cytokine of formula (I)′: A′ is pyrrole; R1′ is phenyl or naphthyl; R2′ is pyridyl or pyrimidinyl; R3′ is (IIa)′, (IIb)′ or (IIc)′: m′ is 1; E′ is nitrogen; D′ is >C(R5′)—, R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 5-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′ is hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′ is alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′ is oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.
摘要翻译：具有抗式产生式（I）的炎性细胞因子的活性化合物的化合物：A'是吡咯; R 1是苯基或萘基; R 2是吡啶基或嘧啶基; （IIa）'，（IIb）'或（IIc）'：m'为1; E'是氮; D'是> C（R 5'） - ，R 5'是氢，取代基α'或取代基β'; B'是含氮5元杂环; R 4'是1至3个取代基α'，取代基β'和取代基γ'的取代基; R 1'和R 3'连接到与R 2'连接的吡咯原子相邻的吡咯的两个原子上; 取代基α'是羟基，硝基，氰基，卤素，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基或-NR a R b B。 R a，O和R b'是氢，烷基，烯基，炔基，芳烷基或烷基磺酰基，或者R a'和R“ b'与氮原子形成杂环基; 取代基β'是烷基，烯基，炔基，芳烷基或环烷基; 取代基γ'是氧代，羟基亚氨基，烷氧基亚氨基，亚烷基，亚烷基二氧基，烷基亚磺酰基，烷基磺酰基，芳基，芳氧基，亚烷基或芳亚烷基。

15. 发明授权

US06887893B1 Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia 失效
标题翻译：用于治疗和预防肿瘤，肿瘤相关疾病和恶病质的方法和组合物
公开(公告)号：US06887893B1
公开(公告)日：2005-05-03
申请号：US09212556
申请日：1998-12-16
申请人： Shinichi Kurakata , Masaharu Hanai , Saori Kanai , Tomio Kimura
发明人： Shinichi Kurakata , Masaharu Hanai , Saori Kanai , Tomio Kimura
IPC分类号： A61K31/10 , A61K31/18 , A61K31/255 , A61K31/341 , A61K31/351 , A61K31/352 , A61K31/36 , A61K31/365 , A61K31/40 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/5415 , A61P3/00 , A61P35/00 , C07D20060101 , C07D207/325 , C07D207/333 , C07D405/10 , C07D405/12 , C07D405/00
CPC分类号： A61K31/541 , A61K31/10 , A61K31/18 , A61K31/255 , A61K31/341 , A61K31/351 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/5415
摘要： Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumors and tumor-related disorders and cachexia.
摘要翻译：某些环氧合酶-2抑制剂可用于治疗和预防肿瘤和肿瘤相关疾病和恶病质。

16. 发明申请

US20050004109A1 Methods and compositions for the treatment and prevention of tumors, tumor-related disorders and cachexia 审中-公开
公开(公告)号：US20050004109A1
公开(公告)日：2005-01-06
申请号：US10902249
申请日：2004-07-29
申请人： Shinichi Kurakata , Masaharu Hanai , Saori Kanai , Tomio Kimura
发明人： Shinichi Kurakata , Masaharu Hanai , Saori Kanai , Tomio Kimura
IPC分类号： A61K31/10 , A61K31/18 , A61K31/255 , A61K31/341 , A61K31/351 , A61K31/352 , A61K31/36 , A61K31/365 , A61K31/40 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/5415 , A61P3/00 , A61P35/00 , C07D20060101 , C07D207/325 , C07D207/333 , C07D405/10 , C07D405/12
CPC分类号： A61K31/541 , A61K31/10 , A61K31/18 , A61K31/255 , A61K31/341 , A61K31/351 , A61K31/352 , A61K31/365 , A61K31/40 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/5415
摘要： Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumors and tumor-related disorders and cachexia.

17. 发明授权

US06837199B2 Valve actuating apparatus for internal combustion engine 失效
标题翻译：内燃机气门执行装置
公开(公告)号：US06837199B2
公开(公告)日：2005-01-04
申请号：US10637007
申请日：2003-08-08
申请人： Katsuya Matsuura , Hitoshi Takahashi , Masaki Takayama , Mitsuru Sugimoto , Teruyoshi Morita , Tomio Kimura
发明人： Katsuya Matsuura , Hitoshi Takahashi , Masaki Takayama , Mitsuru Sugimoto , Teruyoshi Morita , Tomio Kimura
IPC分类号： F01L1/26 , F01L13/00 , F02D13/02 , F02D15/00 , F02D41/04 , F02D41/06 , F02D41/08 , F01L1/34
CPC分类号： F02D13/0207 , F01L1/022 , F01L1/267 , F01L13/0036 , F01L2800/00 , F02D13/0203 , F02D13/0234 , F02D13/0257 , F02D13/0269 , Y02T10/142
摘要： A valve actuating apparatus for an internal combustion engine selectively operating in the normal Otto cycle or the Miller cycle is provided which enables the engine to achieve stable combustion and improved fuel economy during cruising or in a low-load engine operating region. A delayed-closing cam for Miller cycle operation and a normal cam having a cam profile for earlier valve-closing timing of the intake valve than a cam profile of the delayed-closing cam are provided on a camshaft. A cam profile-switching mechanism switches between the delayed-closing cam and the normal cam, for opening and closing the intake valve. An ECU controls the switching mechanism such that when a detected operating condition of the engine indicates starting or idling, the intake valve is operated by the normal cam, and when the detected operating condition indicates cruising, the intake valve is operated by the delayed-closing cam.
摘要翻译：提供了一种用于在正常奥托循环或米勒循环中选择性操作的内燃机的阀致动装置，其使得发动机能够在巡航期间或在低负载发动机运行区域中实现稳定的燃烧和改善的燃料经济性。在凸轮轴上设置有用于米勒循环操作的延迟关闭凸轮和具有凸轮轮廓的普通凸轮，凸轮轮廓用于进气门的早期阀关闭正时，而不是延迟关闭凸轮的凸轮轮廓。凸轮轮廓切换机构在延迟关闭凸轮和正常凸轮之间切换，用于打开和关闭进气门。 ECU控制切换机构，使得当检测到的发动机的运转状况指示起动或空转时，进气门由正常凸轮操作，当检测到的运转状态表示巡航时，进气门由延迟关闭凸轮

18. 发明授权

US06673804B1 Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US06673804B1
公开(公告)日：2004-01-06
申请号：US09678294
申请日：2000-10-02
申请人： Tomio Kimura , Shoujiro Miyazaki , Keiji Ueda , Kazuhiko Tanzawa , Shigeru Ushiyama , Wataru Takasaki
发明人： Tomio Kimura , Shoujiro Miyazaki , Keiji Ueda , Kazuhiko Tanzawa , Shigeru Ushiyama , Wataru Takasaki
IPC分类号： C07D20946
CPC分类号： C07D209/48 , C07C311/29 , C07D209/66 , C07D233/78 , C07D239/54 , C07D239/70 , C07D239/96 , C07D275/06 , C07D277/34 , C07D401/12 , C07D401/14 , C07D471/04 , C07D473/04 , C07D475/02 , C07D495/04
摘要： A compound of the formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof: R1 is H or NHOH. R2 is H, optionally substituted alkyl, cycloalkyl or a group —AR6. A is an alkylene which may be optionally interrupted by O, —S(O)m— or —N(R9). R6 is a group (II), (III), (IV) X is O, S, —N(R10)—, —C(R11)(R12)—. Y is O, CO, —S(O)n—, —N(R10)—, —C(R11)(R12)—. Each of R7 and R8 is H, alkyl, COOH, optionally substituted alkyl, etc. Each of R9, R10, R11, and R12 is H, alkyl, etc. Each of m and n is 0 to 2. R3 is H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl. R4 is optionally substituted (hetero)arylene. R5 is optionally substituted alkyl, optionally substituted (hetero)aryl. These compounds have matrixmetalloproteinase—13 inhibitory activity and aglycanase inhibitory activity.
摘要翻译：式（I）的化合物或其药理学上可接受的盐，酯或其它衍生物：R 1是H或NHOH。 R 2是H，任选取代的烷基，环烷基或基团-AR 6 .A是可以任选被O，-S（O）m - 或-N（R 9）间隔的亚烷基。 R 6为（II），（III），（IV）X为O，S，-N（R 10） - ， - C（R 11）（R 12） Y是O，CO，-S（O）n - ， - N（R 10） - ， - C（R 11）（R 12） - 。 R 7和R 8中的每一个是H，烷基，COOH，任选取代的烷基等。R 9，R 10，R 11和R 12中的每一个是H，烷基等等。m和n各自为0至2.R 3为H，任选取代的烷基，任选取代的环烷基，任选取代的烯基，任选取代的炔基。 R 4是任选取代的（杂）亚芳基。 R 5是任选取代的烷基，任选取代的（杂）芳基。这些化合物具有基质金属蛋白酶-13抑制活性和糖苷连结酶抑制活性。

19. 发明授权

US5688791A Aryl group-or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-hiv agent 失效
标题翻译：芳基或芳族杂环基取代的氨基喹诺酮衍生物和抗-Hiv剂
公开(公告)号：US5688791A
公开(公告)日：1997-11-18
申请号：US526225
申请日：1995-09-11
申请人： Tomio Kimura , Tetsushi Katsube
发明人： Tomio Kimura , Tetsushi Katsube
IPC分类号： C07D487/04 , A61K31/4375 , A61K31/47 , A61K31/535 , A61P31/18 , C07D215/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/06 , C07D487/14 , C07D498/06 , C07D513/04 , C07D513/06 , A61K31/54 , C07D401/02 , C07D403/02
CPC分类号： C07D215/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/06 , C07D513/04 , C07D513/06 , Y10S514/934
摘要： Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): ##STR1## wherein each of the substitutents are defined in the specification, or a salt of the compound, and an AIDS curing agent containing the same as an effective ingredient.
摘要翻译：公开了由式（Ia），（Ib）或（Ic）表示的芳基或杂环基取代的氨基喹诺酮化合物：（Ia）取代基在说明书中定义，或化合物的盐，和含有该有效成分的AIDS固化剂。

20. 发明授权

US4481362A Process for preparing optically active tryptophanes 失效
标题翻译：光学活性色氨酸的制备方法
公开(公告)号：US4481362A
公开(公告)日：1984-11-06
申请号：US494692
申请日：1983-05-17
申请人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
发明人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
IPC分类号： C12N9/80 , C12P13/04 , C12P13/22 , C12P41/00 , C12R1/025 , C12R1/05 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/145 , C12R1/20 , C12R1/225 , C12R1/265 , C12R1/32 , C12R1/365 , C12R1/38 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/65 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/78 , C12R1/80 , C12R1/84 , C12R1/845 , C12R1/85 , C12R1/88 , C12R1/885 , C07D209/20
CPC分类号： C12N9/80 , C12P13/04 , C12P13/227
摘要： Biochemical optical resolution of DL-tryptophanes in which DL-tryptophane amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-tryptophane amides in racemic DL-tryptophane amides are asymmetrically hydrolyzed to form optically active L-tryptophanes at a high yield and almost all D-tryptophane amides remain without being subjected to hydrolysis. The resultant D-tryptophane amides are readily hydrolyzed, after separating L-tryptophanes, to form optically active D-tryptophanes at a high yield.
摘要翻译：描述DL-色氨酰胺与能够产生酰胺酶的微生物或其处理产物相互作用的DL-色氨酸的生物化学光学拆分。外消旋的DL-色氨酰胺中的L-色氨酰胺不对称地水解，以高产率形成光学活性的L-色氨酸，并且几乎所有的D-色氨酸酰胺保持不被水解。得到的D-色氨酰胺在分离L-色氨酸后容易水解，以高产率形成光学活性的D-色氨酸。

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